AU683697B2 - Carbostyril derivative for inhibiting production of interleukin-8 - Google Patents

Carbostyril derivative for inhibiting production of interleukin-8 Download PDF

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Publication number
AU683697B2
AU683697B2 AU78641/94A AU7864194A AU683697B2 AU 683697 B2 AU683697 B2 AU 683697B2 AU 78641/94 A AU78641/94 A AU 78641/94A AU 7864194 A AU7864194 A AU 7864194A AU 683697 B2 AU683697 B2 AU 683697B2
Authority
AU
Australia
Prior art keywords
general formula
derivative represented
carbostyril derivative
quinolon
propionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU78641/94A
Other languages
English (en)
Other versions
AU7864194A (en
Inventor
Miki Aihara
Ken-Ichi Imagawa
Mikio Kikuchi
Takahide Matsuda
Hiroshi Muta
Shigeru Owada
Hisao Takizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of AU7864194A publication Critical patent/AU7864194A/en
Application granted granted Critical
Publication of AU683697B2 publication Critical patent/AU683697B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
AU78641/94A 1993-10-21 1994-10-17 Carbostyril derivative for inhibiting production of interleukin-8 Expired AU683697B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP26341793 1993-10-21
JP5-263418 1993-10-21
JP26341893 1993-10-21
JP26341993 1993-10-21
JP5-263417 1993-10-21
JP5-263419 1993-10-21
JP8964194 1994-04-27
JP6-89641 1994-04-27
PCT/JP1994/001739 WO1995011026A1 (en) 1993-10-21 1994-10-17 Carbostyril derivative for inhibiting production of interleukin-8

Publications (2)

Publication Number Publication Date
AU7864194A AU7864194A (en) 1995-05-08
AU683697B2 true AU683697B2 (en) 1997-11-20

Family

ID=27467652

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78641/94A Expired AU683697B2 (en) 1993-10-21 1994-10-17 Carbostyril derivative for inhibiting production of interleukin-8

Country Status (14)

Country Link
US (1) US5637597A (ref)
EP (1) EP0674515B1 (ref)
JP (1) JP2839847B2 (ref)
KR (1) KR100191191B1 (ref)
CN (1) CN1073418C (ref)
AT (1) ATE184793T1 (ref)
AU (1) AU683697B2 (ref)
CA (1) CA2150546C (ref)
DE (1) DE69420832T2 (ref)
DK (1) DK0674515T3 (ref)
ES (1) ES2138092T3 (ref)
GR (1) GR3032091T3 (ref)
TW (1) TW296983B (ref)
WO (1) WO1995011026A1 (ref)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR004214A1 (es) * 1995-10-12 1998-11-04 Otsuka Pharma Co Ltd Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas
DE10029404B4 (de) * 2000-06-15 2009-10-29 Jagotec Ag Arzneiformulierung enthaltend Ciclosporin und deren Verwendung
FR2812548B1 (fr) * 2000-08-01 2002-09-20 Sanofi Synthelabo Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale
US7408078B2 (en) * 2002-10-08 2008-08-05 Wyeth Anthranilic acid derivatives useful in treating infection with hepatitis C virus
US7879877B2 (en) * 2003-07-30 2011-02-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives for accelerating salivation
TWI340650B (en) * 2004-01-21 2011-04-21 Otsuka Pharma Co Ltd Amine saly of carbostyril derivative
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
WO2009022674A1 (en) * 2007-08-10 2009-02-19 Otsuka Pharmaceutical Co., Ltd. Medical composition containing rebamipide
KR101104634B1 (ko) * 2009-08-25 2012-01-12 한림제약(주) 레바미피드를 포함하는 류마티스 관절염 예방 또는 치료용 약학 조성물
KR101182114B1 (ko) * 2010-03-05 2012-09-12 한림제약(주) 유효성분으로서 레바미피드를 함유하는 골관절염 예방 또는 치료용 약학 조성물
US9248196B2 (en) 2011-02-25 2016-02-02 Nuformix Limited Rebamipide complexes and cocrystals
EP2688552A1 (en) 2011-03-24 2014-01-29 Otsuka Pharmaceutical Co., Ltd. A pharmaceutical composition for treating a disease in the oral cavity comprising rebamipide
JP6294773B2 (ja) * 2014-06-27 2018-03-14 株式会社ナールスコーポレーション 口腔粘膜疾患の予防または治療用経口製剤
WO2022128054A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammatory conditions of human skin (iv)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
WO1992021342A1 (en) * 1991-06-07 1992-12-10 Otsuka Pharmaceutical Co., Ltd. Antidiabetic
WO1994012182A1 (en) * 1992-11-26 1994-06-09 Otsuka Pharmaceutical Co., Ltd. Agent for preventing and treating disturbances of intestinal mucous membrane

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
JPS63119467A (ja) * 1987-10-21 1988-05-24 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPH02178227A (ja) * 1988-12-28 1990-07-11 Otsuka Pharmaceut Co Ltd 腎炎治療剤
JP2812998B2 (ja) * 1989-08-14 1998-10-22 大塚製薬 株式会社 胃炎治療剤
ES2138971T3 (es) * 1991-07-03 2000-02-01 Otsuka Pharma Co Ltd Regulador de la apoptosis.
TW227558B (ref) * 1992-05-14 1994-08-01 Otsuka Pharma Co Ltd
AU5715994A (en) * 1992-12-24 1994-07-19 Otsuka Pharmaceutical Co., Ltd. Psoriasis remedy
AU672288B2 (en) * 1993-03-02 1996-09-26 Akira Matsumori Rejection inhibitor for transplants and IL-1 production inhibitor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
WO1992021342A1 (en) * 1991-06-07 1992-12-10 Otsuka Pharmaceutical Co., Ltd. Antidiabetic
WO1994012182A1 (en) * 1992-11-26 1994-06-09 Otsuka Pharmaceutical Co., Ltd. Agent for preventing and treating disturbances of intestinal mucous membrane

Also Published As

Publication number Publication date
CN1117268A (zh) 1996-02-21
CA2150546A1 (en) 1995-04-27
JPH0812578A (ja) 1996-01-16
TW296983B (ref) 1997-02-01
ATE184793T1 (de) 1999-10-15
KR100191191B1 (ko) 1999-06-15
KR950703957A (ko) 1995-11-17
WO1995011026A1 (en) 1995-04-27
EP0674515B1 (en) 1999-09-22
DK0674515T3 (da) 1999-12-20
DE69420832D1 (de) 1999-10-28
EP0674515A1 (en) 1995-10-04
AU7864194A (en) 1995-05-08
CA2150546C (en) 2004-11-09
JP2839847B2 (ja) 1998-12-16
DE69420832T2 (de) 2000-01-13
US5637597A (en) 1997-06-10
ES2138092T3 (es) 2000-01-01
CN1073418C (zh) 2001-10-24
GR3032091T3 (en) 2000-03-31

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