JP2012532859A5 - - Google Patents
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- Publication number
- JP2012532859A5 JP2012532859A5 JP2012519080A JP2012519080A JP2012532859A5 JP 2012532859 A5 JP2012532859 A5 JP 2012532859A5 JP 2012519080 A JP2012519080 A JP 2012519080A JP 2012519080 A JP2012519080 A JP 2012519080A JP 2012532859 A5 JP2012532859 A5 JP 2012532859A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- fibroblasts
- regulatory
- stem cells
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000130 stem cell Anatomy 0.000 claims 12
- 210000002950 fibroblast Anatomy 0.000 claims 11
- 210000003289 regulatory T cell Anatomy 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 210000004324 lymphatic system Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 208000026278 immune system disease Diseases 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 3
- 108010068370 Glutens Proteins 0.000 claims 2
- 102000006386 Myelin Proteins Human genes 0.000 claims 2
- 108010083674 Myelin Proteins Proteins 0.000 claims 2
- 235000021312 gluten Nutrition 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 210000005210 lymphoid organ Anatomy 0.000 claims 2
- 210000005012 myelin Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000026062 Tissue disease Diseases 0.000 claims 1
- 210000001099 axilla Anatomy 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22427509P | 2009-07-09 | 2009-07-09 | |
| US61/224,275 | 2009-07-09 | ||
| PCT/IB2010/001968 WO2011004264A1 (en) | 2009-07-09 | 2010-07-09 | Methods and compositions for use in cellular therapies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532859A JP2012532859A (ja) | 2012-12-20 |
| JP2012532859A5 true JP2012532859A5 (https=) | 2013-08-15 |
| JP5892931B2 JP5892931B2 (ja) | 2016-03-23 |
Family
ID=42782196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519080A Active JP5892931B2 (ja) | 2009-07-09 | 2010-07-09 | 細胞治療において使用するための方法および組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8679834B2 (https=) |
| EP (2) | EP3150703A1 (https=) |
| JP (1) | JP5892931B2 (https=) |
| KR (1) | KR101788885B1 (https=) |
| CN (2) | CN107007626A (https=) |
| AU (1) | AU2010269962B2 (https=) |
| BR (1) | BR112012000534A2 (https=) |
| CA (1) | CA2767300C (https=) |
| DK (1) | DK2451943T3 (https=) |
| ES (1) | ES2479542T3 (https=) |
| HU (1) | HUE031921T2 (https=) |
| IL (1) | IL217377A (https=) |
| MX (1) | MX359639B (https=) |
| NZ (1) | NZ597975A (https=) |
| PL (1) | PL2451943T3 (https=) |
| PT (1) | PT2451943T (https=) |
| RU (1) | RU2610427C2 (https=) |
| SG (2) | SG177582A1 (https=) |
| WO (1) | WO2011004264A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| EP3184630B1 (en) | 2005-09-23 | 2019-07-17 | TiGenix, S.A.U. | Cell populations having immunoregulatory activity, method for isolation and uses |
| US8846098B2 (en) | 2009-07-10 | 2014-09-30 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Artificial cell constructs for cellular manipulation |
| US11090363B2 (en) | 2009-07-10 | 2021-08-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Vasoactive intestinal peptide release from microparticles |
| EP2663316A2 (en) * | 2011-01-12 | 2013-11-20 | TiGenix, S.A.U. | Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| KR102246369B1 (ko) | 2011-11-30 | 2021-04-29 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
| WO2013149211A2 (en) * | 2012-03-30 | 2013-10-03 | University Of Southern California | Compositions and treatment methods for mesenchymal stem cell-induced immunoregulation |
| US9745551B2 (en) | 2012-07-12 | 2017-08-29 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| US10258652B2 (en) | 2014-12-18 | 2019-04-16 | Pluristem Ltd. | Methods and compositions for treating and preventing muscle wasting disorders |
| WO2016107563A1 (zh) * | 2014-12-29 | 2016-07-07 | 西比曼生物科技（上海）有限公司 | 一种用于治疗上呼吸道疾病的脂肪间充质祖细胞复合物 |
| WO2016151476A1 (en) | 2015-03-23 | 2016-09-29 | Pluristem Ltd. | Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof |
| US20210205370A1 (en) | 2016-02-18 | 2021-07-08 | Pluristem Ltd. | Methods and compositions for treating cancers and neoplasms |
| GB201604304D0 (en) | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| US12161688B2 (en) | 2016-06-30 | 2024-12-10 | Mapi Pharma Ltd | Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells |
| WO2018211486A1 (en) | 2017-05-15 | 2018-11-22 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells |
| AU2018270396B2 (en) | 2017-05-15 | 2025-03-20 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
| CN107281469A (zh) * | 2017-07-17 | 2017-10-24 | 广东颜值科技有限公司 | 一种细胞组合物及其制备方法和应用 |
| CN107349419A (zh) * | 2017-07-17 | 2017-11-17 | 广东颜值科技有限公司 | 一种细胞组合物及其制备方法和应用 |
| US12268714B2 (en) | 2018-09-14 | 2025-04-08 | Luca Science Inc. | Transplantation of mitochondria into lymphoid organ and composition therefor |
| JP2022527455A (ja) * | 2019-03-19 | 2022-06-02 | フィジーン、エルエルシー | 活性化線維芽細胞及びそのエキソソーム誘導体を用いた慢性閉塞性肺疾患及び肺変性の治療 |
| AU2020284114B2 (en) | 2019-05-31 | 2025-06-26 | Fibrobiologics, Inc. | Concurrent activation of regenerative and tolerogenic processes by fibroblast-based compositions for the treatment of multiple sclerosis |
| US20240000850A1 (en) * | 2020-04-08 | 2024-01-04 | Figene, Llc | Methods and compositions for allergy and asthma treatment using fibroblasts |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60334474D1 (de) * | 2002-07-12 | 2010-11-18 | Univ Johns Hopkins | Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren |
| ES2354944T3 (es) * | 2002-12-06 | 2011-03-21 | Northwest Biotherapeutics, Inc. | Administración de células dendríticas maduradas parcialmente in vitro para el tratamiento de tumores. |
| EP3184630B1 (en) | 2005-09-23 | 2019-07-17 | TiGenix, S.A.U. | Cell populations having immunoregulatory activity, method for isolation and uses |
| US8241621B2 (en) * | 2006-12-18 | 2012-08-14 | Medistem Laboratories | Stem cell mediated treg activation/expansion for therapeutic immune modulation |
| EP2578677A1 (en) * | 2007-08-09 | 2013-04-10 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
| US20110262402A1 (en) * | 2007-09-07 | 2011-10-27 | Masahiko Kuroda | Therapeutic and prophylactic agents for arthritis |
| EP2279246A4 (en) * | 2008-05-02 | 2012-03-28 | Massachusetts Inst Technology | METHOD AND COMPOSITIONS FOR MODULATING IMMUNOLOGICAL TOLERANCE |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
-
2010
- 2010-07-09 CA CA2767300A patent/CA2767300C/en active Active
- 2010-07-09 BR BR112012000534A patent/BR112012000534A2/pt not_active Application Discontinuation
- 2010-07-09 US US13/382,426 patent/US8679834B2/en active Active
- 2010-07-09 SG SG2012001574A patent/SG177582A1/en unknown
- 2010-07-09 EP EP16199980.0A patent/EP3150703A1/en not_active Withdrawn
- 2010-07-09 EP EP10752171.8A patent/EP2451943B1/en active Active
- 2010-07-09 WO PCT/IB2010/001968 patent/WO2011004264A1/en not_active Ceased
- 2010-07-09 RU RU2012104529A patent/RU2610427C2/ru active
- 2010-07-09 NZ NZ597975A patent/NZ597975A/en unknown
- 2010-07-09 CN CN201710067652.0A patent/CN107007626A/zh active Pending
- 2010-07-09 AU AU2010269962A patent/AU2010269962B2/en active Active
- 2010-07-09 KR KR1020127003364A patent/KR101788885B1/ko active Active
- 2010-07-09 CN CN2010800308900A patent/CN102549147A/zh active Pending
- 2010-07-09 ES ES10752171.8T patent/ES2479542T3/es active Active
- 2010-07-09 HU HUE10752171A patent/HUE031921T2/en unknown
- 2010-07-09 PL PL10752171T patent/PL2451943T3/pl unknown
- 2010-07-09 JP JP2012519080A patent/JP5892931B2/ja active Active
- 2010-07-09 MX MX2012000396A patent/MX359639B/es active IP Right Grant
- 2010-07-09 PT PT107521718T patent/PT2451943T/pt unknown
- 2010-07-09 SG SG10201403758SA patent/SG10201403758SA/en unknown
- 2010-07-09 DK DK10752171.8T patent/DK2451943T3/en active
-
2012
- 2012-01-05 IL IL217377A patent/IL217377A/en active IP Right Grant
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