JP2022514618A - Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド - Google Patents

Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド Download PDF

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Publication number
JP2022514618A
JP2022514618A JP2021535745A JP2021535745A JP2022514618A JP 2022514618 A JP2022514618 A JP 2022514618A JP 2021535745 A JP2021535745 A JP 2021535745A JP 2021535745 A JP2021535745 A JP 2021535745A JP 2022514618 A JP2022514618 A JP 2022514618A
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JP2022514618A5 (enExample
Inventor
シェン リューホン
クック ジェームズ
マクドネル ケビン
マッド ジェマ
ヴァン リーツチョーテン カテリーヌ
ウパディヤヤ プニット
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BicycleTx Ltd
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BicycleTx Ltd
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Priority claimed from GBGB1820956.9A external-priority patent/GB201820956D0/en
Priority claimed from GBGB1904621.8A external-priority patent/GB201904621D0/en
Priority claimed from GBGB1905631.6A external-priority patent/GB201905631D0/en
Application filed by BicycleTx Ltd filed Critical BicycleTx Ltd
Publication of JP2022514618A publication Critical patent/JP2022514618A/ja
Publication of JP2022514618A5 publication Critical patent/JP2022514618A5/ja
Priority to JP2024174010A priority Critical patent/JP2025020121A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2021535745A 2018-12-21 2019-12-23 Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド Pending JP2022514618A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024174010A JP2025020121A (ja) 2018-12-21 2024-10-03 Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB1820956.9A GB201820956D0 (en) 2018-12-21 2018-12-21 Bicyclic peptide ligands specific for pd-l1
GB1820956.9 2018-12-21
GBGB1904621.8A GB201904621D0 (en) 2019-04-02 2019-04-02 Bicyclic peptide ligands specific for PD-L1
GB1904621.8 2019-04-02
GBGB1905631.6A GB201905631D0 (en) 2019-04-23 2019-04-23 Bicyclic peptide ligands specific for pd-l1
GB1905631.6 2019-04-23
US201962910113P 2019-10-03 2019-10-03
US62/910,113 2019-10-03
PCT/GB2019/053679 WO2020128526A1 (en) 2018-12-21 2019-12-23 Bicyclic peptide ligands specific for pd-l1

Related Child Applications (1)

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JP2024174010A Division JP2025020121A (ja) 2018-12-21 2024-10-03 Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド

Publications (2)

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JP2022514618A true JP2022514618A (ja) 2022-02-14
JP2022514618A5 JP2022514618A5 (enExample) 2022-12-28

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JP2021535745A Pending JP2022514618A (ja) 2018-12-21 2019-12-23 Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド
JP2024174010A Pending JP2025020121A (ja) 2018-12-21 2024-10-03 Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド

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US (2) US12492224B2 (enExample)
EP (1) EP3897849A1 (enExample)
JP (2) JP2022514618A (enExample)
CN (1) CN113474045A (enExample)
WO (1) WO2020128526A1 (enExample)

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NZ731185A (en) 2014-10-29 2024-03-22 Bicyclerd Ltd Bicyclic peptide ligands specific for mt1-mmp
WO2019002842A1 (en) 2017-06-26 2019-01-03 Bicyclerd Limited BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
JP7670481B2 (ja) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
CA3091775A1 (en) 2018-02-23 2019-08-29 Bicycletx Limited Multimeric bicyclic peptide ligands
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
EP3897849A1 (en) 2018-12-21 2021-10-27 BicycleTx Limited Bicyclic peptide ligands specific for pd-l1
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
KR20220007098A (ko) 2019-05-09 2022-01-18 바이사이클티엑스 리미티드 Ox40에 특이적인 이환식 펩티드 리간드
TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
SI4464721T1 (sl) 2019-10-03 2025-08-29 Bicycletx Limited Heterotandemski biciklični peptidni kompleksi
CN116348476A (zh) 2020-08-03 2023-06-27 拜斯科技术开发有限公司 基于肽的接头
CN111961117B (zh) * 2020-08-19 2022-03-11 中山大学 一种环肽化合物及其应用
CN116802190A (zh) * 2020-11-13 2023-09-22 拜斯科技术开发有限公司 特异于转铁蛋白受体1（TfR1）的双环肽配体
EP4251190A4 (en) * 2020-11-30 2024-10-23 Fred Hutchinson Cancer Center PD-L1-BINDING PEPTIDES, PEPTIDE COMPLEXES AND METHODS OF USE THEREOF
CA3206529A1 (en) * 2021-01-08 2022-07-14 Bicycletx Limited Heterotandem bicyclic peptide complexes
AU2022206394A1 (en) * 2021-01-08 2023-08-24 Bicycletx Limited Bicyclic peptide ligands specific for nk cells
US20250186539A2 (en) 2021-01-11 2025-06-12 Bicycletx Limited Methods for treating cancer
EP4382130A4 (en) * 2021-08-17 2025-12-24 Tianjin Conjustar Biologics Co Ltd Conjugated polypeptide-drug with a novel structure and its application
JP2026525826A (ja) 2023-06-23 2026-08-04 バイスクルテクス・リミテッド Ｎｋ細胞に特異的な二環式ペプチドリガンド

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