JP2023545509A - 医学的療法のための、ネオ基質を分解する三環式化合物 - Google Patents

医学的療法のための、ネオ基質を分解する三環式化合物 Download PDF

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JP2023545509A
JP2023545509A JP2023523013A JP2023523013A JP2023545509A JP 2023545509 A JP2023545509 A JP 2023545509A JP 2023523013 A JP2023523013 A JP 2023523013A JP 2023523013 A JP2023523013 A JP 2023523013A JP 2023545509 A JP2023545509 A JP 2023545509A
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heteroaryl
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クリストファー ジー． ナスヴェシュク
コリー ドン アンダーソン
ジェームズ エー． ヘンダーソン
ビクトリア ガルザ
ヤンケ リャン
モーゼ ムースタキム
モーガン ヴェルツェル オーシェア
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シーフォー セラピューティクス， インコーポレイテッド
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JP2023523013A 2020-10-14 2021-10-14 医学的療法のための、ネオ基質を分解する三環式化合物 Pending JP2023545509A (ja)

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US202063091894P 2020-10-14 2020-10-14
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PCT/US2021/055104 WO2022081927A1 (en) 2020-10-14 2021-10-14 Tricyclic compounds to degrade neosubstrates for medical therapy

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JP2023545508A (ja) * 2020-10-14 2023-10-30 シーフォー セラピューティクス， インコーポレイテッド Ｉｋｚｆ２又はｉｋｚｆ４を分解する三環式リガンド
WO2026048766A1 (ja) * 2024-08-27 2026-03-05 第一三共株式会社 多環性化合物

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CN118451068A (zh) 2021-12-30 2024-08-06 上海翰森生物医药科技有限公司 三并环类衍生物抑制剂、其制备方法和应用
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CN117903192A (zh) * 2023-03-12 2024-04-19 上海相辉医药科技有限公司 一种3-甲氧基异喹啉化合物中间体的制备方法
WO2024259303A1 (en) * 2023-06-16 2024-12-19 Oncopia Therapeutics, Inc. D/B/A Sk Life Science Labs Compounds and compositions as cereblon ligands and uses thereof
TW202530189A (zh) 2023-09-29 2025-08-01 日商第一三共股份有限公司 ３－苯基丙基胺衍生物
WO2025162410A1 (zh) * 2024-01-31 2025-08-07 微境生物医药科技(上海)有限公司 新型蛋白降解剂及抗体-蛋白降解剂偶联物
WO2026021557A1 (zh) * 2024-07-26 2026-01-29 上海超阳药业有限公司 苯并吲哚衍生物的药物组合物、制备方法及用途
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WO2020165834A1 (en) * 2019-02-15 2020-08-20 Novartis Ag Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
JP7692362B2 (ja) * 2019-04-12 2025-06-13 シーフォー セラピューティクス， インコーポレイテッド Ｉｋａｒｏｓ及びＡｉｏｌｏｓの三環式分解誘導薬
JP2023538520A (ja) * 2020-08-07 2023-09-08 シーフォー セラピューティクス， インコーポレイテッド Ｉｋａｒｏｓ又はａｉｏｌｏｓによって媒介される障害に対する有利な治療法
JP2023545508A (ja) * 2020-10-14 2023-10-30 シーフォー セラピューティクス， インコーポレイテッド Ｉｋｚｆ２又はｉｋｚｆ４を分解する三環式リガンド
JP2023545507A (ja) * 2020-10-14 2023-10-30 シーフォー セラピューティクス， インコーポレイテッド 標的化タンパク質を分解する三環式ヘテロ二官能性化合物

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Publication number Priority date Publication date Assignee Title
JP2023545508A (ja) * 2020-10-14 2023-10-30 シーフォー セラピューティクス， インコーポレイテッド Ｉｋｚｆ２又はｉｋｚｆ４を分解する三環式リガンド
WO2026048766A1 (ja) * 2024-08-27 2026-03-05 第一三共株式会社 多環性化合物

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