ES2749423T3 - Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico - Google Patents

Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico Download PDF

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ES2749423T3
ES2749423T3 ES10772921T ES10772921T ES2749423T3 ES 2749423 T3 ES2749423 T3 ES 2749423T3 ES 10772921 T ES10772921 T ES 10772921T ES 10772921 T ES10772921 T ES 10772921T ES 2749423 T3 ES2749423 T3 ES 2749423T3
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coa
pathway
microbial organism
hexamethylenediamine
amino
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Mark Burk
Anthony Burgard
Robin Osterhout
Priti Pharkya
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Genomatica Inc
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Genomatica Inc
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12N9/88—Lyases (4.)
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    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
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    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
ES10772921T 2009-05-07 2010-05-07 Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico Active ES2749423T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US17619609P 2009-05-07 2009-05-07
US21936509P 2009-06-22 2009-06-22
US24484409P 2009-09-22 2009-09-22
US24697309P 2009-09-29 2009-09-29
US24753309P 2009-09-30 2009-09-30
PCT/US2010/034144 WO2010129936A1 (en) 2009-05-07 2010-05-07 Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid

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ES2749423T3 true ES2749423T3 (es) 2020-03-20

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US (6) US8377680B2 (enExample)
EP (3) EP2427544B1 (enExample)
JP (6) JP5773990B2 (enExample)
KR (5) KR20200038334A (enExample)
AU (4) AU2010245687A1 (enExample)
BR (1) BRPI1011227A8 (enExample)
DK (1) DK2427544T3 (enExample)
ES (1) ES2749423T3 (enExample)
SI (1) SI2427544T1 (enExample)
WO (1) WO2010129936A1 (enExample)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2265709T1 (en) 2008-03-27 2018-03-30 Genomatica, Inc. MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
KR20110097951A (ko) 2008-12-16 2011-08-31 게노마티카 인코포레이티드 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법
US8404465B2 (en) 2009-03-11 2013-03-26 Celexion, Llc Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks
ES2749423T3 (es) 2009-05-07 2020-03-20 Genomatica Inc Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico
JP2012529889A (ja) 2009-06-10 2012-11-29 ゲノマチカ， インク． Ｍｅｋ及び２−ブタノールの炭素効率のよい生合成のための微生物及び方法
EP2462221B1 (en) 2009-08-05 2017-02-22 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
CN109136161A (zh) 2009-12-10 2019-01-04 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
FR2963362B1 (fr) * 2010-07-30 2012-08-17 Pcas Biosolution Procede d'acylation enzymatique avec un donneur acyl-phosphonate
US20120259138A1 (en) * 2011-04-05 2012-10-11 BioAmber International S.à.r.I. Methods and systems of producing dicarboxylic acids
US9334508B2 (en) 2011-06-17 2016-05-10 Invista North America S.A.R.L. Methods of producing carboxylic acids
US8852899B2 (en) * 2011-06-17 2014-10-07 Invista North America S.A.R.L. Methods of making nylon intermediates from glycerol
US20130034884A1 (en) * 2011-06-22 2013-02-07 Genomatica, Inc. Microorganisms for producing 1,4-butanediol and methods related thereto
AU2012273093A1 (en) * 2011-06-22 2013-05-02 Genomatica, Inc. Microorganisms for producing 6-aminocaproic acid
BR112013033672A2 (pt) 2011-06-30 2017-03-14 Invista Tech Sarl método para converter um composto, cultura substancialmente pura de células hospedeiras e cèlula isolada
SG2014012520A (en) 2011-07-12 2014-06-27 Scientist Of Fortune Sa Recombinant microorganism for the production of useful metabolites
KR101884022B1 (ko) * 2011-10-06 2018-08-02 성균관대학교산학협력단 카프로산 생산용 재조합 미생물 및 이를 이용하여 카프로산을 대량 생산하는 방법
US9102958B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
US9102960B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
CN104066710B (zh) 2012-01-18 2016-06-29 莱诺维亚公司 从5-羟甲基糠醛产生六亚甲基二胺的方法
EP2820141B1 (en) 2012-02-29 2018-04-11 Duke University Novel oxidoreductases for enantioselective reactions
US20130288320A1 (en) * 2012-04-27 2013-10-31 Bioamber Inc. Methods and microorganisms for increasing the biological synthesis of difunctional alkanes
US9803209B2 (en) 2012-05-18 2017-10-31 Novozymes A/S Bacterial mutants with improved transformation efficiency
EP2885400A1 (en) * 2012-08-17 2015-06-24 Celexion, LLC Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
EP2898082B1 (en) * 2012-09-20 2019-09-04 LCY Bioscience Inc. Pathways to adipate semialdehyde and other organic products
WO2014052630A1 (en) 2012-09-27 2014-04-03 Novozymes, Inc. Bacterial mutants with improved transformation efficiency
WO2014093847A2 (en) 2012-12-14 2014-06-19 Invista North America S.A.R.L. METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE
MY175370A (en) 2012-12-17 2020-06-23 Genomatica Inc Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto
EP2746397A1 (de) * 2012-12-21 2014-06-25 Evonik Industries AG Herstellung von Omega-Aminofettsäuren
US10196657B2 (en) 2012-12-31 2019-02-05 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation
EP2938734A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via aromatic compounds
CN105073214A (zh) * 2012-12-31 2015-11-18 英威达技术有限责任公司 通过甲酯保护的碳链延伸生产6碳化学物的方法
EP2938736A2 (en) 2012-12-31 2015-11-04 Invista Technologies S.A R.L. Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis
EP2938732A1 (en) 2012-12-31 2015-11-04 Invista Technologies S.à.r.l. Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage
US9738911B2 (en) 2012-12-31 2017-08-22 Invista North America S.A.R.L. Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation
CN105189770A (zh) 2012-12-31 2015-12-23 英威达技术有限责任公司 通过与环己烷羧酸合成相关的碳链延伸生产7碳化学物的方法
WO2014144293A2 (en) * 2013-03-15 2014-09-18 Genomatica, Inc. Development and use of microbes for impurity reduction in biomass hydrolysates and fermentation broths
EP2971021A4 (en) 2013-03-15 2016-12-21 Genomatica Inc MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION
KR101609448B1 (ko) 2013-05-06 2016-04-05 한국생명공학연구원 6-아미노카프로산의 생물학적 합성 및 이를 위한 형질전환 미생물
WO2014182016A1 (ko) * 2013-05-06 2014-11-13 한국생명공학연구원 6-아미노카프로산의 생물학적 합성 및 이를 위한 형질전환 미생물
BR112016005689A2 (pt) * 2013-09-17 2018-01-30 Zymochem Inc rota de alto rendimento para a produção de compostos a partir de fontes renováveis
US12104160B2 (en) 2013-09-17 2024-10-01 Zymochem, Inc. Production of 4,6-dihydroxy-2-oxo-hexanoic acid
PL3077501T3 (pl) 2013-12-03 2022-01-31 Genomatica, Inc. Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa
WO2015100338A2 (en) 2013-12-27 2015-07-02 Genomatica, Inc. Methods and organisms with increased carbon flux efficiencies
TW201609681A (zh) * 2014-05-12 2016-03-16 微麥得斯公司 自５－（鹵甲基）糠醛製造化合物之方法
CN103937841B (zh) * 2014-05-13 2015-10-28 上海交通大学 烯酰辅酶a水合酶在己二酸生物合成中的应用
CN106574283A (zh) 2014-05-15 2017-04-19 英威达技术有限责任公司 使用2,6‑二氨基庚二酸作为2‑氨基庚二酸的前体生产6‑碳化学品的方法
CN106795519A (zh) 2014-06-16 2017-05-31 英威达技术有限责任公司 用于生成戊二酸和戊二酸甲酯的方法
BR112016029375A2 (pt) 2014-06-16 2017-10-17 Invista Tech Sarl métodos, reagentes e células para biossintetizar compostos
BR112016029388A2 (pt) 2014-06-16 2017-10-17 Invista Tech Sarl métodos, reagentes e células para biossintetizar compostos
BR112016029399A2 (pt) 2014-06-16 2017-10-17 Invista Tech Sarl métodos, reagentes e células para biossintetizar composto
EP3741865B1 (en) 2014-09-18 2024-03-13 Genomatica, Inc. Non-natural microbial organisms with improved energetic efficiency
TW201636096A (zh) 2014-12-02 2016-10-16 瑞諾維亞公司 自５－羥甲基糠醛產生己三醇之方法
EP3237629A1 (en) * 2014-12-23 2017-11-01 Genomatica, Inc. Method of producing&processing diamines
KR101715882B1 (ko) 2015-03-06 2017-03-27 한국생명공학연구원 신규 ε-카프로락탐 전환 효소 및 이를 이용한 ε-카프로락탐 생산 방법
WO2016167519A1 (ko) * 2015-04-13 2016-10-20 한국과학기술원 락탐의 제조방법
KR101839595B1 (ko) 2015-04-13 2018-04-26 한국과학기술원 락탐의 제조방법
WO2016209883A1 (en) * 2015-06-23 2016-12-29 Genomatica, Inc. Microorganisms and methods for the production of biosynthesized target products having reduced levels of byproducts
KR101651239B1 (ko) * 2015-07-02 2016-08-25 씨제이제일제당 주식회사 신규 슈도모나스 종 균주 및 이를 이용한 6-아미노카프로산의 탈아민 방법
KR101750856B1 (ko) 2015-10-22 2017-06-30 한국과학기술원 1,3-다이아미노프로판 생산능을 가지는 재조합 미생물 및 이를 이용한 1,3-다이아미노프로판의 제조방법
US11162121B2 (en) 2015-10-27 2021-11-02 Korea Research Institute Of Bioscience And Biotechnology Method for producing medium chain diamine
SG11201803164SA (en) 2015-10-30 2018-05-30 Genomatica Inc Methanol dehydrogenase fusion proteins
US11939611B2 (en) * 2016-02-19 2024-03-26 Inv Nylon Chemicals Americas, Llc Biocatalytic processes and materials for enhanced carbon utilization
US20230139445A1 (en) 2016-11-15 2023-05-04 Danmarks Tekniske Universitet Bacterial cells with improved tolerance to diacids
CN107164477A (zh) * 2017-05-27 2017-09-15 山西维尔生物乳制品有限公司 一种鉴别罗伦氏隐球酵母的探针、引物和基因芯片
US11708590B2 (en) 2017-07-18 2023-07-25 Arizona Board Of Regents On Behalf Of Arizona State University Synthetic metabolic funneling for biochemical production
KR101971480B1 (ko) 2017-09-26 2019-04-23 한국생명공학연구원 돌연변이 재설계 유전자 회로를 이용한 니트릴계, 락톤계 또는 락탐계 화합물의 감지 및 정량 방법
KR101898171B1 (ko) * 2018-01-19 2018-09-12 씨제이제일제당 주식회사 신규 트랜스아미나제 및 이를 이용한 아미노 화합물의 탈아민 방법
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3814515A2 (en) 2018-06-26 2021-05-05 Genomatica, Inc. Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy
IT201800021409A1 (it) 2018-12-28 2020-06-28 Aquafil S P A Processo per la produzione di epsilon caprolattame dall’acido 6-aminocaproico.
US20220235385A1 (en) * 2019-04-24 2022-07-28 Genomatica, Inc. Engineered microorganisms and methods for improved aldehyde dehydrogenase activity
AU2020262490A1 (en) 2019-04-25 2021-11-25 Zymochem, Inc. Production of chemicals from renewable sources
BR112021021601A2 (pt) 2019-05-10 2021-12-21 Toray Industries Microrganismo geneticamente modificado e método de produção de ácido 3-hidroxiadípico, ácido a-hidromucônico e/ou ácido adípico
US20220213514A1 (en) 2019-05-10 2022-07-07 Toray Industries, Inc. Genetically modified microorganism for producing 3-hydroxyhexanedioic acid, (e)-hex-2-enedioic acid and/or hexanedioic acid, and production method for said chemicals
KR20220032084A (ko) 2019-07-22 2022-03-15 아사히 가세이 가부시키가이샤 유전자 재조합 미생물 및 디아민 화합물의 제조 방법
CN111122720B (zh) * 2019-12-11 2022-09-02 湖北三宁碳磷基新材料产业技术研究院有限公司 己内酰胺、6-氨基己酰胺和6-氨基己腈的分析方法
KR20230003072A (ko) * 2020-04-24 2023-01-05 게노마티카 인코포레이티드 조작된 효소 및 이의 이용 및 제조 방법
CN116406420A (zh) 2020-11-11 2023-07-07 东丽株式会社 用于生产3-羟基己二酸和/或α-氢化己二烯二酸的基因修饰微生物以及该化学品的制造方法
JP2024503868A (ja) 2021-01-17 2024-01-29 ジェノマティカ， インコーポレイテッド アミド化合物を生成する方法および組成物
JP7038241B1 (ja) 2021-03-30 2022-03-17 旭化成株式会社 組換え微生物及びアジピン酸又はその誘導体の製造方法
JPWO2022209994A1 (enExample) 2021-03-30 2022-10-06
WO2022209763A1 (ja) 2021-03-30 2022-10-06 旭化成株式会社 カルボン酸還元活性を有する組換えポリペプチド
WO2022244809A1 (ja) 2021-05-19 2022-11-24 旭化成株式会社 ジアミン生産能を有する組換え微生物およびジアミンの製造方法
CN118591634A (zh) * 2022-02-15 2024-09-03 东丽株式会社 用于生产3-羟基己二酸和/或α-氢化己二烯二酸的基因修饰微生物以及该化学品的制造方法
CN114990043B (zh) * 2022-06-28 2024-04-30 滨州医学院 代谢赖氨酸的工程菌及其构建方法与应用

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3513209A (en) 1968-08-19 1970-05-19 Du Pont Method of making 1,4-cyclohexadiene
US4076948A (en) 1968-10-10 1978-02-28 El Paso Products Company Process for treatment of adipic acid mother liquor
GB1230276A (enExample) 1968-12-09 1971-04-28
US3965182A (en) 1969-10-02 1976-06-22 Ethyl Corporation Preparation of aniline from phenol and ammonia
JPS4831084B1 (enExample) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
JPS5543759B2 (enExample) 1972-06-28 1980-11-07
JPS506776A (enExample) 1973-05-28 1975-01-23
JPS5721310B2 (enExample) * 1974-03-19 1982-05-06
DE2455617C3 (de) 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
US4190495A (en) 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
FR2403571A1 (fr) 1977-09-14 1979-04-13 Cables De Lyon Geoffroy Delore Dispositif mecanique de raccordement de fibres optiques
US4301077A (en) 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
JPS60114197A (ja) 1983-11-25 1985-06-20 Agency Of Ind Science & Technol 微生物によるジカルボン酸の製造法
US4871667A (en) 1984-11-26 1989-10-03 Agency Of Industrial Science & Technology Process for preparing muconic acid
US4652685A (en) 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
US5143834A (en) 1986-06-11 1992-09-01 Glassner David A Process for the production and purification of succinic acid
US5168055A (en) 1986-06-11 1992-12-01 Rathin Datta Fermentation and purification process for succinic acid
ES2036188T3 (es) 1986-06-11 1993-05-16 Michigan Biotechnology Institute Un procedimiento para la produccion de acido succinico por fermentacion anaerobia.
US5182199A (en) 1987-05-27 1993-01-26 Hartley Brian S Thermophilic ethanol production in a two-stage closed system
US5219757A (en) 1988-04-27 1993-06-15 Daicel Chemical Industries, Ltd. Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone
CA2062753C (en) 1989-04-27 2005-04-26 N. Robert Ward, Jr. Precipitate test for microorganisms
US5192673A (en) 1990-04-30 1993-03-09 Michigan Biotechnology Institute Mutant strain of C. acetobutylicum and process for making butanol
US5079143A (en) 1990-05-02 1992-01-07 The Upjohn Company Method of indentifying compounds useful as antiparasitic drugs
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
US5416020A (en) 1992-09-29 1995-05-16 Bio-Technical Resources Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid
US5266694A (en) 1992-10-19 1993-11-30 E. I. Du Pont De Nemours And Company Nylon component reclamation
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
US6136577A (en) 1992-10-30 2000-10-24 Bioengineering Resources, Inc. Biological production of ethanol from waste gases with Clostridium ljungdahlii
US5302756A (en) 1992-12-23 1994-04-12 E. I. Du Pont De Nemours And Company Ammonolysis of nylon
FR2702492B1 (fr) 1993-03-12 1995-05-24 Rhone Poulenc Chimie Procédé de production par fermentation d'acide itaconique.
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5700934A (en) 1995-03-01 1997-12-23 Dsm N.V. Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5863782A (en) 1995-04-19 1999-01-26 Women's And Children's Hospital Synthetic mammalian sulphamidase and genetic sequences encoding same
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
FR2736927B1 (fr) * 1995-07-18 1997-10-17 Rhone Poulenc Fibres & Polymer Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
US5869301A (en) 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
JP2000506012A (ja) 1996-02-27 2000-05-23 ミシガン ステイト ユニヴァーシティー サーモアンエアロバクター・エタノリカス３９ｅの第二級アルコールデヒドロゲナーゼをコードする遺伝子のクローニング及び発現並びに酵素の生化学的特徴付け
US5958745A (en) 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
JP4101295B2 (ja) 1996-07-01 2008-06-18 バイオエンジニアリング・リソーシズ・インコーポレーテツド 廃ガスからの酢酸の生物学的生産
KR100459818B1 (ko) 1996-09-02 2004-12-03 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 ε-카프로락탐의 제조방법
US6117658A (en) 1997-02-13 2000-09-12 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
KR100516986B1 (ko) 1997-02-19 2005-09-26 코닌클리즈케 디에스엠 엔.브이. 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법
US6274790B1 (en) 1997-04-14 2001-08-14 The University Of British Columbia Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis
KR19990013007A (ko) 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법
JPH11103863A (ja) 1997-10-08 1999-04-20 Nippon Shokubai Co Ltd マレイン酸異性化酵素遺伝子
US6280986B1 (en) 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
WO1999053035A1 (en) 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US20030087381A1 (en) 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6444784B1 (en) 1998-05-29 2002-09-03 Exxonmobil Research & Engineering Company Wax crystal modifiers (LAW657)
DE19831889A1 (de) * 1998-07-17 2000-01-27 Basf Ag Verbessertes Verfahren zur Herstellung von Hexamethylendiamin
US5961788A (en) 1998-10-09 1999-10-05 E. I. Du Pont De Nemours And Company Sequential distillation process for removing tetrahydroazepine from aminocapronitrile and/or hexamethylenediamine
DE19856136C2 (de) 1998-12-04 2002-10-24 Pasteur Institut Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension
WO2000046405A2 (en) 1999-02-02 2000-08-10 Bernhard Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
US6365376B1 (en) 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
US6448473B1 (en) 1999-03-05 2002-09-10 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
CA2374482C (en) 1999-05-21 2012-09-18 Cargill Dow Llc Methods and materials for the synthesis of organic products
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6660857B2 (en) 2000-02-03 2003-12-09 Dsm N.V. Process for the preparation of ε-caprolactam
US6878861B2 (en) 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
NZ523484A (en) 2000-07-25 2005-01-28 Emmaus Foundation Inc Methods for increasing the production of ethanol from microbial fermentation
US7698463B2 (en) 2000-09-12 2010-04-13 Sri International System and method for disseminating topology and link-state information to routing nodes in a mobile ad hoc network
US6248926B1 (en) 2000-10-26 2001-06-19 E. I. Du Pont De Nemours And Company Recovery of hexamethylenediamine (HMD) with low polarographically reducible impurities (PRI) from mixtures of HMD, aminocapronitirle and PRI
JP4490628B2 (ja) 2000-11-20 2010-06-30 カーギル インコーポレイテッド ３−ヒドロキシプロピオン酸および他の有機化合物
US7109010B2 (en) 2000-11-22 2006-09-19 Nature Works Llc Methods and materials for the synthesis of organic products
CN1358841A (zh) 2000-12-11 2002-07-17 云南省微生物研究所 云南链霉菌
US7501268B2 (en) 2000-12-28 2009-03-10 Toyota Jidosha Kabushiki Kaisha Methods of producing prenyl alcohols
CA2434224C (en) 2001-01-10 2013-04-02 The Penn State Research Foundation Method and system for modeling cellular metabolism
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
US20030059792A1 (en) 2001-03-01 2003-03-27 Palsson Bernhard O. Models and methods for determining systemic properties of regulated reaction networks
US6743610B2 (en) 2001-03-30 2004-06-01 The University Of Chicago Method to produce succinic acid from raw hydrolysates
CA2356540A1 (en) 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
CA2466133A1 (en) 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
DE60327804D1 (de) 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
WO2003066863A1 (fr) 2002-02-06 2003-08-14 Showa Denko K.K. Gene reductase d'un compose carbonyle alpha-substitue-alpha, beta-insature
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
CA2480216A1 (en) 2002-03-29 2003-10-09 Genomatica, Inc. Human metabolic models and methods
US20050287655A1 (en) 2002-05-10 2005-12-29 Kyowa Hakko Kogyo Co., Ltd. Process for producing mevalonic acid
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
EP1532516A4 (en) 2002-07-10 2007-05-23 Penn State Res Found Method for determining gene knockout strategies
WO2004007688A2 (en) 2002-07-15 2004-01-22 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
AU2003287028B2 (en) 2002-10-04 2008-09-04 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
AU2003222214B2 (en) 2002-10-15 2010-08-12 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
AU2003287625A1 (en) 2002-11-06 2004-06-03 University Of Florida Materials and methods for the efficient production of acetate and other products
US7432091B2 (en) 2003-02-24 2008-10-07 Research Institute Of Innovative Technology For The Earth Highly efficient hydrogen production method using microorganism
US6887352B2 (en) 2003-03-07 2005-05-03 Invista North America S.A.R.L. Distillative method for separating hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine
RU2268300C2 (ru) 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA
US7927859B2 (en) 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
WO2005026349A1 (ja) 2003-09-17 2005-03-24 Mitsubishi Chemical Corporation 非アミノ有機酸の製造方法
US7244610B2 (en) 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
CA2545529A1 (en) 2003-11-26 2005-06-16 E.I. Du Pont De Nemours And Company High flow, toughened, weatherable polyamide compositions containing a blend of stabilizers
FR2864967B1 (fr) 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
CN1926240B (zh) 2004-01-19 2010-06-02 帝斯曼知识产权资产管理有限公司 6-氨基己酸的生物化学合成
US7608700B2 (en) * 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
DE102004031177A1 (de) 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
EA011232B1 (ru) * 2004-07-15 2009-02-27 ДСМ АйПи АССЕТС Б.В. Биохимический синтез 1,4-бутандиамина
US7262046B2 (en) 2004-08-09 2007-08-28 Rice University Aerobic succinate production in bacteria
CN101044245B (zh) 2004-08-27 2012-05-02 莱斯大学 具有增加的琥珀酸产量的突变大肠杆菌菌株
EP2434015B1 (en) 2004-09-09 2013-11-20 Research Institute Of Innovative Technology For The Earth DNA fragment having promoter function
US7468119B2 (en) 2004-09-10 2008-12-23 Invista North America S.A.R.L. Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine
US7208632B2 (en) 2004-09-10 2007-04-24 Invista North America S.A R.L. Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine
EP1789569A2 (en) 2004-09-17 2007-05-30 Rice University High succinate producing bacteria
US7569380B2 (en) 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
JP2006204255A (ja) 2005-01-31 2006-08-10 Canon Inc アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法
EP1874334A4 (en) * 2005-04-15 2011-03-30 Vascular Biogenics Ltd COMPOSITIONS WITH BETA 2-GLYCOPROTEIN I-PEPTIDES FOR THE PREVENTION AND / OR TREATMENT OF VASCULAR DISEASES
KR100679638B1 (ko) 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
KR100676160B1 (ko) 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
AU2006287257A1 (en) 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080274526A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
NZ566406A (en) 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
WO2007103687A2 (en) * 2006-03-01 2007-09-13 Tristrata, Inc. Composition and method for topical treatment of tar-responsive dermatological disorders
US7801128B2 (en) 2006-03-31 2010-09-21 Amazon Technologies, Inc. Managing communications between computing nodes
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
US20070271453A1 (en) 2006-05-19 2007-11-22 Nikia Corporation Identity based flow control of IP traffic
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
US7231906B1 (en) 2006-06-27 2007-06-19 Gm Global Technology Operations, Inc. Simultaneous EGR correction and individual cylinder combustion phase balancing
BRPI0716212A2 (pt) 2006-08-30 2013-10-15 Cargill Inc Beta-alanina/alfa-cetoglutarato aminotransferase para produção de ácido 3-hidroxipropiônico
JP2008061501A (ja) * 2006-09-04 2008-03-21 Hyogo Prefecture 遊離カルボン酸・アミンの直接縮合反応を触媒する酵素の設計方法及びナイロンオリゴマーの酵素的製造方法
US8017364B2 (en) 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
WO2008080124A2 (en) 2006-12-21 2008-07-03 Gevo, Inc. Butanol production by metabolically engineered yeast
CA2678946C (en) 2007-03-16 2019-02-12 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
KR101573775B1 (ko) 2007-04-18 2015-12-04 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산
EP2147111A4 (en) 2007-04-18 2010-06-23 Gevo Inc MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL
US20080274522A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of 2-butanone
WO2008144060A2 (en) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
EP2017344A1 (en) 2007-07-20 2009-01-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Production of itaconic acid
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
AU2008310573A1 (en) 2007-10-12 2009-04-16 The Regents Of The University Of California Microorganism engineered to produce isopropanol
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
US20090246842A1 (en) 2008-02-15 2009-10-01 Gevo, Inc. Engineered microorganisms for producing propanol
TWI701230B (zh) 2008-03-11 2020-08-11 美商吉諾瑪蒂卡股份有限公司 由α-酮庚二酸製備６-胺己酸之技術
ES2655710T3 (es) 2008-03-11 2018-02-21 Genomatica, Inc. Síntesis de éster o tioéster de adipato
SI2265709T1 (en) * 2008-03-27 2018-03-30 Genomatica, Inc. MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
US8357826B2 (en) 2008-10-16 2013-01-22 Karl Kharas Methods and apparatus for synthesis of alcohols from syngas
MY153590A (en) 2008-12-12 2015-02-26 Celexion Llc Biological synthesis of difunctional alkanes from alpha ketoacids
EP3260532A1 (en) 2008-12-12 2017-12-27 CJ Research Center LLC Green process and compositions for producing poly(5hv) and 5 carbon chemicals
ES2749423T3 (es) * 2009-05-07 2020-03-20 Genomatica Inc Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico
US9073867B2 (en) 2011-04-09 2015-07-07 Amyris, Inc. Process for preparing caprolactam and polyamides therefrom
WO2012170059A1 (en) 2011-06-10 2012-12-13 Bioamber S.A.S. Processes for producing hexanediol (hdo), hexamethylenediamine (hmd) from fermentation broths containing adipic acid
US8852899B2 (en) 2011-06-17 2014-10-07 Invista North America S.A.R.L. Methods of making nylon intermediates from glycerol
WO2013090837A2 (en) 2011-12-16 2013-06-20 Invista North America S.A.R.L. METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE
US9102958B2 (en) 2011-12-16 2015-08-11 Invista North America S.á.r.l. Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage
CN104066710B (zh) 2012-01-18 2016-06-29 莱诺维亚公司 从5-羟甲基糠醛产生六亚甲基二胺的方法
CN105073214A (zh) 2012-12-31 2015-11-18 英威达技术有限责任公司 通过甲酯保护的碳链延伸生产6碳化学物的方法
JP2016521562A (ja) 2013-06-12 2016-07-25 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション トランスアミナーゼ生体触媒

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