KR0138262B1 - 5'-인돌리닐-5β-아미도메틸옥사졸리딘-2-온, 3-(융합-고리치환된)페닐-5β-아미도메틸옥사졸리딘-2-온 및 3-(질소 치환된) 페닐-5β-아미도메틸옥사졸리딘-2-온 - Google Patents

5'-인돌리닐-5β-아미도메틸옥사졸리딘-2-온, 3-(융합-고리치환된)페닐-5β-아미도메틸옥사졸리딘-2-온 및 3-(질소 치환된) 페닐-5β-아미도메틸옥사졸리딘-2-온

Info

Publication number
KR0138262B1
KR0138262B1 KR1019900701012A KR900701012A KR0138262B1 KR 0138262 B1 KR0138262 B1 KR 0138262B1 KR 1019900701012 A KR1019900701012 A KR 1019900701012A KR 900701012 A KR900701012 A KR 900701012A KR 0138262 B1 KR0138262 B1 KR 0138262B1
Authority
KR
South Korea
Prior art keywords
oxazolidin
acetamidomethyl
alkyl
mixture
mhz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019900701012A
Other languages
English (en)
Korean (ko)
Other versions
KR900701780A (ko
Inventor
제이 브릭크너 스티븐
Original Assignee
로렌스 티. 웰츠
팔마샤 앤드 업죤 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 로렌스 티. 웰츠, 팔마샤 앤드 업죤 캄파니 filed Critical 로렌스 티. 웰츠
Publication of KR900701780A publication Critical patent/KR900701780A/ko
Application granted granted Critical
Publication of KR0138262B1 publication Critical patent/KR0138262B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019900701012A 1988-09-15 1990-05-15 5'-인돌리닐-5β-아미도메틸옥사졸리딘-2-온, 3-(융합-고리치환된)페닐-5β-아미도메틸옥사졸리딘-2-온 및 3-(질소 치환된) 페닐-5β-아미도메틸옥사졸리딘-2-온 Expired - Fee Related KR0138262B1 (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US24498888A 1988-09-15 1988-09-15
US7/244,988 1988-09-15
US07/244,988 1988-09-15
US25385088A 1988-10-05 1988-10-05
US7/253,850 1988-10-05
US07/253,850 1988-10-05
US32494289A 1989-03-17 1989-03-17
US07/324,942 1989-03-17
US7/324,942 1989-03-17
PCT/US1989/003548 WO1990002744A1 (en) 1988-09-15 1989-08-22 In position 3 substituted-5-beta-amidomethyl-oxazolidin-2-ones

Publications (2)

Publication Number Publication Date
KR900701780A KR900701780A (ko) 1990-12-04
KR0138262B1 true KR0138262B1 (ko) 1998-05-15

Family

ID=27399816

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900701012A Expired - Fee Related KR0138262B1 (ko) 1988-09-15 1990-05-15 5'-인돌리닐-5β-아미도메틸옥사졸리딘-2-온, 3-(융합-고리치환된)페닐-5β-아미도메틸옥사졸리딘-2-온 및 3-(질소 치환된) 페닐-5β-아미도메틸옥사졸리딘-2-온

Country Status (13)

Country Link
EP (3) EP0609905B1 (enExample)
JP (2) JP2865211B2 (enExample)
KR (1) KR0138262B1 (enExample)
AT (2) ATE201870T1 (enExample)
AU (1) AU617871B2 (enExample)
CA (1) CA1335103C (enExample)
DE (2) DE68929303T2 (enExample)
DK (2) DK175696B1 (enExample)
ES (1) ES2157934T3 (enExample)
GR (1) GR3036491T3 (enExample)
LV (1) LV12888B (enExample)
TW (1) TW219936B (enExample)
WO (1) WO1990002744A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231188A (en) * 1989-11-17 1993-07-27 The Upjohn Company Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents
EP0636623B1 (en) * 1990-06-07 2001-08-16 AstraZeneca AB Indole derivatives as 5-HT1- like agonists
BR9206353A (pt) * 1991-08-14 1995-11-07 Procter & Gamble Pharma Uretanos cíclicos utilizáveis como agentes antiarrítmicos e antifibrilatórios
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
WO1994001110A1 (en) * 1992-07-08 1994-01-20 The Upjohn Company 5'-INDOLINYL OXAZOLIDINONES USEFUL AGAINST $i(MYCOBACTERIUM TUBERCULOSIS)
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4425609A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
CN1068325C (zh) * 1994-10-26 2001-07-11 法玛西雅厄普约翰美国公司 苯基噁唑烷酮抗菌剂
ATE233766T1 (de) * 1994-11-15 2003-03-15 Upjohn Co Antibakterielle bizyklische oxazin und thiazin- oxazolidinone
ES2163004T3 (es) * 1995-02-03 2002-01-16 Upjohn Co Feniloxazolidinona sustituida por un anillo heteroaromatico como agente antimicrobiano.
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
FI974180A0 (fi) * 1995-05-11 1997-11-10 Upjohn Co Spirosyklisiä ja bisyklisiä diatsinyyli- ja karbatsinyylioksatsolidinoneja
US5883093A (en) * 1995-09-12 1999-03-16 Pharmacia & Upjohn Company Phenyloxazolidinone antimicrobials
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601627A1 (de) * 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9702213D0 (en) * 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
NZ501412A (en) * 1997-05-30 2001-11-30 Upjohn Co Oxazolidinone antibacterial agents having a thiocarbonyl functionality
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
DE19730847A1 (de) * 1997-07-18 1999-01-28 Bayer Ag Tricyclisch substituierte Oxazolidinone
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
AU739055B2 (en) * 1997-11-12 2001-10-04 Pharmacia & Upjohn Company Oxazolidinone derivatives and pharmaceutical compositions
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
DE19802239A1 (de) * 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
EP1049682A1 (en) 1998-01-23 2000-11-08 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
BR0010982A (pt) 1999-05-27 2002-03-05 Upjohn Co Novas oxazolidinonas bicìclicas como agentes antibacterianos
EP1200416A1 (en) 1999-07-28 2002-05-02 Pharmacia & Upjohn Company Oxazolidinones and their use as antiinfectives
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
CZ2003228A3 (cs) 2000-07-17 2003-06-18 Ranbaxy Laboratories Limited Oxazolidinonové deriváty jako antimikrobiální látky
EP1659125B1 (en) 2000-10-02 2010-06-02 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
PE20020689A1 (es) 2000-11-17 2002-08-03 Upjohn Co Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
GB0118407D0 (en) * 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
US7012088B2 (en) * 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
CA2575702A1 (en) * 2004-08-06 2006-02-16 Pharmacia & Upjohn Company Llc Oxindole oxazolidinones as antibacterial agents
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
CA2603943A1 (en) * 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc An oxindole oxazolidinone as antibacterial agent
JP5425806B2 (ja) * 2007-12-24 2014-02-26 シプラ・リミテッド プロパルギル化アミノインダン誘導体の合成方法
US8598156B2 (en) 2010-03-25 2013-12-03 Glaxosmithkline Llc Chemical compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
DE68918792D1 (de) 1994-11-17
EP0359418A1 (en) 1990-03-21
DK175696B1 (da) 2005-01-24
HK1002234A1 (en) 1998-08-07
ATE201870T1 (de) 2001-06-15
DE68918792T2 (de) 1995-03-30
KR900701780A (ko) 1990-12-04
CA1335103C (en) 1995-04-04
EP0609905B1 (en) 2001-06-06
ATE112773T1 (de) 1994-10-15
WO1990002744A1 (en) 1990-03-22
AU617871B2 (en) 1991-12-05
EP0609905A1 (en) 1994-08-10
DK45591D0 (da) 1991-03-13
LV12888B (en) 2002-12-20
EP0434714A1 (en) 1991-07-03
JP3188418B2 (ja) 2001-07-16
DK200401246A (da) 2004-08-18
JPH04500665A (ja) 1992-02-06
JP2865211B2 (ja) 1999-03-08
GR3036491T3 (en) 2001-11-30
DK175940B1 (da) 2005-08-01
DE68929303T2 (de) 2002-05-02
TW219936B (enExample) 1994-02-01
JPH1180139A (ja) 1999-03-26
AU4195789A (en) 1990-04-02
DK45591A (da) 1991-03-13
EP0359418B1 (en) 1994-10-12
ES2157934T3 (es) 2001-09-01
DE68929303D1 (de) 2001-07-12

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