JP2022031675A5 - - Google Patents
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- JP2022031675A5 JP2022031675A5 JP2021179960A JP2021179960A JP2022031675A5 JP 2022031675 A5 JP2022031675 A5 JP 2022031675A5 JP 2021179960 A JP2021179960 A JP 2021179960A JP 2021179960 A JP2021179960 A JP 2021179960A JP 2022031675 A5 JP2022031675 A5 JP 2022031675A5
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- JP
- Japan
- Prior art keywords
- coa
- naturally occurring
- composition
- microbial organism
- exogenous nucleic
- Prior art date
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- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims description 404
- 230000000813 microbial effect Effects 0.000 claims description 303
- 150000007523 nucleic acids Chemical class 0.000 claims description 248
- 102000039446 nucleic acids Human genes 0.000 claims description 248
- 108020004707 nucleic acids Proteins 0.000 claims description 248
- 230000037361 pathway Effects 0.000 claims description 245
- 102000004316 Oxidoreductases Human genes 0.000 claims description 240
- 108090000854 Oxidoreductases Proteins 0.000 claims description 240
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims description 184
- 102000004190 Enzymes Human genes 0.000 claims description 141
- 108090000790 Enzymes Proteins 0.000 claims description 141
- 238000000034 method Methods 0.000 claims description 105
- 102000003929 Transaminases Human genes 0.000 claims description 87
- 108090000340 Transaminases Proteins 0.000 claims description 87
- 229960002684 aminocaproic acid Drugs 0.000 claims description 63
- 102100026105 3-ketoacyl-CoA thiolase, mitochondrial Human genes 0.000 claims description 40
- 108010003902 Acetyl-CoA C-acyltransferase Proteins 0.000 claims description 40
- 238000004519 manufacturing process Methods 0.000 claims description 36
- 238000012258 culturing Methods 0.000 claims description 35
- 101710088194 Dehydrogenase Proteins 0.000 claims description 24
- 108090001042 Hydro-Lyases Proteins 0.000 claims description 19
- 102000004867 Hydro-Lyases Human genes 0.000 claims description 19
- SPNAEHGLBRRCGL-BIEWRJSYSA-N adipoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 SPNAEHGLBRRCGL-BIEWRJSYSA-N 0.000 claims description 10
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims description 8
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims description 8
- 230000001419 dependent effect Effects 0.000 claims description 8
- OTEACGAEDCIMBS-FOLKQPSDSA-N 3-hydroxyadipyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OTEACGAEDCIMBS-FOLKQPSDSA-N 0.000 claims description 7
- 229960003237 betaine Drugs 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical group C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 2
- 102000052553 3-Hydroxyacyl CoA Dehydrogenase Human genes 0.000 claims 5
- 108700020831 3-Hydroxyacyl-CoA Dehydrogenase Proteins 0.000 claims 5
- VNOYUJKHFWYWIR-ITIYDSSPSA-N succinyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-ITIYDSSPSA-N 0.000 claims 5
- ZFXICKRXPZTFPB-KCQRSJHASA-N trans-2,3-didehydroadipoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)\C=C\CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZFXICKRXPZTFPB-KCQRSJHASA-N 0.000 claims 5
- 239000002609 medium Substances 0.000 claims 3
- 241000186394 Eubacterium Species 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 241000948980 Actinobacillus succinogenes Species 0.000 claims 1
- 241000722955 Anaerobiospirillum Species 0.000 claims 1
- 241000228245 Aspergillus niger Species 0.000 claims 1
- 241001465318 Aspergillus terreus Species 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 241000193401 Clostridium acetobutylicum Species 0.000 claims 1
- 241000186226 Corynebacterium glutamicum Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241001473456 Eutrochium purpureum Species 0.000 claims 1
- 241000589236 Gluconobacter Species 0.000 claims 1
- 241000588749 Klebsiella oxytoca Species 0.000 claims 1
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims 1
- 241001138401 Kluyveromyces lactis Species 0.000 claims 1
- 241000235058 Komagataella pastoris Species 0.000 claims 1
- 240000006024 Lactobacillus plantarum Species 0.000 claims 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 1
- 241000589540 Pseudomonas fluorescens Species 0.000 claims 1
- 241000589776 Pseudomonas putida Species 0.000 claims 1
- 241000235527 Rhizopus Species 0.000 claims 1
- 240000005384 Rhizopus oryzae Species 0.000 claims 1
- 235000013752 Rhizopus oryzae Nutrition 0.000 claims 1
- 244000253911 Saccharomyces fragilis Species 0.000 claims 1
- 235000018368 Saccharomyces fragilis Nutrition 0.000 claims 1
- 241000235343 Saccharomycetales Species 0.000 claims 1
- 241000235347 Schizosaccharomyces pombe Species 0.000 claims 1
- 244000057717 Streptococcus lactis Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
- 241000187432 Streptomyces coelicolor Species 0.000 claims 1
- 241000588902 Zymomonas mobilis Species 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 238000000909 electrodialysis Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 229940031154 kluyveromyces marxianus Drugs 0.000 claims 1
- 229940072205 lactobacillus plantarum Drugs 0.000 claims 1
- 238000000622 liquid--liquid extraction Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000005374 membrane filtration Methods 0.000 claims 1
- 238000005373 pervaporation Methods 0.000 claims 1
- 238000001223 reverse osmosis Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 description 60
- 108090000992 Transferases Proteins 0.000 description 60
- IYNRULSFFKEOLT-UHFFFAOYSA-N 3-oxopimelic acid Chemical compound OC(=O)CCCC(=O)CC(O)=O IYNRULSFFKEOLT-UHFFFAOYSA-N 0.000 description 46
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 description 44
- 102000003960 Ligases Human genes 0.000 description 40
- 108090000364 Ligases Proteins 0.000 description 40
- NMDDZEVVQDPECF-LURJTMIESA-N (2s)-2,7-diaminoheptanoic acid Chemical compound NCCCCC[C@H](N)C(O)=O NMDDZEVVQDPECF-LURJTMIESA-N 0.000 description 35
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 description 34
- SYKWLIJQEHRDNH-CKRMAKSASA-N glutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 SYKWLIJQEHRDNH-CKRMAKSASA-N 0.000 description 33
- MIPJCYQFTDLIGF-HDRQGHTBSA-N s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 6-aminohexanethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCN)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MIPJCYQFTDLIGF-HDRQGHTBSA-N 0.000 description 33
- GSDLHWPNIOWYHJ-UHFFFAOYSA-N 2-amino-7-oxoheptanoic acid Chemical compound OC(=O)C(N)CCCCC=O GSDLHWPNIOWYHJ-UHFFFAOYSA-N 0.000 description 32
- KJXFOFKTZDJLMQ-UYRKPTJQSA-N 3-oxopimeloyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 KJXFOFKTZDJLMQ-UYRKPTJQSA-N 0.000 description 32
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 description 24
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 description 24
- FGSBMPLRSMYGCV-UHFFFAOYSA-N 2,4-dioxooctanoic acid Chemical compound CCCCC(=O)CC(=O)C(O)=O FGSBMPLRSMYGCV-UHFFFAOYSA-N 0.000 description 22
- OKDNHROSUNKBKT-UHFFFAOYSA-N 3-amino-7-oxoheptanoic acid Chemical compound OC(=O)CC(N)CCCC=O OKDNHROSUNKBKT-UHFFFAOYSA-N 0.000 description 18
- 229940040102 levulinic acid Drugs 0.000 description 17
- YMNZNYSOUAKJAV-HDRQGHTBSA-N s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 6-amino-3-oxohexanethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCCN)O[C@H]1N1C2=NC=NC(N)=C2N=C1 YMNZNYSOUAKJAV-HDRQGHTBSA-N 0.000 description 17
- RGUBYIAMAWCQSP-UHFFFAOYSA-N 3-aminoheptanedioic acid Chemical compound OC(=O)CC(N)CCCC(O)=O RGUBYIAMAWCQSP-UHFFFAOYSA-N 0.000 description 16
- PNPPVRALIYXJBW-UHFFFAOYSA-N 6-oxohexanoic acid Chemical compound OC(=O)CCCCC=O PNPPVRALIYXJBW-UHFFFAOYSA-N 0.000 description 16
- 101710202061 N-acetyltransferase Proteins 0.000 description 16
- 108091000080 Phosphotransferase Proteins 0.000 description 16
- 102000020233 phosphotransferase Human genes 0.000 description 16
- JUQLUIFNNFIIKC-UHFFFAOYSA-N 2-aminopimelic acid Chemical compound OC(=O)C(N)CCCCC(O)=O JUQLUIFNNFIIKC-UHFFFAOYSA-N 0.000 description 15
- PJDINCOFOROBQW-UHFFFAOYSA-N 3,7-Diaminoheptanoic Acid Chemical compound NCCCCC(N)CC(O)=O PJDINCOFOROBQW-UHFFFAOYSA-N 0.000 description 15
- 102000002932 Thiolase Human genes 0.000 description 14
- 108060008225 Thiolase Proteins 0.000 description 14
- RRGHQGSYMGPKCO-UHFFFAOYSA-N 7-amino-3-oxoheptanoic acid Chemical compound NCCCCC(=O)CC(O)=O RRGHQGSYMGPKCO-UHFFFAOYSA-N 0.000 description 13
- 108010069175 acyl-CoA transferase Proteins 0.000 description 13
- 101000985286 Escherichia coli 2-oxo-hept-4-ene-1,7-dioate hydratase Proteins 0.000 description 12
- WDSCBUNMANHPFH-UHFFFAOYSA-M 6-acetamidohexanoate Chemical compound CC(=O)NCCCCCC([O-])=O WDSCBUNMANHPFH-UHFFFAOYSA-M 0.000 description 11
- 102000004317 Lyases Human genes 0.000 description 11
- 108090000856 Lyases Proteins 0.000 description 11
- 238000005576 amination reaction Methods 0.000 description 11
- WRJPJZTWQTUPQK-UHFFFAOYSA-N n-(6-aminohexyl)acetamide Chemical compound CC(=O)NCCCCCCN WRJPJZTWQTUPQK-UHFFFAOYSA-N 0.000 description 11
- -1 3-Hydroxy-6-aminohexanoyl-CoA aldehyde Chemical class 0.000 description 10
- 102000001253 Protein Kinase Human genes 0.000 description 10
- 150000001408 amides Chemical class 0.000 description 10
- 108060006633 protein kinase Proteins 0.000 description 10
- 244000005700 microbiome Species 0.000 description 9
- BGJIRLKEICEKSQ-UHFFFAOYSA-N 7-amino-2-oxoheptanoic acid Chemical compound NCCCCCC(=O)C(O)=O BGJIRLKEICEKSQ-UHFFFAOYSA-N 0.000 description 8
- UWMORNRVRUIQPR-HDRQGHTBSA-N S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 6-aminohex-2-enethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C=CCCCN)O[C@H]1N1C2=NC=NC(N)=C2N=C1 UWMORNRVRUIQPR-HDRQGHTBSA-N 0.000 description 8
- PKVRQLMDAMASTB-SNIDVWGTSA-N 2-amino-7-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-7-oxoheptanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCC(N)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 PKVRQLMDAMASTB-SNIDVWGTSA-N 0.000 description 7
- CCYXEHOXJOKCCJ-UHFFFAOYSA-N 6-aminohexanal Chemical compound NCCCCCC=O CCYXEHOXJOKCCJ-UHFFFAOYSA-N 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 6
- 150000001299 aldehydes Chemical class 0.000 description 6
- 210000001808 exosome Anatomy 0.000 description 6
- QAMKYKJQNLRRAJ-UHFFFAOYSA-N 6-amino-3-hydroxyhexanoic acid Chemical compound NCCCC(O)CC(O)=O QAMKYKJQNLRRAJ-UHFFFAOYSA-N 0.000 description 5
- BHDKTGQTZOBVIL-UYRKPTJQSA-N 7-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3,7-dioxoheptanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BHDKTGQTZOBVIL-UYRKPTJQSA-N 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- ZFXICKRXPZTFPB-FZHFFJAKSA-N (Z)-2,3-dehydroadipoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)\C=C/CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZFXICKRXPZTFPB-FZHFFJAKSA-N 0.000 description 4
- FOKABCOGWXJDTD-IMKGSZBMSA-N 2-amino-7-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-5-hydroxy-7-oxoheptanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)CCC(N)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 FOKABCOGWXJDTD-IMKGSZBMSA-N 0.000 description 4
- HABHUTWTLGRDDU-UHFFFAOYSA-N 2-oxopimelic acid Chemical compound OC(=O)CCCCC(=O)C(O)=O HABHUTWTLGRDDU-UHFFFAOYSA-N 0.000 description 4
- SNACICYKKILLEK-UHFFFAOYSA-N 6-aminohex-2-enoic acid Chemical compound NCCCC=CC(O)=O SNACICYKKILLEK-UHFFFAOYSA-N 0.000 description 4
- ICGKEQXHPZUYSF-UHFFFAOYSA-N 6-oxohept-3-enedioic acid Chemical compound OC(=O)CC=CCC(=O)C(O)=O ICGKEQXHPZUYSF-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 108010060146 pyruvate formate-lyase activating enzyme Proteins 0.000 description 4
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 3
- DUXOPGJKCDTPLF-JXUSAFQPSA-N 3-amino-7-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-7-oxoheptanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 DUXOPGJKCDTPLF-JXUSAFQPSA-N 0.000 description 3
- VKKKAAPGXHWXOO-BIEWRJSYSA-N 3-oxoadipyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VKKKAAPGXHWXOO-BIEWRJSYSA-N 0.000 description 3
- PUIRLTLMCJRHFF-UHFFFAOYSA-N 6-amino-3-oxohexanoic acid Chemical compound NCCCC(=O)CC(O)=O PUIRLTLMCJRHFF-UHFFFAOYSA-N 0.000 description 3
- WFSCDWVPBNOBNO-UHFFFAOYSA-N 7-amino-2-oxohept-3-enoic acid Chemical compound NCCCC=CC(=O)C(O)=O WFSCDWVPBNOBNO-UHFFFAOYSA-N 0.000 description 3
- QQUWQLAQVGXPPE-UHFFFAOYSA-N 7-amino-4-hydroxy-2-oxoheptanoic acid Chemical compound NCCCC(O)CC(=O)C(O)=O QQUWQLAQVGXPPE-UHFFFAOYSA-N 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- LKNUIOZKLGQZEF-UHFFFAOYSA-N n-(6-oxohexyl)acetamide Chemical compound CC(=O)NCCCCCC=O LKNUIOZKLGQZEF-UHFFFAOYSA-N 0.000 description 3
- FPZRHFKFGHMXTD-UHFFFAOYSA-N 2,3-dioxooctanoic acid Chemical compound CCCCCC(=O)C(=O)C(O)=O FPZRHFKFGHMXTD-UHFFFAOYSA-N 0.000 description 2
- URKANQMYNHOVKS-RCICKGJNSA-N 3-amino-8-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-8-oxooct-6-enoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C=CCCC(N)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 URKANQMYNHOVKS-RCICKGJNSA-N 0.000 description 2
- RTGHRDFWYQHVFW-UHFFFAOYSA-N 3-oxoadipic acid Chemical compound OC(=O)CCC(=O)CC(O)=O RTGHRDFWYQHVFW-UHFFFAOYSA-N 0.000 description 2
- 108010027577 3-oxoadipyl-coenzyme A thiolase Proteins 0.000 description 2
- HNOAJOYERZTSNK-UHFFFAOYSA-N 4-hydroxy-2-oxoheptanedioic acid Chemical group OC(=O)CCC(O)CC(=O)C(O)=O HNOAJOYERZTSNK-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- 102000057234 Acyl transferases Human genes 0.000 description 2
- 108700016155 Acyl transferases Proteins 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 2
- 235000015250 liver sausages Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- XDWUDFWWMNXIJN-UHFFFAOYSA-N phosphono 6-aminohexanoate Chemical compound NCCCCCC(=O)OP(O)(O)=O XDWUDFWWMNXIJN-UHFFFAOYSA-N 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 238000007363 ring formation reaction Methods 0.000 description 2
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- 230000002269 spontaneous effect Effects 0.000 description 2
- CLGRLBOVAMSRKG-UHFFFAOYSA-N 6-aminohept-3-enedioic acid Chemical compound OC(=O)C(N)CC=CCC(O)=O CLGRLBOVAMSRKG-UHFFFAOYSA-N 0.000 description 1
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- QPMJENKZJUFOON-PLNGDYQASA-N ethyl (z)-3-chloro-2-cyano-4,4,4-trifluorobut-2-enoate Chemical compound CCOC(=O)C(\C#N)=C(/Cl)C(F)(F)F QPMJENKZJUFOON-PLNGDYQASA-N 0.000 description 1
- 108010008221 formate C-acetyltransferase Proteins 0.000 description 1
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- 150000004715 keto acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- OTAIDQCHVKFDQZ-UHFFFAOYSA-N phosphono 6-acetamidohexanoate Chemical compound CC(=O)NCCCCCC(=O)OP(O)(O)=O OTAIDQCHVKFDQZ-UHFFFAOYSA-N 0.000 description 1
- QJRBJEADDJCUDL-CECATXLMSA-N s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 6-acetamidohexanethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCNC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QJRBJEADDJCUDL-CECATXLMSA-N 0.000 description 1
- HJHVQCXHVMGZNC-JCJNLNMISA-M sodium;(2z)-2-[(3r,4s,5s,8s,9s,10s,11r,13r,14s,16s)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoate Chemical compound [Na+].O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C([O-])=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C HJHVQCXHVMGZNC-JCJNLNMISA-M 0.000 description 1
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Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009151728A2 (en) | 2008-03-27 | 2009-12-17 | Genomatica, Inc. | Microorganisms for the production of adipic acid and other compounds |
| WO2009155382A1 (en) | 2008-06-17 | 2009-12-23 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| AU2009327490A1 (en) | 2008-12-16 | 2011-07-28 | Genomatica, Inc. | Microorganisms and methods for conversion of syngas and other carbon sources to useful products |
| US8404465B2 (en) | 2009-03-11 | 2013-03-26 | Celexion, Llc | Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks |
| SI2427544T1 (sl) | 2009-05-07 | 2019-11-29 | Genomatica Inc | Mikroorganizmi in metode za biosintezo adipata, heksametilendiamina in 6-aminokaprojske kisline |
| US8420375B2 (en) | 2009-06-10 | 2013-04-16 | Genomatica, Inc. | Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol |
| BR112012002643A2 (pt) | 2009-08-05 | 2018-08-28 | Genomatica Inc | ácido tereftalático semissintético por meio de micro-organismos que produzem ácido mucônico |
| BR112012014062A2 (pt) | 2009-12-10 | 2017-04-04 | Genomatica Inc | organismo microbiano que não ocorre naturalmente e método para produzir 1,3 bdo |
| US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| FR2963362B1 (fr) * | 2010-07-30 | 2012-08-17 | Pcas Biosolution | Procede d'acylation enzymatique avec un donneur acyl-phosphonate |
| US20120259138A1 (en) * | 2011-04-05 | 2012-10-11 | BioAmber International S.à.r.I. | Methods and systems of producing dicarboxylic acids |
| CN103732569B (zh) | 2011-06-17 | 2016-06-29 | 英威达技术有限责任公司 | 使用水解酶来增加废物流中的单体含量 |
| WO2012174430A2 (en) * | 2011-06-17 | 2012-12-20 | Invista Technologies S.A.R.L. | Methods of making nylon intermediates from glycerol |
| WO2012177721A1 (en) * | 2011-06-22 | 2012-12-27 | Genomatica, Inc. | Microorganisms for producing 6-aminocaproic acid |
| US20130034884A1 (en) | 2011-06-22 | 2013-02-07 | Genomatica, Inc. | Microorganisms for producing 1,4-butanediol and methods related thereto |
| CN104011216A (zh) | 2011-06-30 | 2014-08-27 | 英威达技术有限责任公司 | 用于生产尼龙-7、尼龙-7,7和聚酯的生物转化工艺 |
| PH12013502700A1 (en) | 2011-07-12 | 2014-02-10 | Scientist Of Fortune Sa | Recombinant microorganism for the production of useful metabolites |
| KR101884022B1 (ko) * | 2011-10-06 | 2018-08-02 | 성균관대학교산학협력단 | 카프로산 생산용 재조합 미생물 및 이를 이용하여 카프로산을 대량 생산하는 방법 |
| US9102958B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| US9102960B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| AR089707A1 (es) | 2012-01-18 | 2014-09-10 | Rennovia Inc | Proceso para la produccion de hexametilendiamina a partir de materiales que contienen carbohidratos y compuestos intermedios para la misma |
| CN104245947B (zh) | 2012-02-29 | 2018-01-05 | 杜克大学 | 用于对映选择性反应的新的氧化还原酶 |
| US20130288320A1 (en) * | 2012-04-27 | 2013-10-31 | Bioamber Inc. | Methods and microorganisms for increasing the biological synthesis of difunctional alkanes |
| US9803209B2 (en) | 2012-05-18 | 2017-10-31 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| AU2012327243A1 (en) * | 2012-08-17 | 2014-03-06 | Celexion, Llc | Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks |
| WO2014047407A1 (en) * | 2012-09-20 | 2014-03-27 | Bioamber Inc. | Pathways to adipate semialdehyde and other organic products |
| CN104619721A (zh) | 2012-09-27 | 2015-05-13 | 诺维信股份有限公司 | 具有改进的转化效率的细菌突变体 |
| WO2014093847A2 (en) | 2012-12-14 | 2014-06-19 | Invista North America S.A.R.L. | METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE |
| TW202330912A (zh) | 2012-12-17 | 2023-08-01 | 美商奇諾麥提卡公司 | 用於增加甲醇存在下之還原當量可利用性及用於製造與其相關己二酸、6-胺基己酸、己二胺或己內醯胺之微生物及方法 |
| EP2746397A1 (de) * | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Omega-Aminofettsäuren |
| CN105073214A (zh) * | 2012-12-31 | 2015-11-18 | 英威达技术有限责任公司 | 通过甲酯保护的碳链延伸生产6碳化学物的方法 |
| CN105008543A (zh) | 2012-12-31 | 2015-10-28 | 英威达技术有限责任公司 | 通过芳香族化合物生产7-碳化学物的方法 |
| EP2938731A2 (en) | 2012-12-31 | 2015-11-04 | Invista Technologies S.A R.L. | Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis |
| WO2014105794A2 (en) | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation |
| CN105026570A (zh) | 2012-12-31 | 2015-11-04 | 英威达技术有限责任公司 | 通过氧化裂解从长链脂肪酸生产7-碳化学物的方法 |
| WO2014105797A2 (en) | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation |
| WO2014105790A2 (en) | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis |
| WO2014144293A2 (en) * | 2013-03-15 | 2014-09-18 | Genomatica, Inc. | Development and use of microbes for impurity reduction in biomass hydrolysates and fermentation broths |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| WO2014182016A1 (ko) * | 2013-05-06 | 2014-11-13 | 한국생명공학연구원 | 6-아미노카프로산의 생물학적 합성 및 이를 위한 형질전환 미생물 |
| US10087472B2 (en) | 2013-05-06 | 2018-10-02 | Korea Research Institute Of Bioscience And Biotechnology | Biological synthesis of 6-aminocaproic acid and transgenic microorganism therefor |
| US12104160B2 (en) | 2013-09-17 | 2024-10-01 | Zymochem, Inc. | Production of 4,6-dihydroxy-2-oxo-hexanoic acid |
| CN105745327A (zh) * | 2013-09-17 | 2016-07-06 | 兹莫克姆有限公司 | 由可再生资源生产化合物的高产路线 |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| CA2935069C (en) | 2013-12-27 | 2023-05-09 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| WO2015175528A1 (en) * | 2014-05-12 | 2015-11-19 | Micromidas, Inc. | Methods of producing compounds from 5-(halomethyl)furfural |
| CN103937841B (zh) * | 2014-05-13 | 2015-10-28 | 上海交通大学 | 烯酰辅酶a水合酶在己二酸生物合成中的应用 |
| BR112016026461A2 (pt) | 2014-05-15 | 2017-12-12 | Invista Tech Sarl | métodos de produção de produtos químicos com 6 carbonos com uso de 2,6-diaminopimelato como precursor para 2-aminopimelato |
| WO2015195689A1 (en) | 2014-06-16 | 2015-12-23 | INVISTA Technologies S.á.r.l. | Process for producing glutarate and glutaric acid methyl ester |
| EP3155106A2 (en) | 2014-06-16 | 2017-04-19 | Invista Technologies S.à.r.l. | Methods, reagents and cells for biosynthesizing compound |
| EP3155108A1 (en) | 2014-06-16 | 2017-04-19 | Invista Technologies S.à.r.l. | Methods, reagents and cells for biosynthesizing compounds |
| CN106795534A (zh) | 2014-06-16 | 2017-05-31 | 英威达技术有限责任公司 | 用于生物合成化合物的方法、试剂和细胞 |
| US20170298363A1 (en) | 2014-09-18 | 2017-10-19 | Genomatica, Inc | Non-natural microbial organisms with improved energetic efficiency |
| BR112017009754B1 (pt) | 2014-12-02 | 2021-09-14 | Archer-Daniels-Midland Company | Processo para a preparação de 2,5-bis-hidroximetilfurano, 1,2,6-hexanotriol, e 1,6- exanodiol a partir de 5- hidroximetilfurfural |
| CA2970557A1 (en) * | 2014-12-23 | 2016-06-30 | Genomatica, Inc. | Method of producing & processing diamines |
| KR101715882B1 (ko) | 2015-03-06 | 2017-03-27 | 한국생명공학연구원 | 신규 ε-카프로락탐 전환 효소 및 이를 이용한 ε-카프로락탐 생산 방법 |
| KR101839595B1 (ko) * | 2015-04-13 | 2018-04-26 | 한국과학기술원 | 락탐의 제조방법 |
| WO2016167519A1 (ko) * | 2015-04-13 | 2016-10-20 | 한국과학기술원 | 락탐의 제조방법 |
| EP3314002A4 (en) * | 2015-06-23 | 2019-07-10 | Genomatica, Inc. | MICRO-ORGANISMS AND METHOD FOR PRODUCING BIOSYNTHETIZED TARGET PRODUCTS WITH A REDUCED SUBSTANCE OF BY-PRODUCTS |
| KR101651239B1 (ko) * | 2015-07-02 | 2016-08-25 | 씨제이제일제당 주식회사 | 신규 슈도모나스 종 균주 및 이를 이용한 6-아미노카프로산의 탈아민 방법 |
| KR101750856B1 (ko) | 2015-10-22 | 2017-06-30 | 한국과학기술원 | 1,3-다이아미노프로판 생산능을 가지는 재조합 미생물 및 이를 이용한 1,3-다이아미노프로판의 제조방법 |
| KR101903552B1 (ko) * | 2015-10-27 | 2018-10-04 | 한국생명공학연구원 | 중쇄 디아민의 생산 방법 |
| EP3368548B1 (en) | 2015-10-30 | 2023-08-23 | Genomatica, Inc. | Methanol dehydrogenase fusion proteins |
| BR112018016927A8 (pt) * | 2016-02-19 | 2022-09-06 | Invista Tech Sarl | Processos e materiais biocatalíticos para utilização de carbono aprimorada |
| US20230139445A1 (en) | 2016-11-15 | 2023-05-04 | Danmarks Tekniske Universitet | Bacterial cells with improved tolerance to diacids |
| CN107164477A (zh) * | 2017-05-27 | 2017-09-15 | 山西维尔生物乳制品有限公司 | 一种鉴别罗伦氏隐球酵母的探针、引物和基因芯片 |
| WO2019018302A1 (en) | 2017-07-18 | 2019-01-24 | Arizona Board Of Regents On Behalf Of Arizona State University | SYNTHETIC METABOLIC FUNNEL PASSAGE FOR BIOCHEMICAL PRODUCTION |
| KR101971480B1 (ko) | 2017-09-26 | 2019-04-23 | 한국생명공학연구원 | 돌연변이 재설계 유전자 회로를 이용한 니트릴계, 락톤계 또는 락탐계 화합물의 감지 및 정량 방법 |
| KR101898171B1 (ko) * | 2018-01-19 | 2018-09-12 | 씨제이제일제당 주식회사 | 신규 트랜스아미나제 및 이를 이용한 아미노 화합물의 탈아민 방법 |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| CN113166784A (zh) | 2018-06-26 | 2021-07-23 | 基因组股份公司 | 包括具有合成或增强的甲基营养的那些工程微生物的、具有g3p→3pg酶和/或果糖-1，6-二磷酸酶的工程微生物 |
| IT201800021409A1 (it) | 2018-12-28 | 2020-06-28 | Aquafil S P A | Processo per la produzione di epsilon caprolattame dallacido 6-aminocaproico. |
| US20220348890A1 (en) * | 2019-04-24 | 2022-11-03 | Genomatica, Inc. | Engineered transaminase and methods of making and using |
| CN114026246B (zh) | 2019-04-25 | 2025-12-19 | 兹莫克姆有限公司 | 从可再生来源生产化学品 |
| WO2020230718A1 (ja) | 2019-05-10 | 2020-11-19 | 東レ株式会社 | ３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
| JP7646119B2 (ja) | 2019-05-10 | 2025-03-17 | 東レ株式会社 | ３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
| CN114555779A (zh) | 2019-07-22 | 2022-05-27 | 旭化成株式会社 | 基因重组微生物和二胺化合物的制造方法 |
| CN111122720B (zh) * | 2019-12-11 | 2022-09-02 | 湖北三宁碳磷基新材料产业技术研究院有限公司 | 己内酰胺、6-氨基己酰胺和6-氨基己腈的分析方法 |
| EP4139444A4 (en) * | 2020-04-24 | 2024-11-13 | Genomatica, Inc. | MANIPULATED ENZYMES AND METHODS OF PREPARATION AND USE |
| WO2022102635A1 (ja) | 2020-11-11 | 2022-05-19 | 東レ株式会社 | ３－ヒドロキシアジピン酸および／またはα－ヒドロムコン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 |
| WO2022155554A1 (en) | 2021-01-17 | 2022-07-21 | Genomatica, Inc. | Methods and compositions for making amide compounds |
| JP7038241B1 (ja) | 2021-03-30 | 2022-03-17 | 旭化成株式会社 | 組換え微生物及びアジピン酸又はその誘導体の製造方法 |
| KR20230162685A (ko) | 2021-03-30 | 2023-11-28 | 아사히 가세이 가부시키가이샤 | 아실 CoA 화합물 환원 활성을 갖는 재조합 폴리펩티드 |
| US20250019671A1 (en) | 2021-03-30 | 2025-01-16 | Asahi Kasei Kabushiki Kaisha | Recombinant polypeptide having carboxylic acid reducing activity |
| JP7672486B2 (ja) | 2021-05-19 | 2025-05-07 | 旭化成株式会社 | ジアミン生産能を有する組換え微生物およびジアミンの製造方法 |
| EP4481050A1 (en) * | 2022-02-15 | 2024-12-25 | Toray Industries, Inc. | Genetically modified microorganism for producing 3-hydroxyadipic acid and/or alpha-hydromuconic acid, and method for producing chemical product |
| CN114990043B (zh) * | 2022-06-28 | 2024-04-30 | 滨州医学院 | 代谢赖氨酸的工程菌及其构建方法与应用 |
Family Cites Families (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3513209A (en) | 1968-08-19 | 1970-05-19 | Du Pont | Method of making 1,4-cyclohexadiene |
| US4076948A (en) | 1968-10-10 | 1978-02-28 | El Paso Products Company | Process for treatment of adipic acid mother liquor |
| GB1230276A (enExample) | 1968-12-09 | 1971-04-28 | ||
| US3965182A (en) | 1969-10-02 | 1976-06-22 | Ethyl Corporation | Preparation of aniline from phenol and ammonia |
| JPS4831084B1 (enExample) | 1970-09-04 | 1973-09-26 | ||
| GB1344557A (en) | 1972-06-23 | 1974-01-23 | Mitsubishi Petrochemical Co | Process for preparing 1,4-butanediol |
| JPS5543759B2 (enExample) | 1972-06-28 | 1980-11-07 | ||
| JPS506776A (enExample) | 1973-05-28 | 1975-01-23 | ||
| JPS5721310B2 (enExample) * | 1974-03-19 | 1982-05-06 | ||
| DE2455617C3 (de) | 1974-11-23 | 1982-03-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons |
| DE2501499A1 (de) | 1975-01-16 | 1976-07-22 | Hoechst Ag | Verfahren zur herstellung von butandiol-(1.4) |
| US4190495A (en) | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| FR2403571A1 (fr) | 1977-09-14 | 1979-04-13 | Cables De Lyon Geoffroy Delore | Dispositif mecanique de raccordement de fibres optiques |
| US4301077A (en) | 1980-12-22 | 1981-11-17 | Standard Oil Company | Process for the manufacture of 1-4-butanediol and tetrahydrofuran |
| JPS60114197A (ja) | 1983-11-25 | 1985-06-20 | Agency Of Ind Science & Technol | 微生物によるジカルボン酸の製造法 |
| US4871667A (en) | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
| US4652685A (en) | 1985-11-15 | 1987-03-24 | General Electric Company | Hydrogenation of lactones to glycols |
| ES2036188T3 (es) | 1986-06-11 | 1993-05-16 | Michigan Biotechnology Institute | Un procedimiento para la produccion de acido succinico por fermentacion anaerobia. |
| US5143834A (en) | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| US5168055A (en) | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| US5182199A (en) | 1987-05-27 | 1993-01-26 | Hartley Brian S | Thermophilic ethanol production in a two-stage closed system |
| US5219757A (en) | 1988-04-27 | 1993-06-15 | Daicel Chemical Industries, Ltd. | Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone |
| WO1990012888A1 (en) | 1989-04-27 | 1990-11-01 | Biocontrol Systems, Incorporated | Precipitate test for microorganisms |
| US5192673A (en) | 1990-04-30 | 1993-03-09 | Michigan Biotechnology Institute | Mutant strain of C. acetobutylicum and process for making butanol |
| US5079143A (en) | 1990-05-02 | 1992-01-07 | The Upjohn Company | Method of indentifying compounds useful as antiparasitic drugs |
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| US5416020A (en) | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
| US5266694A (en) | 1992-10-19 | 1993-11-30 | E. I. Du Pont De Nemours And Company | Nylon component reclamation |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| US5302756A (en) | 1992-12-23 | 1994-04-12 | E. I. Du Pont De Nemours And Company | Ammonolysis of nylon |
| FR2702492B1 (fr) | 1993-03-12 | 1995-05-24 | Rhone Poulenc Chimie | Procédé de production par fermentation d'acide itaconique. |
| US5487987A (en) | 1993-09-16 | 1996-01-30 | Purdue Research Foundation | Synthesis of adipic acid from biomass-derived carbon sources |
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5700934A (en) | 1995-03-01 | 1997-12-23 | Dsm N.V. | Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors |
| US5478952A (en) | 1995-03-03 | 1995-12-26 | E. I. Du Pont De Nemours And Company | Ru,Re/carbon catalyst for hydrogenation in aqueous solution |
| US5863782A (en) * | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| FR2736927B1 (fr) | 1995-07-18 | 1997-10-17 | Rhone Poulenc Fibres & Polymer | Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| US5869301A (en) | 1995-11-02 | 1999-02-09 | Lockhead Martin Energy Research Corporation | Method for the production of dicarboxylic acids |
| US5770435A (en) | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| EP0883683A1 (en) | 1996-02-27 | 1998-12-16 | Michigan State University | Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization |
| US5958745A (en) | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
| DE69638265D1 (de) | 1996-07-01 | 2010-11-11 | Emmaus Foundation Inc | BIOLOGISCHE HESTELLUNG VON ESSIGSäURE AUS ABGASEN |
| KR100459818B1 (ko) | 1996-09-02 | 2004-12-03 | 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 | ε-카프로락탐의 제조방법 |
| AU6169498A (en) | 1997-02-13 | 1998-09-08 | James Madison University | Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units |
| KR100516986B1 (ko) | 1997-02-19 | 2005-09-26 | 코닌클리즈케 디에스엠 엔.브이. | 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법 |
| US6274790B1 (en) | 1997-04-14 | 2001-08-14 | The University Of British Columbia | Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis |
| KR19990013007A (ko) | 1997-07-31 | 1999-02-25 | 박원훈 | 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법 |
| JPH11103863A (ja) | 1997-10-08 | 1999-04-20 | Nippon Shokubai Co Ltd | マレイン酸異性化酵素遺伝子 |
| US6280986B1 (en) | 1997-12-01 | 2001-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities |
| US20030087381A1 (en) | 1998-04-13 | 2003-05-08 | University Of Georgia Research Foundation, Inc. | Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals |
| AU760575C (en) | 1998-04-13 | 2005-04-14 | University Of Georgia Research Foundation, Inc., The | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6159738A (en) | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| US6432686B1 (en) | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| US6444784B1 (en) | 1998-05-29 | 2002-09-03 | Exxonmobil Research & Engineering Company | Wax crystal modifiers (LAW657) |
| DE19831889A1 (de) * | 1998-07-17 | 2000-01-27 | Basf Ag | Verbessertes Verfahren zur Herstellung von Hexamethylendiamin |
| US5961788A (en) | 1998-10-09 | 1999-10-05 | E. I. Du Pont De Nemours And Company | Sequential distillation process for removing tetrahydroazepine from aminocapronitrile and/or hexamethylenediamine |
| DE19856136C2 (de) | 1998-12-04 | 2002-10-24 | Pasteur Institut | Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension |
| EP1147229A2 (en) | 1999-02-02 | 2001-10-24 | Bernhard O. Palsson | Methods for identifying drug targets based on genomic sequence data |
| US6686310B1 (en) | 1999-02-09 | 2004-02-03 | E. I. Du Pont De Nemours And Company | High surface area sol-gel route prepared hydrogenation catalysts |
| US6365376B1 (en) | 1999-02-19 | 2002-04-02 | E. I. Du Pont De Nemours And Company | Genes and enzymes for the production of adipic acid intermediates |
| AU3516100A (en) | 1999-03-05 | 2000-09-21 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| JP4637372B2 (ja) | 1999-05-21 | 2011-02-23 | カーギル ダウ エルエルシー | 有機生成物の合成方法および合成材料 |
| US6852517B1 (en) | 1999-08-30 | 2005-02-08 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| US6660857B2 (en) | 2000-02-03 | 2003-12-09 | Dsm N.V. | Process for the preparation of ε-caprolactam |
| US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
| DE60121335T2 (de) | 2000-07-25 | 2007-08-02 | Emmaus Foundation, Inc., Fayetteville | Verfahren zur steigerung der ethanolproduktion bei der mikrobiellen fermentation |
| US7698463B2 (en) * | 2000-09-12 | 2010-04-13 | Sri International | System and method for disseminating topology and link-state information to routing nodes in a mobile ad hoc network |
| US6248926B1 (en) | 2000-10-26 | 2001-06-19 | E. I. Du Pont De Nemours And Company | Recovery of hexamethylenediamine (HMD) with low polarographically reducible impurities (PRI) from mixtures of HMD, aminocapronitirle and PRI |
| JP4490628B2 (ja) | 2000-11-20 | 2010-06-30 | カーギル インコーポレイテッド | ３−ヒドロキシプロピオン酸および他の有機化合物 |
| AU2002237676A1 (en) | 2000-11-22 | 2002-06-03 | Cargill Dow Polymers, Llc | Methods and materials for the synthesis of organic products |
| CN1358841A (zh) | 2000-12-11 | 2002-07-17 | 云南省微生物研究所 | 云南链霉菌 |
| CN1491282A (zh) | 2000-12-28 | 2004-04-21 | 丰田自动车株式会社 | 异戊二烯醇的制备方法 |
| EP1362319A2 (en) | 2001-01-10 | 2003-11-19 | The Penn State Research Foundation | Method and system for modeling cellular metabolism |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| WO2002070730A2 (en) | 2001-03-01 | 2002-09-12 | The Regents Of The University Of California | Models and methods for determining systemic properties of regulated reaction networks |
| US6743610B2 (en) | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| CA2356540A1 (en) | 2001-08-30 | 2003-02-28 | Emory University | Expressed dna sequences involved in mitochondrial functions |
| EP1483378B1 (en) | 2001-11-02 | 2013-01-02 | Rice University | Recycling system for manipulation of intracellular nadh availability |
| EP1575881B1 (en) | 2002-01-18 | 2009-05-27 | Novozymes A/S | Alanine 2,3- aminomutase |
| AU2003211492A1 (en) | 2002-02-06 | 2003-09-02 | Showa Denko K.K. | Alpha-SUBSTITUTED-Alpha,Beta-UNSATURATED CARBONYL COMPOUND REDUCTASE GENE |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| CA2480216A1 (en) | 2002-03-29 | 2003-10-09 | Genomatica, Inc. | Human metabolic models and methods |
| WO2003095651A1 (fr) | 2002-05-10 | 2003-11-20 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production d'acide mevalonique |
| US7856317B2 (en) | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
| US7826975B2 (en) | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| US8027821B2 (en) | 2002-07-10 | 2011-09-27 | The Penn State Research Foundation | Method for determining gene knockouts |
| US7413878B2 (en) | 2002-07-15 | 2008-08-19 | Kosan Biosciences, Inc. | Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit |
| JP4592418B2 (ja) | 2002-10-04 | 2010-12-01 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 高収率での１，３−プロパンジオールの生物生産のための方法 |
| WO2004035009A2 (en) | 2002-10-15 | 2004-04-29 | The Regents Of The University Of California | Methods and systems to identify operational reaction pathways |
| WO2004044210A2 (en) | 2002-11-06 | 2004-05-27 | University Of Florida | Materials and methods for the efficient production of acetate and other products |
| WO2004074495A1 (ja) | 2003-02-24 | 2004-09-02 | Research Institute Of Innovative Technology For The Earth | 微生物による高効率水素製造方法 |
| US6887352B2 (en) | 2003-03-07 | 2005-05-03 | Invista North America S.A.R.L. | Distillative method for separating hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine |
| RU2268300C2 (ru) | 2003-04-07 | 2006-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA |
| US7927859B2 (en) | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| WO2005026349A1 (ja) | 2003-09-17 | 2005-03-24 | Mitsubishi Chemical Corporation | 非アミノ有機酸の製造方法 |
| US7244610B2 (en) | 2003-11-14 | 2007-07-17 | Rice University | Aerobic succinate production in bacteria |
| EP1694772A1 (en) * | 2003-11-26 | 2006-08-30 | E. I. du Pont de Nemours and Company | High flow, toughened, weatherable polyamide compositions containing a blend of stabilizers |
| FR2864967B1 (fr) | 2004-01-12 | 2006-05-19 | Metabolic Explorer Sa | Microorganisme evolue pour la production de 1,2-propanediol |
| WO2005068643A2 (en) * | 2004-01-19 | 2005-07-28 | Dsm Ip Assets B.V. | Biochemical synthesis of 6-amino caproic acid |
| US7608700B2 (en) * | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
| DE102004031177A1 (de) | 2004-06-29 | 2006-01-19 | Henkel Kgaa | Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren |
| DE602005027356D1 (de) * | 2004-07-15 | 2011-05-19 | Dsm Ip Assets Bv | Biochemische synthese von 1,4-butandiamin |
| US7262046B2 (en) | 2004-08-09 | 2007-08-28 | Rice University | Aerobic succinate production in bacteria |
| WO2006031424A2 (en) | 2004-08-27 | 2006-03-23 | Rice University | Mutant e. coli strain with increased succinic acid production |
| EP1790721A4 (en) | 2004-09-09 | 2008-12-10 | Res Inst Innovative Tech Earth | DNA FRAGMENT WITH PROMOTER FUNCTION |
| US7208632B2 (en) | 2004-09-10 | 2007-04-24 | Invista North America S.A R.L. | Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine |
| US7468119B2 (en) | 2004-09-10 | 2008-12-23 | Invista North America S.A.R.L. | Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine |
| CN101023178A (zh) | 2004-09-17 | 2007-08-22 | 莱斯大学 | 高琥珀酸产出细菌 |
| WO2006069174A2 (en) | 2004-12-22 | 2006-06-29 | Rice University | Simultaneous anaerobic production of isoamyl acetate and succinic acid |
| JP2006204255A (ja) | 2005-01-31 | 2006-08-10 | Canon Inc | アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法 |
| WO2006109312A2 (en) * | 2005-04-15 | 2006-10-19 | Vascular Biogenics Ltd. | Compositions containing beta 2-glycoprotein i-derived peptides for the prevention and/or treatment of vascular disease |
| KR100676160B1 (ko) | 2005-08-19 | 2007-02-01 | 한국과학기술원 | 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| KR100679638B1 (ko) | 2005-08-19 | 2007-02-06 | 한국과학기술원 | 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법 |
| US20070111294A1 (en) | 2005-09-09 | 2007-05-17 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of succinate |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| BRPI0619325B8 (pt) | 2005-10-26 | 2020-11-17 | Butamax Advanced Biofuels Llc | célula hospedeira microbiana recombinante e método para produção de isobutanol |
| US20080274526A1 (en) * | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of isobutanol |
| CA2644311C (en) * | 2006-03-01 | 2012-07-10 | Tristrata, Inc. | Composition and method for topical treatment of tar-responsive dermatological disorders |
| US7801128B2 (en) * | 2006-03-31 | 2010-09-21 | Amazon Technologies, Inc. | Managing communications between computing nodes |
| US8962298B2 (en) | 2006-05-02 | 2015-02-24 | Butamax Advanced Biofuels Llc | Recombinant host cell comprising a diol dehydratase |
| US20070271453A1 (en) * | 2006-05-19 | 2007-11-22 | Nikia Corporation | Identity based flow control of IP traffic |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| US7231906B1 (en) | 2006-06-27 | 2007-06-19 | Gm Global Technology Operations, Inc. | Simultaneous EGR correction and individual cylinder combustion phase balancing |
| CN101528918B (zh) | 2006-08-30 | 2012-09-26 | 诺沃奇梅兹A/S | 生产3-羟基丙酸的β-丙氨酸/α-酮戊二酸氨基转移酶 |
| JP2008061501A (ja) * | 2006-09-04 | 2008-03-21 | Hyogo Prefecture | 遊離カルボン酸・アミンの直接縮合反応を触媒する酵素の設計方法及びナイロンオリゴマーの酵素的製造方法 |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| CA2715092A1 (en) | 2006-12-21 | 2008-07-03 | Gevo, Inc. | Butanol production by metabolically engineered yeast |
| WO2008115840A2 (en) | 2007-03-16 | 2008-09-25 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| WO2008131286A1 (en) | 2007-04-18 | 2008-10-30 | Gevo, Inc. | Engineered microorganisms for producing isopropanol |
| BRPI0808600A2 (pt) * | 2007-04-18 | 2018-12-26 | Du Pont | "método para a conversão de acetolactato em dihidroxi-isovalerato, método para a produção de isobutanol, célula hospedeira recombinante e método para a identificação e isolameno de uma construção genética" |
| US20080274522A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of 2-butanone |
| CA2691998A1 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| EP2017344A1 (en) | 2007-07-20 | 2009-01-21 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Production of itaconic acid |
| US7947483B2 (en) * | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| BRPI0817545A2 (pt) | 2007-10-12 | 2014-11-25 | Univ California | Microorganismo recombinante, métodos para produzir um microorganismo recombinante e para produzir isopropanol, vetor recombinante, e, célula hospedeira recombinante. |
| US7803589B2 (en) | 2008-01-22 | 2010-09-28 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| US20090246842A1 (en) * | 2008-02-15 | 2009-10-01 | Gevo, Inc. | Engineered microorganisms for producing propanol |
| MY156225A (en) | 2008-03-11 | 2016-01-29 | Dsm Ip Assets Bv | Preparation of 6-aminocaproic acid from 5-formyl valeri c acid |
| TWI461538B (zh) | 2008-03-11 | 2014-11-21 | Dsm Ip Assets Bv | 己二酸（酯或硫酯）之合成技術 |
| WO2009151728A2 (en) * | 2008-03-27 | 2009-12-17 | Genomatica, Inc. | Microorganisms for the production of adipic acid and other compounds |
| WO2009155382A1 (en) | 2008-06-17 | 2009-12-23 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| US8354563B2 (en) | 2008-10-16 | 2013-01-15 | Maverick Biofuels, Inc. | Methods and apparatus for synthesis of alcohols from syngas |
| CN102317437B (zh) * | 2008-12-12 | 2013-08-21 | 麦特波力克斯公司 | 用于制备聚(5-羟基戊酸)和5碳化合物的绿色工艺和组合物 |
| CN102317464B (zh) | 2008-12-12 | 2014-10-29 | 塞莱西翁有限公司 | 从α-酮酸生物合成双官能烷烃 |
| SI2427544T1 (sl) * | 2009-05-07 | 2019-11-29 | Genomatica Inc | Mikroorganizmi in metode za biosintezo adipata, heksametilendiamina in 6-aminokaprojske kisline |
| WO2012141997A1 (en) | 2011-04-09 | 2012-10-18 | Amyris, Inc. | Process for preparing caprolactam and polyamides therefrom |
| WO2012170059A1 (en) | 2011-06-10 | 2012-12-13 | Bioamber S.A.S. | Processes for producing hexanediol (hdo), hexamethylenediamine (hmd) from fermentation broths containing adipic acid |
| WO2012174430A2 (en) | 2011-06-17 | 2012-12-20 | Invista Technologies S.A.R.L. | Methods of making nylon intermediates from glycerol |
| BR112014014675A2 (pt) | 2011-12-16 | 2017-06-13 | Invista Tech Sarl | método para biossintetizar um ou mais produtos e hospedeiro recombinante |
| US9102958B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| AR089707A1 (es) | 2012-01-18 | 2014-09-10 | Rennovia Inc | Proceso para la produccion de hexametilendiamina a partir de materiales que contienen carbohidratos y compuestos intermedios para la misma |
| CN105073214A (zh) | 2012-12-31 | 2015-11-18 | 英威达技术有限责任公司 | 通过甲酯保护的碳链延伸生产6碳化学物的方法 |
| KR20160026977A (ko) | 2013-06-12 | 2016-03-09 | 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 | 트랜스아미나제 생물촉매 |
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