JP2011503008A5 - - Google Patents
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- Publication number
- JP2011503008A5 JP2011503008A5 JP2010532334A JP2010532334A JP2011503008A5 JP 2011503008 A5 JP2011503008 A5 JP 2011503008A5 JP 2010532334 A JP2010532334 A JP 2010532334A JP 2010532334 A JP2010532334 A JP 2010532334A JP 2011503008 A5 JP2011503008 A5 JP 2011503008A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- antibody
- treatment
- symptoms
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000024891 symptom Diseases 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 3
- 102000002227 Interferon Type I Human genes 0.000 claims 2
- 108010014726 Interferon Type I Proteins 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- ZKRFOXLVOKTUTA-KQYNXXCUSA-N 9-(5-phosphoribofuranosyl)-6-mercaptopurine Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=S)=C2N=C1 ZKRFOXLVOKTUTA-KQYNXXCUSA-N 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102100030323 Epigen Human genes 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 101000938352 Homo sapiens Epigen Proteins 0.000 claims 1
- 101000998969 Homo sapiens Inositol-3-phosphate synthase 1 Proteins 0.000 claims 1
- 101001006892 Homo sapiens Krueppel-like factor 10 Proteins 0.000 claims 1
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100036881 Inositol-3-phosphate synthase 1 Human genes 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102100027798 Krueppel-like factor 10 Human genes 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 claims 1
- 238000011529 RT qPCR Methods 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 206010040867 Skin hypertrophy Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 206010040882 skin lesion Diseases 0.000 claims 1
- 231100000444 skin lesion Toxicity 0.000 claims 1
- 230000007838 tissue remodeling Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99617507P | 2007-11-05 | 2007-11-05 | |
| US60/996,175 | 2007-11-05 | ||
| US10045408P | 2008-09-26 | 2008-09-26 | |
| US61/100,454 | 2008-09-26 | ||
| PCT/US2008/082481 WO2009061818A1 (en) | 2007-11-05 | 2008-11-05 | Methods of treating scleroderma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014075310A Division JP2014144966A (ja) | 2007-11-05 | 2014-04-01 | 強皮症の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503008A JP2011503008A (ja) | 2011-01-27 |
| JP2011503008A5 true JP2011503008A5 (https=) | 2011-12-08 |
| JP5767475B2 JP5767475B2 (ja) | 2015-08-19 |
Family
ID=43087976
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532334A Active JP5767475B2 (ja) | 2007-11-05 | 2008-11-05 | 強皮症の治療方法 |
| JP2014075310A Pending JP2014144966A (ja) | 2007-11-05 | 2014-04-01 | 強皮症の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014075310A Pending JP2014144966A (ja) | 2007-11-05 | 2014-04-01 | 強皮症の治療方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20110008365A1 (https=) |
| EP (1) | EP2219452B1 (https=) |
| JP (2) | JP5767475B2 (https=) |
| KR (1) | KR20100098620A (https=) |
| CN (1) | CN101909444B (https=) |
| AU (1) | AU2008324800B2 (https=) |
| BR (1) | BRPI0819195A2 (https=) |
| CA (1) | CA2703705A1 (https=) |
| CY (1) | CY1117251T1 (https=) |
| DK (1) | DK2219452T3 (https=) |
| ES (1) | ES2557352T3 (https=) |
| HR (1) | HRP20151403T1 (https=) |
| HU (1) | HUE025787T2 (https=) |
| IL (1) | IL205452A (https=) |
| MX (1) | MX2010004814A (https=) |
| NZ (1) | NZ585064A (https=) |
| PL (1) | PL2219452T3 (https=) |
| PT (1) | PT2219452E (https=) |
| RU (1) | RU2530561C2 (https=) |
| SI (1) | SI2219452T1 (https=) |
| WO (1) | WO2009061818A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160070165A (ko) | 2008-02-08 | 2016-06-17 | 메디뮨 엘엘씨 | Ｆｃ 리간드 친화성이 감소된 항-ＩＦＮＡＲ１ 항체 |
| BR112013030242A2 (pt) * | 2011-05-25 | 2016-12-06 | Medimmune Llc | método de tratamento de um distúrbio autoimune em um sujeito humano |
| KR102320059B1 (ko) * | 2012-06-13 | 2021-11-01 | 아스트라제네카 아베 | 항-i형 인터페론 수용체(ifnar) 항체에 대한 고정 투여 계획 |
| WO2017087634A1 (en) * | 2015-11-17 | 2017-05-26 | The Regents Of The University Of Colorado, A Body Corporate | Novel multiplex assays to diagnose or evaluate diseases or disorders in mammals |
| CN120392997A (zh) | 2021-04-23 | 2025-08-01 | 阿斯利康(瑞典)有限公司 | 用于皮下注射的抗ifnar1给药方案 |
| CN118320101B (zh) * | 2024-06-14 | 2024-09-17 | 天津嘉氏堂科技有限公司 | iNOS抑制剂在制备治疗硬皮病胶原沉积药物中的应用 |
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| US3461808A (en) | 1967-07-03 | 1969-08-19 | Wood John Co | Diaphragm hand pumps |
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| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| GB8303165D0 (en) | 1983-02-04 | 1983-03-09 | Secher D S | Monoclonal antibody |
| EP0139676B1 (en) | 1983-02-04 | 1992-11-25 | Cytoclonal Pharmaceutics Inc. | Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins |
| DE3306060A1 (de) | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
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| EP0216846B2 (en) | 1985-04-01 | 1995-04-26 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| EP0205404B1 (en) | 1985-06-11 | 1992-07-15 | Ciba-Geigy Ag | Hybrid interferons |
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| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3923126A1 (de) | 1989-07-13 | 1991-01-17 | Stark Henric | Lautsprecherbox |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
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| AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
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-
2008
- 2008-11-05 NZ NZ585064A patent/NZ585064A/xx unknown
- 2008-11-05 PT PT88476809T patent/PT2219452E/pt unknown
- 2008-11-05 SI SI200831557T patent/SI2219452T1/sl unknown
- 2008-11-05 KR KR1020107012340A patent/KR20100098620A/ko not_active Ceased
- 2008-11-05 CN CN2008801242621A patent/CN101909444B/zh active Active
- 2008-11-05 EP EP08847680.9A patent/EP2219452B1/en active Active
- 2008-11-05 ES ES08847680.9T patent/ES2557352T3/es active Active
- 2008-11-05 HR HRP20151403TT patent/HRP20151403T1/hr unknown
- 2008-11-05 HU HUE08847680A patent/HUE025787T2/en unknown
- 2008-11-05 CA CA2703705A patent/CA2703705A1/en not_active Abandoned
- 2008-11-05 DK DK08847680.9T patent/DK2219452T3/en active
- 2008-11-05 US US12/741,262 patent/US20110008365A1/en not_active Abandoned
- 2008-11-05 WO PCT/US2008/082481 patent/WO2009061818A1/en not_active Ceased
- 2008-11-05 MX MX2010004814A patent/MX2010004814A/es active IP Right Grant
- 2008-11-05 BR BRPI0819195A patent/BRPI0819195A2/pt not_active Application Discontinuation
- 2008-11-05 AU AU2008324800A patent/AU2008324800B2/en active Active
- 2008-11-05 RU RU2010122644/15A patent/RU2530561C2/ru active
- 2008-11-05 JP JP2010532334A patent/JP5767475B2/ja active Active
- 2008-11-05 PL PL08847680T patent/PL2219452T3/pl unknown
-
2010
- 2010-04-29 IL IL205452A patent/IL205452A/en active IP Right Grant
-
2014
- 2014-04-01 JP JP2014075310A patent/JP2014144966A/ja active Pending
-
2016
- 2016-01-11 CY CY20161100012T patent/CY1117251T1/el unknown
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