CN115666521A - 法尼醇x受体激动剂的结晶形式 - Google Patents

法尼醇x受体激动剂的结晶形式 Download PDF

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Publication number
CN115666521A
CN115666521A CN202180036362.4A CN202180036362A CN115666521A CN 115666521 A CN115666521 A CN 115666521A CN 202180036362 A CN202180036362 A CN 202180036362A CN 115666521 A CN115666521 A CN 115666521A
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China
Prior art keywords
crystalline form
disease
xrpd
crystalline
compound
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CN202180036362.4A
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English (en)
Chinese (zh)
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尼古拉斯·D·史密斯
罗伯特·曼斯菲尔德
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Eli Lilly and Co
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Metacrine Inc
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Publication of CN115666521A publication Critical patent/CN115666521A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180036362.4A 2020-03-18 2021-03-17 法尼醇x受体激动剂的结晶形式 Pending CN115666521A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062991213P 2020-03-18 2020-03-18
US62/991,213 2020-03-18
PCT/US2021/022790 WO2021188692A1 (en) 2020-03-18 2021-03-17 Crystalline forms of a farnesoid x receptor agonist

Publications (1)

Publication Number Publication Date
CN115666521A true CN115666521A (zh) 2023-01-31

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CN202180036362.4A Pending CN115666521A (zh) 2020-03-18 2021-03-17 法尼醇x受体激动剂的结晶形式

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US (2) US12545660B2 (cg-RX-API-DMAC10.html)
EP (1) EP4121010A4 (cg-RX-API-DMAC10.html)
JP (2) JP7664278B2 (cg-RX-API-DMAC10.html)
KR (1) KR20220155356A (cg-RX-API-DMAC10.html)
CN (1) CN115666521A (cg-RX-API-DMAC10.html)
AR (1) AR121596A1 (cg-RX-API-DMAC10.html)
AU (1) AU2021236648A1 (cg-RX-API-DMAC10.html)
BR (1) BR112022018596A2 (cg-RX-API-DMAC10.html)
CA (1) CA3171987A1 (cg-RX-API-DMAC10.html)
IL (1) IL296532A (cg-RX-API-DMAC10.html)
MX (2) MX2022011582A (cg-RX-API-DMAC10.html)
TW (1) TW202144332A (cg-RX-API-DMAC10.html)
WO (1) WO2021188692A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3852748B1 (en) * 2018-09-18 2025-09-03 Eli Lilly and Company Farnesoid x receptor agonists and uses thereof
CN120227340A (zh) 2020-03-18 2025-07-01 伊莱利利公司 法尼醇x受体激动剂的制剂
JP7664278B2 (ja) 2020-03-18 2025-04-17 オルガノボ，インク． ファルネソイドｘ受容体アゴニストの結晶質形態

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110637011A (zh) * 2017-03-15 2019-12-31 梅塔科林公司 法尼醇x受体激动剂及其用途
CN110637015A (zh) * 2017-03-15 2019-12-31 梅塔科林公司 法尼醇x受体激动剂及其用途

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TW202144332A (zh) 2021-12-01
AR121596A1 (es) 2022-06-22
MX2022011582A (es) 2022-12-13
EP4121010A1 (en) 2023-01-25
KR20220155356A (ko) 2022-11-22
MX2025009319A (es) 2025-09-02
US20230147756A1 (en) 2023-05-11
US12545660B2 (en) 2026-02-10
JP2025121901A (ja) 2025-08-20
CA3171987A1 (en) 2021-09-23
US20260226028A1 (en) 2026-08-06
AU2021236648A1 (en) 2022-10-13
WO2021188692A1 (en) 2021-09-23
JP2023518399A (ja) 2023-05-01
EP4121010A4 (en) 2024-04-10
IL296532A (en) 2022-11-01
BR112022018596A2 (pt) 2023-03-07
JP7664278B2 (ja) 2025-04-17

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