JP2944048B2 - 二環式テトラヒドロピラゾロピリジン - Google Patents

二環式テトラヒドロピラゾロピリジン

Info

Publication number
JP2944048B2
JP2944048B2 JP7503938A JP50393895A JP2944048B2 JP 2944048 B2 JP2944048 B2 JP 2944048B2 JP 7503938 A JP7503938 A JP 7503938A JP 50393895 A JP50393895 A JP 50393895A JP 2944048 B2 JP2944048 B2 JP 2944048B2
Authority
JP
Japan
Prior art keywords
ethyl
oxo
pyridine
tetrahydro
pyrazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP7503938A
Other languages
English (en)
Japanese (ja)
Other versions
JPH08507084A (ja
Inventor
デユプランテイアー，アレン・ヤコブ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPH08507084A publication Critical patent/JPH08507084A/ja
Application granted granted Critical
Publication of JP2944048B2 publication Critical patent/JP2944048B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP7503938A 1993-07-06 1994-06-16 二環式テトラヒドロピラゾロピリジン Expired - Lifetime JP2944048B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US088,292 1987-08-24
US8829293A 1993-07-06 1993-07-06
US08/088,292 1993-07-06
PCT/IB1994/000156 WO1995001980A1 (en) 1993-07-06 1994-06-16 Bicyclic tetrahydro pyrazolopyridines

Publications (2)

Publication Number Publication Date
JPH08507084A JPH08507084A (ja) 1996-07-30
JP2944048B2 true JP2944048B2 (ja) 1999-08-30

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7503938A Expired - Lifetime JP2944048B2 (ja) 1993-07-06 1994-06-16 二環式テトラヒドロピラゾロピリジン

Country Status (20)

Country Link
EP (1) EP0707585A1 (cs)
JP (1) JP2944048B2 (cs)
KR (1) KR100228949B1 (cs)
CN (1) CN1048015C (cs)
AU (1) AU695301B2 (cs)
BR (1) BR9406946A (cs)
CA (1) CA2166721C (cs)
CZ (1) CZ3696A3 (cs)
EG (1) EG20513A (cs)
FI (1) FI943208A7 (cs)
HU (1) HUT74170A (cs)
IL (1) IL110175A (cs)
MX (1) MX9405132A (cs)
NO (1) NO305029B1 (cs)
NZ (1) NZ266525A (cs)
PL (1) PL312426A1 (cs)
RU (1) RU2131876C1 (cs)
TW (1) TW316904B (cs)
WO (1) WO1995001980A1 (cs)
ZA (1) ZA944844B (cs)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09511758A (ja) * 1994-10-20 1997-11-25 フアイザー・インコーポレイテツド 二環式テトラヒドロピラゾロピリジンおよび医薬としてのその使用
US6004974A (en) * 1995-06-06 1999-12-21 Pfizer Inc Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-α]pyridines
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
EP0931075A1 (en) * 1996-09-04 1999-07-28 Pfizer Inc. Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)
CA2305370C (en) * 1997-09-26 2006-11-28 Gerald Mcmahon Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
IL142959A0 (en) 1998-12-23 2002-04-21 Du Pont Pharm Co Nitrogen containing heterobicycles as factor xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
TR200909479T2 (tr) 1999-08-21 2012-02-21 Nycomed Gmbh Sinerjistik kombinasyon.
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
ES2349762T3 (es) * 2000-08-10 2011-01-11 Pfizer Italia S.R.L. Biciclo-pirazoles activos como inhibidores de quinasas, procedimientos para su preparación y composiciones farmacéuticas que los comprenden.
US6953793B2 (en) * 2000-08-14 2005-10-11 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrazoles
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
EP1379245A4 (en) 2001-04-18 2006-07-26 Bristol Myers Squibb Co 1, 4, 5, 6-TETRAHYDROPYRAZOLO- 3, 4-C-PYRIDINE-7-ONE AS FACTOR XA HEMMER
US6706730B2 (en) 2001-04-18 2004-03-16 Bristol-Myers Squibb Pharma Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors
JP4196678B2 (ja) 2001-04-26 2008-12-17 味の素株式会社 複素環化合物
ES2329881T3 (es) * 2001-09-21 2009-12-02 Bristol-Myers Squibb Company Compuestos que contienen lactama y derivados de los mismos como inhibidores del factor xa.
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DK1611131T3 (da) 2003-02-27 2011-01-17 Palau Pharma Sa Pyrazolopyridin-derivater
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
BRPI0409229A (pt) 2003-04-01 2006-03-28 Applied Research Systems inibidores das fosfodiesterases na infertilidade
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP3366698A1 (en) 2011-03-01 2018-08-29 Synergy Pharmaceuticals Inc. Guanylate cyclase c agonists
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365459A (en) 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365459A (en) 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｃｈｅｎ，Ｐｈａｒｍ，Ｂｕｌｌ，２４（８），１８７０〜８（１９７６）

Also Published As

Publication number Publication date
CN1129940A (zh) 1996-08-28
KR960703852A (ko) 1996-08-31
FI943208A0 (fi) 1994-07-05
EP0707585A1 (en) 1996-04-24
IL110175A (en) 2000-01-31
FI943208L (fi) 1995-01-07
AU695301B2 (en) 1998-08-13
BR9406946A (pt) 1996-08-06
KR100228949B1 (ko) 1999-11-01
MX9405132A (es) 1995-01-31
CA2166721A1 (en) 1995-01-19
NZ266525A (en) 1997-10-24
ZA944844B (en) 1996-01-05
HU9503934D0 (en) 1996-03-28
JPH08507084A (ja) 1996-07-30
HUT74170A (en) 1996-11-28
IL110175A0 (en) 1994-10-07
WO1995001980A1 (en) 1995-01-19
CZ3696A3 (en) 1997-06-11
EG20513A (en) 1999-06-30
NO960056L (no) 1996-01-05
FI943208A7 (fi) 1995-01-07
PL312426A1 (en) 1996-04-29
CA2166721C (en) 1999-07-27
AU6805794A (en) 1995-02-06
NO960056D0 (no) 1996-01-05
NO305029B1 (no) 1999-03-22
CN1048015C (zh) 2000-01-05
TW316904B (cs) 1997-10-01
RU2131876C1 (ru) 1999-06-20

Similar Documents

Publication Publication Date Title
JP2944048B2 (ja) 二環式テトラヒドロピラゾロピリジン
JP3000674B2 (ja) ジヒドロピラゾロピロール類
JP6289485B2 (ja) Ｐｄｅ４のヘテロアリール阻害剤
US6492520B1 (en) Substituted pyrido-or pyrimido-containing 6,6- or 6,7-bicyclic derivatives
JP2891544B2 (ja) ピラゾロおよびピロロピリジン類
TWI404721B (zh) 胺基－雜環化合物
CN102317287B (zh) 作为磷酸二酯酶抑制剂、用于治疗皮肤病的三唑并吡啶化合物
JP4790703B2 (ja) 環式化合物
JP3152940B2 (ja) ホスホジエステラーゼ（ｐｄｅ）ｉｖ型および腫瘍壊死因子（ｔｎｆ）阻害物質としての置換インダゾール誘導体及びその使用法
EP1296981B1 (en) Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors
US6127398A (en) Substituted indazole derivatives and related compounds
JPH09511758A (ja) 二環式テトラヒドロピラゾロピリジンおよび医薬としてのその使用
WO2007032466A1 (ja) 複素環化合物、その製造方法並びに用途
JP6506833B2 (ja) イミダゾピリダジン化合物
US7589206B2 (en) Pyrrolopyridine derivatives
HUP0301165A2 (hu) CRF-repector antagonista hatású tetrahidropiridin- és piperidin-heterociklusos-származékok és alkalmazásuk
KR20080058456A (ko) 비만, 정신 질환 및 신경 질환의 치료를 위한테트라히드로피롤로[3,2-ｃ]피리딘-4-온 유도체의 제조 및용도
AU2014220351A1 (en) Azabenzimidazole compounds as inhibitors of PDE4 isozymes for the treatment of CNS and other disorders
JP2008543921A (ja) インドリジン誘導体
JP3939246B2 (ja) インドロキナゾリノン類
WO2018019222A1 (zh) 作为jak抑制剂杂环化合物，该化合物的盐类及其治疗用途
JP2008530211A (ja) ケモカイン受容体のモジュレーターとなる置換ピラゾール
CA2201728A1 (en) Bicyclic tetrahydro pyrazolopyridines and their use as medicaments