EA201000085A1 - dsPHK, ПРЕДНАЗНАЧЕННАЯ ДЛЯ ЛЕЧЕНИЯ ВИРУСНОЙ ИНФЕКЦИИ - Google Patents

dsPHK, ПРЕДНАЗНАЧЕННАЯ ДЛЯ ЛЕЧЕНИЯ ВИРУСНОЙ ИНФЕКЦИИ

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Publication number
EA201000085A1
EA201000085A1 EA201000085A EA201000085A EA201000085A1 EA 201000085 A1 EA201000085 A1 EA 201000085A1 EA 201000085 A EA201000085 A EA 201000085A EA 201000085 A EA201000085 A EA 201000085A EA 201000085 A1 EA201000085 A1 EA 201000085A1
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EA
Eurasian Patent Office
Prior art keywords
kinase
pik4cb
polypeptide
human
phosphatidylnositol
Prior art date
Application number
EA201000085A
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English (en)
Inventor
Марк Арон Лейбоу
Ларри Александер Гейтер
Джейсон Боравски
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Новартис Аг
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201000085A1 publication Critical patent/EA201000085A1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

В заявке описаны двухцепочечные рибонуклеиновые кислоты (dsPHK), оказывающие направленное воздействие на экспрессию фосфатидилинозитол-4-киназы (PI4K), в частности человеческой фосфатидилинозитол-4-киназы, каталитической, бета-полипептида (PIK4CB), или человеческой фосфатидилинозитол-4-киназы, каталитической, альфа-полипептида (PIK4CA), и их применение для лечения инфекции, вызываемой РНКовыми вирусами с позитивной цепью, такими как вирус гепатита С (HCV). Каждая dsPHK содержит антисмысловую цепь, которая имеет нуклеотидную последовательность, состоящую по меньшей мере из 30 нуклеотидов, как правило 19-25 нуклеотидов, и которая практически комплементарна по меньшей мере части мРНК PIK4CB- или PIK4CA-мишени. Для достижения благоприятного терапевтического действия можно применять несколько указанных dsPHK. В заявке описана также фармацевтическая композиция, которая содержит dsPHK в сочетании с фармацевтически приемлемым носителем и включает устройство для введения, такое как полностью капсулированные липосомы или липидные комплексы.
EA201000085A 2007-07-05 2008-07-04 dsPHK, ПРЕДНАЗНАЧЕННАЯ ДЛЯ ЛЕЧЕНИЯ ВИРУСНОЙ ИНФЕКЦИИ EA201000085A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94810007P 2007-07-05 2007-07-05
PCT/EP2008/058706 WO2009004085A2 (en) 2007-07-05 2008-07-04 Dsrna for treating viral infection

Publications (1)

Publication Number Publication Date
EA201000085A1 true EA201000085A1 (ru) 2010-10-29

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EA201000085A EA201000085A1 (ru) 2007-07-05 2008-07-04 dsPHK, ПРЕДНАЗНАЧЕННАЯ ДЛЯ ЛЕЧЕНИЯ ВИРУСНОЙ ИНФЕКЦИИ

Country Status (11)

Country Link
US (5) US20100184823A1 (ru)
EP (3) EP2164966A2 (ru)
JP (2) JP5558346B2 (ru)
KR (1) KR101722263B1 (ru)
CN (2) CN101688206B (ru)
AU (1) AU2008270209B2 (ru)
BR (1) BRPI0814189A2 (ru)
CA (1) CA2692503C (ru)
EA (1) EA201000085A1 (ru)
ES (2) ES2428009T3 (ru)
WO (1) WO2009004085A2 (ru)

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RU2789127C2 (ru) * 2018-01-17 2023-01-30 Глаксосмиткляйн Интеллектуал Проперти Девелопмент Лимитед Ингибиторы p14kiii бета

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GB201115665D0 (en) 2011-09-09 2011-10-26 Univ Leuven Kath Autoimmune and inflammatory disorder therapy
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US20180002702A1 (en) 2014-12-26 2018-01-04 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
US10792299B2 (en) 2014-12-26 2020-10-06 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
PT3236974T (pt) * 2014-12-26 2020-06-01 Nitto Denko Corp Agentes de interferência de rna para modulação génica de gst-pi
US10264976B2 (en) * 2014-12-26 2019-04-23 The University Of Akron Biocompatible flavonoid compounds for organelle and cell imaging
US10059949B2 (en) * 2015-11-16 2018-08-28 Olix Pharmaceuticals, Inc. Treatment of age-related macular degeneration using RNA complexes that target MYD88 or TLR3
JP2019508379A (ja) * 2017-02-16 2019-03-28 日東電工株式会社 悪性腫瘍に対する治療方法及び治療用組成物
TW202126294A (zh) * 2019-07-05 2021-07-16 大陸商挪貝肽醫藥科技（上海）有限公司 小分子PI4KIIIα抑制劑組合物、其製備方法及用途
CN112662690B (zh) * 2020-12-31 2022-07-19 山西大学 飞蝗Rab5基因及其dsRNA在飞蝗防治中的应用
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