JP2014502628A5 - - Google Patents
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- JP2014502628A5 JP2014502628A5 JP2013548903A JP2013548903A JP2014502628A5 JP 2014502628 A5 JP2014502628 A5 JP 2014502628A5 JP 2013548903 A JP2013548903 A JP 2013548903A JP 2013548903 A JP2013548903 A JP 2013548903A JP 2014502628 A5 JP2014502628 A5 JP 2014502628A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- million
- dose
- cell
- million cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 25
- 210000000130 stem cell Anatomy 0.000 claims 9
- 210000002950 fibroblast Anatomy 0.000 claims 5
- 210000003289 regulatory T cell Anatomy 0.000 claims 4
- 210000004324 lymphatic system Anatomy 0.000 claims 3
- 108010068370 Glutens Proteins 0.000 claims 2
- 102000006386 Myelin Proteins Human genes 0.000 claims 2
- 108010083674 Myelin Proteins Proteins 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 235000021312 gluten Nutrition 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 210000005210 lymphoid organ Anatomy 0.000 claims 2
- 210000005012 myelin Anatomy 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 e.g. Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11250025 | 2011-01-12 | ||
| EP11250025.1 | 2011-01-12 | ||
| PCT/IB2012/000097 WO2012095743A2 (en) | 2011-01-12 | 2012-01-12 | Methods and compositions for use in intralymphatic cellular therapies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016190665A Division JP2017035094A (ja) | 2011-01-12 | 2016-09-29 | 自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502628A JP2014502628A (ja) | 2014-02-03 |
| JP2014502628A5 true JP2014502628A5 (https=) | 2015-03-05 |
| JP6018081B2 JP6018081B2 (ja) | 2016-11-02 |
Family
ID=45558792
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013548903A Active JP6018081B2 (ja) | 2011-01-12 | 2012-01-12 | 自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞 |
| JP2016190665A Pending JP2017035094A (ja) | 2011-01-12 | 2016-09-29 | 自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016190665A Pending JP2017035094A (ja) | 2011-01-12 | 2016-09-29 | 自己免疫および炎症性疾患におけるリンパ系内投与用の脂肪由来間葉系幹細胞 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140154274A1 (https=) |
| EP (1) | EP2663316A2 (https=) |
| JP (2) | JP6018081B2 (https=) |
| KR (1) | KR101900664B1 (https=) |
| ES (1) | ES2479544T1 (https=) |
| WO (1) | WO2012095743A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| KR101536239B1 (ko) | 2005-09-23 | 2015-07-13 | 셀레릭스, 에스.엘. | 면역조절활성을 갖는 세포 개체군, 분리 방법 및 용도 |
| EP3013943B1 (en) * | 2013-06-25 | 2019-04-10 | TiGenix, S.A.U. | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
| US20150104470A1 (en) * | 2013-10-11 | 2015-04-16 | Neil H. Riordan | Immune modulation by peri-lymphatic or intra-lymphatic cell therapy |
| US20170121685A1 (en) * | 2015-11-02 | 2017-05-04 | Tigenix S.A.U. | Mesenchymal stem cell-derived exosomes and their uses |
| GB201604304D0 (en) | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| EP3453391A4 (en) * | 2016-05-06 | 2020-01-08 | Educational Foundation of Osaka Medical and Pharmaceutical University | PREPARATION OF NANOPARTICLES CONTAINING A STATINE TO IMPROVE THE FUNCTION OF STEM CELLS TO TREAT INFLAMMATORY DISEASE, AND FUNCTIONALLY IMPROVED STEM CELLS CONTAINING IT TO TREAT INFLAMMATORY DISEASE |
| JP6788003B2 (ja) * | 2016-08-26 | 2020-11-18 | 学校法人大阪医科薬科大学 | スタチン封入ナノ粒子を含有する機能増強幹細胞を含む炎症性疾患治療用細胞製剤 |
| EP4046642A4 (en) | 2019-10-17 | 2022-12-21 | TERUMO Kabushiki Kaisha | CELL CULTURE FOR THE TREATMENT OF INFLAMMATORY DISEASES |
| US20240000850A1 (en) * | 2020-04-08 | 2024-01-04 | Figene, Llc | Methods and compositions for allergy and asthma treatment using fibroblasts |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9694038B2 (en) * | 2000-04-06 | 2017-07-04 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| DE60334474D1 (de) * | 2002-07-12 | 2010-11-18 | Univ Johns Hopkins | Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren |
| EP3461884B1 (en) * | 2004-03-22 | 2025-05-28 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| WO2005097147A1 (en) * | 2004-03-30 | 2005-10-20 | Boston Scientific Limited (Incorporated In Ireland) | Restenosis therapy using mesenchymal stem cells |
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| KR101536239B1 (ko) | 2005-09-23 | 2015-07-13 | 셀레릭스, 에스.엘. | 면역조절활성을 갖는 세포 개체군, 분리 방법 및 용도 |
| BRPI0909541A2 (pt) * | 2008-05-27 | 2016-10-11 | Pluristem Ltd | ''método para tratamento de doenças inflamatórias do cólon'' |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| JPWO2010101249A1 (ja) * | 2009-03-06 | 2012-09-10 | 国立大学法人三重大学 | Ｔ細胞の機能増強方法 |
| EP3150703A1 (en) * | 2009-07-09 | 2017-04-05 | TiGenix, S.A.U. | Cells for use in a method for treating inflammatory and/or immune disorders |
| WO2011047345A2 (en) * | 2009-10-15 | 2011-04-21 | Tai June Yoo | Methods of treating diseases of conditions using mesenchymal stem cells |
-
2012
- 2012-01-12 US US13/979,308 patent/US20140154274A1/en not_active Abandoned
- 2012-01-12 ES ES12701941.2T patent/ES2479544T1/es active Pending
- 2012-01-12 JP JP2013548903A patent/JP6018081B2/ja active Active
- 2012-01-12 WO PCT/IB2012/000097 patent/WO2012095743A2/en not_active Ceased
- 2012-01-12 EP EP12701941.2A patent/EP2663316A2/en not_active Ceased
- 2012-01-12 KR KR1020137021276A patent/KR101900664B1/ko active Active
-
2016
- 2016-09-29 JP JP2016190665A patent/JP2017035094A/ja active Pending
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