JP2023545509A5 - - Google Patents
Info
- Publication number
- JP2023545509A5 JP2023545509A5 JP2023523013A JP2023523013A JP2023545509A5 JP 2023545509 A5 JP2023545509 A5 JP 2023545509A5 JP 2023523013 A JP2023523013 A JP 2023523013A JP 2023523013 A JP2023523013 A JP 2023523013A JP 2023545509 A5 JP2023545509 A5 JP 2023545509A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- alkyl
- ring
- aryl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063091894P | 2020-10-14 | 2020-10-14 | |
| US63/091,894 | 2020-10-14 | ||
| PCT/US2021/055104 WO2022081927A1 (en) | 2020-10-14 | 2021-10-14 | Tricyclic compounds to degrade neosubstrates for medical therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023545509A JP2023545509A (ja) | 2023-10-30 |
| JP2023545509A5 true JP2023545509A5 (https=) | 2024-10-22 |
Family
ID=81208653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023523013A Pending JP2023545509A (ja) | 2020-10-14 | 2021-10-14 | 医学的療法のための、ネオ基質を分解する三環式化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240018118A1 (https=) |
| EP (1) | EP4228624A4 (https=) |
| JP (1) | JP2023545509A (https=) |
| KR (1) | KR20230107807A (https=) |
| CN (1) | CN116457339A (https=) |
| AU (1) | AU2021360596A1 (https=) |
| CA (1) | CA3194351A1 (https=) |
| IL (1) | IL302036A (https=) |
| MX (1) | MX2023004369A (https=) |
| WO (1) | WO2022081927A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| MX2023004374A (es) * | 2020-10-14 | 2023-07-06 | C4 Therapeutics Inc | Ligandos tricíclicos para la degradación de la familia ikaros 2 o la familia ikaros 4. |
| CA3228839A1 (en) * | 2021-08-27 | 2023-03-02 | Liqiang Fu | Isoindolinone compound and use thereof |
| CN118451068A (zh) | 2021-12-30 | 2024-08-06 | 上海翰森生物医药科技有限公司 | 三并环类衍生物抑制剂、其制备方法和应用 |
| EP4584259A1 (en) * | 2022-09-09 | 2025-07-16 | Innovo Therapeutics, Inc. | Ck1alpha and dual ck1alpha / gspt1 degrading compounds |
| WO2024073507A1 (en) | 2022-09-28 | 2024-04-04 | Theseus Pharmaceuticals, Inc. | Macrocyclic compounds and uses thereof |
| CN119998290A (zh) | 2022-10-03 | 2025-05-13 | 公立大学法人横滨市立大学 | 具有二环性结构的咪唑并吡啶衍生物 |
| WO2024096753A1 (en) | 2022-11-02 | 2024-05-10 | Captor Therapeutics S.A. | Nek7 degraders and methods of use thereof |
| CN120530105A (zh) * | 2023-01-20 | 2025-08-22 | 海南先声再明医药股份有限公司 | 取代的三环化合物及其应用 |
| CN120569372A (zh) | 2023-01-24 | 2025-08-29 | 第一三共株式会社 | 经取代的苯化合物 |
| CN117903192A (zh) * | 2023-03-12 | 2024-04-19 | 上海相辉医药科技有限公司 | 一种3-甲氧基异喹啉化合物中间体的制备方法 |
| WO2024259303A1 (en) * | 2023-06-16 | 2024-12-19 | Oncopia Therapeutics, Inc. D/B/A Sk Life Science Labs | Compounds and compositions as cereblon ligands and uses thereof |
| TW202530189A (zh) | 2023-09-29 | 2025-08-01 | 日商第一三共股份有限公司 | ３－苯基丙基胺衍生物 |
| WO2025162410A1 (zh) * | 2024-01-31 | 2025-08-07 | 微境生物医药科技(上海)有限公司 | 新型蛋白降解剂及抗体-蛋白降解剂偶联物 |
| WO2026021557A1 (zh) * | 2024-07-26 | 2026-01-29 | 上海超阳药业有限公司 | 苯并吲哚衍生物的药物组合物、制备方法及用途 |
| WO2026048766A1 (ja) * | 2024-08-27 | 2026-03-05 | 第一三共株式会社 | 多環性化合物 |
| WO2026065268A1 (en) * | 2024-09-29 | 2026-04-02 | Biofront Ltd | Novel conjugates for protein degradation, compositions comprising the same, and methods of using the same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1675550A4 (en) * | 2003-09-24 | 2007-10-10 | Combinatorx Inc | THERAPEUTIC DOSAGE DIAGRAMS FOR ADMINISTRATION OF MEDICINAL COMBINATIONS |
| WO2016105518A1 (en) * | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| CN111662226B (zh) * | 2015-01-28 | 2022-03-18 | 中国科学院广州生物医药与健康研究院 | 一种2-氧代-1,2-二氢苯并[cd]吲哚类化合物 |
| WO2017197056A1 (en) * | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
| IL312367A (en) * | 2017-01-31 | 2024-06-01 | Arvinas Operations Inc | Cereblon ligands and bifunctional compounds comprising the same |
| SG11202002218VA (en) * | 2017-09-15 | 2020-04-29 | Aduro Biotech Inc | Pyrazolopyrimidinone compounds and uses thereof |
| WO2019148055A1 (en) * | 2018-01-26 | 2019-08-01 | Yale University | Imide-based modulators of proteolysis and methods of use |
| CA3101338A1 (en) * | 2018-06-13 | 2019-12-19 | Biotheryx, Inc. | Aminoamide compounds |
| US12030892B2 (en) * | 2018-06-29 | 2024-07-09 | Dana-Farber Cancer Institute, Inc. | CRBN modulators |
| AR116109A1 (es) * | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| CA3123519A1 (en) * | 2019-02-15 | 2020-08-20 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| WO2020210630A1 (en) * | 2019-04-12 | 2020-10-15 | C4 Therapeutics, Inc. | Tricyclic degraders of ikaros and aiolos |
| EP4077319A1 (en) * | 2019-12-20 | 2022-10-26 | Calico Life Sciences LLC | Protein tyrosine phosphatase degraders and methods of use thereof |
| TWI887465B (zh) * | 2020-08-07 | 2025-06-21 | 美商Ｃ４醫藥公司 | 用於伊卡洛斯(ikaros)或愛露斯(aiolos)介導之病症之有利療法 |
| MX2023004374A (es) * | 2020-10-14 | 2023-07-06 | C4 Therapeutics Inc | Ligandos tricíclicos para la degradación de la familia ikaros 2 o la familia ikaros 4. |
| CN116723839A (zh) * | 2020-10-14 | 2023-09-08 | C4医药公司 | 用于降解靶蛋白质的三环杂双官能化合物 |
-
2021
- 2021-10-14 CA CA3194351A patent/CA3194351A1/en active Pending
- 2021-10-14 JP JP2023523013A patent/JP2023545509A/ja active Pending
- 2021-10-14 EP EP21881144.6A patent/EP4228624A4/en active Pending
- 2021-10-14 AU AU2021360596A patent/AU2021360596A1/en active Pending
- 2021-10-14 CN CN202180079148.7A patent/CN116457339A/zh active Pending
- 2021-10-14 MX MX2023004369A patent/MX2023004369A/es unknown
- 2021-10-14 WO PCT/US2021/055104 patent/WO2022081927A1/en not_active Ceased
- 2021-10-14 IL IL302036A patent/IL302036A/en unknown
- 2021-10-14 KR KR1020237015799A patent/KR20230107807A/ko active Pending
-
2023
- 2023-04-14 US US18/134,990 patent/US20240018118A1/en active Pending
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