JP2023520396A5 - - Google Patents

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Publication number
JP2023520396A5
JP2023520396A5 JP2022559582A JP2022559582A JP2023520396A5 JP 2023520396 A5 JP2023520396 A5 JP 2023520396A5 JP 2022559582 A JP2022559582 A JP 2022559582A JP 2022559582 A JP2022559582 A JP 2022559582A JP 2023520396 A5 JP2023520396 A5 JP 2023520396A5
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compound
tautomer
pharmaceutically acceptable
acceptable salt
variables
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JP2022559582A
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JP2023520396A (ja
JP7732999B2 (ja
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Priority claimed from PCT/US2021/025601 external-priority patent/WO2021203014A1/en
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JP2022559582A 2020-04-03 2021-04-02 アルファ1-アンチトリプシンのモジュレーター Active JP7732999B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063004702P 2020-04-03 2020-04-03
US63/004,702 2020-04-03
PCT/US2021/025601 WO2021203014A1 (en) 2020-04-03 2021-04-02 Pyrano[4,3-b]l ndole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)

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JP2023520396A JP2023520396A (ja) 2023-05-17
JP2023520396A5 true JP2023520396A5 (https=) 2024-04-10
JP7732999B2 JP7732999B2 (ja) 2025-09-02

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US (1) US12502376B2 (https=)
EP (1) EP4126881A1 (https=)
JP (1) JP7732999B2 (https=)
CN (1) CN115768772A (https=)
AU (1) AU2021248641A1 (https=)
CA (1) CA3178470A1 (https=)
WO (1) WO2021203014A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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CA3114672A1 (en) 2018-10-05 2020-04-23 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
JP7732999B2 (ja) 2020-04-03 2025-09-02 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ1-アンチトリプシンのモジュレーター
WO2022104353A1 (en) 2020-11-12 2022-05-19 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat
CN116812917B (zh) * 2022-03-21 2026-04-07 中国科学院化学研究所 一种水溶性富勒烯材料及其在防治肝损伤/肝衰竭中的应用
WO2025090827A1 (en) 2023-10-27 2025-05-01 Sub21, Inc. A1at modulators

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JP7732999B2 (ja) 2020-04-03 2025-09-02 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ1-アンチトリプシンのモジュレーター
CN115776984A (zh) 2020-04-03 2023-03-10 弗特克斯药品有限公司 作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1-抗胰蛋白酶调节剂的吡咯并[2,3-f]吲唑和2,4,5,10-四氮杂三环[7.3.0.03,7]十二碳-1,3(7),5,8,11-五烯衍生物
AU2021246104A1 (en) 2020-04-03 2022-10-20 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
WO2022026372A2 (en) 2020-07-27 2022-02-03 Vertex Pharmaceuticals Incorporated Processes for preparing modulators of alpha-1 antitrypsin
WO2022104353A1 (en) 2020-11-12 2022-05-19 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat
AU2021381509A1 (en) 2020-11-17 2023-06-22 Vertex Pharmaceuticals Incorporated Solid forms of 4-(5-(4-fluorophenyl)-6-tetrahydro-2h-pyran-4-yl)- 1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid
PE20251573A1 (es) 2022-09-09 2025-06-12 Vertex Pharma Moduladores de la alfa-1 antitripsina

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