DE60044125D1 - Zusammensetzungen und verfahren zur auslösung einer immunantwort auf basis alphavirus-vektoren-systeme - Google Patents
Zusammensetzungen und verfahren zur auslösung einer immunantwort auf basis alphavirus-vektoren-systemeInfo
- Publication number
- DE60044125D1 DE60044125D1 DE60044125T DE60044125T DE60044125D1 DE 60044125 D1 DE60044125 D1 DE 60044125D1 DE 60044125 T DE60044125 T DE 60044125T DE 60044125 T DE60044125 T DE 60044125T DE 60044125 D1 DE60044125 D1 DE 60044125D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- trigging
- compositions
- vector systems
- immune response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12949899P | 1999-04-14 | 1999-04-14 | |
US14808699P | 1999-08-09 | 1999-08-09 | |
US19136300P | 2000-03-22 | 2000-03-22 | |
PCT/US2000/010722 WO2000061772A2 (en) | 1999-04-14 | 2000-04-14 | Compositions and methods for generating an immune response utilizing alphavirus-based vector systems |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60044125D1 true DE60044125D1 (de) | 2010-05-20 |
Family
ID=27383889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60044125T Expired - Lifetime DE60044125D1 (de) | 1999-04-14 | 2000-04-14 | Zusammensetzungen und verfahren zur auslösung einer immunantwort auf basis alphavirus-vektoren-systeme |
Country Status (9)
Country | Link |
---|---|
US (1) | US7771979B2 (de) |
EP (2) | EP2196472A3 (de) |
JP (1) | JP4637368B2 (de) |
AT (1) | ATE463578T1 (de) |
AU (1) | AU4366000A (de) |
CA (2) | CA2373300C (de) |
DE (1) | DE60044125D1 (de) |
DK (1) | DK1175497T3 (de) |
WO (1) | WO2000061772A2 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002080982A2 (en) | 2001-01-12 | 2002-10-17 | Chiron Corporation | Nucleic acid mucosal immunization |
ATE472335T1 (de) | 2001-05-31 | 2010-07-15 | Novartis Vaccines & Diagnostic | Chimere alphavirus-replikon-partikel |
AU2002327614B2 (en) | 2001-09-06 | 2007-12-06 | Alphavax, Inc. | Alphavirus replicon vector systems |
CN1708320A (zh) * | 2002-11-07 | 2005-12-14 | 郎基·常 | 经修饰的树突状细胞 |
ES2890023T3 (es) | 2002-12-13 | 2022-01-17 | Alphavax Inc | Partículas alfavíricas y métodos de preparación |
US20040208848A1 (en) | 2002-12-13 | 2004-10-21 | Smith Jonathan F. | Multi-antigenic alphavirus replicon particles and methods |
DK1608762T3 (da) | 2003-03-20 | 2014-04-07 | Alphavax Inc | Forbedrede alphavirusreplikoner og hjælperkonstrukter |
US7419674B2 (en) | 2003-07-11 | 2008-09-02 | Alpha Vax, Inc. | Alpha virus-based cytomegalovirus vaccines |
US8828957B2 (en) * | 2003-12-11 | 2014-09-09 | Microvax, Llc | Methods for generating immunity to antigen |
AU2005245956B2 (en) | 2004-05-18 | 2011-05-19 | Alphavax, Inc. | TC-83-derived alphavirus vectors, particles and methods |
EP2848692B1 (de) | 2004-05-21 | 2017-08-16 | Novartis Vaccines and Diagnostics, Inc. | Alphavirus-Vektoren für Influenzavirus-Impfstoffe |
CA2611056C (en) | 2005-06-01 | 2016-06-28 | California Institute Of Technology | Method of targeted gene delivery using viral vectors |
EP1945247A1 (de) | 2005-10-18 | 2008-07-23 | Novartis Vaccines and Diagnostics, Inc. | Mukosale und systemische immunisierungen mit alphavirus-replicon-teilchen |
JP5215865B2 (ja) | 2005-11-22 | 2013-06-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | ノロウイルス抗原およびサポウイルス抗原 |
EP2520168B1 (de) * | 2006-07-21 | 2014-03-19 | California Institute of Technology | Zielgesteuerte Genabgabe für die Immunisierung mit Dendritenzellen |
US7850977B2 (en) | 2007-06-21 | 2010-12-14 | Alphavax, Inc. | Promoterless cassettes for expression of alphavirus structural proteins |
AU2008314485B9 (en) | 2007-10-15 | 2015-02-26 | Jingang Medicine (Australia) Pty Ltd | Expression system for modulating an immune response |
DK2770061T3 (en) | 2009-07-24 | 2019-01-07 | Immune Design Corp | NON-INTEGRATING LENTIVIRUS VECTORS |
US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
US9422529B2 (en) * | 2010-12-22 | 2016-08-23 | The Board Of Regents Of The University Of Texas System | Alphavirus compositions and methods of use |
WO2012088473A1 (en) * | 2010-12-22 | 2012-06-28 | The Board Of Regents Of The University Of Texas System | Alphavirus compositions and methods of use |
US9487563B2 (en) | 2011-01-31 | 2016-11-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Virus-like particles and methods of use |
RU2014104090A (ru) | 2011-07-06 | 2015-08-20 | Новартис Аг | Липосомы с эффективным соотношением n:p для доставки молекул phk |
US8323662B1 (en) | 2012-03-30 | 2012-12-04 | Immune Design Corp. | Methods useful for generating highly mannosylated pseudotyped lentiviral vector particles comprising a Vpx protein |
EA038702B1 (ru) | 2012-03-30 | 2021-10-07 | Иммьюн Дизайн Корп. | Лентивирусные векторные частицы, имеющие улучшенную эффективность трансдукции клеток, экспрессирующих dc-sign |
US9713635B2 (en) | 2012-03-30 | 2017-07-25 | Immune Design Corp. | Materials and methods for producing improved lentiviral vector particles |
EP2869842A1 (de) * | 2012-07-06 | 2015-05-13 | Novartis AG | Immunogene zusammensetzungen und verwendungen davon |
EP2895191B1 (de) | 2012-09-14 | 2019-06-05 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Brachyury-protein, adenovirale vektoren zur codierung von brachyury-protein und deren verwendung |
KR101650364B1 (ko) * | 2012-12-05 | 2016-08-23 | 더백스 제네틱스 백신 코포레이션, 엘티디. | 항원-특이적인 t 세포 반응을 유도하는 면역 강화제로서 사용을 위한 융합 단백질 |
CA2930693A1 (en) | 2013-11-15 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Methods of treating heart failure with agonists of hypocretin receptor 2 |
EP3313863B1 (de) | 2015-06-29 | 2020-12-23 | The Board of Trustees of the Leland Stanford Junior University | Degronfusionskonstrukte und verfahren zur steuerung der proteinproduktion |
CN108289940B (zh) | 2015-08-03 | 2023-01-13 | 美国卫生和人力服务部 | Brachyury缺失突变体、编码brachyury缺失突变体的非酵母载体及其用途 |
KR20180083437A (ko) | 2015-12-09 | 2018-07-20 | 애드메더스 백신스 피티와이 리미티드 | 치료를 위한 면역조절용 조성물 |
JP2019511255A (ja) | 2016-01-11 | 2019-04-25 | バーンダリ,インク. | マイクロニードル組成物およびそれを使用する方法 |
BR112019023477A2 (pt) | 2017-05-08 | 2020-06-30 | Gritstone Oncology, Inc. | vetores de neoantígeno de alfavírus |
BR112020013679A2 (pt) | 2018-01-04 | 2020-12-01 | Iconic Therapeutics, Inc. | anticorpos de fator antitecidual, conjugados anticorpo-fármaco e métodos relacionados |
NL2022538B1 (en) | 2019-02-08 | 2020-08-19 | Academisch Ziekenhuis Groningen | Methods for providing purified viral particles of Semliki Forest Virus (SFV), preparations obtainable thereby, and uses thereof. |
BR122024002387A2 (pt) | 2019-05-30 | 2024-03-12 | Gritstone Bio, Inc. | Vetores de adenovírus, composição farmacêutica, sequência de nucleotídeo isolada, célula isolada, vetor, kit, usos de um vetor, método para fabricar o vetor, métodos para produzir um vírus e vetor viral |
CN116196405A (zh) | 2019-12-31 | 2023-06-02 | 伊利克斯根治疗公司 | 核酸和蛋白质向细胞和组织的基于温度的瞬时递送 |
CN116438308A (zh) | 2020-08-06 | 2023-07-14 | 磨石生物公司 | 多表位疫苗盒 |
WO2023070072A1 (en) | 2021-10-21 | 2023-04-27 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Retroelement-generated transcription factor decoys |
CA3237482A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
WO2023183589A1 (en) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Rt-dna fidelity and retron genome editing |
WO2023183588A1 (en) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Methods of assessing engineered retron activity, and uses thereof |
WO2023183627A1 (en) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Production of reverse transcribed dna (rt-dna) using a retron reverse transcriptase from exogenous rna |
WO2024020346A2 (en) | 2022-07-18 | 2024-01-25 | Renagade Therapeutics Management Inc. | Gene editing components, systems, and methods of use |
WO2024044673A1 (en) | 2022-08-24 | 2024-02-29 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Dual cut retron editors for genomic insertions and deletions |
WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
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US5171568A (en) | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
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US5811407A (en) | 1997-02-19 | 1998-09-22 | The University Of North Carolina At Chapel Hill | System for the in vivo delivery and expression of heterologous genes in the bone marrow |
AU754320B2 (en) * | 1998-04-08 | 2002-11-14 | University Of North Carolina At Chapel Hill, The | Methods and modified cells for the treatment of cancer |
-
2000
- 2000-04-14 CA CA2373300A patent/CA2373300C/en not_active Expired - Fee Related
- 2000-04-14 DE DE60044125T patent/DE60044125D1/de not_active Expired - Lifetime
- 2000-04-14 JP JP2000611695A patent/JP4637368B2/ja not_active Expired - Fee Related
- 2000-04-14 EP EP10075073A patent/EP2196472A3/de not_active Withdrawn
- 2000-04-14 AU AU43660/00A patent/AU4366000A/en not_active Abandoned
- 2000-04-14 CA CA2760534A patent/CA2760534A1/en not_active Abandoned
- 2000-04-14 AT AT00923558T patent/ATE463578T1/de active
- 2000-04-14 EP EP00923558A patent/EP1175497B1/de not_active Expired - Lifetime
- 2000-04-14 DK DK00923558.1T patent/DK1175497T3/da active
- 2000-04-14 WO PCT/US2000/010722 patent/WO2000061772A2/en active Application Filing
-
2007
- 2007-02-27 US US11/712,044 patent/US7771979B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20080226598A1 (en) | 2008-09-18 |
CA2373300A1 (en) | 2000-10-19 |
ATE463578T1 (de) | 2010-04-15 |
EP2196472A3 (de) | 2011-04-13 |
DK1175497T3 (da) | 2010-05-31 |
AU4366000A (en) | 2000-11-14 |
EP1175497B1 (de) | 2010-04-07 |
JP4637368B2 (ja) | 2011-02-23 |
EP2196472A2 (de) | 2010-06-16 |
EP1175497A2 (de) | 2002-01-30 |
CA2760534A1 (en) | 2000-10-19 |
WO2000061772A2 (en) | 2000-10-19 |
WO2000061772A3 (en) | 2001-02-08 |
JP2002541814A (ja) | 2002-12-10 |
CA2373300C (en) | 2012-02-21 |
US7771979B2 (en) | 2010-08-10 |
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