MX2018012803A - Derivados de las toxinas de amanita y su conjugacion a una molecula de union celular. - Google Patents
Derivados de las toxinas de amanita y su conjugacion a una molecula de union celular.Info
- Publication number
- MX2018012803A MX2018012803A MX2018012803A MX2018012803A MX2018012803A MX 2018012803 A MX2018012803 A MX 2018012803A MX 2018012803 A MX2018012803 A MX 2018012803A MX 2018012803 A MX2018012803 A MX 2018012803A MX 2018012803 A MX2018012803 A MX 2018012803A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- conjugation
- binding molecule
- cell binding
- toxins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invención se refiere a nuevos agentes citotóxicos, derivados de toxinas de Amanita de la Fórmula (I), en donde, , , R1, R2, R3, R4, R5, R7, R8, R9, R10, X, L, m, n y Q se definen en la presente, así como la preparación y los usos terapéuticos en el tratamiento dirigido de cánceres, trastornos autoinmunes y enfermedades infecciosas. (VER FORMULA).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2016/052246 WO2017046658A1 (en) | 2016-04-20 | 2016-04-20 | Derivatives of amanita toxins and their conjugation to a cell binding molecule |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018012803A true MX2018012803A (es) | 2019-06-24 |
Family
ID=58288166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018012803A MX2018012803A (es) | 2016-04-20 | 2016-04-20 | Derivados de las toxinas de amanita y su conjugacion a una molecula de union celular. |
Country Status (15)
Country | Link |
---|---|
US (1) | US10836796B2 (es) |
EP (1) | EP3445401A4 (es) |
JP (2) | JP7295640B2 (es) |
KR (1) | KR102295190B1 (es) |
CN (2) | CN115181164A (es) |
AU (1) | AU2016322708B2 (es) |
BR (1) | BR112018071465A2 (es) |
CA (1) | CA3016172C (es) |
MX (1) | MX2018012803A (es) |
MY (1) | MY197235A (es) |
NZ (1) | NZ744936A (es) |
PH (1) | PH12018501777A1 (es) |
SG (1) | SG11201807652SA (es) |
WO (1) | WO2017046658A1 (es) |
ZA (1) | ZA201807613B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016202632B2 (en) | 2016-02-04 | 2021-09-09 | Hangzhou Dac Biotech Co, Ltd | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof |
AU2017204139B2 (en) | 2016-06-17 | 2018-08-09 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cells |
KR20220147720A (ko) * | 2016-11-14 | 2022-11-03 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
IL268058B2 (en) | 2017-01-20 | 2023-09-01 | Magenta Therapeutics Inc | Compositions and methods for depleting cd137 plus cells |
US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
KR20210122319A (ko) * | 2017-04-06 | 2021-10-08 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 비스-링키지를 사용한 세포독성 약물의 접합 |
CN110997676B (zh) * | 2017-08-07 | 2022-12-20 | 海德堡医药研究有限责任公司 | 合成鹅膏蕈碱的新方法 |
JP7335260B2 (ja) * | 2017-08-18 | 2023-08-29 | バイリ-バイオ(チェンドゥ)ファーマスーティカル シーオー.,エルティーディー. | 非天然アマニチン類抗体複合物 |
KR20190043031A (ko) * | 2017-10-17 | 2019-04-25 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
JP7280254B2 (ja) | 2017-10-24 | 2023-05-23 | マジェンタ セラピューティクス インコーポレイテッド | Cd117+細胞を減少させるための組成物及び方法 |
US10882915B2 (en) | 2017-10-24 | 2021-01-05 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD117+ cells |
MX2020006192A (es) * | 2017-12-31 | 2020-08-20 | Hangzhou Dac Biotech Co Ltd | Un conjugado de un analogo de tubulisina con enlazadores ramificados. |
CN109096128B (zh) * | 2018-01-12 | 2021-03-09 | 江苏金斯瑞生物科技有限公司 | 一种氨基聚乙二醇丙酸的制备方法 |
CN116920115A (zh) * | 2018-12-17 | 2023-10-24 | 荣昌生物制药(烟台)股份有限公司 | 一种用于抗体药物偶联物的连接子及其应用 |
CN113423430A (zh) * | 2019-01-31 | 2021-09-21 | 杭州多禧生物科技有限公司 | 含支链连接子的鹅膏毒素偶联物 |
CA3137373A1 (en) | 2019-04-24 | 2020-10-29 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
US20230115871A1 (en) * | 2019-06-24 | 2023-04-13 | Hangzhou Dac Biotech Co., Ltd | A conjugate of a cytotoxic agent to a cell binding molecule with branched linkers |
KR102092817B1 (ko) * | 2019-08-22 | 2020-03-24 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
TWI710488B (zh) | 2019-09-18 | 2020-11-21 | 亞慶股份有限公司 | 高爾夫球車煞車系統的自駕煞車暨手駕煞車連接組件 |
AR120218A1 (es) * | 2019-10-15 | 2022-02-02 | Heidelberg Pharma Res Gmbh | Conjugados de amatoxina y anticuerpo específico de linfocitos b |
WO2021122744A1 (en) * | 2019-12-16 | 2021-06-24 | Heidelberg Pharma Research Gmbh | Synthesis of amanin and its derivatives |
CN111233949A (zh) * | 2020-02-10 | 2020-06-05 | 天津科技大学 | 一种神经节苷脂gm3和/或其类似物、合成方法和应用 |
WO2021255217A1 (en) * | 2020-06-19 | 2021-12-23 | Heidelberg Pharma Research Gmbh | Amatoxin and amatoxin conjugates for use in inhibition of rna virus replication |
CN116284224B (zh) * | 2023-05-12 | 2023-07-25 | 中国农业大学 | 一种结合Claudin 18.2的环肽及其应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001270863A (ja) * | 2000-03-23 | 2001-10-02 | Mitsui Chemicals Inc | 6−置換インドール誘導体の製造方法 |
SI3192529T1 (sl) | 2009-04-08 | 2020-07-31 | Faulstich, Heinz Dr. | Z amatoksinom ojačane vezne komponente terapevtske celične površine, zasnovane za zdravljenje tumorjev |
ES2402254T3 (es) | 2010-09-30 | 2013-04-30 | Heidelberg Pharma Ag | Conjugados de amatoxinas con ligadores mejorados |
RU2748733C2 (ru) * | 2011-02-15 | 2021-05-31 | Иммуноджен, Инк. | Цитотоксические производные бензодиазепина |
EP2497499A1 (en) | 2011-03-10 | 2012-09-12 | Heidelberg Pharma GmbH | Amatoxin-conjugates with improved linkages |
US20150218220A1 (en) * | 2012-09-12 | 2015-08-06 | Brian Alan MENDELSOHN | Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase |
CN115124573A (zh) | 2013-09-02 | 2022-09-30 | 杭州多禧生物科技有限公司 | 应用于细胞结合分子-药物共轭体的新型细胞毒性分子 |
AU2015242213A1 (en) * | 2015-07-12 | 2018-03-08 | Hangzhou Dac Biotech Co., Ltd | Bridge linkers for conjugation of cell-binding molecules |
WO2015155753A2 (en) * | 2015-08-10 | 2015-10-15 | Suzhou M-Conj Biotech Co., Ltd | Novel linkers and their uses in specific conjugation of drugs to a biological molecule |
AU2016202632B2 (en) * | 2016-02-04 | 2021-09-09 | Hangzhou Dac Biotech Co, Ltd | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof |
-
2016
- 2016-04-20 BR BR112018071465A patent/BR112018071465A2/pt not_active Application Discontinuation
- 2016-04-20 CN CN202210785106.1A patent/CN115181164A/zh active Pending
- 2016-04-20 AU AU2016322708A patent/AU2016322708B2/en active Active
- 2016-04-20 MX MX2018012803A patent/MX2018012803A/es unknown
- 2016-04-20 CA CA3016172A patent/CA3016172C/en active Active
- 2016-04-20 JP JP2018554563A patent/JP7295640B2/ja active Active
- 2016-04-20 MY MYPI2018703127A patent/MY197235A/en unknown
- 2016-04-20 CN CN201680084667.1A patent/CN109689107B/zh active Active
- 2016-04-20 NZ NZ744936A patent/NZ744936A/en unknown
- 2016-04-20 WO PCT/IB2016/052246 patent/WO2017046658A1/en active Application Filing
- 2016-04-20 EP EP16845791.9A patent/EP3445401A4/en active Pending
- 2016-04-20 KR KR1020187028837A patent/KR102295190B1/ko active IP Right Grant
- 2016-04-20 US US16/078,080 patent/US10836796B2/en active Active
- 2016-04-20 SG SG11201807652SA patent/SG11201807652SA/en unknown
-
2018
- 2018-08-20 PH PH12018501777A patent/PH12018501777A1/en unknown
- 2018-11-13 ZA ZA2018/07613A patent/ZA201807613B/en unknown
-
2022
- 2022-12-16 JP JP2022201500A patent/JP2023051977A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US10836796B2 (en) | 2020-11-17 |
EP3445401A4 (en) | 2019-11-20 |
EP3445401A1 (en) | 2019-02-27 |
KR20180125154A (ko) | 2018-11-22 |
CA3016172C (en) | 2024-03-12 |
WO2017046658A1 (en) | 2017-03-23 |
BR112018071465A2 (pt) | 2019-02-05 |
CN109689107A (zh) | 2019-04-26 |
JP2019515907A (ja) | 2019-06-13 |
SG11201807652SA (en) | 2018-10-30 |
CA3016172A1 (en) | 2017-03-23 |
US20200079820A1 (en) | 2020-03-12 |
NZ744936A (en) | 2022-01-28 |
MY197235A (en) | 2023-06-07 |
ZA201807613B (en) | 2022-02-23 |
KR102295190B1 (ko) | 2021-08-30 |
JP2023051977A (ja) | 2023-04-11 |
JP7295640B2 (ja) | 2023-06-21 |
CN115181164A (zh) | 2022-10-14 |
PH12018501777A1 (en) | 2019-05-15 |
AU2016322708A1 (en) | 2018-08-23 |
CN109689107B (zh) | 2022-08-16 |
AU2016322708B2 (en) | 2020-08-20 |
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