|
JPS5991308A
(ja)
*
|
1982-11-16 |
1984-05-26 |
Kawasaki Heavy Ind Ltd |
平面の検出方法
|
|
DK1146908T3
(da)
|
1999-01-27 |
2005-10-10 |
Becker David Dr |
Formuleringer omfattende antisense-nukleotider mod connexiner
|
|
EP1197553A1
(en)
*
|
2000-10-12 |
2002-04-17 |
A3D GmbH, Antisense Design & Drug Development |
Antisense nucleic acid against alphaV integrin
|
|
US20050119211A1
(en)
*
|
2001-05-18 |
2005-06-02 |
Sirna Therapeutics, Inc. |
RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
|
|
CA3059497A1
(en)
*
|
2003-12-03 |
2005-06-16 |
Ocunexus Therapeutics, Inc. |
Antisense compounds targeted to connexins and methods of use thereof
|
|
US9408381B2
(en)
|
2004-12-21 |
2016-08-09 |
Musc Foundation For Research Development |
Alpha Connexin c-Terminal (ACT) peptides for use in transplant
|
|
SG158153A1
(en)
|
2004-12-21 |
2010-01-29 |
Musc Found For Res Dev |
Compositions and methods for promoting wound healing and tissue regeneration
|
|
DK1959981T3
(da)
|
2005-02-03 |
2020-01-27 |
Coda Therapeutics Ltd |
Anti-connexin 43 forbindelser til behandling af kroniske sår
|
|
WO2007055224A1
(ja)
*
|
2005-11-08 |
2007-05-18 |
Kansai Technology Licensing Organization Co., Ltd. |
角膜疾患治療剤
|
|
JP5713377B2
(ja)
|
2005-12-28 |
2015-05-07 |
ザ スクリプス リサーチ インスティテュート |
薬物標的としての天然アンチセンスおよび非コードｒｎａ転写物
|
|
JP2010507387A
(ja)
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のｓｉＲＮＡおよびその使用方法
|
|
EP2091557A2
(en)
*
|
2006-11-15 |
2009-08-26 |
Coda Therapeutics, INC. |
Improved methods and compositions for wound healing
|
|
AU2014204482B2
(en)
*
|
2006-12-11 |
2016-07-07 |
Coda Therapeutics, Inc. |
Anticonnexin polynucleotides as impaired wound healing compositions
|
|
CN101835476B
(zh)
|
2006-12-11 |
2016-08-17 |
科达治疗公司 |
作为受损伤口愈合组合物的抗连接蛋白多核苷酸
|
|
DK2166845T3
(en)
*
|
2007-06-21 |
2016-02-01 |
Musc Found For Res Dev |
ALFA-connexin C-terminal (ACT) peptides FOR THE TREATMENT OF AGE-related macular degeneration
|
|
RU2487716C2
(ru)
|
2007-10-03 |
2013-07-20 |
Кварк Фармасьютикалс, Инк. |
Новые структуры малых интерферирующих рнк (sirna)
|
|
EP2245158A2
(en)
*
|
2007-12-11 |
2010-11-03 |
Coda Therapeutics, Inc. |
Impaired wound healing compositions and treatments
|
|
US20110300130A1
(en)
|
2007-12-11 |
2011-12-08 |
Becker David L |
Impaired wound healing compositions and treatments
|
|
CA2710232A1
(en)
*
|
2007-12-21 |
2009-07-09 |
Coda Therapeutics, Inc. |
Treatment of abnormal or excessive scars
|
|
JP2011507861A
(ja)
*
|
2007-12-21 |
2011-03-10 |
コーダ セラピューティクス， インコーポレイテッド |
線維症性の状態の治療のための抗コネキシンポリヌクレオチド剤と組み合わせた抗コネキシンポリペプチド剤の使用
|
|
US8975237B2
(en)
*
|
2007-12-21 |
2015-03-10 |
Coda Therapeutics, Inc. |
Treatment of fibrotic conditions
|
|
US20110144182A1
(en)
*
|
2007-12-21 |
2011-06-16 |
David Lawrence Becker |
Treatment of surgical adhesions
|
|
CA2710375A1
(en)
*
|
2007-12-21 |
2009-07-09 |
Coda Therapeutics, Inc. |
Treatment of orthopedic conditions
|
|
JP2011507599A
(ja)
|
2007-12-21 |
2011-03-10 |
コーダ セラピューティクス， インコーポレイテッド |
改良医療デバイス
|
|
US20110243964A1
(en)
*
|
2007-12-21 |
2011-10-06 |
Bradford James Duft |
Treatment of orthopedic conditions
|
|
AU2008343758A1
(en)
*
|
2007-12-21 |
2009-07-09 |
Coda Therapeutics, Inc. |
Use of anti-connexin 43 polynucleotides for the treatment of abnormal or excessive scars
|
|
AU2008343839A1
(en)
*
|
2007-12-21 |
2009-07-09 |
Coda Therapeutics, Inc. |
Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of surgical adhesions
|
|
US20110038920A1
(en)
*
|
2008-01-07 |
2011-02-17 |
Ryoichi Mori |
Wound healing compositions and treatments
|
|
EP2342340A1
(en)
|
2008-09-22 |
2011-07-13 |
Rxi Pharmaceuticals Corporation |
Rna interference in skin indications
|
|
CN102239260B
(zh)
|
2008-10-03 |
2017-04-12 |
库尔纳公司 |
通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病
|
|
US20110294870A1
(en)
|
2008-12-04 |
2011-12-01 |
Opko Curna, Llc |
Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
|
|
ES2600781T3
(es)
|
2008-12-04 |
2017-02-10 |
Curna, Inc. |
Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf
|
|
ES2629630T3
(es)
|
2008-12-04 |
2017-08-11 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con eritropoyetina (EPO) mediante inhibición del transcrito antisentido natural a EPO
|
|
US8669941B2
(en)
*
|
2009-01-05 |
2014-03-11 |
Nuance Communications, Inc. |
Method and apparatus for text entry
|
|
ES2762610T3
(es)
|
2009-02-12 |
2020-05-25 |
Curna Inc |
Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF
|
|
CN102482677B
(zh)
|
2009-03-16 |
2017-10-17 |
库尔纳公司 |
通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病
|
|
WO2010107740A2
(en)
|
2009-03-17 |
2010-09-23 |
Curna, Inc. |
Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
|
|
CN103223177B
(zh)
|
2009-05-06 |
2016-08-10 |
库尔纳公司 |
通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
|
|
ES2609655T3
(es)
|
2009-05-06 |
2017-04-21 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP
|
|
JP5931720B2
(ja)
|
2009-05-08 |
2016-06-08 |
クルナ・インコーポレーテッド |
Ｄｍｄファミリーに対する天然アンチセンス転写物の抑制によるジストロフィンファミリー関連疾患の治療
|
|
DK2432881T3
(en)
|
2009-05-18 |
2018-02-26 |
Curna Inc |
TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR
|
|
CA2762987A1
(en)
|
2009-05-22 |
2010-11-25 |
Joseph Collard |
Treatment of transcription factor e3 (tfe3) and insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to tfe3
|
|
KR101704988B1
(ko)
|
2009-05-28 |
2017-02-08 |
큐알엔에이, 인크. |
항바이러스 유전자에 대한 천연 안티센스 전사체의 억제에 의한 항바이러스 유전자 관련된 질환의 치료
|
|
WO2010148050A2
(en)
|
2009-06-16 |
2010-12-23 |
Curna, Inc. |
Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
|
|
US8951981B2
(en)
|
2009-06-16 |
2015-02-10 |
Curna, Inc. |
Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
|
|
WO2010151671A2
(en)
|
2009-06-24 |
2010-12-29 |
Curna, Inc. |
Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
|
|
EP2446037B1
(en)
|
2009-06-26 |
2016-04-20 |
CuRNA, Inc. |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
|
CN102712925B
(zh)
|
2009-07-24 |
2017-10-27 |
库尔纳公司 |
通过抑制sirtuin(sirt)的天然反义转录物来治疗sirtuin(sirt)相关性疾病
|
|
CN102762731B
(zh)
|
2009-08-05 |
2018-06-22 |
库尔纳公司 |
通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病
|
|
CN104313027B
(zh)
|
2009-08-11 |
2018-11-20 |
库尔纳公司 |
通过抑制脂连蛋白(adipoq)的天然反义转录物治疗脂连蛋白(adipoq)相关疾病
|
|
KR101805213B1
(ko)
|
2009-08-21 |
2017-12-06 |
큐알엔에이, 인크. |
Ｃｈｉｐ에 대한 천연 안티센스 전사체의 억제에 의한 “ｈｓｐ70-상호작용 단백질(ｃｈｉｐ)의 ｃ-말단” 관련된 질환의 치료
|
|
CA2771172C
(en)
|
2009-08-25 |
2021-11-30 |
Opko Curna, Llc |
Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
|
|
US20120295952A1
(en)
|
2009-09-25 |
2012-11-22 |
Curna, Inc. |
Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity
|
|
JP6025567B2
(ja)
|
2009-12-16 |
2016-11-16 |
カッパーアールエヌエー，インコーポレイテッド |
膜結合転写因子ペプチダーゼ、部位１（ｍｂｔｐｓ１）に対する天然アンチセンス転写物の阻害によるｍｂｔｐｓ１関連性疾患の治療
|
|
RU2619185C2
(ru)
|
2009-12-23 |
2017-05-12 |
Курна, Инк. |
Лечение заболеваний, связанных с разобщающим белком 2 (ucp2), путем ингибирования природного антисмыслового транскрипта к ucp2
|
|
CN102869776B
(zh)
|
2009-12-23 |
2017-06-23 |
库尔纳公司 |
通过抑制肝细胞生长因子(hgf)的天然反义转录物而治疗hgf相关疾病
|
|
EP2519633B1
(en)
|
2009-12-29 |
2017-10-25 |
CuRNA, Inc. |
Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1
|
|
ES2585829T3
(es)
|
2009-12-29 |
2016-10-10 |
Curna, Inc. |
Tratamiento de las enfermedades relacionadas con la proteína tumoral 63 (p63) por inhibición de transcripción antisentido natural a p63
|
|
CA2785727C
(en)
|
2009-12-31 |
2020-01-07 |
Curna, Inc. |
Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
|
|
CA2785832A1
(en)
|
2010-01-04 |
2011-07-07 |
Curna, Inc. |
Treatment of interferon regulatory factor 8 (irf8) related diseases by inhibition of natural antisense transcript to irf8
|
|
KR101853509B1
(ko)
|
2010-01-06 |
2018-04-30 |
큐알엔에이, 인크. |
췌장 발달 유전자에 대한 천연 안티센스 전사체의 억제에 의한 췌장 발달 유전자와 관련된 질환의 치료
|
|
JP6027893B2
(ja)
|
2010-01-11 |
2016-11-16 |
カッパーアールエヌエー，インコーポレイテッド |
性ホルモン結合グロブリン（ｓｈｂｇ）に対する天然アンチセンス転写物の阻害による性ホルモン結合グロブリン（ｓｈｂｇ）関連疾患の治療
|
|
EP2529015B1
(en)
|
2010-01-25 |
2017-11-15 |
CuRNA, Inc. |
Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1
|
|
CN102844435B
(zh)
|
2010-02-22 |
2017-05-10 |
库尔纳公司 |
通过抑制吡咯啉‑5‑羧酸还原酶1(pycr1)的天然反义转录物而治疗pycr1相关疾病
|
|
EP3560503B1
(en)
|
2010-03-24 |
2021-11-17 |
Phio Pharmaceuticals Corp. |
Rna interference in dermal and fibrotic indications
|
|
RU2612884C2
(ru)
|
2010-04-02 |
2017-03-13 |
Курна, Инк. |
Лечение заболеваний, связанных с колониестимулирующим фактором 3 (csf3), путем ингибирования природного антисмыслового транскрипта k csf3
|
|
WO2011127337A2
(en)
|
2010-04-09 |
2011-10-13 |
Opko Curna Llc |
Treatment of fibroblast growth factor 21 (fgf21) related diseases by inhibition of natural antisense transcript to fgf21
|
|
WO2011139387A1
(en)
|
2010-05-03 |
2011-11-10 |
Opko Curna, Llc |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
|
TWI531370B
(zh)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
|
|
US8895528B2
(en)
|
2010-05-26 |
2014-11-25 |
Curna, Inc. |
Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
|
|
ES2664585T3
(es)
|
2010-05-26 |
2018-04-20 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con metionina sulfóxido reductasa (MSRA) mediante inhibición del transcrito antisentido natural a MSRA
|
|
CN109112126B
(zh)
|
2010-06-23 |
2024-06-14 |
库尔纳公司 |
通过抑制电压门控钠通道α亚基(SCNA)的天然反义转录物而治疗SCNA相关疾病
|
|
JP5998131B2
(ja)
|
2010-07-14 |
2016-09-28 |
カッパーアールエヌエー，インコーポレイテッド |
Ｄｉｓｃｓｌａｒｇｅｈｏｍｏｌｏｇ（ｄｌｇ）ｄｌｇ１への天然アンチセンス転写物の阻害によるｄｌｇ関連疾患の治療
|
|
CN103210086B
(zh)
|
2010-10-06 |
2017-06-09 |
库尔纳公司 |
通过抑制唾液酸酶4(neu4)的天然反义转录物而治疗neu4相关疾病
|
|
KR101865433B1
(ko)
|
2010-10-22 |
2018-07-13 |
큐알엔에이, 인크. |
알파-l 이두로니다아제 (idua)에 대한 자연 안티센스 전사체의 저해에 의한 idua 관련된 질환의 치료
|
|
US10000752B2
(en)
|
2010-11-18 |
2018-06-19 |
Curna, Inc. |
Antagonat compositions and methods of use
|
|
WO2012071238A2
(en)
|
2010-11-23 |
2012-05-31 |
Opko Curna Llc |
Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog
|
|
KR102043422B1
(ko)
|
2011-06-09 |
2019-11-11 |
큐알엔에이, 인크. |
프라탁신 (fxn)에 대한 자연 안티센스 전사체의 저해에 의한 프라탁신 (fxn) 관련된 질환의 치료
|
|
MX365525B
(es)
|
2011-09-06 |
2019-06-06 |
Curna Inc |
Compuestos que regulan la expresión de subunidades alfa de canales de sodio regulados por voltaje en enfermedades relacionadas con epilepsia mioclónica severa de la infancia.
|
|
US9308163B2
(en)
|
2012-02-15 |
2016-04-12 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods of treating and preventing diseases and disorders of the central nervous system
|
|
CA2866115C
(en)
|
2012-03-01 |
2020-03-24 |
Firststring Research, Inc. |
Topical gels containing alpha connexin c-terminal (act) peptides
|
|
HK1210211A1
(en)
|
2012-03-15 |
2016-04-15 |
科纳公司 |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
|
CA2868534A1
(en)
|
2012-03-27 |
2013-10-03 |
Coda Therapeutics, Inc. |
Compositions and treatments based on cadherin modulation
|
|
US20140274872A1
(en)
*
|
2013-03-15 |
2014-09-18 |
Coda Therapeutics, Inc. |
Compositions and treatments based on cadherin modulation
|
|
WO2014164805A1
(en)
*
|
2013-03-11 |
2014-10-09 |
University Of North Carolina At Chapel Hill |
Compositions and methods for targeting o-linked n-acetylglucosamine transferase and promoting wound healing
|
|
US9156896B2
(en)
|
2013-03-15 |
2015-10-13 |
Coda Therapeutics, Inc. |
Wound healing compositions and treatments
|
|
CN105960265A
(zh)
*
|
2013-12-04 |
2016-09-21 |
阿克赛医药公司 |
利用经化学修饰的寡核苷酸处理伤口愈合的方法
|
|
WO2015130840A2
(en)
*
|
2014-02-25 |
2015-09-03 |
Coda Therapeutics, Inc. |
Treatment of resistant lesions
|
|
WO2015191795A1
(en)
|
2014-06-12 |
2015-12-17 |
The Research Foundation For The State University Of New York |
Methods of using gap junctions as therapeutic targets for the treatment of degenerative disorders of the retina
|
|
US10465188B2
(en)
|
2014-08-22 |
2019-11-05 |
Auckland Uniservices Limited |
Channel modulators
|
|
US10900039B2
(en)
|
2014-09-05 |
2021-01-26 |
Phio Pharmaceuticals Corp. |
Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
|
|
EP3419998A4
(en)
*
|
2016-02-26 |
2019-09-25 |
The Board of Regents of The University of Texas System |
CONNEXIN (CX) 43 HEMICANAL BINDING ANTIBODIES AND USES THEREOF
|
|
US12544344B2
(en)
*
|
2017-04-19 |
2026-02-10 |
Phio Pharmaceuticals Corp. |
Topical delivery of nucleic acid compounds
|
|
CN111201247A
(zh)
|
2017-04-28 |
2020-05-26 |
奥克兰联合服务有限公司 |
治疗方法和新颖构建体
|
|
EP3685824A1
(en)
*
|
2019-01-25 |
2020-07-29 |
Breitenbronn-Consulting GbR |
Composition for administering and releasing oligonucleotides
|
|
JP2023546757A
(ja)
|
2020-10-22 |
2023-11-07 |
シークエル・バイオ・インコーポレイテッド |
ペプチド製剤および眼科におけるその使用
|
|
US20250289864A1
(en)
*
|
2022-05-13 |
2025-09-18 |
University Of Utah Research Foundation |
Gja1-20k to limited cardiac arrhythmias
|