|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4722848A
(en)
|
1982-12-08 |
1988-02-02 |
Health Research, Incorporated |
Method for immunizing animals with synthetically modified vaccinia virus
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
GB8311018D0
(en)
|
1983-04-22 |
1983-05-25 |
Amersham Int Plc |
Detecting mutations in dna
|
|
US6090406A
(en)
|
1984-04-12 |
2000-07-18 |
The Liposome Company, Inc. |
Potentiation of immune responses with liposomal adjuvants
|
|
US5019369A
(en)
|
1984-10-22 |
1991-05-28 |
Vestar, Inc. |
Method of targeting tumors in humans
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5223427A
(en)
|
1987-03-31 |
1993-06-29 |
The Scripps Research Institute |
Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
|
|
US5217879A
(en)
|
1989-01-12 |
1993-06-08 |
Washington University |
Infectious Sindbis virus vectors
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
FR2650840B1
(fr)
|
1989-08-11 |
1991-11-29 |
Bertin & Cie |
Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
|
|
US5240846A
(en)
|
1989-08-22 |
1993-08-31 |
The Regents Of The University Of Michigan |
Gene therapy vector for cystic fibrosis
|
|
EP0452457B1
(en)
|
1989-11-03 |
1997-08-20 |
Vanderbilt University |
Method of in vivo delivery of functioning foreign genes
|
|
US5279833A
(en)
|
1990-04-04 |
1994-01-18 |
Yale University |
Liposomal transfection of nucleic acids into animal cells
|
|
US5204253A
(en)
|
1990-05-29 |
1993-04-20 |
E. I. Du Pont De Nemours And Company |
Method and apparatus for introducing biological substances into living cells
|
|
US6770283B1
(en)
|
1990-12-13 |
2004-08-03 |
Bioption Ab |
DNA expression systems based on alphaviruses
|
|
US6004744A
(en)
|
1991-03-05 |
1999-12-21 |
Molecular Tool, Inc. |
Method for determining nucleotide identity through extension of immobilized primer
|
|
US6037135A
(en)
|
1992-08-07 |
2000-03-14 |
Epimmune Inc. |
Methods for making HLA binding peptides and their uses
|
|
US6174666B1
(en)
|
1992-03-27 |
2001-01-16 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of eliminating inhibitory/instability regions from mRNA
|
|
EP0646178A1
(en)
|
1992-06-04 |
1995-04-05 |
The Regents Of The University Of California |
expression cassette with regularoty regions functional in the mammmlian host
|
|
US5662907A
(en)
|
1992-08-07 |
1997-09-02 |
Cytel Corporation |
Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes
|
|
US9340577B2
(en)
|
1992-08-07 |
2016-05-17 |
Epimmune Inc. |
HLA binding motifs and peptides and their uses
|
|
US20050271676A1
(en)
|
1993-03-05 |
2005-12-08 |
Epimmune Inc. |
Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions
|
|
CN1135181A
(zh)
|
1993-09-14 |
1996-11-06 |
Cytel有限公司 |
使用泛dr结合肽改变免疫应答
|
|
US6413935B1
(en)
|
1993-09-14 |
2002-07-02 |
Epimmune Inc. |
Induction of immune response against desired determinants
|
|
WO1995007994A2
(en)
|
1993-09-15 |
1995-03-23 |
Viagene, Inc. |
Recombinant alphavirus vectors
|
|
US6015686A
(en)
|
1993-09-15 |
2000-01-18 |
Chiron Viagene, Inc. |
Eukaryotic layered vector initiation systems
|
|
DE69433922T2
(de)
|
1993-11-09 |
2005-07-28 |
Medical College Of Ohio, Toledo |
Stabile zellinie, die in der lage ist, das replikationsgen des adenoassoziertenvirus zu exprimieren
|
|
US5505947A
(en)
|
1994-05-27 |
1996-04-09 |
The University Of North Carolina At Chapel Hill |
Attenuating mutations in Venezuelan Equine Encephalitis virus
|
|
FR2726285B1
(fr)
|
1994-10-28 |
1996-11-29 |
Centre Nat Rech Scient |
Adenovirus depourvus de particules contaminantes viables, preparation et utilisation
|
|
CA2203809C
(en)
|
1994-10-28 |
2008-06-03 |
James M. Wilson |
Recombinant adenovirus and methods of use thereof
|
|
US6071890A
(en)
|
1994-12-09 |
2000-06-06 |
Genzyme Corporation |
Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
|
|
US5552350A
(en)
|
1994-12-12 |
1996-09-03 |
Ceramco Inc. |
Low-fusing temperature porcelain
|
|
US5792462A
(en)
|
1995-05-23 |
1998-08-11 |
University Of North Carolina At Chapel Hill |
Alphavirus RNA replicon systems
|
|
US5851796A
(en)
|
1995-06-07 |
1998-12-22 |
Yale University |
Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes
|
|
UY24367A1
(es)
|
1995-11-23 |
2000-10-31 |
Boehringer Ingelheim Int |
Vacunas contra tumores y procedimiento para su produccion
|
|
US5849589A
(en)
|
1996-03-11 |
1998-12-15 |
Duke University |
Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
|
|
US6451592B1
(en)
*
|
1996-04-05 |
2002-09-17 |
Chiron Corporation |
Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
|
|
EP0803573A1
(en)
|
1996-04-25 |
1997-10-29 |
Gesellschaft für Biotechnologische Forschung mbH (GBF) |
Polycistronic expression construct with cytokines for multivalent vaccines
|
|
US6514731B1
(en)
|
1996-05-24 |
2003-02-04 |
Chiron Corporation |
Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
|
|
JP2001503735A
(ja)
|
1996-07-03 |
2001-03-21 |
ユニバーシティ オブ ピッツバーグ |
親水性活性試薬のためのエマルジョン処方物
|
|
US6083716A
(en)
|
1996-09-06 |
2000-07-04 |
The Trustees Of The University Of Pennsylvania |
Chimpanzee adenovirus vectors
|
|
US7732129B1
(en)
|
1998-12-01 |
2010-06-08 |
Crucell Holland B.V. |
Method for the production and purification of adenoviral vectors
|
|
US5849561A
(en)
|
1997-05-22 |
1998-12-15 |
Cornell Research Foundation, Inc. |
Method for the production of non-group C adenoviral vectors
|
|
US5891994A
(en)
|
1997-07-11 |
1999-04-06 |
Thymon L.L.C. |
Methods and compositions for impairing multiplication of HIV-1
|
|
GB9720585D0
(en)
|
1997-09-26 |
1997-11-26 |
Smithkline Beecham Biolog |
Vaccine
|
|
EP1000628A1
(en)
|
1998-09-28 |
2000-05-17 |
Fondation Mondiale Recherche et Prevention SIDA |
Use of antigenic complexes of HIV envelope and HLA class I antigens as HIV vaccine
|
|
US20030072767A1
(en)
|
1998-09-30 |
2003-04-17 |
Alexander Gaiger |
Compositions and methods for WT1 specific immunotherapy
|
|
US20080050393A1
(en)
|
1998-12-03 |
2008-02-28 |
Tang Y Tom |
Novel nucleic acids and polypeptides
|
|
WO2000034445A2
(en)
|
1998-12-07 |
2000-06-15 |
U.S. Medical Research Institute Of Infectious Diseases |
Live attenuated venezuelan equine encephalitis vaccine
|
|
AU2992600A
(en)
|
1999-02-11 |
2000-08-29 |
Genzyme Corporation |
Antigenic peptide concatomers
|
|
US7262049B2
(en)
|
1999-03-16 |
2007-08-28 |
Dana-Farber Cancer Institute, Inc. |
Pseudotyped lentiviral vectors and uses thereof
|
|
ATE386127T1
(de)
|
1999-04-08 |
2008-03-15 |
Novartis Vaccines & Diagnostic |
Verbesserung der immunantwort als anwendung in impfstoff und gentherapie
|
|
US8647864B2
(en)
|
1999-04-14 |
2014-02-11 |
Novartis Ag |
Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
|
|
CA2373300C
(en)
|
1999-04-14 |
2012-02-21 |
Chiron Corporation |
Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
|
|
WO2003104467A1
(en)
|
2002-04-25 |
2003-12-18 |
Crucell Holland B.V. |
Means and methods for the production of adenovirus vectors
|
|
US6365394B1
(en)
|
1999-09-29 |
2002-04-02 |
The Trustees Of The University Of Pennsylvania |
Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus
|
|
US20040037843A1
(en)
|
1999-12-21 |
2004-02-26 |
John Fikes |
Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions
|
|
US20040248113A1
(en)
|
1999-12-28 |
2004-12-09 |
Alessandro Sette |
Method and system for optimizing multi-epitope nucleic acid constructs and peptides encoded thereby
|
|
US7462354B2
(en)
|
1999-12-28 |
2008-12-09 |
Pharmexa Inc. |
Method and system for optimizing minigenes and peptides encoded thereby
|
|
WO2001055393A2
(en)
|
2000-01-28 |
2001-08-02 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Mhc class ii restricted t cell epitopes from the cancer antigen ny-eso-1
|
|
JP2003523365A
(ja)
|
2000-01-28 |
2003-08-05 |
スタテンズ セーラム インスティテュート |
Hiv感染の診断及びコントロールのためのhivペプチド及びそれをエンコードする核酸
|
|
JP2003529559A
(ja)
|
2000-01-31 |
2003-10-07 |
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム |
新規用途
|
|
AU2001252945A1
(en)
|
2000-03-24 |
2001-10-08 |
Corixa Corporation |
Compositions and methods for therapy and diagnosis of colon cancer
|
|
US6436703B1
(en)
|
2000-03-31 |
2002-08-20 |
Hyseq, Inc. |
Nucleic acids and polypeptides
|
|
US20040115625A1
(en)
|
2000-10-02 |
2004-06-17 |
Reinhard Ebner |
Cancer gene determination and therapeutic screening using signature gene sets
|
|
US6783939B2
(en)
|
2000-07-07 |
2004-08-31 |
Alphavax, Inc. |
Alphavirus vectors and virosomes with modified HIV genes for use in vaccines
|
|
WO2002027007A2
(en)
|
2000-09-25 |
2002-04-04 |
Regents Of The University Of Michigan |
Production of viral vectors
|
|
US20020137081A1
(en)
|
2001-01-08 |
2002-09-26 |
Olga Bandman |
Genes differentially expressed in vascular tissue activation
|
|
WO2002061113A2
(en)
|
2001-02-01 |
2002-08-08 |
The Johns Hopkins University |
Nucleic acid derived vaccine that encodes an antigen linked to a polypeptide that promotes antigen presentation
|
|
CA2448066A1
(en)
|
2001-05-31 |
2002-12-12 |
Chiron Corporation |
Chimeric alphavirus replicon particles
|
|
US20030232324A1
(en)
|
2001-05-31 |
2003-12-18 |
Chiron Corporation |
Chimeric alphavirus replicon particles
|
|
US7344872B2
(en)
|
2001-06-22 |
2008-03-18 |
The Trustees Of The University Of Pennsylvania |
Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
|
|
AU2003222068A1
(en)
*
|
2002-03-25 |
2003-10-13 |
University Of North Carolina At Chapel Hill |
Improved methods for achieving expression from alphavirus vectors
|
|
CA2478508C
(en)
|
2002-04-25 |
2013-07-02 |
Crucell Holland B.V. |
Stable adenoviral vectors and methods for propagation thereof
|
|
WO2004023973A2
(en)
|
2002-09-12 |
2004-03-25 |
Incyte Corporation |
Molecules for diagnostics and therapeutics
|
|
CA2500687A1
(en)
|
2002-10-02 |
2004-04-15 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
EP1571909A4
(en)
|
2002-10-03 |
2009-11-11 |
Idm Pharma Inc |
OPTIMIZED MULTIPOPOP CONSTRUCTS AND USES THEREOF
|
|
AU2003297039B2
(en)
|
2002-12-13 |
2009-03-05 |
Alphavax, Inc. |
Multi-antigenic alphavirus replicon particles and methods
|
|
AU2003297041B2
(en)
|
2002-12-13 |
2009-02-26 |
Alphavax, Inc. |
Alphavirus particles and methods for preparation
|
|
GB2398300A
(en)
|
2003-02-17 |
2004-08-18 |
Isis Innovation |
Method and compositions for boosting immune response
|
|
US20050008618A1
(en)
|
2003-02-27 |
2005-01-13 |
Howard Kaufman |
Composition for delivering an agent to a target cell and uses thereof
|
|
US7425328B2
(en)
|
2003-04-22 |
2008-09-16 |
Purdue Pharma L.P. |
Tissue factor antibodies and uses thereof
|
|
WO2005033265A2
(en)
|
2003-04-25 |
2005-04-14 |
Epimmune Inc. |
Optimized multi-epitope constructs and uses thereof
|
|
US7605235B2
(en)
|
2003-05-30 |
2009-10-20 |
Centocor, Inc. |
Anti-tissue factor antibodies and compositions
|
|
US7541038B2
(en)
|
2003-06-05 |
2009-06-02 |
Wyeth Holdings Corporation |
Fusogenic, self-propagating blebs as immunogenic compositions
|
|
US7291498B2
(en)
|
2003-06-20 |
2007-11-06 |
The Trustees Of The University Of Pennsylvania |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
|
|
DE10347710B4
(de)
|
2003-10-14 |
2006-03-30 |
Johannes-Gutenberg-Universität Mainz |
Rekombinante Impfstoffe und deren Verwendung
|
|
JP4814800B2
(ja)
|
2004-01-23 |
2011-11-16 |
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー |
チンパンジーアデノウイルスワクチン担体
|
|
US8119336B2
(en)
|
2004-03-03 |
2012-02-21 |
Ibis Biosciences, Inc. |
Compositions for use in identification of alphaviruses
|
|
WO2006078279A2
(en)
|
2004-04-28 |
2006-07-27 |
The Trustees Of The University Of Pennsylvania |
Sequential delivery of immunogenic molecules via adenovirus and adeno-associated virus-mediated administrations
|
|
US9592284B2
(en)
|
2004-04-28 |
2017-03-14 |
The Trustees Of The University Of Pennsylvania |
Immunization regimen with E4-deleted adenovirus prime and E1-deleted adenovirus boost
|
|
US20090104226A1
(en)
|
2004-05-21 |
2009-04-23 |
Novartis Vaccines And Diagnostics Inc. |
Alphavirus Vectors for Respiratory Pathogen Vaccines
|
|
US9024001B2
(en)
|
2004-05-25 |
2015-05-05 |
Novartis Vaccines And Diagnostics, Inc. |
Alphavirus replicon packaging constructs
|
|
WO2006007712A1
(en)
|
2004-07-19 |
2006-01-26 |
Protiva Biotherapeutics, Inc. |
Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
|
|
MX2007004028A
(es)
|
2004-10-04 |
2007-09-11 |
Biovaxim Ltd |
Vacunas con virus enteros inactivados con subtipo coincidente para tratar pacientes con infeccion por vih.
|
|
US20060198854A1
(en)
|
2004-12-28 |
2006-09-07 |
Peter Pushko |
Vector platforms derived from the alphavirus vaccines
|
|
US7220549B2
(en)
|
2004-12-30 |
2007-05-22 |
Helicos Biosciences Corporation |
Stabilizing a nucleic acid for nucleic acid sequencing
|
|
FR2882557A1
(fr)
|
2005-02-25 |
2006-09-01 |
Centre Nat Rech Scient |
Epitopes de vih et composition pharmaceutique les contenant
|
|
US7283337B2
(en)
|
2005-03-04 |
2007-10-16 |
Headway Technologies, Inc. |
Abutted exchange bias design for sensor stabilization
|
|
DK2002003T3
(en)
|
2005-05-27 |
2016-03-21 |
Ospedale San Raffaele Srl |
Gene vector comprising miRNA
|
|
EP2385059A3
(en)
|
2005-06-17 |
2012-02-15 |
Mannkind Corporation |
Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma
|
|
PL2578685T3
(pl)
|
2005-08-23 |
2020-01-31 |
The Trustees Of The University Of Pennsylvania |
Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania
|
|
EP1945247A1
(en)
|
2005-10-18 |
2008-07-23 |
Novartis Vaccines and Diagnostics, Inc. |
Mucosal and systemic immunizations with alphavirus replicon particles
|
|
WO2007098267A2
(en)
|
2006-02-27 |
2007-08-30 |
The Board Of Regents Of The University Of Texas System |
Pseudoinfectious flavivirus and uses thereof
|
|
US20090022760A1
(en)
|
2006-09-12 |
2009-01-22 |
Alphavax |
Alphavirus Replicon Particles Matched to Protein Antigens as Immunological Adjuvants
|
|
US9085638B2
(en)
|
2007-03-07 |
2015-07-21 |
The Johns Hopkins University |
DNA vaccine enhancement with MHC class II activators
|
|
GB0706914D0
(en)
|
2007-04-10 |
2007-05-16 |
Isis Innovation |
Novel adenovirus vectors
|
|
MX2009012609A
(es)
|
2007-05-22 |
2009-12-07 |
Amgen Inc |
Composiciones y metodos para producir proteinas de fusion bioactivas.
|
|
WO2008145685A1
(en)
|
2007-05-31 |
2008-12-04 |
Genimmune N.V. |
Hpv polyepitope constructs and uses thereof
|
|
DK2947149T3
(en)
|
2007-06-21 |
2018-06-06 |
Alphavax Inc |
ALPHAVIRUS REPLICATION PARTICLES FOR USE IN VACCINATION
|
|
US20100015179A1
(en)
|
2007-08-16 |
2010-01-21 |
Frolov Ilya V |
Attenuation of encephalitogenic alphavirus and uses thereof
|
|
JP2010537645A
(ja)
*
|
2007-08-31 |
2010-12-09 |
エーラス グローバル ティービー ワクチン ファウンデーション |
I型インターフェロン応答抑制剤類の発現によるウイルスベースワクチンベクター類からのトランスジーン発現の増強
|
|
EP2201023A2
(en)
|
2007-09-14 |
2010-06-30 |
GENimmune N.V. |
Affinity tag
|
|
US20100285050A1
(en)
|
2007-10-05 |
2010-11-11 |
Isis Innovation Limited |
Compositions and Methods
|
|
GB0719526D0
(en)
|
2007-10-05 |
2007-11-14 |
Isis Innovation |
Compositions and methods
|
|
WO2009079185A2
(en)
|
2007-11-26 |
2009-06-25 |
Novartis Vaccines And Diagnostics, Inc. |
Methods of generating alphavirus particles
|
|
WO2009092113A2
(en)
|
2008-01-19 |
2009-07-23 |
Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods and compositions for the delivery of vaccines to disrupted epithelium
|
|
US20090253184A1
(en)
|
2008-01-23 |
2009-10-08 |
Introgen Therapeutics, Inc. |
Compositions and methods related to an adenoviral trans-complementing cell line
|
|
JP5758632B2
(ja)
|
2008-01-24 |
2015-08-05 |
ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システムThe Board Of Regents Of The University Of Texas System |
蚊において複製不可能な弱毒化組み換えアルファウイルス属及びそれらの使用
|
|
US20110142880A1
(en)
|
2008-03-28 |
2011-06-16 |
Franck Yann Lemiale |
Lentivirus-based immunogenic vectors
|
|
CA2726914A1
(en)
|
2008-06-03 |
2009-12-10 |
Okairos Ag |
A vaccine for the prevention and therapy of hcv infections
|
|
WO2010005704A2
(en)
|
2008-06-13 |
2010-01-14 |
New York University |
Novel helper plasmid, defective sindbis viral vectors and methods of use thereof
|
|
WO2010008576A2
(en)
|
2008-07-17 |
2010-01-21 |
Medigen, Inc. |
Idna vaccines and methods for using the same
|
|
ES2536465T3
(es)
|
2008-10-01 |
2015-05-25 |
Immatics Biotechnologies Gmbh |
Composición de péptidos tumor-asociados y relacionados con la vacuna contra el cáncer para el tratamiento de glioblastoma (GBM) y otros cánceres
|
|
WO2010037402A1
(en)
|
2008-10-02 |
2010-04-08 |
Dako Denmark A/S |
Molecular vaccines for infectious disease
|
|
WO2010044515A1
(ko)
|
2008-10-17 |
2010-04-22 |
Lee Jeong-Min |
병뚜껑
|
|
CN101721698B
(zh)
|
2008-10-24 |
2014-04-02 |
法罗斯疫苗公司 |
抗口蹄疫疫苗组合物及其制备和应用
|
|
CN102317308A
(zh)
|
2008-11-26 |
2012-01-11 |
美国国有健康与人类服务部 |
类病毒组合物颗粒及其使用方法
|
|
US8680258B2
(en)
|
2008-12-01 |
2014-03-25 |
Alphavax, Inc. |
Use of microRNAs to control virus helper nucleic acids
|
|
DE102008061522A1
(de)
|
2008-12-10 |
2010-06-17 |
Biontech Ag |
Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung
|
|
CN101579528B
(zh)
|
2009-06-24 |
2011-06-29 |
中国人民解放军军事医学科学院军事兽医研究所 |
一种hiv复合多表位dna疫苗及其应用
|
|
GB0918154D0
(en)
|
2009-10-16 |
2009-12-02 |
Isis Innovation |
Mycobacterial vaccines
|
|
WO2011082388A2
(en)
|
2009-12-31 |
2011-07-07 |
Medigen, Inc . |
Infectious dna vaccines against chikungunya virus
|
|
GB201006405D0
(en)
|
2010-04-16 |
2010-06-02 |
Isis Innovation |
Poxvirus expression system
|
|
US9115402B2
(en)
|
2010-05-14 |
2015-08-25 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods of identifying tumor specific neoantigens
|
|
PT3243526T
(pt)
|
2010-07-06 |
2020-03-04 |
Glaxosmithkline Biologicals Sa |
Distribuição de arn para despoletar múltiplas vias imunitárias
|
|
FI4005592T3
(fi)
|
2010-07-06 |
2023-01-13 |
|
Virionin kaltaisia kuljetuspartikkeleita itsereplikoituville rna-molekyyleille
|
|
US9192661B2
(en)
|
2010-07-06 |
2015-11-24 |
Novartis Ag |
Delivery of self-replicating RNA using biodegradable polymer particles
|
|
US9770463B2
(en)
|
2010-07-06 |
2017-09-26 |
Glaxosmithkline Biologicals Sa |
Delivery of RNA to different cell types
|
|
CA2804591C
(en)
|
2010-07-06 |
2019-01-22 |
Novartis Ag |
Cationic oil-in-water emulsions
|
|
CN103153284B
(zh)
|
2010-07-06 |
2015-11-25 |
诺华股份有限公司 |
含有其pKa值有利于RNA递送的脂质的脂质体
|
|
US10487332B2
(en)
|
2010-07-06 |
2019-11-26 |
Glaxosmithkline Biologicals Sa |
Immunisation of large mammals with low doses of RNA
|
|
EP3542789A3
(en)
|
2010-08-31 |
2020-01-01 |
GlaxoSmithKline Biologicals SA |
Lipids suitable for liposomal delivery of protein-coding rna
|
|
RS63890B1
(sr)
|
2010-08-31 |
2023-02-28 |
Glaxosmithkline Biologicals Sa |
Mali lipozomi za isporuku rnk koja kodira imunogen
|
|
JP5911870B2
(ja)
|
2010-08-31 |
2016-04-27 |
ノバルティス アーゲー |
免疫原をコードするrnaの送達のためのpeg化リポソーム
|
|
EP3225697A3
(en)
|
2010-12-30 |
2017-11-22 |
Foundation Medicine, Inc. |
Optimization of multigene analysis of tumor samples
|
|
WO2012106356A2
(en)
|
2011-01-31 |
2012-08-09 |
GOVERNMENT OF THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES |
Virus-like particles and methods of use
|
|
WO2012114323A1
(en)
|
2011-02-22 |
2012-08-30 |
Biondvax Pharmaceuticals Ltd. |
Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
|
|
US8722044B2
(en)
|
2011-03-15 |
2014-05-13 |
Janssen Biotech, Inc. |
Human tissue factor antibody and uses thereof
|
|
RS56748B1
(sr)
|
2011-05-13 |
2018-03-30 |
Glaxosmithkline Biologicals Sa |
Pre-fuzioni rsv f antigeni
|
|
LT2714071T
(lt)
|
2011-05-24 |
2019-10-10 |
Biontech Rna Pharmaceuticals Gmbh |
Individualizuotos vakcinos nuo vėžio
|
|
GB201108879D0
(en)
|
2011-05-25 |
2011-07-06 |
Isis Innovation |
Vector
|
|
WO2012171541A1
(en)
|
2011-06-15 |
2012-12-20 |
Scil Proteins Gmbh |
Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins
|
|
RU2014104090A
(ru)
|
2011-07-06 |
2015-08-20 |
Новартис Аг |
Липосомы с эффективным соотношением n:p для доставки молекул phk
|
|
US11058762B2
(en)
|
2011-07-06 |
2021-07-13 |
Glaxosmithkline Biologicals Sa |
Immunogenic compositions and uses thereof
|
|
JP2014522842A
(ja)
|
2011-07-06 |
2014-09-08 |
ノバルティス アーゲー |
免疫原性組み合わせ組成物およびその使用
|
|
KR102067760B1
(ko)
|
2011-08-16 |
2020-01-17 |
삼성전자주식회사 |
세포 내 전달용 단백질 복합체 및 그의 용도
|
|
PT2750707T
(pt)
|
2011-08-31 |
2019-01-23 |
Glaxosmithkline Biologicals Sa |
Lipossomas peguilados para distribuição de arn que codifica imunogénio
|
|
BR112014008694A2
(pt)
|
2011-10-11 |
2017-06-20 |
Novartis Ag |
moléculas de ácido nucleico policistrônico recombinante
|
|
US9089574B2
(en)
|
2011-11-30 |
2015-07-28 |
Emory University |
Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
|
|
MX357202B
(es)
|
2012-02-16 |
2018-06-28 |
Vlp Therapeutics Llc |
Composicion de particula tipo virus.
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US20160289674A1
(en)
|
2012-04-02 |
2016-10-06 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of membrane proteins
|
|
AU2013262626B2
(en)
|
2012-05-18 |
2018-11-29 |
The Trustees Of The University Of Pennsylvania |
Subfamily E simian adenoviruses A1302, A1320, A1331 and A1337 and uses thereof
|
|
EP2870236B1
(en)
|
2012-07-04 |
2018-01-10 |
Sirion Biotech GmbH |
Means and methods to increase adenovirus production
|
|
EP2869842A1
(en)
|
2012-07-06 |
2015-05-13 |
Novartis AG |
Immunogenic compositions and uses thereof
|
|
US8961995B2
(en)
|
2012-09-20 |
2015-02-24 |
Uab Research Foundation |
Methods and compositions for alphavirus replicons
|
|
GB201220119D0
(en)
|
2012-11-08 |
2012-12-26 |
Univ Cork |
Vector
|
|
US9402888B2
(en)
|
2013-03-14 |
2016-08-02 |
The Wistar Institute Of Anatomy And Biology |
Methods and compositions for treating cancer
|
|
AU2014251207B2
(en)
|
2013-04-07 |
2019-06-13 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for personalized neoplasia vaccines
|
|
SG11201509614SA
(en)
|
2013-06-03 |
2015-12-30 |
Vlp Therapeutics Llc |
Malaria vaccine
|
|
EP3524262A1
(en)
|
2013-11-01 |
2019-08-14 |
Pfizer Inc |
Vectors for expression of prostate-associated antigens
|
|
GB201319446D0
(en)
|
2013-11-04 |
2013-12-18 |
Immatics Biotechnologies Gmbh |
Personalized immunotherapy against several neuronal and brain tumors
|
|
JP6740127B2
(ja)
|
2013-12-06 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新生物ワクチン用製剤
|
|
JP7060324B2
(ja)
|
2013-12-20 |
2022-04-26 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
ネオ抗原ワクチンによる併用療法
|
|
KR20190062617A
(ko)
|
2014-09-03 |
2019-06-05 |
버베리안 노딕 에이/에스 |
면역 반응을 증대시키기 위한 방법 및 조성물
|
|
WO2016040901A1
(en)
|
2014-09-12 |
2016-03-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Identification and use of circulating nucleic acids
|
|
SG11201702191YA
(en)
|
2014-09-17 |
2017-04-27 |
Univ Johns Hopkins |
Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells
|
|
SG10201913978RA
(en)
|
2014-11-26 |
2020-03-30 |
The United States Of America As Represented By The Secretary |
Anti-mutated kras t cell receptors
|
|
US10975442B2
(en)
|
2014-12-19 |
2021-04-13 |
Massachusetts Institute Of Technology |
Molecular biomarkers for cancer immunotherapy
|
|
EP3234130B1
(en)
|
2014-12-19 |
2020-11-25 |
The Broad Institute, Inc. |
Methods for profiling the t-cell- receptor repertoire
|
|
WO2016122414A1
(en)
|
2015-01-29 |
2016-08-04 |
Agency For Science, Technology And Research |
Nanocapsules carrying chikungunya-associated peptides
|
|
US20180030140A1
(en)
|
2015-02-06 |
2018-02-01 |
Navigo Proteins Gmbh |
Novel binding proteins comprising a ubiquitin mutein and antibodies or antibody fragments
|
|
WO2016154047A2
(en)
|
2015-03-20 |
2016-09-29 |
Memorial Sloan-Kettering Cancer Center |
Monoclonal antigen-binding proteins to intracellular oncogene products
|
|
EP3286222A4
(en)
|
2015-03-23 |
2018-08-08 |
The Johns Hopkins University |
Hla-restricted epitopes encoded by somatically mutated genes
|
|
JP6913032B2
(ja)
|
2015-05-20 |
2021-08-04 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
共通ネオ抗原
|
|
DK4276189T3
(da)
|
2015-09-21 |
2026-05-26 |
Trilink Biotechnologies Llc |
Initierende oligonukleotidprimere med kappe til syntesering af 5'-ende RNA'er med kappe
|
|
CN115418401A
(zh)
|
2015-10-08 |
2022-12-02 |
会聚基因学有限公司 |
用于膀胱癌的尿监测的诊断测定
|
|
CN108601820A
(zh)
|
2015-10-12 |
2018-09-28 |
南托米克斯有限责任公司 |
用于病毒癌症新表位的组合物和方法
|
|
JP7114477B2
(ja)
|
2015-12-16 |
2022-08-08 |
グリットストーン バイオ インコーポレイテッド |
新生抗原の特定、製造、および使用
|
|
WO2017151524A1
(en)
|
2016-02-29 |
2017-09-08 |
Foundation Medicine, Inc. |
Methods and systems for evaluating tumor mutational burden
|
|
WO2017151940A2
(en)
|
2016-03-03 |
2017-09-08 |
Cue Biopharma, Inc. |
T-cell modulatory multimeric polypeptides and methods of use thereof
|
|
SG11201808196UA
(en)
|
2016-03-31 |
2018-10-30 |
Neon Therapeutics Inc |
Neoantigens and methods of their use
|
|
AU2017254477A1
(en)
|
2016-04-18 |
2018-11-01 |
Jennifer G. ABELIN |
Improved HLA epitope prediction
|
|
WO2017192924A1
(en)
|
2016-05-04 |
2017-11-09 |
Fred Hutchinson Cancer Research Center |
Cell-based neoantigen vaccines and uses thereof
|
|
WO2017208191A1
(en)
|
2016-06-02 |
2017-12-07 |
Glaxosmithkline Biologicals Sa |
Zika viral antigen constructs
|
|
CN117018170A
(zh)
|
2016-06-20 |
2023-11-10 |
Isa制药有限公司 |
肽疫苗制剂
|
|
CN107698593A
(zh)
|
2016-08-09 |
2018-02-16 |
南京天印健华医药科技有限公司 |
作为fgfr抑制剂的杂环化合物
|
|
WO2018039131A1
(en)
|
2016-08-22 |
2018-03-01 |
Protiva Biotherapeutics, Inc. |
Anti-pd-1 antibodies, or fragments thereof, for treating hepatitis b
|
|
RU2019119272A
(ru)
|
2016-11-23 |
2020-12-24 |
Гритстоун Онколоджи, Инк. |
Вирусная доставка неоантигенов
|
|
WO2018102585A1
(en)
|
2016-11-30 |
2018-06-07 |
Advaxis, Inc. |
Personalized immunotherapy in combination with immunotherapy targeting recurrent cancer mutations
|
|
GB201620968D0
(en)
|
2016-12-09 |
2017-01-25 |
Glaxosmithkline Biologicals Sa |
Adenovirus polynucleotides and polypeptides
|
|
GB201621732D0
(en)
|
2016-12-20 |
2017-02-01 |
Agricultural Research Council |
A multi-epitope dna vaccine for heartwater
|
|
AU2017379901B2
(en)
|
2016-12-21 |
2024-02-15 |
Arbutus Biopharma Corporation |
Methods for ameliorating infusion reactions
|
|
EP3606550A2
(en)
|
2017-04-03 |
2020-02-12 |
Neon Therapeutics, Inc. |
Protein antigens and uses thereof
|
|
AU2018254526B2
(en)
*
|
2017-04-19 |
2024-02-15 |
Seattle Project Corp. |
Neoantigen identification, manufacture, and use
|
|
KR102945203B1
(ko)
|
2017-05-08 |
2026-03-31 |
시애틀 프로젝트 코포레이션 |
알파바이러스 신생항원 벡터
|
|
CA3066635A1
(en)
|
2017-06-09 |
2018-12-13 |
Gritstone Oncology, Inc. |
Neoantigen identification, manufacture, and use
|
|
AR112166A1
(es)
|
2017-06-16 |
2019-09-25 |
Arbutus Biopharma Corp |
Composiciones terapéuticas y métodos para el tratamiento de hepatitis b
|
|
AU2018304458B2
(en)
|
2017-07-21 |
2021-12-09 |
Foundation Medicine, Inc. |
Therapeutic and diagnostic methods for cancer
|
|
KR20250047324A
(ko)
|
2017-08-07 |
2025-04-03 |
더 존스 홉킨스 유니버시티 |
암을 평가하고 치료하기 위한 방법 및 재료
|
|
EP3704268B1
(en)
|
2017-11-03 |
2025-01-22 |
Guardant Health, Inc. |
Normalizing tumor mutation burden
|
|
TW201930340A
(zh)
|
2017-12-18 |
2019-08-01 |
美商尼恩醫療公司 |
新抗原及其用途
|
|
EP3762512A1
(en)
|
2018-03-06 |
2021-01-13 |
Cancer Research Technology Limited |
Improvements in variant detection
|
|
AU2019275070A1
(en)
|
2018-05-23 |
2021-01-14 |
Gritstone Bio, Inc. |
Immune checkpoint inhibitor co-expression vectors
|
|
TW202000907A
(zh)
|
2018-05-23 |
2020-01-01 |
美商葛利史東腫瘤科技公司 |
共有抗原
|
|
KR20210137110A
(ko)
|
2019-03-06 |
2021-11-17 |
그릿스톤 바이오, 인코포레이티드 |
Mhc 클래스 ii 모델을 사용한 신생항원 동정
|
|
CN110003314B
(zh)
|
2019-04-11 |
2023-06-09 |
上海市计划生育科学研究所 |
H1n1流感病毒血凝素可诱发广谱保护性抗体的表位肽及其应用
|
|
SG11202113187WA
(en)
|
2019-05-30 |
2021-12-30 |
Gritstone Bio Inc |
Modified adenoviruses
|
|
AU2020298552A1
(en)
|
2019-07-02 |
2022-03-03 |
Seattle Project Corp. |
HIV antigens and MHC complexes
|
|
EP4125973A4
(en)
|
2019-11-04 |
2024-03-13 |
Gritstone bio, Inc. |
NEOANTIGEN VACCINE THERAPY
|
|
CA3160433A1
(en)
|
2019-12-09 |
2021-06-17 |
Daewoong Pharmaceutical Co., Ltd. |
Method for preparation of mesenchymal stem cell from human pluripotent stem cell and mesenchymal stem cells prepared thereby
|
|
WO2021119545A1
(en)
|
2019-12-11 |
2021-06-17 |
Gritstone Bio, Inc. |
Durable vaccination
|
|
WO2021142437A1
(en)
|
2020-01-10 |
2021-07-15 |
Gritstone Bio, Inc. |
Cell-free dna monitoring
|
|
JP2023521662A
(ja)
|
2020-04-03 |
2023-05-25 |
グリットストーン バイオ インコーポレイテッド |
感染症抗原及びワクチン
|
|
AU2021258191A1
(en)
|
2020-04-21 |
2022-12-01 |
Seattle Project Corp. |
Antigen-encoding cassettes
|
|
CA3178115A1
(en)
|
2020-05-19 |
2021-11-25 |
Roman YELENSKY |
Sars-cov-2 vaccines
|
|
IL300026A
(en)
|
2020-08-06 |
2023-03-01 |
Gritstone Bio Inc |
Multiepitope vaccine cassettes
|
|
WO2023081936A2
(en)
|
2021-11-08 |
2023-05-11 |
Gritstone Bio, Inc. |
Sars-cov-2 vaccines
|
|
WO2024238412A1
(en)
|
2023-05-13 |
2024-11-21 |
Cisco Technology, Inc. |
A charging exchange method for ambient power devices
|