JP2025121901A5 - - Google Patents

Info

Publication number
JP2025121901A5
JP2025121901A5 JP2025062686A JP2025062686A JP2025121901A5 JP 2025121901 A5 JP2025121901 A5 JP 2025121901A5 JP 2025062686 A JP2025062686 A JP 2025062686A JP 2025062686 A JP2025062686 A JP 2025062686A JP 2025121901 A5 JP2025121901 A5 JP 2025121901A5
Authority
JP
Japan
Prior art keywords
crystal
crystalline form
disease
endotherm
onset
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2025062686A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025121901A (ja
Filing date
Publication date
Priority claimed from JP2022555915A external-priority patent/JP7664278B2/ja
Application filed filed Critical
Publication of JP2025121901A publication Critical patent/JP2025121901A/ja
Publication of JP2025121901A5 publication Critical patent/JP2025121901A5/ja
Pending legal-status Critical Current

Links

JP2025062686A 2020-03-18 2025-04-04 ファルネソイドｘ受容体アゴニストの結晶質形態 Pending JP2025121901A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062991213P 2020-03-18 2020-03-18
US62/991,213 2020-03-18
JP2022555915A JP7664278B2 (ja) 2020-03-18 2021-03-17 ファルネソイドｘ受容体アゴニストの結晶質形態
PCT/US2021/022790 WO2021188692A1 (en) 2020-03-18 2021-03-17 Crystalline forms of a farnesoid x receptor agonist

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2022555915A Division JP7664278B2 (ja) 2020-03-18 2021-03-17 ファルネソイドｘ受容体アゴニストの結晶質形態

Publications (2)

Publication Number Publication Date
JP2025121901A JP2025121901A (ja) 2025-08-20
JP2025121901A5 true JP2025121901A5 (cg-RX-API-DMAC10.html) 2025-12-02

Family

ID=77771306

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022555915A Active JP7664278B2 (ja) 2020-03-18 2021-03-17 ファルネソイドｘ受容体アゴニストの結晶質形態
JP2025062686A Pending JP2025121901A (ja) 2020-03-18 2025-04-04 ファルネソイドｘ受容体アゴニストの結晶質形態

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2022555915A Active JP7664278B2 (ja) 2020-03-18 2021-03-17 ファルネソイドｘ受容体アゴニストの結晶質形態

Country Status (13)

Country Link
US (2) US12545660B2 (cg-RX-API-DMAC10.html)
EP (1) EP4121010A4 (cg-RX-API-DMAC10.html)
JP (2) JP7664278B2 (cg-RX-API-DMAC10.html)
KR (1) KR20220155356A (cg-RX-API-DMAC10.html)
CN (1) CN115666521A (cg-RX-API-DMAC10.html)
AR (1) AR121596A1 (cg-RX-API-DMAC10.html)
AU (1) AU2021236648A1 (cg-RX-API-DMAC10.html)
BR (1) BR112022018596A2 (cg-RX-API-DMAC10.html)
CA (1) CA3171987A1 (cg-RX-API-DMAC10.html)
IL (1) IL296532A (cg-RX-API-DMAC10.html)
MX (2) MX2022011582A (cg-RX-API-DMAC10.html)
TW (1) TW202144332A (cg-RX-API-DMAC10.html)
WO (1) WO2021188692A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3852748B1 (en) * 2018-09-18 2025-09-03 Eli Lilly and Company Farnesoid x receptor agonists and uses thereof
CN120227340A (zh) 2020-03-18 2025-07-01 伊莱利利公司 法尼醇x受体激动剂的制剂
JP7664278B2 (ja) 2020-03-18 2025-04-17 オルガノボ，インク． ファルネソイドｘ受容体アゴニストの結晶質形態

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4537900A (en) 1999-05-17 2000-12-05 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
EP1187810A2 (en) 1999-05-25 2002-03-20 Sepracor, Inc. Heterocyclic analgesic compounds and their use
US6511980B2 (en) 2000-05-05 2003-01-28 Ortho Mcneil Pharmaceutical, Inc. Substituted diamine derivatives useful as motilin antagonists
WO2001092226A1 (en) 2000-05-25 2001-12-06 Sepracor, Inc. Heterocyclic analgesic compounds and method of use thereof
HUP0303360A2 (hu) 2000-09-25 2004-01-28 Actelion Pharmaceuticals Ltd. Maláriaellenes hatású szubsztituált amino-aza-cikloalkánok és ezeket tartalmazó gyógyszerkészítmények
FR2815032B1 (fr) 2000-10-10 2003-08-08 Pf Medicament Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations
FR2825706B1 (fr) 2001-06-06 2003-12-12 Pf Medicament Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase
FR2839974B1 (fr) 2002-05-24 2004-07-16 Pf Medicament Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament
WO2004009549A2 (en) 2002-07-18 2004-01-29 Actelion Pharmaceuticals Ltd Piperidines useful for the treatment of central nervous system disorders
MXPA05003054A (es) 2002-09-20 2005-05-27 Pfizer Prod Inc Ligandos de amida y sulfonamida para el receptor de estrogenos.
AU2003290796A1 (en) 2002-11-14 2004-06-15 The Scripps Research Institute Non-steroidal fxr agonists
US20050143449A1 (en) * 2002-11-15 2005-06-30 The Salk Institute For Biological Studies Non-steroidal farnesoid X receptor modulators and methods for the use thereof
WO2004046323A2 (en) 2002-11-15 2004-06-03 The Salk Institute For Biological Studies Structure of the farnesoid x receptor ligand binding domain and methods of use therefor
GB0309781D0 (en) 2003-04-29 2003-06-04 Glaxo Group Ltd Compounds
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
US7754711B2 (en) 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
EP2316827B1 (en) 2003-07-30 2016-01-27 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
WO2005058822A1 (en) 2003-12-17 2005-06-30 Actelion Pharmaceuticals Ltd Substituted amino-cycloalkanes
CN1914205A (zh) 2003-12-19 2007-02-14 葛兰素集团有限公司 吡唑并[3,4－b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
WO2005089316A2 (en) 2004-03-12 2005-09-29 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using fxr ligands
JP2007530582A (ja) 2004-03-26 2007-11-01 ライジェル ファーマシューティカルズ， インコーポレイテッド 代謝可能部分を含む複素環抗ウイルス化合物およびその使用
US20050272784A1 (en) 2004-05-07 2005-12-08 Xiaobing Li Inhibitors of bacterial Type III protein secretion systems
JP2006199656A (ja) 2005-01-24 2006-08-03 Kowa Co アミド基を有する環状アミン化合物
MY144229A (en) 2006-01-26 2011-08-15 Xenon Pharmaceuticals Inc Pyridazine derivatives and their use as therapeutic agents
CN101395170A (zh) 2006-02-14 2009-03-25 英特塞普特药品公司 用于预防或治疗fxr介导的疾病或状态的作为fxr配体的胆汁酸衍生物
CA2644369A1 (en) 2006-03-28 2007-10-04 Novartis Ag Amide derivatives and their application for the treatment of g protein related diseases
US20080081824A1 (en) 2006-09-29 2008-04-03 Bristol-Myers Squibb Company Substituted piperidines as modulators of chemokine receptor activity
WO2008065500A2 (en) 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
EP2234977A4 (en) 2007-12-19 2011-04-13 Boehringer Ingelheim Int VIRAL POLYMERASE INHIBITORS
US20090270418A1 (en) 2008-01-09 2009-10-29 Marianne Sloss Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith
US20100029657A1 (en) 2008-02-29 2010-02-04 Wyeth Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof
WO2010001869A1 (ja) 2008-06-30 2010-01-07 武田薬品工業株式会社 ４置換ベンゼン化合物およびその用途
JP2010077109A (ja) 2008-08-28 2010-04-08 Takeda Chem Ind Ltd 複素環化合物およびその用途
CA2749893A1 (en) 2009-02-04 2010-08-12 Pfizer Inc. 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives
AU2010272523A1 (en) 2009-07-15 2012-02-02 Merck Serono S.A. Tetrazole derivatives
US8435980B2 (en) 2009-07-15 2013-05-07 Abbvie Inc. Pyrrolopyridine inhibitors of kinases
FR2963005B1 (fr) 2010-07-23 2012-08-17 Sanofi Aventis Derives d'oxadiazoles et de pyridazines, leur preparation et leur application en therapeutique
JP2014500319A (ja) 2010-12-20 2014-01-09 アイアールエム・リミテッド・ライアビリティ・カンパニー ファルネソイドｘ受容体を調節するための組成物および方法
RU2600739C2 (ru) 2011-03-18 2016-10-27 Байер Интеллектчуал Проперти Гмбх N-(3-карбамоилфенил)-1н-пиразол-5-карбоксамидные производные и их применение для борьбы с животными-вредителями
ME02754B (me) 2011-03-23 2018-01-20 Trevena Inc Ligandi opioidnih receptora i postupci njihove upotrebe i pripreme
WO2013008706A1 (ja) 2011-07-13 2013-01-17 エム・テクニック株式会社 結晶子径を制御された微粒子の製造方法
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
WO2013037482A1 (en) 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
RU2543485C2 (ru) 2013-02-26 2015-03-10 Андрей Александрович Иващенко Гетероциклические агонисты рецепторов желчных кислот tgr5, фармацевтическая композиция, способы их получения и применения
MX377523B (es) 2013-09-11 2025-03-10 Inst Nat Sante Rech Med Metodos y composiciones farmaceuticas para el tratamiento de la infeccion por el virus de la hepatitis b.
GB201316824D0 (en) 2013-09-23 2013-11-06 R & D Vernalis Ltd New Chemical Entities
JP2017511304A (ja) 2014-03-13 2017-04-20 ソーク インスティチュート フォー バイオロジカル スタディーズ フェキサラミン類似体ならびに作製方法および使用方法
US20150258052A1 (en) 2014-03-13 2015-09-17 Salk Institute For Biological Studies Methods of using fexaramine and agents that increase sympathetic nervous system activity to promote browning of white adipose tissue
CA2942403A1 (en) 2014-03-13 2015-09-17 Salk Institute For Biological Studies Fxr agonists and methods for making and using
US10301268B2 (en) 2014-03-13 2019-05-28 The Salk Institute For Biological Studies Analogs of fexaramine and methods of making and using
US10077268B2 (en) 2014-03-13 2018-09-18 Salk Institute For Biological Studies FXR agonists and methods for making and using
US20180116993A1 (en) 2015-01-22 2018-05-03 Xiamen University Modulators of farnesoid x receptor and methods for the use thereof
AU2016233579A1 (en) 2015-03-13 2017-10-12 Salk Institute For Biological Studies Treating latent autoimmune diabetes of adults with farnesoid X receptor agonists to activate intestinal receptors
WO2017018751A1 (ko) 2015-07-24 2017-02-02 동국대학교 산학협력단 Blt 저해 활성을 갖는 신규 화합물 및 이를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 조성물
WO2017049176A1 (en) 2015-09-16 2017-03-23 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
EP3350165B1 (en) 2015-09-16 2023-07-26 Organovo, Inc. Farnesoid x receptor agonists and uses thereof
US10626081B2 (en) 2015-09-16 2020-04-21 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
EP3350166A4 (en) 2015-09-16 2019-05-01 Metacrine, Inc. FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF
BR112018006471B1 (pt) 2015-10-01 2024-02-27 Senomyx, Inc Composto, composição, método de modular o membro de melastina do canal potencial do receptor transitório 8 (trpm8), método de modular a sensação de resfrescância de uma composição e método de induzir uma sensação de refrescância em um ser humano ou animal
CN105477636B (zh) 2015-10-16 2019-09-17 厦门大学 使用阿维菌素及其衍生物治疗代谢疾病的方法
WO2017078928A1 (en) 2015-11-06 2017-05-11 Salk Institute For Biological Studies Fxr agonists and methods for making and using
CN107126419B (zh) 2016-02-26 2020-06-19 石药集团中诺药业（石家庄）有限公司 一种奥贝胆酸片剂及其制备方法
KR102316645B1 (ko) 2016-03-31 2021-10-25 가부시키가이샤 아데카 감광성 조성물 및 신규 화합물
DK3596053T3 (da) * 2017-03-15 2023-09-25 Organovo Inc Farnesoid-x-receptoragonister og anvendelser deraf
WO2018170173A1 (en) 2017-03-15 2018-09-20 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
AU2018236275B2 (en) * 2017-03-15 2022-05-12 Eli Lilly And Company Farnesoid X receptor agonists and uses thereof
US20200131132A1 (en) 2017-03-15 2020-04-30 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
WO2018170165A1 (en) 2017-03-15 2018-09-20 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
CZ2017298A3 (cs) 2017-05-26 2018-12-05 Zentiva, K.S. Amorfní formy obeticholové kyseliny
WO2020060007A1 (ko) 2018-09-17 2020-03-26 엘지전자 주식회사 5g 이동통신에서 pdu 세션을 핸들링하는 방법 및 무선 기기
US20220047553A1 (en) 2018-09-18 2022-02-17 Metacrine, Inc. Farnesoid x receptor agonists for the treatment of disease
BR112021004931A2 (pt) 2018-09-18 2021-06-01 Metacrine, Inc. formas cristalinas de um agonista de receptor farnesoide x
WO2020061117A1 (en) * 2018-09-18 2020-03-26 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
CN113056264A (zh) * 2018-09-18 2021-06-29 梅塔科林公司 法尼醇x受体激动剂及其用途
EP3852748B1 (en) * 2018-09-18 2025-09-03 Eli Lilly and Company Farnesoid x receptor agonists and uses thereof
WO2020061118A1 (en) 2018-09-18 2020-03-26 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
WO2020061116A1 (en) 2018-09-18 2020-03-26 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
JP7664278B2 (ja) 2020-03-18 2025-04-17 オルガノボ，インク． ファルネソイドｘ受容体アゴニストの結晶質形態
CN120227340A (zh) 2020-03-18 2025-07-01 伊莱利利公司 法尼醇x受体激动剂的制剂
KR20220154801A (ko) * 2020-03-18 2022-11-22 메타크린, 인크. 질환의 치료를 위한 파르네소이드 x 수용체 작용제

Similar Documents

Publication Publication Date Title
DK2800748T3 (en) CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE AND APPLICATIONS THEREOF
KR100826817B1 (ko) 치환된 베타-카볼린
CN112608318B (zh) 一种作为蛋白质激酶抑制剂的化合物及其用途
TW200848043A (en) Substituted isoquinoline and isoquinolinone derivatives
RU2014150437A (ru) Твердые формы антивирусного соединения
TW200800185A (en) Acid secretion inhibitor
KR20090086121A (ko) 용매화 일라프라졸의 결정형
WO2020006294A1 (en) Methods of treating liver fibrosis using calpain inhibitors
JP2014510746A5 (cg-RX-API-DMAC10.html)
CN114181198A (zh) 嘧啶衍生物类己酮糖激酶抑制剂及其用途
WO2024217531A1 (zh) Cyp11a1抑制剂及其用途
RU2733723C1 (ru) Новое пирролопиридиновое соединение, способ его получения и его применение
AU2012367780B2 (en) Derivatives of aza adamantane and uses thereof
WO2018217050A1 (ko) 헤테로사이클 유도체 화합물의 제조방법, 상기 화합물을 포함하는 조성물 및 상기 화합물의 수화물
JP2009538862A (ja) エンドセリン受容体拮抗剤としてのニトロ複素環式化合物
JPWO2002096904A1 (ja) 新規複素環誘導体およびその医薬用途
CN116134017B (zh) 双环化合物及其应用
RU2632884C2 (ru) Производное пиразола
CA2994377C (en) Novel catechol derivative and pharmaceutical composition comprising the same
CN119365448A (zh) 一种6-甲氧基吡啶-3-基衍生物的制备方法
CN103502240A (zh) 吡咯衍生物
TW200922586A (en) Thiophene 1,2,4-triazole derivatives as modulators of mGluR5
KR20120113886A (ko) 잔틴 옥시다아제 저해제로서 효과적인 신규 화합물 및 그를 함유한 약제학적 조성물
KR100804827B1 (ko) 티아졸리딘-4-온 유도체, 그 제조방법 및 약제학적 조성물
HK40115402A (en) Method for preparing 6-methoxypyridin-3-yl derivatives