USRE35338E - Sustained release delivery of water soluble bio-molecules and drugs using phosphokipid-coated microcrystals, microdroplets and high-concentration lipsomes - Google Patents
Sustained release delivery of water soluble bio-molecules and drugs using phosphokipid-coated microcrystals, microdroplets and high-concentration lipsomes Download PDFInfo
- Publication number
- USRE35338E USRE35338E US08/304,225 US30422594A USRE35338E US RE35338 E USRE35338 E US RE35338E US 30422594 A US30422594 A US 30422594A US RE35338 E USRE35338 E US RE35338E
- Authority
- US
- United States
- Prior art keywords
- water
- solid
- membrane
- particles
- bio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Definitions
- the core material can also be selected from water-insoluble drugs, including but not limited to oxytetracycline (antibiotic), phenylbutazone (anti-inflammatory), cyclosporin (immunosuppressant) or an immunostimulating drug.
- water-insoluble drugs including but not limited to oxytetracycline (antibiotic), phenylbutazone (anti-inflammatory), cyclosporin (immunosuppressant) or an immunostimulating drug.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/304,225 USRE35338E (en) | 1990-04-26 | 1994-09-12 | Sustained release delivery of water soluble bio-molecules and drugs using phosphokipid-coated microcrystals, microdroplets and high-concentration lipsomes |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/514,012 US5091188A (en) | 1990-04-26 | 1990-04-26 | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US07/800,520 US5246707A (en) | 1990-04-26 | 1991-12-03 | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
US08/304,225 USRE35338E (en) | 1990-04-26 | 1994-09-12 | Sustained release delivery of water soluble bio-molecules and drugs using phosphokipid-coated microcrystals, microdroplets and high-concentration lipsomes |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/514,012 Continuation US5091188A (en) | 1990-04-26 | 1990-04-26 | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US07/800,520 Reissue US5246707A (en) | 1990-04-26 | 1991-12-03 | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
Publications (1)
Publication Number | Publication Date |
---|---|
USRE35338E true USRE35338E (en) | 1996-09-24 |
Family
ID=24045456
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/514,012 Expired - Lifetime US5091188A (en) | 1990-04-26 | 1990-04-26 | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US08/304,225 Expired - Lifetime USRE35338E (en) | 1990-04-26 | 1994-09-12 | Sustained release delivery of water soluble bio-molecules and drugs using phosphokipid-coated microcrystals, microdroplets and high-concentration lipsomes |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/514,012 Expired - Lifetime US5091188A (en) | 1990-04-26 | 1990-04-26 | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
Country Status (16)
Country | Link |
---|---|
US (2) | US5091188A (en) |
EP (1) | EP0533690B1 (en) |
JP (1) | JP3261129B2 (en) |
KR (1) | KR0159114B1 (en) |
AT (1) | ATE181234T1 (en) |
AU (1) | AU7852891A (en) |
CA (1) | CA2078990C (en) |
DE (1) | DE69131349T2 (en) |
DK (1) | DK0533690T3 (en) |
ES (1) | ES2134776T3 (en) |
GR (1) | GR3030825T3 (en) |
MX (1) | MX25532A (en) |
RU (1) | RU2100030C1 (en) |
TW (1) | TW203559B (en) |
WO (1) | WO1991016068A1 (en) |
ZA (1) | ZA913122B (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2757768A1 (en) * | 1996-12-27 | 1998-07-03 | Biovector Therapeutics Sa | HOMEOCHARGE PARTICULATE VECTOR AND PHARMACEUTICAL OR COSMETIC COMPOSITION CONTAINING THE SAME |
US5895653A (en) * | 1995-03-27 | 1999-04-20 | Tempo G | Adjuvant based on colloidal iron compounds |
US6130200A (en) | 1996-12-20 | 2000-10-10 | Alza Corporation | Gel composition and methods |
US20020127278A1 (en) * | 2000-12-22 | 2002-09-12 | Kipp James E. | Microprecipitation method for preparing submicron suspensions |
US20020150615A1 (en) * | 2001-02-12 | 2002-10-17 | Howard Sands | Injectable pharmaceutical composition comprising microdroplets of a camptothecin |
US6497896B2 (en) | 2001-02-12 | 2002-12-24 | Supergen, Inc. | Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin |
US20030003155A1 (en) * | 2000-12-22 | 2003-01-02 | Kipp James E. | Microprecipitation method for preparing submicron suspensions |
US20030013693A1 (en) * | 1998-02-11 | 2003-01-16 | Rtp Pharma Inc. | Method and composition for treatment of inflammatory conditions |
US6509027B2 (en) | 2001-02-12 | 2003-01-21 | Supergen, Inc. | Injectable pharmaceutical composition comprising coated particles of camptothecin |
US20030031719A1 (en) * | 2000-12-22 | 2003-02-13 | Kipp James E. | Method for preparing submicron particle suspensions |
US20030044433A1 (en) * | 2000-12-22 | 2003-03-06 | Jane Werling | Method for preparing submicron suspensions with polymorph control |
US20030059472A1 (en) * | 2001-09-26 | 2003-03-27 | Sean Brynjelsen | Preparation of submicron sized nanoparticles via dispersion lyophilization |
US20030059435A1 (en) * | 1999-08-24 | 2003-03-27 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
US6541001B1 (en) | 1999-08-24 | 2003-04-01 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
US6576264B1 (en) | 1995-10-17 | 2003-06-10 | Skyepharma Canada Inc. | Insoluble drug delivery |
US20030180367A1 (en) * | 1996-08-22 | 2003-09-25 | Skyepharma Canada, Inc. | Microparticles of water-insoluble substances |
US6634576B2 (en) | 2000-08-31 | 2003-10-21 | Rtp Pharma Inc. | Milled particles |
US6682761B2 (en) | 2000-04-20 | 2004-01-27 | Rtp Pharma, Inc. | Water-insoluble drug particle process |
US20040022862A1 (en) * | 2000-12-22 | 2004-02-05 | Kipp James E. | Method for preparing small particles |
US20040086571A1 (en) * | 2001-02-22 | 2004-05-06 | Skyepharma Canada Inc. | Fibrate-statin combinations with reduced fed-fasted effects |
US20040247661A1 (en) * | 2002-07-03 | 2004-12-09 | Dov Michaeli | Liposomal vaccine |
US20040245662A1 (en) * | 2000-12-22 | 2004-12-09 | Mahesh Chaubal | Method for preparing submicron particles of antineoplastic agents |
US20050169979A1 (en) * | 2002-07-03 | 2005-08-04 | Dov Michaeli | Liposomal vaccine |
US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
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US7939106B2 (en) | 1998-11-20 | 2011-05-10 | Jagotec Ag | Process for preparing a rapidly dispersing solid drug dosage form |
US8263131B2 (en) | 2000-12-22 | 2012-09-11 | Baxter International Inc. | Method for treating infectious organisms normally considered to be resistant to an antimicrobial drug |
US8415329B1 (en) | 1998-05-29 | 2013-04-09 | Jagotec Ag | Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
US8586094B2 (en) | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
US8722091B2 (en) | 2001-09-26 | 2014-05-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion lyophilization |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705187A (en) * | 1989-12-22 | 1998-01-06 | Imarx Pharmaceutical Corp. | Compositions of lipids and stabilizing materials |
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AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
US5552160A (en) * | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
AU3662093A (en) * | 1992-02-14 | 1993-09-03 | Robert Lamb | Phosphate derivatives of vitamin e to protect cells from effects of aging and injury |
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US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
US5336507A (en) * | 1992-12-11 | 1994-08-09 | Sterling Winthrop Inc. | Use of charged phospholipids to reduce nanoparticle aggregation |
US20030073642A1 (en) * | 1993-02-22 | 2003-04-17 | American Bioscience, Inc. | Methods and formulations for delivery of pharmacologically active agents |
US20070117862A1 (en) * | 1993-02-22 | 2007-05-24 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
FR2702160B1 (en) | 1993-03-02 | 1995-06-02 | Biovecteurs As | Synthetic particulate vectors and method of preparation. |
DE19609538A1 (en) * | 1996-03-11 | 1997-09-18 | Basf Ag | Finely divided carotenoid and retinoid suspensions and process for their preparation |
DE4322158C2 (en) * | 1993-07-03 | 1997-04-10 | Rhone Poulenc Rorer Gmbh | Phospholipidic composition and use of such a composition |
US5393461A (en) * | 1993-10-04 | 1995-02-28 | Rtd Corporation | Preparation of stable aqueous emulsions of water-insoluble particles |
DE69633222T2 (en) * | 1995-02-24 | 2005-09-08 | Elan Pharma International Ltd. | NANOPARTICLE DISPERSIONS CONTAINING AEROSOLS |
US5747001A (en) * | 1995-02-24 | 1998-05-05 | Nanosystems, L.L.C. | Aerosols containing beclomethazone nanoparticle dispersions |
US5785975A (en) * | 1995-06-26 | 1998-07-28 | Research Triangle Pharmaceuticals | Adjuvant compositions and vaccine formulations comprising same |
US5931809A (en) * | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
US5834025A (en) | 1995-09-29 | 1998-11-10 | Nanosystems L.L.C. | Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions |
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US8137684B2 (en) | 1996-10-01 | 2012-03-20 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US20070185032A1 (en) * | 1996-12-11 | 2007-08-09 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
AU735406B2 (en) * | 1997-02-27 | 2001-07-05 | Novartis Ag | Pharmaceutical composition |
WO1998047492A1 (en) * | 1997-04-18 | 1998-10-29 | Vertex Pharmaceuticals Incorporated | Nanosized aspartyl protease inhibitors |
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
IL133672A0 (en) * | 1997-06-27 | 2001-04-30 | Vivorx Pharmaceuticals Inc | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
US20060165606A1 (en) * | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
WO1999027961A1 (en) * | 1997-12-02 | 1999-06-10 | Powderject Vaccines, Inc. | Transdermal delivery of particulate vaccine compositions |
US20010003580A1 (en) * | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
US7343710B2 (en) * | 1998-07-03 | 2008-03-18 | I.D.A Limited | Method and apparatus for controlling pests |
GB9814507D0 (en) * | 1998-07-03 | 1998-09-02 | Univ Southampton | A method and apparatus for controlling pests |
US7097849B2 (en) * | 1998-08-19 | 2006-08-29 | Jagotec Ag | Injectable aqueous dispersions of propofol |
DE69930294T2 (en) * | 1998-10-19 | 2006-11-02 | Powderject Vaccines, Inc., Madison | MINIMUM PROMOTERS AND THEIR USE |
US6881723B1 (en) | 1998-11-05 | 2005-04-19 | Powderject Vaccines, Inc. | Nucleic acid constructs |
US6180136B1 (en) * | 1998-11-10 | 2001-01-30 | Idexx Laboratories, Inc. | Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use |
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US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US6251886B1 (en) | 1998-12-07 | 2001-06-26 | Schering Corporation | Methods of using temozolomide in the treatment of cancers |
US6682758B1 (en) | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
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US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
WO2000050009A1 (en) * | 1999-02-26 | 2000-08-31 | Idexx Laboratories, Inc. | Methods for administering pharmacologically active compounds to vertebrates |
US6551842B1 (en) | 1999-03-26 | 2003-04-22 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6511814B1 (en) | 1999-03-26 | 2003-01-28 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6602719B1 (en) | 1999-03-26 | 2003-08-05 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US20030236236A1 (en) * | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
IL148685A0 (en) * | 1999-09-21 | 2002-09-12 | Rtp Pharma Inc | Surface modified particulate compositions of biologically active substances |
US6919009B2 (en) * | 1999-10-01 | 2005-07-19 | Nanoplex Technologies, Inc. | Method of manufacture of colloidal rod particles as nanobarcodes |
US7225082B1 (en) * | 1999-10-01 | 2007-05-29 | Oxonica, Inc. | Colloidal rod particles as nanobar codes |
US20040209376A1 (en) * | 1999-10-01 | 2004-10-21 | Surromed, Inc. | Assemblies of differentiable segmented particles |
US7045049B1 (en) * | 1999-10-01 | 2006-05-16 | Nanoplex Technologies, Inc. | Method of manufacture of colloidal rod particles as nanobar codes |
US20050032226A1 (en) * | 1999-10-01 | 2005-02-10 | Natan Michael J. | Encoded nanoparticles in paper manufacture |
US20040178076A1 (en) * | 1999-10-01 | 2004-09-16 | Stonas Walter J. | Method of manufacture of colloidal rod particles as nanobarcodes |
US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
GB0009773D0 (en) * | 2000-04-19 | 2000-06-07 | Univ Cardiff | Particulate composition |
DE60133270T2 (en) | 2000-05-10 | 2009-04-23 | Jagotec Ag | CRUSHING BY MEANS OF GRINDING BODY |
JP2003535884A (en) | 2000-06-16 | 2003-12-02 | スカイファーマ・カナダ・インコーポレーテッド | Improved injectable dispersion of propofol |
US6579519B2 (en) * | 2000-09-18 | 2003-06-17 | Registrar, University Of Delhi | Sustained release and long residing ophthalmic formulation and the process of preparing the same |
ES2372746T3 (en) * | 2000-09-20 | 2012-01-26 | Jagotec Ag | STABILIZED FIBRATE MICROPARTURES. |
US20100173876A1 (en) * | 2000-12-19 | 2010-07-08 | The Board Of Regents Of The University Of Texas System | Oil-based nsaid compositions and methods for making and using same |
US20040077604A1 (en) | 2001-12-19 | 2004-04-22 | Lenard Lichtenberger | Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity |
CN1543358A (en) | 2000-12-19 | 2004-11-03 | �ÿ���˹ϵͳ��ѧ���»� | Nsaid formulations comprising lecithin oils for protecting the gastrointestinal tract and providing enhanced therapeutic activity |
US20030096013A1 (en) * | 2000-12-22 | 2003-05-22 | Jane Werling | Preparation of submicron sized particles with polymorph control |
US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
EP1383376A4 (en) * | 2001-03-19 | 2006-03-08 | Praecis Pharm Inc | Pharmaceutical formulations for sustained release |
EP1389089B1 (en) * | 2001-03-27 | 2009-08-26 | Phares Pharmaceutical Research N.V. | Method and composition for solubilising a biologically active compound with low water solubility |
AU2002307090A1 (en) * | 2001-04-03 | 2002-10-21 | Surromed, Inc. | Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples |
WO2002080881A2 (en) * | 2001-04-05 | 2002-10-17 | UNIVERSITé LAVAL | Process for making protein delivery matrix and uses thereof |
GB0114532D0 (en) * | 2001-06-14 | 2001-08-08 | Jagotec Ag | Novel compositions |
US6676958B2 (en) * | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
US7758890B2 (en) | 2001-06-23 | 2010-07-20 | Lyotropic Therapeutics, Inc. | Treatment using dantrolene |
GB0119480D0 (en) * | 2001-08-09 | 2001-10-03 | Jagotec Ag | Novel compositions |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
US20030129242A1 (en) * | 2002-01-04 | 2003-07-10 | Bosch H. William | Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer |
KR100836035B1 (en) * | 2002-02-19 | 2008-06-09 | (주)아모레퍼시픽 | Oil-in-water nanoemulsions containing saturated and unsaturated lecithin and cosmetic composition containing the same |
US20080220075A1 (en) * | 2002-03-20 | 2008-09-11 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
AU2003230691A1 (en) * | 2002-03-20 | 2003-10-08 | Elan Pharma International Ltd. | Nanoparticulate compositions of angiogenesis inhibitors |
US7101566B2 (en) * | 2002-06-28 | 2006-09-05 | Ethicon, Inc. | Polymer coated microparticles for sustained release |
US7838034B2 (en) * | 2002-07-30 | 2010-11-23 | Grunenthal Gmbh | Intravenous pharmaceutical form of administration |
US8003690B2 (en) * | 2002-12-13 | 2011-08-23 | Jagotec Ag | Topical nanoparticulate spironolactone formulation |
US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
CA2516667C (en) | 2003-03-04 | 2012-05-29 | Lyotropic Therapeutics, Inc. | Treatment using dantrolene |
US20050019556A1 (en) * | 2003-06-17 | 2005-01-27 | Surromed, Inc. | Labeling and authentication of metal objects |
DE10327839A1 (en) * | 2003-06-20 | 2005-01-05 | Arvinmeritor Gmbh | Vehicle roof module |
US9044381B2 (en) * | 2003-06-24 | 2015-06-02 | Baxter International Inc. | Method for delivering drugs to the brain |
US8986736B2 (en) * | 2003-06-24 | 2015-03-24 | Baxter International Inc. | Method for delivering particulate drugs to tissues |
US20080051373A1 (en) * | 2003-07-31 | 2008-02-28 | The Board Of Regents Of The University Of Texas System | Parenteral preparations of GI-safer phospholipid-associated anti-inflammatories and methods of preparation and use |
US20050049209A1 (en) * | 2003-08-06 | 2005-03-03 | Chen Andrew Xian | Pharmaceutical compositions for delivering macrolides |
JP2005097295A (en) * | 2003-09-01 | 2005-04-14 | Wakunaga Pharmaceut Co Ltd | Stabilized vitamin liquid preparation |
EP1663321B1 (en) | 2003-09-22 | 2012-08-29 | Baxter International Inc. | High-pressure sterilization to terminally sterilize pharmaceutical preparations and medical products |
US20060003002A1 (en) * | 2003-11-03 | 2006-01-05 | Lipocine, Inc. | Pharmaceutical compositions with synchronized solubilizer release |
KR20060123384A (en) * | 2003-12-24 | 2006-12-01 | 가부시키가이샤 엘티티 바이오파마 | Drug-containing nanoparticle, process for producing the same and parenterally administered preparation from the nanoparticle |
US20050202094A1 (en) * | 2004-01-29 | 2005-09-15 | Werling Jane O. | Nanosuspensions of anti-retroviral agents for increased central nervous system delivery |
EP1711163A2 (en) * | 2004-02-05 | 2006-10-18 | Baxter International Inc. | Dispersions prepared by use of self-stabilizing agents |
EP1730516A1 (en) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Method and device for evaluation of pharmaceutical compositions |
KR20070027564A (en) * | 2004-05-28 | 2007-03-09 | 쉐링 코포레이션 | Injectable pharmaceutical suspension comprising posaconazole |
US20060009469A1 (en) * | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
US20060160823A1 (en) * | 2004-05-28 | 2006-07-20 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmaceutical compositions of Posaconazole |
JP2008502706A (en) * | 2004-06-15 | 2008-01-31 | バクスター・インターナショナル・インコーポレイテッド | Ex vivo application of solid particulate therapeutic agents |
WO2006034147A2 (en) * | 2004-09-16 | 2006-03-30 | Abraxis Bioscience, Inc. | Compositions and methods for the preparation and administration of poorly water soluble drugs |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
WO2006138202A2 (en) * | 2005-06-14 | 2006-12-28 | Baxter International Inc. | Pharmaceutical formulations for minimizing drug-drug interactions |
US20070134341A1 (en) * | 2005-11-15 | 2007-06-14 | Kipp James E | Compositions of lipoxygenase inhibitors |
EP2013016B8 (en) | 2006-03-29 | 2014-10-08 | Wayne State University | Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery |
WO2008054508A2 (en) * | 2006-04-13 | 2008-05-08 | Alza Corporation | Stable nanosized amorphous drug |
CN101453982B (en) | 2006-05-30 | 2011-05-04 | 精达制药公司 | Two-piece, internal-channel osmotic delivery system flow modulator |
WO2008002485A2 (en) * | 2006-06-23 | 2008-01-03 | Alza Corporation | Increased amorphous stability of poorly water soluble drugs by nanosizing |
EP2068833B1 (en) * | 2006-07-26 | 2013-01-09 | The Board of Regents of the University of Texas System | Parenteral preparations of gi-safer phospholipid-associated anti-inflammatories and methods of preparation and use |
WO2008021133A2 (en) | 2006-08-09 | 2008-02-21 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
EP2061583B1 (en) * | 2006-09-14 | 2019-04-10 | Yissum Research Development Company, of The Hebrew University of Jerusalem | Organic nanoparticles obtained from microemulsions by solvent evaporation |
AR063704A1 (en) | 2006-09-14 | 2009-02-11 | Makhteshim Chem Works Ltd | PESTICIDE NANOPARTICLES OBTAINED OBTAINED FROM MICROEMULSIONS AND NANOEMULSIONS |
WO2008065502A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein |
WO2008080047A2 (en) * | 2006-12-23 | 2008-07-03 | Baxter International Inc. | Magnetic separation of fine particles from compositions |
WO2008125940A2 (en) * | 2007-04-17 | 2008-10-23 | Pfizer Products Inc. | Nanoparticles comprising non-crystalline drug |
EP2157967B1 (en) | 2007-04-23 | 2013-01-16 | Intarcia Therapeutics, Inc | Suspension formulations of insulinotropic peptides and uses thereof |
US8309129B2 (en) * | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
WO2008135852A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Pharmaceutical compositions comprising nanoparticles and casein |
WO2008135855A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
US8530463B2 (en) * | 2007-05-07 | 2013-09-10 | Hale Biopharma Ventures Llc | Multimodal particulate formulations |
JP2010526822A (en) * | 2007-05-07 | 2010-08-05 | クエスター ファーマシューティカルズ,インク. | Nasal administration of benzodiazepines |
US20080292663A1 (en) * | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
US20080293814A1 (en) * | 2007-05-22 | 2008-11-27 | Deepak Tiwari | Concentrate esmolol |
US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
EP2162120B1 (en) * | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
US20080319039A1 (en) * | 2007-06-25 | 2008-12-25 | Jacqueline Rose Bersch | Unit dosage forms of temozolomide |
US20100215747A1 (en) * | 2007-07-13 | 2010-08-26 | Corey Jay Bloom | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
WO2009039628A1 (en) | 2007-09-27 | 2009-04-02 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
US9724362B2 (en) * | 2007-12-06 | 2017-08-08 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
EP2240162A4 (en) * | 2007-12-06 | 2013-10-09 | Bend Res Inc | Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer |
US20110159078A1 (en) | 2008-01-22 | 2011-06-30 | Vapogenix, Inc | Volatile Anesthetic Compositions and Methods of Use |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
RU2496482C2 (en) | 2008-03-05 | 2013-10-27 | Бакстер Интернэшнл Инк. | Compositions and methods for drug delivery |
US8861813B2 (en) * | 2008-03-13 | 2014-10-14 | Mallinckrodt Llc | Multi-function, foot-activated controller for imaging system |
ES2586032T3 (en) | 2008-03-28 | 2016-10-11 | Hale Biopharma Ventures, Llc | Administration of benzodiazepine compositions |
JP5715051B2 (en) | 2008-06-05 | 2015-05-07 | イムノバクシーン・テクノロジーズ・インコーポレイテッドImmunovaccine Technologies Inc. | Composition comprising carrier comprising liposome, antigen, polynucleotide and continuous phase of hydrophobic substance |
US8173621B2 (en) * | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
GB2462022B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof |
EP2376514A2 (en) * | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Nucleoside analogs |
EP2376088B1 (en) | 2008-12-23 | 2017-02-22 | Gilead Pharmasset LLC | 6-O-Substituted-2-amino-purine nucleoside phosphoramidates |
TW201031675A (en) | 2008-12-23 | 2010-09-01 | Pharmasset Inc | Synthesis of purine nucleosides |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
WO2010129686A1 (en) * | 2009-05-05 | 2010-11-11 | Vapogenix, Inc. | Novel formulations of volatile anesthetics and methods of use for reducing inflammation |
US10952965B2 (en) * | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
TWI598358B (en) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | Nucleoside phosphoramidates |
CN104323981B (en) | 2009-09-28 | 2019-03-12 | 精达制药公司 | The quick foundation and/or termination of basic steady-state drug delivery |
UY33312A (en) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | PURINE NUCLEOSIDE PHOSPHORAMIDATE |
UY33311A (en) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | NUCLEOSID PHOSPHORAMIDATES |
US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
CA2819635A1 (en) | 2010-12-01 | 2012-06-07 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
ES2917973T3 (en) | 2011-06-14 | 2022-07-12 | Neurelis Inc | Benzodiazepine administration |
AU2012315545B2 (en) | 2011-09-29 | 2017-03-09 | Plx Opco Inc. | pH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same |
JP6240077B2 (en) | 2011-10-06 | 2017-11-29 | イムノバクシーン・テクノロジーズ・インコーポレイテッドImmunovaccine Technologies Inc. | Liposome composition comprising an adjuvant that activates or increases its activity and its use |
EP4218808A3 (en) | 2012-03-12 | 2023-08-09 | Advanced BioAdjuvants, LLC | Adjuvant and vaccine compositions |
AU2014227996B2 (en) | 2013-03-15 | 2018-08-23 | Vapogenix, Inc. | Novel analgesic compositions |
RU2541156C1 (en) * | 2013-07-09 | 2015-02-10 | Общество с ограниченной ответственностью Научно-производственное объединение "Клеточные технологии" | Transdermal anthelmintic agent of silicone niosomes with albendazole |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
WO2016196851A2 (en) | 2015-06-03 | 2016-12-08 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
MX2018014016A (en) | 2016-05-16 | 2019-08-01 | Intarcia Therapeutics Inc | Glucagon-receptor selective polypeptides and methods of use thereof. |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
EP3544614A4 (en) | 2016-11-28 | 2020-08-05 | Lipocine Inc. | Oral testosterone undecanoate therapy |
CN110225762A (en) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | The method of the co-administration of continuous administration and drug including GLP-1 receptor stimulating agent |
CA3172595A1 (en) | 2020-03-26 | 2021-09-30 | Ronald Zimmerman | Pharmaceutical carriers capable of ph dependent reconstitution and methods for making and using same |
US11992483B2 (en) | 2021-03-31 | 2024-05-28 | Cali Biosciences Us, Llc | Emulsions for local anesthetics |
CN116687847B (en) * | 2023-06-26 | 2024-03-29 | 石家庄四药有限公司 | Medicine microcrystal injection and preparation method thereof |
Citations (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4053585A (en) * | 1974-06-25 | 1977-10-11 | National Research Development Corporation | Immunological preparations |
US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
US4133874A (en) * | 1976-06-10 | 1979-01-09 | The University Of Illinois Foundation | Lipid encapsulated hemoglobin cells |
GB2046094A (en) * | 1979-04-11 | 1980-11-12 | Nattermann A & Cie | Stabilized parenterally administrable solutions |
US4325871A (en) * | 1979-06-20 | 1982-04-20 | Ricoh Company, Ltd. | Ortho-Bis (2-substituted azostyryl) benzene compounds |
US4331654A (en) * | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
US4411894A (en) * | 1979-06-22 | 1983-10-25 | Hoffmann-La Roche Inc. | Pharmaceutical preparations |
WO1985000011A1 (en) * | 1983-06-17 | 1985-01-03 | Univ Miami | Microdroplets of water-insoluble drugs |
US4515736A (en) * | 1983-05-12 | 1985-05-07 | The Regents Of The University Of California | Method for encapsulating materials into liposomes |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
WO1987004592A1 (en) * | 1986-02-10 | 1987-08-13 | Liposome Technology, Inc. | Controlled-release liposome delivery system |
US4687762A (en) * | 1984-03-31 | 1987-08-18 | Green Cross Corporation | Water soluble drug complex and method for production of same |
US4752442A (en) * | 1986-05-26 | 1988-06-21 | Shoei Chemical Inc. | Bonding wire |
EP0272091A2 (en) * | 1986-12-15 | 1988-06-22 | Nexstar Pharmaceuticals, Inc. | Delivery vehicles with amphiphile-associated active ingredient |
US4756910A (en) * | 1985-11-29 | 1988-07-12 | Kabushiki Kaisha Vitamin Kenkyusyo | Adriamycin-entrapping liposome preparation |
US4761288A (en) * | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
US4762720A (en) * | 1984-09-21 | 1988-08-09 | Shionogi & Co., Ltd. | Process for preparing liposome compositions |
US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
US4806350A (en) * | 1986-04-18 | 1989-02-21 | Norden Laboratories, Inc. | Vaccine formulation |
US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
US4826687A (en) * | 1985-06-06 | 1989-05-02 | National Institute Of Health | Influenza vaccine |
WO1991004011A1 (en) * | 1989-09-20 | 1991-04-04 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
US5030453A (en) * | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4298594A (en) * | 1978-04-14 | 1981-11-03 | Arthur D. Little, Inc. | Xenobiotic delivery vehicles, method of forming them and method of using them |
DE2856333C2 (en) * | 1978-12-27 | 1983-09-22 | A. Nattermann & Cie GmbH, 5000 Köln | Oral medicines with anti-inflammatory effects |
US4421747A (en) * | 1978-12-27 | 1983-12-20 | A. Nattermann & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
US4378354A (en) * | 1978-12-27 | 1983-03-29 | A. Nattermann & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
US4345588A (en) * | 1979-04-23 | 1982-08-24 | Northwestern University | Method of delivering a therapeutic agent to a target capillary bed |
AR220263A1 (en) * | 1980-02-19 | 1980-10-15 | Bago Lab Sa | PROCEDURE FOR OBTAINING A LOW IRRITABILITY POTENTIATED SULFONAMIDE INJECTABLE PREPARATION |
US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
US4492720A (en) * | 1983-11-15 | 1985-01-08 | Benjamin Mosier | Method of preparing microspheres for intravascular delivery |
CA1338736C (en) * | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcrystals containing an active ingredient with affinity for phospholipids and at least one phospholipid; process for preparing the same |
US4839111A (en) * | 1987-02-02 | 1989-06-13 | The University Of Tennessee Research Corporation | Preparation of solid core liposomes |
FR2651680B1 (en) * | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | NOVEL PROCESS FOR THE PREPARATION OF LIPID MICROPARTICLES. |
-
1990
- 1990-04-26 US US07/514,012 patent/US5091188A/en not_active Expired - Lifetime
-
1991
- 1991-04-23 EP EP91908933A patent/EP0533690B1/en not_active Expired - Lifetime
- 1991-04-23 KR KR1019920702656A patent/KR0159114B1/en not_active IP Right Cessation
- 1991-04-23 JP JP50885491A patent/JP3261129B2/en not_active Expired - Lifetime
- 1991-04-23 WO PCT/US1991/002804 patent/WO1991016068A1/en active IP Right Grant
- 1991-04-23 CA CA002078990A patent/CA2078990C/en not_active Expired - Lifetime
- 1991-04-23 AT AT91908933T patent/ATE181234T1/en not_active IP Right Cessation
- 1991-04-23 DK DK91908933T patent/DK0533690T3/en active
- 1991-04-23 ES ES91908933T patent/ES2134776T3/en not_active Expired - Lifetime
- 1991-04-23 AU AU78528/91A patent/AU7852891A/en not_active Abandoned
- 1991-04-23 DE DE69131349T patent/DE69131349T2/en not_active Expired - Lifetime
- 1991-04-23 RU RU9292016352A patent/RU2100030C1/en active
- 1991-04-25 ZA ZA913122A patent/ZA913122B/en unknown
- 1991-04-26 MX MX2553291A patent/MX25532A/en unknown
- 1991-05-22 TW TW080103981A patent/TW203559B/zh not_active IP Right Cessation
-
1994
- 1994-09-12 US US08/304,225 patent/USRE35338E/en not_active Expired - Lifetime
-
1999
- 1999-07-20 GR GR990401915T patent/GR3030825T3/en unknown
Patent Citations (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4053585A (en) * | 1974-06-25 | 1977-10-11 | National Research Development Corporation | Immunological preparations |
US4133874A (en) * | 1976-06-10 | 1979-01-09 | The University Of Illinois Foundation | Lipid encapsulated hemoglobin cells |
US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
GB2046094A (en) * | 1979-04-11 | 1980-11-12 | Nattermann A & Cie | Stabilized parenterally administrable solutions |
US4325871A (en) * | 1979-06-20 | 1982-04-20 | Ricoh Company, Ltd. | Ortho-Bis (2-substituted azostyryl) benzene compounds |
US4411894A (en) * | 1979-06-22 | 1983-10-25 | Hoffmann-La Roche Inc. | Pharmaceutical preparations |
US4331654A (en) * | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
US5030453A (en) * | 1983-03-24 | 1991-07-09 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
US4515736A (en) * | 1983-05-12 | 1985-05-07 | The Regents Of The University Of California | Method for encapsulating materials into liposomes |
WO1985000011A1 (en) * | 1983-06-17 | 1985-01-03 | Univ Miami | Microdroplets of water-insoluble drugs |
US4622219A (en) * | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
US4687762A (en) * | 1984-03-31 | 1987-08-18 | Green Cross Corporation | Water soluble drug complex and method for production of same |
US4762720A (en) * | 1984-09-21 | 1988-08-09 | Shionogi & Co., Ltd. | Process for preparing liposome compositions |
US4761288A (en) * | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
US4826687A (en) * | 1985-06-06 | 1989-05-02 | National Institute Of Health | Influenza vaccine |
US4756910A (en) * | 1985-11-29 | 1988-07-12 | Kabushiki Kaisha Vitamin Kenkyusyo | Adriamycin-entrapping liposome preparation |
WO1987004592A1 (en) * | 1986-02-10 | 1987-08-13 | Liposome Technology, Inc. | Controlled-release liposome delivery system |
US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
US4806350A (en) * | 1986-04-18 | 1989-02-21 | Norden Laboratories, Inc. | Vaccine formulation |
US4752442A (en) * | 1986-05-26 | 1988-06-21 | Shoei Chemical Inc. | Bonding wire |
US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
EP0272091A2 (en) * | 1986-12-15 | 1988-06-22 | Nexstar Pharmaceuticals, Inc. | Delivery vehicles with amphiphile-associated active ingredient |
WO1991004011A1 (en) * | 1989-09-20 | 1991-04-04 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
Cited By (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5895653A (en) * | 1995-03-27 | 1999-04-20 | Tempo G | Adjuvant based on colloidal iron compounds |
US6576264B1 (en) | 1995-10-17 | 2003-06-10 | Skyepharma Canada Inc. | Insoluble drug delivery |
US6974593B2 (en) | 1995-10-17 | 2005-12-13 | Jagotec Ag | Insoluble drug delivery |
US8206746B2 (en) | 1996-08-22 | 2012-06-26 | Jagotec Ag | Microparticles of water-insoluble substances |
US20030180367A1 (en) * | 1996-08-22 | 2003-09-25 | Skyepharma Canada, Inc. | Microparticles of water-insoluble substances |
US20020034532A1 (en) * | 1996-12-20 | 2002-03-21 | Brodbeck Kevin J. | Injectable depot gel composition and method of preparing the composition |
US6130200A (en) | 1996-12-20 | 2000-10-10 | Alza Corporation | Gel composition and methods |
US6468961B1 (en) | 1996-12-20 | 2002-10-22 | Alza Corporation | Gel composition and methods |
FR2757768A1 (en) * | 1996-12-27 | 1998-07-03 | Biovector Therapeutics Sa | HOMEOCHARGE PARTICULATE VECTOR AND PHARMACEUTICAL OR COSMETIC COMPOSITION CONTAINING THE SAME |
WO1998029102A1 (en) * | 1996-12-27 | 1998-07-09 | Biovector Therapeutics S.A. | Homogeneously charged particulate vector and pharmaceutical or cosmetic composition containing same |
US20030013693A1 (en) * | 1998-02-11 | 2003-01-16 | Rtp Pharma Inc. | Method and composition for treatment of inflammatory conditions |
US8415329B1 (en) | 1998-05-29 | 2013-04-09 | Jagotec Ag | Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations |
US7939105B2 (en) | 1998-11-20 | 2011-05-10 | Jagotec Ag | Process for preparing a rapidly dispersing solid drug dosage form |
US7939106B2 (en) | 1998-11-20 | 2011-05-10 | Jagotec Ag | Process for preparing a rapidly dispersing solid drug dosage form |
US7192588B2 (en) | 1999-08-24 | 2007-03-20 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
US20030059435A1 (en) * | 1999-08-24 | 2003-03-27 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
US6541001B1 (en) | 1999-08-24 | 2003-04-01 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
US6592869B2 (en) | 1999-08-24 | 2003-07-15 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US6682761B2 (en) | 2000-04-20 | 2004-01-27 | Rtp Pharma, Inc. | Water-insoluble drug particle process |
US6634576B2 (en) | 2000-08-31 | 2003-10-21 | Rtp Pharma Inc. | Milled particles |
US8586094B2 (en) | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
US8703202B2 (en) | 2000-09-20 | 2014-04-22 | Jagotec Ag | Coated tablets |
US20030044433A1 (en) * | 2000-12-22 | 2003-03-06 | Jane Werling | Method for preparing submicron suspensions with polymorph control |
US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
US20040022862A1 (en) * | 2000-12-22 | 2004-02-05 | Kipp James E. | Method for preparing small particles |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20020127278A1 (en) * | 2000-12-22 | 2002-09-12 | Kipp James E. | Microprecipitation method for preparing submicron suspensions |
US20040245662A1 (en) * | 2000-12-22 | 2004-12-09 | Mahesh Chaubal | Method for preparing submicron particles of antineoplastic agents |
US20020168402A1 (en) * | 2000-12-22 | 2002-11-14 | Kipp James E. | Microprecipitation method for preparing submicron suspensions |
US8263131B2 (en) | 2000-12-22 | 2012-09-11 | Baxter International Inc. | Method for treating infectious organisms normally considered to be resistant to an antimicrobial drug |
US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
US20030003155A1 (en) * | 2000-12-22 | 2003-01-02 | Kipp James E. | Microprecipitation method for preparing submicron suspensions |
US7037528B2 (en) | 2000-12-22 | 2006-05-02 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US20030031719A1 (en) * | 2000-12-22 | 2003-02-13 | Kipp James E. | Method for preparing submicron particle suspensions |
US20030206959A9 (en) * | 2000-12-22 | 2003-11-06 | Kipp James E. | Method for preparing submicron particle suspensions |
US6497896B2 (en) | 2001-02-12 | 2002-12-24 | Supergen, Inc. | Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin |
US20020150615A1 (en) * | 2001-02-12 | 2002-10-17 | Howard Sands | Injectable pharmaceutical composition comprising microdroplets of a camptothecin |
US6509027B2 (en) | 2001-02-12 | 2003-01-21 | Supergen, Inc. | Injectable pharmaceutical composition comprising coated particles of camptothecin |
US20040086571A1 (en) * | 2001-02-22 | 2004-05-06 | Skyepharma Canada Inc. | Fibrate-statin combinations with reduced fed-fasted effects |
US6835396B2 (en) | 2001-09-26 | 2004-12-28 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion lyophilization |
US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
US20050037083A1 (en) * | 2001-09-26 | 2005-02-17 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
US20030059472A1 (en) * | 2001-09-26 | 2003-03-27 | Sean Brynjelsen | Preparation of submicron sized nanoparticles via dispersion lyophilization |
US8722091B2 (en) | 2001-09-26 | 2014-05-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion lyophilization |
US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
US20050169979A1 (en) * | 2002-07-03 | 2005-08-04 | Dov Michaeli | Liposomal vaccine |
US20040247661A1 (en) * | 2002-07-03 | 2004-12-09 | Dov Michaeli | Liposomal vaccine |
EP2298806A1 (en) | 2002-10-16 | 2011-03-23 | Purdue Pharma L.P. | Antibodies that bind cell-associated CA 125/0722P and methods of use thereof |
EP2891666A1 (en) | 2002-10-16 | 2015-07-08 | Purdue Pharma L.P. | Antibodies that bind cell-associated CA 125/O722P and methods of use thereof |
EP3301114A1 (en) | 2002-10-16 | 2018-04-04 | Purdue Pharma LP | Fusion polypeptides of antibodies that bind cell-associated ca 125/o722p |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
Also Published As
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ZA913122B (en) | 1992-04-29 |
KR0159114B1 (en) | 1998-12-01 |
ATE181234T1 (en) | 1999-07-15 |
US5091188A (en) | 1992-02-25 |
CA2078990A1 (en) | 1991-10-27 |
DE69131349D1 (en) | 1999-07-22 |
MX25532A (en) | 1993-10-01 |
TW203559B (en) | 1993-04-11 |
DE69131349T2 (en) | 1999-11-18 |
AU7852891A (en) | 1991-11-11 |
EP0533690A4 (en) | 1993-04-14 |
JPH05507685A (en) | 1993-11-04 |
EP0533690A1 (en) | 1993-03-31 |
CA2078990C (en) | 2002-06-04 |
WO1991016068A1 (en) | 1991-10-31 |
ES2134776T3 (en) | 1999-10-16 |
EP0533690B1 (en) | 1999-06-16 |
RU2100030C1 (en) | 1997-12-27 |
JP3261129B2 (en) | 2002-02-25 |
DK0533690T3 (en) | 1999-11-22 |
GR3030825T3 (en) | 1999-11-30 |
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