CN116457339A - 用于医学治疗的降解新底物的三环化合物 - Google Patents

用于医学治疗的降解新底物的三环化合物 Download PDF

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CN116457339A
CN116457339A CN202180079148.7A CN202180079148A CN116457339A CN 116457339 A CN116457339 A CN 116457339A CN 202180079148 A CN202180079148 A CN 202180079148A CN 116457339 A CN116457339 A CN 116457339A
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certain embodiments
compound
ring
formula
heteroaryl
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Chinese (zh)
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C·G·纳斯维舒克
C·D·安德森
J·A·亨德森
V·加尔扎
梁焱科
M·穆斯塔基姆
M·W·奥沙
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C4 Therapeutics Inc
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C4 Therapeutics Inc
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • C07D209/80—[b, c]- or [b, d]-condensed
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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  • Chemical & Material Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202180079148.7A 2020-10-14 2021-10-14 用于医学治疗的降解新底物的三环化合物 Pending CN116457339A (zh)

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US202063091894P 2020-10-14 2020-10-14
US63/091,894 2020-10-14
PCT/US2021/055104 WO2022081927A1 (en) 2020-10-14 2021-10-14 Tricyclic compounds to degrade neosubstrates for medical therapy

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US (1) US20240018118A1 (https=)
EP (1) EP4228624A4 (https=)
JP (1) JP2023545509A (https=)
KR (1) KR20230107807A (https=)
CN (1) CN116457339A (https=)
AU (1) AU2021360596A1 (https=)
CA (1) CA3194351A1 (https=)
IL (1) IL302036A (https=)
MX (1) MX2023004369A (https=)
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JP2023545509A (ja) 2023-10-30
MX2023004369A (es) 2023-07-06
EP4228624A4 (en) 2025-04-23
IL302036A (en) 2023-06-01
CA3194351A1 (en) 2022-04-21
US20240018118A1 (en) 2024-01-18
AU2021360596A9 (en) 2024-02-08
KR20230107807A (ko) 2023-07-18
AU2021360596A1 (en) 2023-06-08

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