JP2022541483A5 - - Google Patents

Info

Publication number
JP2022541483A5
JP2022541483A5 JP2022502556A JP2022502556A JP2022541483A5 JP 2022541483 A5 JP2022541483 A5 JP 2022541483A5 JP 2022502556 A JP2022502556 A JP 2022502556A JP 2022502556 A JP2022502556 A JP 2022502556A JP 2022541483 A5 JP2022541483 A5 JP 2022541483A5
Authority
JP
Japan
Prior art keywords
methyl
piperazine
oxo
carboxamide
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022502556A
Other languages
English (en)
Japanese (ja)
Other versions
JP7641944B2 (ja
JP2022541483A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2020/070306 external-priority patent/WO2021013735A1/en
Publication of JP2022541483A publication Critical patent/JP2022541483A/ja
Publication of JP2022541483A5 publication Critical patent/JP2022541483A5/ja
Application granted granted Critical
Publication of JP7641944B2 publication Critical patent/JP7641944B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022502556A 2019-07-19 2020-07-17 Parp1阻害薬 Active JP7641944B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962876065P 2019-07-19 2019-07-19
US62/876,065 2019-07-19
PCT/EP2020/070306 WO2021013735A1 (en) 2019-07-19 2020-07-17 Parp1 inhibitors

Publications (3)

Publication Number Publication Date
JP2022541483A JP2022541483A (ja) 2022-09-26
JP2022541483A5 true JP2022541483A5 (https=) 2023-07-26
JP7641944B2 JP7641944B2 (ja) 2025-03-07

Family

ID=71728735

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022502556A Active JP7641944B2 (ja) 2019-07-19 2020-07-17 Parp1阻害薬

Country Status (37)

Country Link
US (2) US11325906B2 (https=)
EP (2) EP4529952A3 (https=)
JP (1) JP7641944B2 (https=)
KR (1) KR102929356B1 (https=)
CN (1) CN114144413B (https=)
AR (1) AR119424A1 (https=)
AU (1) AU2020318599B2 (https=)
BR (1) BR112022000534A2 (https=)
CA (1) CA3145644A1 (https=)
CL (1) CL2022000110A1 (https=)
CO (1) CO2022001590A2 (https=)
CR (1) CR20220070A (https=)
DK (1) DK3999506T3 (https=)
DO (1) DOP2022000006A (https=)
EC (1) ECSP22012826A (https=)
ES (1) ES3021859T3 (https=)
FI (1) FI3999506T3 (https=)
HR (1) HRP20250373T1 (https=)
HU (1) HUE071067T2 (https=)
IL (1) IL289534B2 (https=)
JO (1) JOP20220008A1 (https=)
LT (1) LT3999506T (https=)
MA (1) MA57972B1 (https=)
MX (1) MX2022000711A (https=)
MY (1) MY208549A (https=)
NZ (1) NZ784224A (https=)
PE (1) PE20221339A1 (https=)
PH (1) PH12022550098A1 (https=)
PL (1) PL3999506T3 (https=)
PT (1) PT3999506T (https=)
RS (1) RS66682B1 (https=)
SI (1) SI3999506T1 (https=)
SM (1) SMT202500146T1 (https=)
TW (1) TWI837403B (https=)
UA (1) UA129093C2 (https=)
UY (1) UY38793A (https=)
WO (1) WO2021013735A1 (https=)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3099155A1 (en) 2018-05-14 2019-11-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CA3138197A1 (en) 2019-05-14 2020-11-19 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
SI3999506T1 (sl) 2019-07-19 2025-06-30 Astrazeneca Ab Zaviralci PARP1
EP4058464A1 (en) 2019-11-13 2022-09-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
US11795158B2 (en) 2020-06-25 2023-10-24 Astrazeneca Ab Chemical compounds
TW202228693A (zh) * 2020-10-08 2022-08-01 瑞典商阿斯特捷利康公司 用於治療癌症之組合療法
JP2023545096A (ja) 2020-10-09 2023-10-26 アストラゼネカ ユーケー リミテッド 抗体-薬物コンジュゲート及びparp1選択的阻害薬の組み合わせ
MX2023011241A (es) 2021-03-23 2023-10-03 Nuvation Bio Inc Compuestos dirigidos a receptores de hormonas nucleares contra el cancer.
EP4326713A4 (en) * 2021-04-12 2025-03-19 Impact Therapeutics (Shanghai), Inc. Substituted fused bicyclic compounds as parp inhibitors and the use thereof
US11591331B2 (en) 2021-04-19 2023-02-28 Xinthera, Inc. PARP1 inhibitors and uses thereof
EP4328224A4 (en) * 2021-04-22 2025-06-18 Wigen Biomedicine Technology (Shanghai) Co., Ltd. PARP INHIBITOR WITH PIPERAZINE STRUCTURE, MANUFACTURING METHOD THEREOF AND PHARMACEUTICAL USE THEREOF
WO2022222965A1 (zh) * 2021-04-23 2022-10-27 成都百裕制药股份有限公司 吡啶衍生物及其在医药上的应用
AU2022261029A1 (en) * 2021-04-23 2023-10-19 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Heterocyclic derivative inhibitor and preparation method therefor and application thereof
WO2022222966A1 (zh) * 2021-04-23 2022-10-27 成都百裕制药股份有限公司 一种选择性parp1抑制剂及其应用
CN115702156A (zh) * 2021-04-23 2023-02-14 南京明德新药研发有限公司 吡啶酰胺类化合物
JP2024516024A (ja) * 2021-05-03 2024-04-11 ニューベイション・バイオ・インコーポレイテッド 抗がん核内ホルモン受容体標的化化合物
MA63136A1 (fr) * 2021-05-18 2024-06-28 Onconic Therapeutics Inc. Agent thérapeutique contre le cancer résistant à un inhibiteur de parp
BR112023022496A2 (pt) * 2021-05-24 2024-01-16 Jiangsu Hengrui Pharmaceuticals Co Ltd Composto heterocíclico contendo nitrogênio, método de preparação do mesmo, e aplicação do mesmo em medicamentos
CN115403595A (zh) * 2021-05-27 2022-11-29 江苏恒瑞医药股份有限公司 含氮杂环类化合物、其制备方法及其在医药上的应用
BR112023024942A2 (pt) * 2021-06-16 2024-02-15 Repare Therapeutics Inc Uso de inibidores de atr em combinação com inibidores de parp para tratamento de câncer
US20240366584A1 (en) 2021-06-21 2024-11-07 Tesaro, Inc. Combination treatment of cancer with a parp inhibitor and a lipophilic statin
AU2022334408A1 (en) 2021-08-27 2024-02-15 Impact Therapeutics (Shanghai), Inc. Substituted tricyclic compounds as parp inhibitors and use thereof
CN118119618A (zh) * 2021-09-09 2024-05-31 南京奥利墨斯医药科技有限公司 一种杂芳环类化合物及其应用
WO2023046034A1 (zh) * 2021-09-22 2023-03-30 明慧医药(杭州)有限公司 一种含氮杂环化合物、其制备方法、其中间体及其应用
WO2023046149A1 (zh) * 2021-09-26 2023-03-30 张文燕 喹喔啉类化合物及其医药用途
WO2023046158A1 (zh) * 2021-09-26 2023-03-30 张文燕 氮杂喹啉酮类化合物及其医药用途
EP4410792A4 (en) 2021-09-30 2025-12-03 Xizang Haisco Pharmaceutical Co Ltd NITROGEN-CONTAINS HETEROCYCLIC DERIVATIVE FOR USE AS A PARP INHIBITOR AND ITS USE
WO2023051716A1 (zh) * 2021-09-30 2023-04-06 海思科医药集团股份有限公司 杂芳基衍生物parp抑制剂及其用途
EP4410791A4 (en) 2021-09-30 2025-10-22 Xizang Haisco Pharmaceutical Co Ltd BICYCLIC DERIVATIVE PARP INHIBITOR AND ITS USE
KR102867210B1 (ko) * 2021-10-01 2025-10-14 신테라, 인크. 아제티딘 및 피롤리딘 parp1 저해제, 및 이의 용도
WO2023061406A1 (zh) * 2021-10-12 2023-04-20 微境生物医药科技(上海)有限公司 含三并环结构的parp抑制剂、及其制备方法和医药用途
EP4421074A4 (en) * 2021-10-22 2025-12-03 Xizang Haisco Pharmaceutical Co Ltd PARP-1 DEGRADING AGENT AND ITS USE
AU2022392822A1 (en) 2021-11-18 2024-05-02 Astrazeneca Uk Limited Combination of antibody-drug conjugate and parp1 selective inhibitor
US20250289800A1 (en) * 2021-11-19 2025-09-18 Kangbaida (Sichuan) Biotechnology Co., Ltd. Selective Parp1 Inhibitor And Application Thereof
WO2023096915A1 (en) * 2021-11-24 2023-06-01 Slap Pharmaceuticals Llc Multicyclic compounds
KR20240144125A (ko) * 2021-12-17 2024-10-02 키테라 (쑤저우) 바이오-파마슈티컬스 컴퍼니 리미티드 Parp 억제제, 이를 포함하는 약제학적 조성물, 및 이의 용도
EP4452256B1 (en) * 2021-12-21 2025-12-10 Astrazeneca AB Methods of treating brain tumours and neuroblastomas
US20250163022A1 (en) * 2021-12-22 2025-05-22 Synnovation Therapeutics, Inc. Parp1 inhibitors
WO2023133413A1 (en) * 2022-01-07 2023-07-13 Slap Pharmaceuticals Llc Multicyclic compounds
KR20240134366A (ko) * 2022-01-13 2024-09-09 에이스랜드 테라퓨틱스 (홍콩) 리미티드 피페라진 고리 함유 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 용도
CN118434725B (zh) * 2022-01-20 2026-01-02 微境生物医药科技(上海)有限公司 吡啶酰胺类parp抑制剂、及其制备方法和医药用途
CN120081844A (zh) * 2022-01-21 2025-06-03 新特拉有限公司 Parp1抑制剂及其用途
JP7794989B2 (ja) * 2022-01-27 2026-01-06 シンセラ, インコーポレイテッド Parp1阻害薬及びその使用
WO2023146960A1 (en) * 2022-01-28 2023-08-03 Xinthera, Inc. Parp1 inhibitors and uses thereof
CN116693501B (zh) * 2022-02-10 2025-12-19 康百达(四川)生物医药科技有限公司 一种喹唑啉酮衍生物及其在医药上的应用
TW202348252A (zh) 2022-02-16 2023-12-16 英商梅迪繆思有限公司 用治療性結合分子治療癌症的組合療法
WO2023165501A1 (zh) * 2022-03-01 2023-09-07 杭州领业医药科技有限公司 Azd5305的晶型及其制备方法和用途
AU2023235233A1 (en) * 2022-03-14 2024-09-12 Slap Pharmaceuticals Llc Multicyclic compounds
US20250213556A1 (en) 2022-04-07 2025-07-03 Astrazeneca Ab Combination therapy for treating cancer
CN118973572A (zh) 2022-04-07 2024-11-15 阿斯利康(瑞典)有限公司 用于治疗癌症的组合疗法
IL316019A (en) 2022-04-07 2024-11-01 Astrazeneca Ab Combined treatment for cancer
WO2023201338A1 (en) 2022-04-15 2023-10-19 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a parp inhibitor
WO2023207284A1 (en) * 2022-04-28 2023-11-02 Ningbo Newbay Technology Development Co., Ltd Piperazine derivatives as parp1 inhibitiors
CN119487027A (zh) * 2022-04-28 2025-02-18 宁波新湾科技发展有限公司 作为parp1抑制剂的化合物
AU2023259236B2 (en) 2022-04-28 2025-01-09 Xinthera, Inc. Tricyclic parp1 inhibitors and uses thereof
JP7835895B2 (ja) * 2022-05-07 2026-03-25 サイブランチ セラピューティクス カンパニー リミテッド Parp1を選択的に阻害するフルオロキノキサリノン誘導体
EP4534537A4 (en) * 2022-05-25 2025-12-10 Xizang Haisco Pharmaceutical Co Ltd BICYCLE-DERIVED PARP INHIBITOR AND ITS USE
US20250346573A1 (en) * 2022-06-02 2025-11-13 Chengdu Easton Biopharmaceuticals Co., Ltd. Azaquinolinone derivative, preparation method therefor and use thereof
US20250352539A1 (en) 2022-06-15 2025-11-20 Astrazeneca Ab Combination therapy for treating cancer
TW202408509A (zh) * 2022-07-14 2024-03-01 大陸商西藏海思科製藥有限公司 雜芳基衍生物的藥物組合物及其在醫藥上的應用
CN115919859B (zh) * 2022-07-14 2024-01-05 四川海思科制药有限公司 一种杂芳基衍生物的药物组合物及其在医药上的应用
CN115232129B (zh) * 2022-08-18 2023-12-01 上海闻耐医药科技有限公司 一种parp1选择性抑制剂及其制备方法和用途
CN119677736A (zh) * 2022-08-24 2025-03-21 四川海思科制药有限公司 一种杂芳基衍生物parp抑制剂药学上可接受的盐及其用途
WO2024041608A1 (zh) * 2022-08-24 2024-02-29 四川海思科制药有限公司 一种杂芳基衍生物parp抑制剂的晶体形式及其用途
WO2024041643A1 (zh) * 2022-08-25 2024-02-29 江苏恒瑞医药股份有限公司 稠合三环类化合物、其制备方法及其在医药上的应用
WO2024046420A1 (zh) * 2022-08-31 2024-03-07 江苏恒瑞医药股份有限公司 稠合二环类化合物、其制备方法及其在医药上的应用
CN117658983A (zh) * 2022-09-01 2024-03-08 浙江文达医药科技有限公司 选择性parp1抑制剂
CN118119629A (zh) * 2022-09-30 2024-05-31 中国医药研究开发中心有限公司 含氮杂环类化合物及其医药用途
WO2024067694A1 (zh) * 2022-09-30 2024-04-04 中国医药研究开发中心有限公司 含氮杂环类化合物及其医药用途
US20240174669A1 (en) * 2022-10-06 2024-05-30 Xinthera, Inc. Crystalline forms of a parp1 inhibitor
WO2024083218A1 (zh) * 2022-10-20 2024-04-25 成都赜灵生物医药科技有限公司 取代四氢吡啶类化合物及其用途
WO2024083211A1 (zh) * 2022-10-20 2024-04-25 成都赜灵生物医药科技有限公司 并杂环类氘代化合物及其用途
WO2024083201A1 (zh) * 2022-10-20 2024-04-25 成都赜灵生物医药科技有限公司 并杂环类化合物及其用途
EP4606802A1 (en) * 2022-10-21 2025-08-27 Shanghai Hansoh Biomedical Co., Ltd. Salt and crystal form of heterocyclic derivative inhibitor, and preparation method therefor and use thereof
EP4612133A1 (en) * 2022-11-02 2025-09-10 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
KR20250103668A (ko) * 2022-11-10 2025-07-07 치아타이 티안큉 파마수티컬 그룹 주식회사 축합 이환 화합물
CN120035596A (zh) 2022-11-23 2025-05-23 江苏恒瑞医药股份有限公司 一种含氮杂环类化合物的可药用盐、晶型及制备方法
KR20250116727A (ko) 2022-12-06 2025-08-01 아스트라제네카 아베 Polq 저해제
AU2023412594A1 (en) * 2022-12-23 2025-07-10 Zhejiang Yangli Pharmaceutical Technology Co., Ltd. Parp1 inhibitors
CN117903159A (zh) * 2022-12-30 2024-04-19 成都硕德药业有限公司 一种内酰胺类衍生物、其制备方法及用途
CN120936382A (zh) 2023-02-16 2025-11-11 阿斯利康(瑞典)有限公司 采用治疗性结合分子治疗癌症的组合疗法
CN116396214B (zh) * 2023-03-06 2026-03-31 爱斯特(成都)生物制药股份有限公司 一种parp1抑制剂中间体的制备方法
KR20250165438A (ko) 2023-03-31 2025-11-25 아스트라제네카 아베 Azd5305의 투여 레지먼
TW202508573A (zh) 2023-05-11 2025-03-01 瑞典商阿斯特捷利康公司 用於治療癌症之組合療法
CN121311226A (zh) 2023-05-17 2026-01-09 特沙诺有限公司 聚adp核糖聚合酶(parp)抑制剂在治疗癌症中的新用途
CN121358725A (zh) 2023-06-14 2026-01-16 海思科医药集团股份有限公司 双环衍生物parp抑制剂及其用途
GB2630970A (en) * 2023-06-15 2024-12-18 Duke Street Bio Ltd PARP1 inhibitor compounds
WO2024264072A2 (en) * 2023-06-23 2024-12-26 Stablix, Inc. Parp inhibitors
WO2025026195A1 (zh) 2023-07-28 2025-02-06 广东东阳光药业股份有限公司 取代的含氮双环化合物及其用途
US20250129051A1 (en) 2023-10-23 2025-04-24 Gilead Sciences, Inc. Parp1 inhibitors and uses thereof
WO2025092973A1 (zh) * 2023-11-03 2025-05-08 成都赜灵生物医药科技有限公司 Parp1靶向化合物及其用途
TW202535479A (zh) 2023-12-05 2025-09-16 英商阿斯特捷利康英國股份有限公司 抗體藥物結合物與血腦屏障穿透性parp1選擇性抑制劑之組合
TW202545525A (zh) 2024-01-19 2025-12-01 瑞典商阿斯特捷利康公司 包含azd5305之藥物組成物
CN120398887A (zh) * 2024-01-31 2025-08-01 西藏海思科制药有限公司 一种双环衍生物parp抑制剂的晶型及其制备方法和应用
WO2025168048A1 (zh) * 2024-02-08 2025-08-14 上海璎黎药业有限公司 一种三键结构化合物、其药物组合物及其应用
KR20250128449A (ko) 2024-02-20 2025-08-28 주식회사 종근당 Parp1 억제제로서의 화합물 및 이를 포함하는 약학적 조성물
WO2025248117A1 (en) 2024-05-31 2025-12-04 Astrazeneca Ab 6-aminopurine derivatives useful as polq inhibitors
TW202547478A (zh) 2024-05-31 2025-12-16 瑞典商阿斯特捷利康公司 Polq抑制劑
WO2025261449A1 (zh) * 2024-06-19 2025-12-26 浙江扬厉医药技术有限公司 一种parp1抑制剂吡啶酰胺类化合物、中间体及其制备方法
WO2026028140A1 (en) 2024-08-01 2026-02-05 Chong Kun Dang Pharmaceutical Corp. Compound as parp1 inhibitor and pharmaceutical composition comprising the same
CN118978529A (zh) * 2024-08-02 2024-11-19 上海信诺维生物医药有限公司 一类含吡啶的杂环化合物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE201445T1 (de) 1994-08-12 2001-06-15 Myriad Genetics Inc Mutationen des mit 17q verbundenen ovarial- und brustkrebs empfindlichkeitsgens
ATE198623T1 (de) 1994-08-12 2001-01-15 Myriad Genetics Inc Verfahren zum nachweis von prädisposition von ovarial- und brustkrebs
AUPS137402A0 (en) * 2002-03-26 2002-05-09 Fujisawa Pharmaceutical Co., Ltd. Novel tricyclic compounds
PL1633724T3 (pl) 2003-03-12 2011-10-31 Kudos Pharm Ltd Pochodne ftalazynonu
CA2546002C (en) 2003-11-20 2012-09-18 Janssen Pharmaceutica N.V. 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
BRPI0416206A (pt) 2003-11-20 2006-12-26 Janssen Pharmaceutica Nv 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose)
SG151249A1 (en) 2003-12-05 2009-04-30 Janssen Pharmaceutica Nv 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
US7652014B2 (en) 2003-12-10 2010-01-26 Janssen Pharmaceutica Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
JP2008510783A (ja) 2004-08-26 2008-04-10 クドス ファーマシューティカルズ リミテッド 4−ヘテロアリールメチル置換フタラジノン誘導体
JP2010507387A (ja) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のsiRNAおよびその使用方法
ES2393326T3 (es) 2006-12-18 2012-12-20 Amgen, Inc Compuestos basados en azaquinolona que presentan actividad inhibidora de prolil hidroxilasas, composiciones y usos de los mismos
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US20090023727A1 (en) 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
CN102341394B (zh) * 2009-01-23 2015-04-15 武田药品工业株式会社 聚(adp-核糖)聚合酶(parp)抑制剂
WO2010111626A2 (en) 2009-03-27 2010-09-30 Takeda Pharmaceutical Company Limited Poly (adp-ribose) polymerase (parp) inhibitors
EP2459561A1 (en) 2009-07-30 2012-06-06 Takeda Pharmaceutical Company Limited Poly (adp-ribose) polymerase (parp) inhibitors
EP2972381A2 (en) 2013-03-14 2016-01-20 Galapagos NV Molecular targets and compounds, and methods to identify the same, useful in the treatment of diseases associated with epithelial mesenchymal transition
TW202246503A (zh) 2013-07-19 2022-12-01 美商百健Ma公司 用於調節τ蛋白表現之組合物
MX375707B (es) 2015-06-09 2025-03-06 Onconic Therapeutics Inc Compuesto derivativo triciclico, metodo para prepararlo y composicion farmaceutica que comprende el mismo.
RU2018102554A (ru) 2015-07-08 2019-08-08 ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД Производные пиридин-3-ил уксусной кислоты в качестве ингибиторов репликации вируса иммунодефицита человека
SI3999506T1 (sl) 2019-07-19 2025-06-30 Astrazeneca Ab Zaviralci PARP1
US11795158B2 (en) 2020-06-25 2023-10-24 Astrazeneca Ab Chemical compounds

Similar Documents

Publication Publication Date Title
JP2022541483A5 (https=)
JP2023532257A5 (https=)
HRP20250373T1 (hr) Inhibitori parp1
US10016426B2 (en) Pharmaceutical compositions for substituted quinazolinones
JP6021805B2 (ja) 腫瘍治療剤
JP2021102630A (ja) 血液学的悪性疾患および固形腫瘍の処置のためのidh1阻害剤
TWI351949B (en) Cftr inhibitor compounds and uses thereof
JP2021121636A (ja) 悪性腫瘍の処置の方法
WO2001095912A1 (fr) Compositions permettant de reguler la plage et/ou la vitesse de liberation du ph
JP2005511722A6 (ja) Birb796bsの投与方法
JP2005511722A (ja) Birb796bsの投与方法
RU2006109769A (ru) Применение антагонистов crth2 в терапии
JP2015508749A5 (https=)
TW201249800A (en) Method of treating cancer and bone cancer pain
JP2011509301A5 (https=)
WO2012155806A1 (zh) 4-氨基喹唑啉衍生物及其应用
JP2010540666A5 (https=)
JP2009513713A5 (https=)
EP3181554B1 (en) Quinazoline derivative
JP2017536342A5 (https=)
JP2023550902A5 (https=)
JP2011524362A5 (https=)
CN117412751A (zh) 用于预防或治疗肺纤维化的药物制剂
CN105358148A (zh) 用于治疗肾小球疾病的losmapimod
CN108349937A (zh) 二氨基吡啶衍生物