JP3219408B2 - ステロイドスルファターゼインヒビター - Google Patents

ステロイドスルファターゼインヒビター

Info

Publication number
JP3219408B2
JP3219408B2 JP50503293A JP50503293A JP3219408B2 JP 3219408 B2 JP3219408 B2 JP 3219408B2 JP 50503293 A JP50503293 A JP 50503293A JP 50503293 A JP50503293 A JP 50503293A JP 3219408 B2 JP3219408 B2 JP 3219408B2
Authority
JP
Japan
Prior art keywords
estrone
compound
steroid sulfatase
sulfamate
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP50503293A
Other languages
English (en)
Japanese (ja)
Other versions
JPH07501515A (ja
Inventor
ジョン リード，マイケル
ビクター ロイド ポッター，バリー
Original Assignee
ステリックス リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ステリックス リミテッド filed Critical ステリックス リミテッド
Publication of JPH07501515A publication Critical patent/JPH07501515A/ja
Application granted granted Critical
Publication of JP3219408B2 publication Critical patent/JP3219408B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP50503293A 1991-08-29 1992-08-28 ステロイドスルファターゼインヒビター Expired - Fee Related JP3219408B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors
GB9118478,8 1991-08-29
PCT/GB1992/001587 WO1993005064A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP21141399A Division JP3581802B2 (ja) 1991-08-29 1999-07-26 ステロイドスルファターゼインヒビター
JP2000163410A Division JP3581820B2 (ja) 1991-08-29 2000-05-31 ステロイドスルファターゼインヒビター
JP2000163411A Division JP3581821B2 (ja) 1991-08-29 2000-05-31 ステロイドスルファターゼインヒビター

Publications (2)

Publication Number Publication Date
JPH07501515A JPH07501515A (ja) 1995-02-16
JP3219408B2 true JP3219408B2 (ja) 2001-10-15

Family

ID=10700604

Family Applications (6)

Application Number Title Priority Date Filing Date
JP50503293A Expired - Fee Related JP3219408B2 (ja) 1991-08-29 1992-08-28 ステロイドスルファターゼインヒビター
JP21141399A Expired - Fee Related JP3581802B2 (ja) 1991-08-29 1999-07-26 ステロイドスルファターゼインヒビター
JP2000163411A Expired - Fee Related JP3581821B2 (ja) 1991-08-29 2000-05-31 ステロイドスルファターゼインヒビター
JP2000163410A Expired - Fee Related JP3581820B2 (ja) 1991-08-29 2000-05-31 ステロイドスルファターゼインヒビター
JP2002017765A Withdrawn JP2002255993A (ja) 1991-08-29 2002-01-25 ステロイドスルファターゼインヒビター
JP2002355920A Withdrawn JP2003176297A (ja) 1991-08-29 2002-12-06 ステロイドスルファターゼインヒビター

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP21141399A Expired - Fee Related JP3581802B2 (ja) 1991-08-29 1999-07-26 ステロイドスルファターゼインヒビター
JP2000163411A Expired - Fee Related JP3581821B2 (ja) 1991-08-29 2000-05-31 ステロイドスルファターゼインヒビター
JP2000163410A Expired - Fee Related JP3581820B2 (ja) 1991-08-29 2000-05-31 ステロイドスルファターゼインヒビター
JP2002017765A Withdrawn JP2002255993A (ja) 1991-08-29 2002-01-25 ステロイドスルファターゼインヒビター
JP2002355920A Withdrawn JP2003176297A (ja) 1991-08-29 2002-12-06 ステロイドスルファターゼインヒビター

Country Status (25)

Country Link
US (3) US5616574A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (6) EP0921130B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (6) JP3219408B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (4) KR100258396B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (5) ATE246706T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (2) AU689043B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9206434A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (4) CA2305758A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (4) CY2253B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ295939B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (5) DE69233149T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (4) DK0641355T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (4) ES2148178T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (5) FI940903A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB9118478D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GE (6) GEP20063773B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3034579T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT66097A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LV (1) LV12618B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (6) NO307301B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (4) RU2001125673A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (7) SG88783A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (4) SK282187B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UA (4) UA41875C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1993005064A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
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GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
JP4931312B2 (ja) 1999-12-13 2012-05-16 ステリックス リミテッド ステロイドスルファターゼのインヒビターとしてのハロゲン化スルファメート−、ホスホネート−、チオホスホネート−、スルホネート−、およびスルホンアミド−化合物
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ATE464293T1 (de) 2003-05-21 2010-04-15 Aska Pharm Co Ltd Cyclisches aminophenylsulfamatderivativ
TWI331154B (en) * 2003-11-12 2010-10-01 Solvay Pharm Gmbh Novel 17-hydroxysteroid dehydrogenase type i inhibitors
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
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US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
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WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
JP5543920B2 (ja) 2007-09-17 2014-07-09 プレグレム エスアー 閉経前の女性におけるエストロゲン依存症状の治療
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KR20190116576A (ko) 2009-05-06 2019-10-14 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
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Also Published As

Publication number Publication date
AU689043B2 (en) 1998-03-19
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
HU9400583D0 (en) 1994-05-30
DE69233053D1 (de) 2003-06-12
AU668882B2 (en) 1996-05-23
UA70956C2 (uk) 2004-11-15
SK24694A3 (en) 1994-11-09
JP2000355598A (ja) 2000-12-26
DE69231280D1 (de) 2000-08-24
ATE239753T1 (de) 2003-05-15
ES2204059T3 (es) 2004-04-16
FI940903A7 (fi) 1994-04-20
HK1020672A1 (en) 2000-05-19
JPH07501515A (ja) 1995-02-16
AU2490592A (en) 1993-04-05
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CA2114630A1 (en) 1993-03-18
NO308903B1 (no) 2000-11-13
NO995075D0 (no) 1999-10-18
AU5837396A (en) 1996-09-05
JP2000038341A (ja) 2000-02-08
EP0982032A3 (en) 2002-03-20
FI20002259A7 (fi) 2000-10-13
FI20002261A7 (fi) 2000-10-13
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
ATE194843T1 (de) 2000-08-15
CA2114630C (en) 2003-09-30
GEP20022637B (en) 2002-02-25
EP1099706B1 (en) 2004-10-06
KR100321019B1 (ko) 2002-03-20
HK1019753A1 (en) 2000-02-25
DE69233020D1 (de) 2003-05-22
DE69233431T2 (de) 2006-02-23
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
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SG88782A1 (en) 2002-05-21
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US5830886A (en) 1998-11-03
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JP2000355542A (ja) 2000-12-26
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JP3581802B2 (ja) 2004-10-27
NO940635L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-04-29
NO307301B1 (no) 2000-03-13
EP1099706A3 (en) 2002-09-04
ATE246706T1 (de) 2003-08-15
DE69233149T2 (de) 2004-06-24
EP0982032B1 (en) 2003-08-06
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FI20050991L (fi) 2005-10-03
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UA70957C2 (uk) 2004-11-15
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EP0921130B1 (en) 2003-05-07
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HK1025051A1 (en) 2000-11-03
NO20025725D0 (no) 2002-11-28
FI20002260A7 (fi) 2000-10-13
LV12618A (en) 2001-02-20
NO308774B1 (no) 2000-10-30
EP0982032A2 (en) 2000-03-01
GEP20022802B (en) 2002-09-25
NO995075L (no) 1994-04-29
AU1007799A (en) 1999-03-04
FI940903A0 (fi) 1994-02-25
NO995076L (no) 1994-04-29
SK282189B6 (sk) 2001-12-03
EP0921130A2 (en) 1999-06-09
NO318009B1 (no) 2005-01-17
EP0641355A1 (en) 1995-03-08
JP3581820B2 (ja) 2004-10-27
LV12618B (en) 2001-07-20
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HUT66097A (en) 1994-09-28
NO20025725L (no) 1994-04-29
FI20002260L (fi) 2000-10-13
NO995076D0 (no) 1999-10-18
EP1099706A2 (en) 2001-05-16
RU2210574C2 (ru) 2003-08-20
SG115508A1 (en) 2005-10-28
NO20002595D0 (no) 2000-05-19
NO940635D0 (no) 1994-02-24
NO20044458L (no) 1994-04-29
UA41875C2 (uk) 2001-10-15
US6159960A (en) 2000-12-12
FI20002259L (fi) 2000-10-13
DK0921130T3 (da) 2003-07-21
ES2193475T3 (es) 2003-11-01
SG103374A1 (en) 2004-04-29
ES2148178T3 (es) 2000-10-16
SG106116A1 (en) 2004-09-30
SG103820A1 (en) 2004-05-26
BR9206434A (pt) 1994-09-27
RU2182152C2 (ru) 2002-05-10
JP3581821B2 (ja) 2004-10-27
KR100321018B1 (ko) 2002-03-20
CA2305767A1 (en) 1993-03-18
KR100258396B1 (ko) 2000-08-01
JP2002255993A (ja) 2002-09-11
SK282187B6 (sk) 2001-12-03
JP2003176297A (ja) 2003-06-24
US5616574A (en) 1997-04-01
FI20002261L (fi) 2000-10-13
RU2001125673A (ru) 2003-06-27
RU2207134C2 (ru) 2003-06-27
EP1522543A1 (en) 2005-04-13
SG88783A1 (en) 2002-05-21
NO2595A (no) 1994-04-29
EP0928609A2 (en) 1999-07-14
GEP20022766B (en) 2002-08-26
CY2253B1 (en) 2003-07-04
AU717116B2 (en) 2000-03-16
DE69233020T2 (de) 2003-11-06
DE69233053T2 (de) 2003-11-20
SK282186B6 (sk) 2001-12-03
DE69231280T2 (de) 2000-11-30
ATE278704T1 (de) 2004-10-15
ES2196483T3 (es) 2003-12-16
KR100322650B1 (ko) 2002-03-20
GR3034579T3 (en) 2001-01-31
GEP20033094B (en) 2003-10-27
FI20050991A7 (fi) 2005-10-03
CA2305749A1 (en) 1993-03-18
GB9118478D0 (en) 1991-10-16
NO314287B1 (no) 2003-03-03
WO1993005064A1 (en) 1993-03-18

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