JP2025106240A5 - - Google Patents

Info

Publication number
JP2025106240A5
JP2025106240A5 JP2025033599A JP2025033599A JP2025106240A5 JP 2025106240 A5 JP2025106240 A5 JP 2025106240A5 JP 2025033599 A JP2025033599 A JP 2025033599A JP 2025033599 A JP2025033599 A JP 2025033599A JP 2025106240 A5 JP2025106240 A5 JP 2025106240A5
Authority
JP
Japan
Prior art keywords
amino acid
pcsk9
terminal domain
inhibitor
acid residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2025033599A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025106240A (ja
Filing date
Publication date
Priority claimed from PCT/US2020/013882 external-priority patent/WO2020150474A1/en
Application filed filed Critical
Publication of JP2025106240A publication Critical patent/JP2025106240A/ja
Publication of JP2025106240A5 publication Critical patent/JP2025106240A5/ja
Pending legal-status Critical Current

Links

JP2025033599A 2019-01-18 2025-03-04 Pcsk9阻害剤及びその使用方法 Pending JP2025106240A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962794239P 2019-01-18 2019-01-18
US62/794,239 2019-01-18
PCT/US2020/013882 WO2020150474A1 (en) 2019-01-18 2020-01-16 Pcsk9 inhibitors and methods of use thereof
JP2021541180A JP2022518016A (ja) 2019-01-18 2020-01-16 Pcsk9阻害剤及びその使用方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2021541180A Division JP2022518016A (ja) 2019-01-18 2020-01-16 Pcsk9阻害剤及びその使用方法

Publications (2)

Publication Number Publication Date
JP2025106240A JP2025106240A (ja) 2025-07-15
JP2025106240A5 true JP2025106240A5 (https=) 2026-01-06

Family

ID=71608564

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021541180A Withdrawn JP2022518016A (ja) 2019-01-18 2020-01-16 Pcsk9阻害剤及びその使用方法
JP2025033599A Pending JP2025106240A (ja) 2019-01-18 2025-03-04 Pcsk9阻害剤及びその使用方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2021541180A Withdrawn JP2022518016A (ja) 2019-01-18 2020-01-16 Pcsk9阻害剤及びその使用方法

Country Status (15)

Country Link
US (2) US11603523B2 (https=)
EP (1) EP3911640A4 (https=)
JP (2) JP2022518016A (https=)
KR (2) KR20210116549A (https=)
CN (1) CN113412258A (https=)
AU (3) AU2020209216A1 (https=)
BR (1) BR112021013924A2 (https=)
CA (1) CA3125767A1 (https=)
EA (1) EA202191890A1 (https=)
IL (1) IL284661A (https=)
MA (1) MA54758A (https=)
MX (2) MX2021008661A (https=)
MY (1) MY210469A (https=)
SG (1) SG11202107615TA (https=)
WO (1) WO2020150474A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202107614PA (en) * 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
AU2020209216A1 (en) * 2019-01-18 2021-08-26 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
CN113248501B (zh) * 2021-06-17 2021-10-08 南京韦尔优众医药有限公司 Cly系列化合物及其制备方法和制备药物的用途
CN113735846A (zh) * 2021-10-11 2021-12-03 河北师范大学 一种苯并噻唑衍生物及其医药用途
WO2023084449A1 (en) * 2021-11-12 2023-05-19 Novartis Ag Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors
US20240217951A1 (en) 2022-09-23 2024-07-04 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
US20240228469A1 (en) 2022-09-23 2024-07-11 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
CN121850939A (zh) * 2022-10-14 2026-04-14 上海翰森生物医药科技有限公司 含氮杂环类衍生物抑制剂、其制备方法和应用
AU2024290864A1 (en) * 2023-07-04 2026-02-12 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Nitrogen-containing heterocyclic derivative inhibitor, and preparation method therefor and use thereof
CN121443616A (zh) 2023-07-27 2026-01-30 上海拓界生物医药科技有限公司 二氨基环戊基取代的杂芳基衍生物及其用途和制备方法
TW202547505A (zh) 2024-02-05 2025-12-16 瑞典商阿斯特捷利康公司 包含azd0780之醫藥組合物
WO2025168652A1 (en) 2024-02-05 2025-08-14 Astrazeneca Ab Azd-0780 in combination with a statin for use in lowering ldl-c levels and treating cardiovacular diseases
WO2025183455A1 (ko) * 2024-02-29 2025-09-04 재단법인 대구경북첨단의료산업진흥재단 Pcsk9 억제제로서의 벤즈옥사졸 유도체
TW202539678A (zh) * 2024-03-20 2025-10-16 瑞典商阿斯特捷利康公司 Pcsk9抑制劑及其使用方法
WO2025214500A1 (zh) * 2024-04-12 2025-10-16 上海翰森生物医药科技有限公司 含氮杂环类衍生物的自由碱晶型和酸式盐及其晶型、其制备方法和应用
WO2025238159A1 (en) 2024-05-16 2025-11-20 Astrazeneca Ab Combination therapy comprising azd0780 and ezetimibe
WO2026021380A1 (zh) * 2024-07-22 2026-01-29 深圳信立泰药业股份有限公司 PCSK9和HMG-CoA双靶化合物与应用
WO2026026878A1 (zh) * 2024-07-30 2026-02-05 成都施贝康生物医药科技有限公司 一种杂环衍生物抑制剂及其制备和用途

Family Cites Families (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
DE69531543T2 (de) 1994-06-17 2004-06-24 F. Hoffmann-La Roche Ag N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria-mittel
AU4515696A (en) 1994-12-12 1996-07-03 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
NZ325248A (en) 1995-12-23 1999-09-29 Pfizer Res & Dev Quinoline and quinazoline compounds useful in therapy
SE9603285D0 (sv) 1996-09-10 1996-09-10 Astra Ab New compounds
US5874438A (en) 1996-10-11 1999-02-23 Bayer Aktiengesellschaft 2,2'-bridged bis-2,4-diaminoquinazolines
DK0999825T3 (da) 1997-07-29 2004-02-09 Alcon Lab Inc Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater
US6110973A (en) 1998-01-29 2000-08-29 Sepracor Methods for treating obesity and weight gain using optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US20040138284A1 (en) 2000-02-11 2004-07-15 Matthias Wiesner Indol-3-yl derivatives
GB0014022D0 (en) 2000-06-08 2000-08-02 Novartis Ag Organic compounds
WO2002020500A2 (en) 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
CA2461202C (en) 2001-09-21 2011-07-12 Donald Pinto Lactam-containing compounds and derivatives thereof as factor xa inhibitors
AU2003209321A1 (en) 2002-01-18 2003-07-30 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
US7312214B2 (en) 2002-05-10 2007-12-25 Bristol-Myers Squibb Company 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors
US20040087590A1 (en) 2002-08-23 2004-05-06 University Of Connecticut Novel biphenyl and biphenyl-like cannabinoids
AU2003286711A1 (en) 2002-10-25 2004-05-13 Vertex Pharmaceuticals Incorporated Indazolinone compositions useful as kinase inhibitors
AU2003299790A1 (en) 2002-12-20 2004-07-22 Bayer Pharmaceuticals Corporation Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
US20050197350A1 (en) 2003-03-31 2005-09-08 Taisho Pharmaceutical Co., Ltd. Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
KR20050114283A (ko) 2003-04-22 2005-12-05 아바니르 파마슈티컬스 고콜레스테롤혈증을 치료하기 위한 역 콜레스테롤 수송의매개제
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
CA2534484A1 (en) 2003-08-07 2005-02-17 Allergan, Inc. Compositions for delivery of therapeutics into the eyes and methods for making and using same
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
MXJL06000069A (es) * 2004-06-09 2007-04-10 Avanir Pharmaceuticals Derivados heterociclicos para el tratamiento de hiperlipidemia y enfermedades relacionadas.
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
US20080090863A1 (en) 2004-09-30 2008-04-17 Taisho Pharmaceutical Co., Ltd. Pyridine Derivatives and Their Use as Medicaments for Treating Diseases Related to Mch Receptor
US7381732B2 (en) 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
EP1814856A1 (en) 2004-11-12 2007-08-08 Galapagos N.V. Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes
GB0428082D0 (en) 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
JP2008531596A (ja) 2005-02-25 2008-08-14 ライジェル ファーマシューティカルズ, インコーポレイテッド Hcv感染を治療または予防するのに有用なベンゾイソチアゾール
CA2603830A1 (en) * 2005-05-24 2006-11-30 Pharmacia & Upjohn Co Llc PYRIDINE [2,3-B] PYRAZINONES
JP5118029B2 (ja) 2005-06-14 2013-01-16 タイゲン バイオテクノロジー カンパニー,リミテッド ピリミジン化合物
US20070203236A1 (en) 2006-01-11 2007-08-30 Smith Jeffrey W Novel antagonists of the human fatty acid synthase thioesterase
JP2007291087A (ja) 2006-03-29 2007-11-08 Taisho Pharmaceut Co Ltd ピリジン誘導体及びその使用に関連する治療法
UA95644C2 (ru) 2006-07-25 2011-08-25 Сефалон, Инк. Пиридазиноновые производные, фармацевтическая композиция и способ лечения заболеваний
US20080255155A1 (en) 2006-10-18 2008-10-16 Stephane Raeppel Kinase inhibitors and uses thereof
WO2008061796A2 (en) 2006-11-24 2008-05-29 Ac Immune Sa Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
KR101442288B1 (ko) 2006-12-13 2014-09-19 지보당 네덜란드 서비시즈 비.브이. 카복실산과 퓨린, 피리미딘, 뉴클레오사이드 또는 뉴클레오타이드의 향미 조절 유도체
EP2205639B1 (en) * 2007-10-26 2015-12-23 Merck Sharp & Dohme Corp. Anti-pcsk9 and methods for treating lipid and cholesterol disorders
US7803809B2 (en) 2008-11-12 2010-09-28 Amgen Inc. Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
NZ624963A (en) 2009-04-29 2016-07-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
WO2011008931A2 (en) 2009-07-15 2011-01-20 Cystic Fibrosis Foundation Therapeutics, Inc. Arylpyrimidine compounds and combination therapy comprising same for treating cystic fibrosis & related disorders
MX2012001504A (es) 2009-08-05 2012-06-01 Versitech Ltd Compuestos antivirales y metodos para elaborarlos y usarlos.
AU2011253058A1 (en) 2010-05-13 2012-12-06 Amgen Inc. Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors
WO2011147199A1 (en) 2010-05-28 2011-12-01 Versitech Limited Compounds and methods for treating viral infections
CN102933559B (zh) 2010-06-04 2016-01-27 兴和株式会社 光学活性二苄胺衍生物及其制备方法
JP5925771B2 (ja) 2010-06-24 2016-05-25 トラスティーズ オブ タフツ カレッジ ナイアシン模倣体、およびその使用方法
WO2011163612A1 (en) 2010-06-24 2011-12-29 Trustees Of Tufts College Niacin mimetics, and methods of use thereof
EP2592933B1 (en) 2010-07-16 2017-04-05 Anderson Gaweco Mif inhibitors and their uses
WO2012016133A2 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
WO2012088438A1 (en) 2010-12-22 2012-06-28 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
JP2014506878A (ja) 2011-01-28 2014-03-20 ノバルティス アーゲー Cdk9阻害剤としての置換ビ−ヘテロアリール化合物およびそれらの使用
US9133164B2 (en) 2011-04-13 2015-09-15 Innov88 Llc MIF inhibitors and their uses
WO2012162635A1 (en) 2011-05-26 2012-11-29 Sunovion Pharmaceuticals Inc. Metabotropic glutamate receptors 5 modulators and methods of use thereof
US8815909B2 (en) 2011-07-18 2014-08-26 Bristol-Myers Squibb Company Diaminocyclohexane compounds and uses thereof
JP5741850B2 (ja) 2011-09-13 2015-07-01 コニカミノルタ株式会社 光学フィルム、それを含む偏光板および液晶表示装置
US10028926B2 (en) 2012-01-06 2018-07-24 Gemphire Therapeutics Inc. Methods of reducing risk of cardiovascular disease
TW201348231A (zh) 2012-02-29 2013-12-01 Amgen Inc 雜雙環化合物
WO2013134047A2 (en) 2012-03-07 2013-09-12 The Mclean Hospital Corporation Aminoquinoline derivatives and uses thereof
JPWO2013137371A1 (ja) 2012-03-15 2015-08-03 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
WO2013158939A1 (en) 2012-04-18 2013-10-24 Hemoshear, Llc In vitro model for pathological or physiologic conditions
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
CA2874244A1 (en) 2012-05-25 2013-11-28 Catabasis Pharmaceuticals, Inc. Methods of lowering proprotein convertase subtilisin/kexin type 9 (pcsk9)
US9434695B2 (en) 2012-07-18 2016-09-06 Sunshine Lake Pharma Co., Ltd Nitrogenous heterocyclic derivatives and their application in drugs
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
AR092924A1 (es) 2012-10-09 2015-05-06 Sanofi Sa Derivados de pirrolidinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados
HK1211232A1 (en) 2012-12-21 2016-05-20 Sanofi Exendin-4 derivatives as dual glp1/gip or trigonal glp1/gip/glucagon agonists
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Flap調節劑
AU2014211727B2 (en) 2013-02-04 2018-07-26 Prexton Therapeutics Sa Positive allosteric modulators of mGluR3
SI3527563T1 (sl) 2013-03-12 2022-01-31 Vertex Pharmaceuticals Incorporated Inhibitorji DNA-PK
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
TWI682780B (zh) 2013-05-30 2020-01-21 美商再生元醫藥公司 醫藥組成物用於製造治療與pcsk9功能獲得性突變有關之體染色體顯性高膽固醇血症的藥物之用途
TW202021614A (zh) 2013-06-07 2020-06-16 法商賽諾菲生物技術公司 藉由投與pcsk9抑制劑抑制動脈粥狀硬化的方法
WO2014201173A1 (en) 2013-06-12 2014-12-18 Amgen Inc. Bicyclic sulfonamide compounds as sodium channel inhibitors
AR092240A1 (es) 2013-08-26 2015-04-08 Sunshine Lake Pharma Co Ltd Derivados heterociclicos nitrogenados y su aplicacion en farmacos
CN105658232A (zh) 2013-08-30 2016-06-08 阿尔莫生物科技股份有限公司 使用白细胞介素-10治疗疾病和病症的方法
KR20220048051A (ko) 2013-10-11 2022-04-19 사노피 바이오테크놀로지 고지혈증을 치료하기 위한 pcsk9 억제제의 용도
CN104558685B (zh) 2013-10-24 2017-09-29 中国石油化工股份有限公司 一种磷氮膨胀型阻燃剂及其合成方法
JP2017019724A (ja) 2013-10-25 2017-01-26 第一三共株式会社 置換ピリジン化合物および他の医薬の組み合わせ
EP3080148A2 (en) 2013-12-11 2016-10-19 Glycotope GmbH Glycosylated glycophorin peptides
WO2015086732A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues
EP3080152A1 (en) 2013-12-13 2016-10-19 Sanofi Non-acylated exendin-4 peptide analogues
EP3080155A1 (en) 2013-12-13 2016-10-19 Sanofi Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重glp-1/gip受體促效劑
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
LT3119757T (lt) 2014-03-17 2018-07-10 Pfizer Inc. Diacilglicerolio aciltransferazės 2 inhibitoriai, skirti panaudoti metabolinių ir susijusių ligų gydyme
AR099936A1 (es) 2014-04-04 2016-08-31 Sanofi Sa Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados
AR099937A1 (es) 2014-04-04 2016-08-31 Sanofi Sa Compuestos de isoindolinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados
EP3126346B1 (en) 2014-04-04 2018-07-11 Sanofi Substituted indanone compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自exendin-4之雙重glp-1/升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
EP3148537B1 (en) 2014-05-30 2018-09-26 Université Paris Descartes Cyclic compounds having a 1,3 diamino-functionality for use in the treatment of hiv infection
WO2015187295A2 (en) 2014-06-02 2015-12-10 Armo Biosciences, Inc. Methods of lowering serum cholesterol
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
RU2723018C2 (ru) 2014-07-16 2020-06-08 Санофи Байотекнолоджи Способы лечения пациентов с высоким риском возникновения сердечно-сосудистых заболеваний, имеющих гиперхолестеринемию
ES2826443T3 (es) 2014-09-25 2021-05-18 Araxes Pharma Llc Inhibidores de proteínas mutantes KRAS G12C
US10245254B2 (en) 2014-10-03 2019-04-02 University of Pittsburgh—of the Commonwealth System of Higher Education Glutaminase inhibitors
BR112017015273A2 (pt) 2015-01-20 2018-01-09 Merial Inc. compostos e composições antihelmínticos e método de utilizações dos mesmos
WO2016127102A2 (en) 2015-02-06 2016-08-11 Ernesto Abel-Santos Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
AR103954A1 (es) 2015-03-18 2017-06-14 Zealand Pharma As Análogos de amilina
EP3973958A3 (en) 2015-03-20 2022-06-22 Aarhus Universitet Inhibitors of pcsk9 for treatment of lipoprotein metabolism disorders
US10336802B2 (en) 2015-04-16 2019-07-02 Zealand Pharma A/S Acylated glucagon analogue
AU2016348638A1 (en) 2015-11-06 2018-06-07 Gemphire Therapeutics Inc. Gemcabene combinations for the treatment of cardiovascular disease
TW201731867A (zh) 2015-12-02 2017-09-16 賽諾菲公司 Fgf21變異體
IL303850A (en) 2015-12-11 2023-08-01 Univ Pennsylvania Gene therapy for treating familial hypercholesterolemia
WO2017125506A1 (en) 2016-01-20 2017-07-27 Janssen Sciences Ireland Uc Aryl substituted pyrimidines for use in influenza virus infection
CN108697677A (zh) 2016-02-26 2018-10-23 燿石治疗公司 对正接受降脂疗法的纯合型家族性高胆固醇血症患者的治疗
CN109152784B (zh) 2016-03-16 2021-12-28 库拉肿瘤学公司 经取代的menin-mll抑制剂及使用方法
JP2019513802A (ja) 2016-04-14 2019-05-30 ルシー マイケル 組み合わせ組成物およびその使用方法
TW201808888A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
AU2017292184A1 (en) 2016-07-08 2019-02-07 Staten Biotechnology B.V. Anti-Apoc3 antibodies and methods of use thereof
JP2019532049A (ja) 2016-09-15 2019-11-07 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. Drp1阻害を通じたpcsk9およびldlrのモジュレーション法
LT3529360T (lt) 2016-10-18 2024-07-25 Novartis Ag Metodai, skirti širdies ir kraujagyslių ligų prevencijai mažinant proproteinų konvertazės subtilizino keksino 9 (pcsk9) baltymo kiekį
SG11201903945XA (en) 2016-11-10 2019-05-30 Csl Ltd Reconstituted high density lipoprotein treatment of myocardial infarction
JOP20190112A1 (ar) 2016-11-14 2019-05-14 Amgen Inc علاجات مدمجة لتصلب الشرايين، شاملة مرض قلبي وعائي تصلبي
WO2018106820A1 (en) 2016-12-07 2018-06-14 Kura Oncology, Inc. Methods of promoting beta cell proliferation
WO2018106818A1 (en) 2016-12-07 2018-06-14 Kura Oncology, Inc. Methods of promoting beta cell proliferation
CN110267964B (zh) 2016-12-13 2022-05-03 百时美施贵宝公司 作为IL-12、IL-23及/或IFNα响应调节剂的经取代的杂芳基氧化膦化合物
EP3579782B1 (en) 2017-02-08 2024-05-01 Brooke Schumm Intra-operative radiation therapy capsule with cylindrical shell radiation containment shutter system
CN110637027B (zh) 2017-02-08 2024-08-30 百时美施贵宝公司 包含药代动力学增强子的修饰的松弛素多肽及其用途
AR110988A1 (es) 2017-02-21 2019-05-22 Sanofi Sa Compuestos de azetidina como moduladores de gpr119 para el tratamiento de la diabetes, la obesidad, la dislipidemia y trastornos relacionados
WO2018165718A1 (en) 2017-03-17 2018-09-20 Cardio Therapeutics Pty Ltd Heterocyclic inhibitors of pcsk9
CN110691779B (zh) 2017-03-24 2023-10-10 库拉肿瘤学公司 治疗血液系统恶性肿瘤和尤因肉瘤的方法
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ApoC3抗体およびその使用方法
IL271149B2 (en) 2017-06-14 2024-05-01 Trevena Inc Compounds for modulating s1p1 activity and methods of using the same
WO2019001379A1 (zh) 2017-06-26 2019-01-03 深圳市塔吉瑞生物医药有限公司 用于抑制激酶活性的吲唑类化合物及其组合物及应用
CN109384712B (zh) 2017-08-14 2021-05-07 北京宽厚医药科技有限公司 靶向nk1受体拮抗剂及其在化疗所致恶心、呕吐治疗中的应用
WO2019079701A1 (en) 2017-10-20 2019-04-25 Dana-Farber Cancer Institute, Inc. HETEROBIFUNCTIONAL COMPOUNDS HAVING IMPROVED SPECIFICITY FOR BRD4 BROMODOMAINE
EP3687538B1 (en) 2017-10-30 2024-04-17 Montreal Heart Institute Methods of treating elevated plasma cholesterol
KR20200074975A (ko) 2017-10-31 2020-06-25 스태튼 바이오테크놀로지 비.브이. 항-ApoC3 항체 및 이의 사용 방법
UY37957A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
MX2020005210A (es) 2017-11-21 2020-08-20 Bristol Myers Squibb Co Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona.
WO2019111225A1 (en) 2017-12-08 2019-06-13 Avaliv Therapeutics Compounds and methods for the treatment of non‑alcoholic steatohepatitis
WO2019126071A1 (en) 2017-12-18 2019-06-27 Regeneron Pharmaceuticals, Inc. Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof
CA3088788A1 (en) 2018-01-17 2019-07-25 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
US11513131B2 (en) 2018-01-22 2022-11-29 Global Genomics Group, LLC Low density lipoprotein triglycerides (LDL-TG) as a biomarker of cardiovascular disease and uses thereof
JP2021512051A (ja) 2018-01-23 2021-05-13 ギラ セラピューティクス インコーポレイテッドGila Therapeutics, Inc. ペプチドyy薬学的調剤物、組成物、および方法
JP2021517141A (ja) 2018-03-09 2021-07-15 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド 心血管疾患のための組み合わせ治療
EP3768667B1 (en) 2018-03-22 2023-04-12 Bristol-Myers Squibb Company Heterocyclic compounds comprising pyridine useful as modulators of il-12, il-23 and/or ifn alpha responses
CN110384801B (zh) 2018-04-20 2021-09-14 中国科学院上海药物研究所 miRNA552簇的微小RNA在治疗LDLC相关代谢性疾病中的应用
ES2969982T3 (es) 2018-04-24 2024-05-23 Vertex Pharma Compuestos de pteridinona y usos de los mismos
US20190374526A1 (en) 2018-06-06 2019-12-12 Merck Sharp & Dohme Corp. Substituted Heterocyclic Compounds as Inhibitors of PRDM9
US11442072B2 (en) 2018-07-10 2022-09-13 Jenny and Antti Wihuri Foundation Method for measuring LDL aggregation
CR20210110A (es) 2018-08-31 2021-05-13 Pfizer Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas
WO2020070678A2 (en) 2018-10-03 2020-04-09 Staten Biotechnology B.V. Antibodies specific for human and cynomolgus apoc3 and methods of use thereof
AU2019364336B2 (en) 2018-10-22 2023-11-16 Alumis Inc. TYK2 inhibitors and uses thereof
CN113286885A (zh) 2018-11-09 2021-08-20 诺华股份有限公司 用靶向apo(a)的经缀合的反义化合物降低心血管事件的风险的方法
CA3122035A1 (en) 2018-12-06 2020-06-11 Zora Biosciences Oy Biomarkers for cardiovascular events
AU2020209216A1 (en) * 2019-01-18 2021-08-26 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
SG11202107614PA (en) * 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
CN111484480B (zh) 2019-01-29 2023-08-11 上海翰森生物医药科技有限公司 一种多环类衍生物抑制剂、其制备方法和应用
WO2020160518A1 (en) 2019-02-01 2020-08-06 Memorial Sloan Kettering Cancer Center Senolytic car-t cells targeting upar, a cell surface and secreted senescence biomarker
WO2020214753A1 (en) 2019-04-17 2020-10-22 Ngm Biopharmaceuticals, Inc. Combination therapy for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
WO2020234726A1 (en) 2019-05-20 2020-11-26 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
JP2023506732A (ja) 2019-12-10 2023-02-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ホモ接合型家族性高コレステロール血症を処置するためのpcsk9阻害剤の使用
WO2021209808A1 (en) 2020-04-16 2021-10-21 Abionyx Pharma Sa Cer-001 therapy for treating kidney disease
CN113713107B (zh) 2020-05-26 2022-09-23 中国科学院上海药物研究所 miRNA552簇的微小RNA在治疗糖脂代谢病中的应用
CA3179316A1 (en) 2020-05-29 2021-12-02 Andrew W. HAMER Pcsk9 inhibitors and methods of use thereof to treat cholesterol-related disorders
TWI897977B (zh) 2020-06-10 2025-09-21 荷蘭商菲林公司 用於治療動脈粥樣硬化性心血管疾病之藥物化合物
WO2022028317A1 (en) 2020-08-05 2022-02-10 Rezubio Pharmaceuticals Co., Ltd Antidiabetic compounds and compositions
WO2022029334A1 (en) 2020-08-07 2022-02-10 Gbiotech S.À.R.L. Combination therapies for treating coronavirus infection
WO2022040371A1 (en) 2020-08-19 2022-02-24 Biogen Ma Inc. Methods for treating hypercholesterolemia
JP2023543409A (ja) 2020-09-15 2023-10-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 疼痛に対するleprアゴニストの使用
PL4232448T3 (pl) 2020-10-20 2025-10-13 Halo Therapeutics Ltd Agoniści receptora 1 wolnych kwasów tłuszczowych i ich zastosowanie w chorobach związanych z wymienionym receptorem
WO2022098841A1 (en) 2020-11-05 2022-05-12 Amgen Inc. METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS
US12419888B2 (en) 2020-12-11 2025-09-23 Institut De Cardiologie De Montreal Methods of treating elevated plasma cholesterol
WO2022123120A1 (en) 2020-12-11 2022-06-16 Helsingin Yliopisto Method for determining a likelihood of a subject to respond to lipid lowering therapy
PL4294257T3 (pl) 2021-02-22 2026-02-09 Regeneron Pharmaceuticals, Inc. Sposób diagnozowania i leczenia częściowej lipodystrofii
WO2022182918A1 (en) 2021-02-25 2022-09-01 Icahn School Of Medicine At Mount Sinai Methods for inhibiting inflammation and progression of atherosclerotic plaques and cardiovascular events in patients with cerebro- and cardio-vascular disease
EP4312978A2 (en) 2021-03-27 2024-02-07 TRX Biosciences Limited Compositions having improved bioavailability of therapeutics
AU2022299514A1 (en) 2021-06-24 2024-01-18 Sirnaomics, Inc. Products and compositions
EP4359441A1 (en) 2021-06-25 2024-05-01 Amgen Inc. Treatment of cardiovascular disease with trem-1 antigen binding proteins
WO2023285583A1 (en) 2021-07-14 2023-01-19 Eternygen Uk Ltd. 5,6,7,8-tetrahydro-2,6- and 2,7-naphthyridine derivatives for use in the treatment of diseases responsive to citrate transporter modulation
WO2023052783A1 (en) 2021-09-30 2023-04-06 Sitryx Therapeutics Limited Novel compounds
WO2023079294A1 (en) 2021-11-05 2023-05-11 Sitryx Therapeutics Limited Phthalazine derivatives as pyruvate kinase modulators
EP4446307A4 (en) 2021-11-12 2025-12-10 Shenzhen Jingtai Tech Co Ltd ASPARTIC ACID DERIVATIVE AND ITS USE IN THE TREATMENT OF METABOLIC DISEASES SUCH AS HEPATIC FIBROSIS AND NON-ALCOHOLIC HEPATITIS
CN114277032A (zh) 2021-12-31 2022-04-05 华中科技大学同济医学院附属协和医院 一种低密度脂蛋白受体基因突变体及其应用
US20250223281A1 (en) 2022-01-14 2025-07-10 Rezubio Pharmaceuticals Co., Ltd Antidiabetic compounds and compositions
TW202345865A (zh) 2022-01-24 2023-12-01 大陸商上海舶望製藥有限公司 抑制LPA(Apo(a))蛋白表達的組合物和方法
CN116617390A (zh) 2022-02-11 2023-08-22 武汉大学 Asgr1抑制剂在促进胆固醇外排和治疗非酒精性脂肪性肝病中的应用
US20250177377A1 (en) 2022-03-11 2025-06-05 University Of Florida Research Foundation, Incorporated Targeting ptchd1 and neuronal cholesterol to enhance safety of opioid analgesics
US20230338419A1 (en) 2022-03-21 2023-10-26 The Trustees Of The University Of Pennsylvania Methods and apparatus for diagnosis and detection of cardiac allograft vasculopathy
CN119161484A (zh) 2022-04-25 2024-12-20 武汉大学 抗asgr1单克隆抗体及其应用
US20250295724A1 (en) 2022-05-13 2025-09-25 Zhejiang Yangshengtang Institute Of Natural Medication Co., Ltd. Composition of malus niedzwetzkyana dieck and prunus cerasifera ehrhart and use thereof in terms of resisting atherosclerosis
CN115581694A (zh) 2022-11-10 2023-01-10 正大青春宝药业有限公司 洋川芎内脂i在制备治疗高血脂症药物中的应用
CN117180404A (zh) 2023-10-24 2023-12-08 清华大学 Cholesin在调节胆固醇稳态中的用途
CN117482076A (zh) 2023-11-24 2024-02-02 中国人民解放军陆军军医大学第二附属医院 甲硫氨酸类化合物在制备pcsk9抑制剂中的应用

Similar Documents

Publication Publication Date Title
JP2025106240A5 (https=)
Joffe et al. Treatment of depression and menopause-related symptoms with the serotonin-norepinephrine reuptake inhibitor duloxetine
Thomas et al. MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity
WO2008050329A3 (en) Novel sirnas and methods of use thereof
NO20071930L (no) t4Metoder og sammensetninger til behandling av hyperlipidemi.
EP3276004A3 (en) Methods for treating chronic kidney disease
JP2013503110A5 (https=)
WO2009044392A3 (en) Novel sirna structures
JP2007527914A5 (https=)
JP2019514871A5 (https=)
CL2011000798A1 (es) Uso de etexilato de dabigatran o una sal del mismo para preparar un medicamento util para la prevencion del ictus en pacientes que padecen fibrilacion auricular.
US11098309B2 (en) Compositions and methods for reactivating latent immunodeficiency virus
JP2009517473A5 (https=)
BRPI0922789A2 (pt) peptídeo de ligação de albumina intermediador para reconhecimento de doença
ECSP11011029A (es) Método para tratar o prevenir la trombosis usando etexilato de dabigatrán o una sal del mismo con una eficacia mejorada sobre la terapia con warfarina convencional.
Ueda et al. Addition of cilostazol to aspirin therapy for secondary prevention of cardiovascular and cerebrovascular disease in patients undergoing percutaneous coronary intervention: A randomized, open-label trial
JP2009545526A5 (https=)
Martin-Ventura et al. Treatment with amlodipine and atorvastatin has additive effect on blood and plaque inflammation in hypertensive patients with carotid atherosclerosis: New strategies to prevent cardiovascular risk in chronic kidney disease
JP2011503008A5 (https=)
Remington Rational pharmacotherapy in early psychosis
RU2012129839A (ru) Комбинация теобромина с деконгестантом и ее применение для лечения кашля
CA2633077A1 (en) Solid-state form of amg 706 and pharmaceutical compositions thereof
Thase et al. Citalopram treatment of paroxetine‐intolerant depressed patients
CO6351711A2 (es) Combinacion de dosis fija en la forma de una tableta de dos copas o de una sola capa de alisquireno y amlodipina
WO2005028616A3 (en) Morphogen compositions and methods of use thereof to treat heart disorders