JP2011510647A5 - - Google Patents
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- Publication number
- JP2011510647A5 JP2011510647A5 JP2010544739A JP2010544739A JP2011510647A5 JP 2011510647 A5 JP2011510647 A5 JP 2011510647A5 JP 2010544739 A JP2010544739 A JP 2010544739A JP 2010544739 A JP2010544739 A JP 2010544739A JP 2011510647 A5 JP2011510647 A5 JP 2011510647A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- composition
- vector
- mrna
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091033319 polynucleotide Proteins 0.000 claims 19
- 239000002157 polynucleotide Substances 0.000 claims 19
- 102000040430 polynucleotide Human genes 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 17
- 108020004999 messenger RNA Proteins 0.000 claims 15
- 239000013598 vector Substances 0.000 claims 12
- 108091026838 U1 spliceosomal RNA Proteins 0.000 claims 8
- 208000035473 Communicable disease Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000001613 neoplastic effect Effects 0.000 claims 6
- 108091027967 Small hairpin RNA Proteins 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 239000004055 small Interfering RNA Substances 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 108091035707 Consensus sequence Proteins 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 230000001629 suppression Effects 0.000 claims 3
- 241000710929 Alphavirus Species 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 241000713666 Lentivirus Species 0.000 claims 2
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 241001529453 unidentified herpesvirus Species 0.000 claims 2
- 241001430294 unidentified retrovirus Species 0.000 claims 2
- 229940122498 Gene expression inhibitor Drugs 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001124 posttranscriptional effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200800222 | 2008-01-29 | ||
| PCT/ES2009/000045 WO2009095517A2 (es) | 2008-01-29 | 2009-01-29 | Métodos y composiciones capaces de provocar un silenciamiento post-transcripcional de la expresión génica de forma sinérgica |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011510647A JP2011510647A (ja) | 2011-04-07 |
| JP2011510647A5 true JP2011510647A5 (https=) | 2012-03-08 |
Family
ID=40807539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544739A Pending JP2011510647A (ja) | 2008-01-29 | 2009-01-29 | 遺伝子発現の転写後抑制を相乗的に生じさせることができる方法および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110030075A1 (https=) |
| EP (1) | EP2246432A2 (https=) |
| JP (1) | JP2011510647A (https=) |
| CN (1) | CN101981189A (https=) |
| AU (1) | AU2009209571A1 (https=) |
| BR (1) | BRPI0906657A2 (https=) |
| CA (1) | CA2713458A1 (https=) |
| MX (1) | MX2010008326A (https=) |
| RU (1) | RU2010136040A (https=) |
| WO (1) | WO2009095517A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8907075B2 (en) | 2007-03-30 | 2014-12-09 | Samuel Ian Gunderson | Compositions and methods for gene silencing |
| US9441221B2 (en) | 2007-03-30 | 2016-09-13 | Rutgers, The State University Of New Jersey | Compositions and methods for gene silencing |
| US8343941B2 (en) | 2007-03-30 | 2013-01-01 | Rutgers, The State University Of New Jersey | Compositions and methods for gene silencing |
| WO2012045894A1 (es) * | 2010-10-05 | 2012-04-12 | Proyecto De Biomedicina Cima, S.L. | Compuestos y composiciones para el tratamiento de enfermedades debidas a la infección por el virus de la hepatitis b |
| KR102413498B1 (ko) * | 2013-04-20 | 2022-06-24 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 엑손 2-표적 U7snRNA 폴리뉴클레오티드 작제물의 재조합형 아데노 부속 바이러스 전달 |
| EP2853595A1 (en) * | 2013-09-30 | 2015-04-01 | Soluventis GmbH | NOTCH 1 specific siRNA molecules |
| CN107746857B (zh) * | 2017-08-07 | 2021-02-05 | 中国农业大学 | 一种抑制基因表达的rna干扰方法 |
| CN108893487A (zh) * | 2018-07-19 | 2018-11-27 | 中国农业科学院北京畜牧兽医研究所 | 一种含有C-Myc蛋白融合标签的植物表达质粒载体及其载体的构建方法 |
| KR20220002882A (ko) * | 2019-03-08 | 2022-01-07 | 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 | 헌팅톤병을 치료하기 위한 조성물 및 방법 |
| CN114159459A (zh) * | 2021-12-20 | 2022-03-11 | 塔里木大学 | miR-26a在制备治疗子宫内膜炎的药物中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2164088C (en) | 1993-06-07 | 2005-06-14 | Gary J. Nabel | Plasmids suitable for gene therapy |
| CA2225460A1 (en) | 1995-06-23 | 1997-01-09 | Winston Campbell Patterson | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
| US6692910B2 (en) * | 1997-07-28 | 2004-02-17 | The University Of Connecticut | Inhibition of a target messenger RNA with a modified U1 small nuclear RNA |
| EP1384784A1 (en) | 2001-03-30 | 2004-01-28 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Method for reversible inhibition of gene expression by modified ribonucleoproteins |
| EP2390331B1 (en) | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| WO2003093441A2 (en) | 2002-05-03 | 2003-11-13 | Duke University | A method of regulating gene expression |
| US20050060771A1 (en) | 2003-09-11 | 2005-03-17 | Farmer Andrew Alan | siRNA encoding constructs and methods for using the same |
| WO2006012221A2 (en) | 2004-06-25 | 2006-02-02 | The Regents Of The University Of California | Target cell-specific short interfering rna and methods of use thereof |
| WO2006135436A2 (en) | 2004-10-22 | 2006-12-21 | University Of Florida Research Foundation, Inc. | Inhibition of gene expression and therapeutic uses thereof |
| EP2311967B1 (en) | 2005-10-20 | 2017-09-20 | UniQure IP B.V. | Improved AAV vectors produced in insect cells |
| EP1969000A2 (en) | 2005-12-06 | 2008-09-17 | Centre National de la Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| KR101589259B1 (ko) | 2006-06-21 | 2016-02-01 | 유니큐어 아이피 비.브이. | 곤충세포 내 ａａｖ의 생산에 유용한 ａａｖ-ｒｅｐ78의 번역을 위한 변형된 개시 코돈을 갖는 벡터 |
| GB0701722D0 (en) * | 2007-01-30 | 2007-03-07 | Scottish Crop Res Inst | Inhibition of gene expression |
-
2009
- 2009-01-29 CN CN2009801118031A patent/CN101981189A/zh active Pending
- 2009-01-29 WO PCT/ES2009/000045 patent/WO2009095517A2/es not_active Ceased
- 2009-01-29 JP JP2010544739A patent/JP2011510647A/ja active Pending
- 2009-01-29 RU RU2010136040/10A patent/RU2010136040A/ru not_active Application Discontinuation
- 2009-01-29 BR BRPI0906657-8A patent/BRPI0906657A2/pt not_active IP Right Cessation
- 2009-01-29 EP EP09705069A patent/EP2246432A2/en not_active Withdrawn
- 2009-01-29 US US12/865,046 patent/US20110030075A1/en not_active Abandoned
- 2009-01-29 CA CA2713458A patent/CA2713458A1/en not_active Abandoned
- 2009-01-29 MX MX2010008326A patent/MX2010008326A/es not_active Application Discontinuation
- 2009-01-29 AU AU2009209571A patent/AU2009209571A1/en not_active Abandoned
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