JP2865211B2 - ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類 - Google Patents

５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類

Info

Publication number
JP2865211B2
JP2865211B2 JP1509255A JP50925589A JP2865211B2 JP 2865211 B2 JP2865211 B2 JP 2865211B2 JP 1509255 A JP1509255 A JP 1509255A JP 50925589 A JP50925589 A JP 50925589A JP 2865211 B2 JP2865211 B2 JP 2865211B2
Authority
JP
Japan
Prior art keywords
alkyl
acetamidomethyl
oxazolidine
oxazolidin
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP1509255A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04500665A (ja
Inventor
ブリックナー，スティーブン・ジェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUARUMASHIA ANDO ATSUPUJON CO
Original Assignee
FUARUMASHIA ANDO ATSUPUJON CO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUARUMASHIA ANDO ATSUPUJON CO filed Critical FUARUMASHIA ANDO ATSUPUJON CO
Publication of JPH04500665A publication Critical patent/JPH04500665A/ja
Application granted granted Critical
Publication of JP2865211B2 publication Critical patent/JP2865211B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP1509255A 1988-09-15 1989-08-22 ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類 Expired - Fee Related JP2865211B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24498888A 1988-09-15 1988-09-15
US244,988 1988-09-15
US25385088A 1988-10-05 1988-10-05
US253,850 1988-10-05
US32494289A 1989-03-17 1989-03-17
US324,942 1994-10-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP19194998A Division JP3188418B2 (ja) 1988-09-15 1998-07-07 ３−（縮合環置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類および３−（窒素原子置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類

Publications (2)

Publication Number Publication Date
JPH04500665A JPH04500665A (ja) 1992-02-06
JP2865211B2 true JP2865211B2 (ja) 1999-03-08

Family

ID=27399816

Family Applications (2)

Application Number Title Priority Date Filing Date
JP1509255A Expired - Fee Related JP2865211B2 (ja) 1988-09-15 1989-08-22 ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類
JP19194998A Expired - Fee Related JP3188418B2 (ja) 1988-09-15 1998-07-07 ３−（縮合環置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類および３−（窒素原子置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP19194998A Expired - Fee Related JP3188418B2 (ja) 1988-09-15 1998-07-07 ３−（縮合環置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類および３−（窒素原子置換）フェニル−５β−アミドメチルオキサゾリジン−２−オン類

Country Status (14)

Country Link
EP (3) EP0434714A1 (enExample)
JP (2) JP2865211B2 (enExample)
KR (1) KR0138262B1 (enExample)
AT (2) ATE112773T1 (enExample)
AU (1) AU617871B2 (enExample)
CA (1) CA1335103C (enExample)
DE (2) DE68929303T2 (enExample)
DK (2) DK175696B1 (enExample)
ES (1) ES2157934T3 (enExample)
GR (1) GR3036491T3 (enExample)
HK (1) HK1002234A1 (enExample)
LV (1) LV12888B (enExample)
TW (1) TW219936B (enExample)
WO (1) WO1990002744A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
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US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
CZ288351B6 (en) * 1990-06-07 2001-05-16 Astrazeneca Ab Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
DK0599968T3 (da) * 1991-08-14 2000-04-17 Procter & Gamble Pharma Oxazolidinonderivater, der er egnede som antiarytmi- og antifibrilleringsmidler
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
KR950702417A (ko) * 1992-07-08 1995-07-29 로렌스 티. 웰츠 마이코박테륨 투베르쿨로시스에 대해 유용한 5′-인돌리닐 옥사졸리디논(5′-indolinyl oxazolidinones useful against mycobacterium tuberculosis)
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
DE69522234T2 (de) * 1994-10-26 2002-05-16 Pharmacia & Upjohn Co., Kalamazoo Phenyloxazolidinone mit antimikrobieller wirkung
BR9509673A (pt) * 1994-11-15 1997-09-30 Upjohn Co Compostos e uso dos mesmos
DK0807112T3 (da) * 1995-02-03 2001-12-17 Upjohn Co Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
US6090820A (en) * 1995-05-11 2000-07-18 Pharmacia & Upjohn Company Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601627A1 (de) * 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
FI19992555A7 (fi) 1997-05-30 1999-11-30 Upjohn Co Antibakteerisia oksatosolidinoniaineita, joilla on tiokarbonyylifunktionaalisuus
DE19730847A1 (de) * 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
AU739055B2 (en) * 1997-11-12 2001-10-04 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
DE19802239A1 (de) * 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
CA2318969A1 (en) * 1998-01-23 1999-07-29 Mikhail F. Gordeev Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
EP1181288B1 (en) * 1999-05-27 2003-07-30 PHARMACIA & UPJOHN COMPANY Bicyclic oxazolidinones as antibacterial agent
CN1367780A (zh) 1999-07-28 2002-09-04 法玛西雅厄普约翰美国公司 噁唑烷酮类化合物、其制备方法及其应用
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2002006278A1 (en) 2000-07-17 2002-01-24 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
DE60121986T2 (de) 2000-10-02 2007-07-26 Emory University Triptpolidanaloge zur verendung in der behandlung von autoimmunbedingten und entzündlichen erkrankungen
PE20020689A1 (es) 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
GB0118407D0 (en) * 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
US20080262056A1 (en) * 2004-08-06 2008-10-23 Pfizer Inc Oxindole Oxazolidinones as Antibacterial Agents
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
EA200701895A1 (ru) * 2005-04-06 2008-04-28 ФАРМАЦИЯ ЭНД АПДЖОН КОМПАНИ ЭлЭлСи Оксиндол-оксазолидинон в качестве антибактериального агента
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
WO2009081148A1 (en) * 2007-12-24 2009-07-02 Cipla Limited Process for the synthesis of propargylated aminoindan derivatives
US8598156B2 (en) 2010-03-25 2013-12-03 Glaxosmithkline Llc Chemical compounds

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Publication number Priority date Publication date Assignee Title
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
DK175696B1 (da) 2005-01-24
AU4195789A (en) 1990-04-02
DK45591A (da) 1991-03-13
DK200401246A (da) 2004-08-18
TW219936B (enExample) 1994-02-01
AU617871B2 (en) 1991-12-05
CA1335103C (en) 1995-04-04
LV12888B (en) 2002-12-20
DE68929303T2 (de) 2002-05-02
JPH04500665A (ja) 1992-02-06
GR3036491T3 (en) 2001-11-30
KR900701780A (ko) 1990-12-04
JP3188418B2 (ja) 2001-07-16
ATE112773T1 (de) 1994-10-15
ES2157934T3 (es) 2001-09-01
WO1990002744A1 (en) 1990-03-22
DK45591D0 (da) 1991-03-13
EP0359418A1 (en) 1990-03-21
DE68918792T2 (de) 1995-03-30
DK175940B1 (da) 2005-08-01
EP0434714A1 (en) 1991-07-03
EP0609905B1 (en) 2001-06-06
ATE201870T1 (de) 2001-06-15
EP0609905A1 (en) 1994-08-10
DE68918792D1 (de) 1994-11-17
JPH1180139A (ja) 1999-03-26
HK1002234A1 (en) 1998-08-07
DE68929303D1 (de) 2001-07-12
KR0138262B1 (ko) 1998-05-15
EP0359418B1 (en) 1994-10-12

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