JP2839847B2 - インターロイキン−８産生抑制剤 - Google Patents
インターロイキン−８産生抑制剤Info
- Publication number
- JP2839847B2 JP2839847B2 JP6250473A JP25047394A JP2839847B2 JP 2839847 B2 JP2839847 B2 JP 2839847B2 JP 6250473 A JP6250473 A JP 6250473A JP 25047394 A JP25047394 A JP 25047394A JP 2839847 B2 JP2839847 B2 JP 2839847B2
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- agent
- disease
- inflammatory
- carbostyril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 230000000284 resting effect Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000015175 salami Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 239000012176 shellac wax Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000002630 speech therapy Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 201000008587 ulcerative stomatitis Diseases 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 230000037418 vocal dysfunction Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6250473A JP2839847B2 (ja) | 1993-10-21 | 1994-10-17 | インターロイキン−８産生抑制剤 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26341793 | 1993-10-21 | ||
| JP5-263418 | 1993-10-21 | ||
| JP26341893 | 1993-10-21 | ||
| JP26341993 | 1993-10-21 | ||
| JP5-263417 | 1993-10-21 | ||
| JP5-263419 | 1993-10-21 | ||
| JP8964194 | 1994-04-27 | ||
| JP6-89641 | 1994-04-27 | ||
| JP6250473A JP2839847B2 (ja) | 1993-10-21 | 1994-10-17 | インターロイキン−８産生抑制剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0812578A JPH0812578A (ja) | 1996-01-16 |
| JP2839847B2 true JP2839847B2 (ja) | 1998-12-16 |
Family
ID=27467652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6250473A Expired - Fee Related JP2839847B2 (ja) | 1993-10-21 | 1994-10-17 | インターロイキン−８産生抑制剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5637597A (ref) |
| EP (1) | EP0674515B1 (ref) |
| JP (1) | JP2839847B2 (ref) |
| KR (1) | KR100191191B1 (ref) |
| CN (1) | CN1073418C (ref) |
| AT (1) | ATE184793T1 (ref) |
| AU (1) | AU683697B2 (ref) |
| CA (1) | CA2150546C (ref) |
| DE (1) | DE69420832T2 (ref) |
| DK (1) | DK0674515T3 (ref) |
| ES (1) | ES2138092T3 (ref) |
| GR (1) | GR3032091T3 (ref) |
| TW (1) | TW296983B (ref) |
| WO (1) | WO1995011026A1 (ref) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016011262A (ja) * | 2014-06-27 | 2016-01-21 | 株式会社ナールスコーポレーション | 口腔粘膜疾患の予防または治療用経口製剤 |
| US9248196B2 (en) | 2011-02-25 | 2016-02-02 | Nuformix Limited | Rebamipide complexes and cocrystals |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR004214A1 (es) * | 1995-10-12 | 1998-11-04 | Otsuka Pharma Co Ltd | Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas |
| DE10029404B4 (de) * | 2000-06-15 | 2009-10-29 | Jagotec Ag | Arzneiformulierung enthaltend Ciclosporin und deren Verwendung |
| FR2812548B1 (fr) * | 2000-08-01 | 2002-09-20 | Sanofi Synthelabo | Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale |
| US7408078B2 (en) * | 2002-10-08 | 2008-08-05 | Wyeth | Anthranilic acid derivatives useful in treating infection with hepatitis C virus |
| US7879877B2 (en) * | 2003-07-30 | 2011-02-01 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives for accelerating salivation |
| TWI340650B (en) * | 2004-01-21 | 2011-04-21 | Otsuka Pharma Co Ltd | Amine saly of carbostyril derivative |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| WO2009022674A1 (en) * | 2007-08-10 | 2009-02-19 | Otsuka Pharmaceutical Co., Ltd. | Medical composition containing rebamipide |
| KR101104634B1 (ko) * | 2009-08-25 | 2012-01-12 | 한림제약(주) | 레바미피드를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물 |
| KR101182114B1 (ko) * | 2010-03-05 | 2012-09-12 | 한림제약(주) | 유효성분으로서 레바미피드를 함유하는 골관절염 예방 또는 치료용 약학 조성물 |
| EP2688552A1 (en) | 2011-03-24 | 2014-01-29 | Otsuka Pharmaceutical Co., Ltd. | A pharmaceutical composition for treating a disease in the oral cavity comprising rebamipide |
| WO2022128054A1 (en) | 2020-12-14 | 2022-06-23 | Symrise Ag | Medicament for fighting inflammatory conditions of human skin (iv) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4578381A (en) * | 1982-07-05 | 1986-03-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| GB8334494D0 (en) * | 1983-12-24 | 1984-02-01 | Tanabe Seiyaku Co | Carbostyril derivatives |
| JPS63119467A (ja) * | 1987-10-21 | 1988-05-24 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
| JPH02178227A (ja) * | 1988-12-28 | 1990-07-11 | Otsuka Pharmaceut Co Ltd | 腎炎治療剤 |
| JP2812998B2 (ja) * | 1989-08-14 | 1998-10-22 | 大塚製薬 株式会社 | 胃炎治療剤 |
| EP0543018B1 (en) * | 1991-06-07 | 1996-01-10 | Otsuka Pharmaceutical Co., Ltd. | Antidiabetic agent |
| ES2138971T3 (es) * | 1991-07-03 | 2000-02-01 | Otsuka Pharma Co Ltd | Regulador de la apoptosis. |
| TW227558B (ref) * | 1992-05-14 | 1994-08-01 | Otsuka Pharma Co Ltd | |
| JP2872546B2 (ja) * | 1992-11-26 | 1999-03-17 | 大塚製薬株式会社 | 腸粘膜障害保護剤 |
| AU5715994A (en) * | 1992-12-24 | 1994-07-19 | Otsuka Pharmaceutical Co., Ltd. | Psoriasis remedy |
| AU672288B2 (en) * | 1993-03-02 | 1996-09-26 | Akira Matsumori | Rejection inhibitor for transplants and IL-1 production inhibitor |
-
1994
- 1994-10-17 AT AT94929670T patent/ATE184793T1/de active
- 1994-10-17 EP EP94929670A patent/EP0674515B1/en not_active Expired - Lifetime
- 1994-10-17 DK DK94929670T patent/DK0674515T3/da active
- 1994-10-17 JP JP6250473A patent/JP2839847B2/ja not_active Expired - Fee Related
- 1994-10-17 DE DE69420832T patent/DE69420832T2/de not_active Expired - Lifetime
- 1994-10-17 KR KR1019950702533A patent/KR100191191B1/ko not_active Expired - Fee Related
- 1994-10-17 CN CN94190812.7A patent/CN1073418C/zh not_active Expired - Lifetime
- 1994-10-17 US US08/448,577 patent/US5637597A/en not_active Expired - Lifetime
- 1994-10-17 AU AU78641/94A patent/AU683697B2/en not_active Expired
- 1994-10-17 CA CA002150546A patent/CA2150546C/en not_active Expired - Lifetime
- 1994-10-17 WO PCT/JP1994/001739 patent/WO1995011026A1/en not_active Ceased
- 1994-10-17 ES ES94929670T patent/ES2138092T3/es not_active Expired - Lifetime
- 1994-10-20 TW TW083109726A patent/TW296983B/zh not_active IP Right Cessation
-
1999
- 1999-12-08 GR GR990403182T patent/GR3032091T3/el unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9248196B2 (en) | 2011-02-25 | 2016-02-02 | Nuformix Limited | Rebamipide complexes and cocrystals |
| JP2016011262A (ja) * | 2014-06-27 | 2016-01-21 | 株式会社ナールスコーポレーション | 口腔粘膜疾患の予防または治療用経口製剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU683697B2 (en) | 1997-11-20 |
| CN1117268A (zh) | 1996-02-21 |
| CA2150546A1 (en) | 1995-04-27 |
| JPH0812578A (ja) | 1996-01-16 |
| TW296983B (ref) | 1997-02-01 |
| ATE184793T1 (de) | 1999-10-15 |
| KR100191191B1 (ko) | 1999-06-15 |
| KR950703957A (ko) | 1995-11-17 |
| WO1995011026A1 (en) | 1995-04-27 |
| EP0674515B1 (en) | 1999-09-22 |
| DK0674515T3 (da) | 1999-12-20 |
| DE69420832D1 (de) | 1999-10-28 |
| EP0674515A1 (en) | 1995-10-04 |
| AU7864194A (en) | 1995-05-08 |
| CA2150546C (en) | 2004-11-09 |
| DE69420832T2 (de) | 2000-01-13 |
| US5637597A (en) | 1997-06-10 |
| ES2138092T3 (es) | 2000-01-01 |
| CN1073418C (zh) | 2001-10-24 |
| GR3032091T3 (en) | 2000-03-31 |
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