BR112016029375A2 - métodos, reagentes e células para biossintetizar compostos - Google Patents
métodos, reagentes e células para biossintetizar compostosInfo
- Publication number
- BR112016029375A2 BR112016029375A2 BR112016029375A BR112016029375A BR112016029375A2 BR 112016029375 A2 BR112016029375 A2 BR 112016029375A2 BR 112016029375 A BR112016029375 A BR 112016029375A BR 112016029375 A BR112016029375 A BR 112016029375A BR 112016029375 A2 BR112016029375 A2 BR 112016029375A2
- Authority
- BR
- Brazil
- Prior art keywords
- biosynthesize
- reagents
- cells
- compounds
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/99—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
- C12Y102/99006—Carboxylate reductase (1.2.99.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Polymers & Plastics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
este documento descreve vias bioquímicas para produzir ácido glutárico, ácido 5-aminopentanoico, ácido 5-hidroxipentanoico, cadaverina ou 1,5-pentanodiol por meio da formação de um ou dois grupos funcionais terminais, compreendidos de grupo carboxila, amina ou hidroxila, em um substrato de cadeia principal c5 como 2-oxoglutarato, em que o substrato é 2-oxo-adipato.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462012592P | 2014-06-16 | 2014-06-16 | |
PCT/US2015/036092 WO2015195707A1 (en) | 2014-06-16 | 2015-06-16 | Methods, reagents and cells for biosynthesizing compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016029375A2 true BR112016029375A2 (pt) | 2017-10-17 |
Family
ID=53443064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016029375A BR112016029375A2 (pt) | 2014-06-16 | 2015-06-16 | métodos, reagentes e células para biossintetizar compostos |
Country Status (5)
Country | Link |
---|---|
US (2) | US9957535B2 (pt) |
EP (1) | EP3155107A1 (pt) |
CN (1) | CN106795534A (pt) |
BR (1) | BR112016029375A2 (pt) |
WO (1) | WO2015195707A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
CN108624632A (zh) * | 2017-03-15 | 2018-10-09 | 中国科学院微生物研究所 | 5-氨基戊酸的生物转化方法 |
TW202020148A (zh) | 2018-07-31 | 2020-06-01 | 德商拜耳廠股份有限公司 | 編碼改良之轉胺酶蛋白質之核酸 |
CN110791439B (zh) * | 2019-10-10 | 2022-04-19 | 天津科技大学 | 一株基因工程构建发酵生产苹果酸的重组黑曲霉菌株及应用 |
WO2022270597A1 (ja) * | 2021-06-25 | 2022-12-29 | 旭化成株式会社 | アミノ基転移酵素活性を有する組換えポリペプチド |
CN116083329A (zh) * | 2022-09-26 | 2023-05-09 | 北京绿色康成生物技术有限公司 | 发酵生产γ-丁内酯或1,4-丁二醇的方法 |
CN116790698B (zh) * | 2023-06-21 | 2024-06-18 | 南京大学 | 基于氧化脱羧酶的硫醛合成方法及其应用 |
Family Cites Families (63)
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US2439513A (en) | 1945-11-30 | 1948-04-13 | Du Pont | Adipic acid process |
US2557282A (en) | 1949-03-31 | 1951-06-19 | Du Pont | Adipic acid process |
US2791566A (en) | 1953-09-16 | 1957-05-07 | Ici Ltd | Catalyst recovery process |
US2840607A (en) | 1956-02-20 | 1958-06-24 | Union Oil Co | Separation of dibasic acids |
US2971010A (en) | 1958-06-26 | 1961-02-07 | Du Pont | Production of dicarboxylic acid anhydrides |
NL255708A (pt) | 1959-09-08 | |||
US3338959A (en) | 1962-08-22 | 1967-08-29 | Du Pont | Process for separation and recovery of glutaric, succinic, and adipic acids |
US3365490A (en) | 1966-08-05 | 1968-01-23 | Du Pont | Process for the production of dicarboxylic acids |
US3719561A (en) | 1966-08-26 | 1973-03-06 | Kyowa Hakko Kogyo Kk | Process for producing diaminopimelic acid |
US3515751A (en) | 1967-09-25 | 1970-06-02 | Firestone Tire & Rubber Co | Process for oxidation of cyclohexane |
US4058555A (en) | 1969-07-18 | 1977-11-15 | El Paso Products Company | Process for the purification of mixed acids |
DE19706023A1 (de) | 1997-02-17 | 1998-08-20 | Bayer Ag | Abbau von biologisch abbaubaren Polymeren mit Enzymen |
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KR20160025043A (ko) * | 2008-12-12 | 2016-03-07 | 메타볼릭스 인코포레이티드 | 폴리(5hv)및 5 탄소 화학물질의 생산을 위한 녹색 공정 및 조성물 |
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WO2014105796A2 (en) | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via aromatic compounds |
US9580731B2 (en) | 2012-12-31 | 2017-02-28 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme B synthesis |
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US20150111262A1 (en) | 2013-08-27 | 2015-04-23 | INVISTA North America S.á r.l. | Methods and materials for producing five carbon building blocks from proline |
-
2015
- 2015-06-16 WO PCT/US2015/036092 patent/WO2015195707A1/en active Application Filing
- 2015-06-16 BR BR112016029375A patent/BR112016029375A2/pt not_active Application Discontinuation
- 2015-06-16 US US14/741,342 patent/US9957535B2/en active Active
- 2015-06-16 EP EP15730679.6A patent/EP3155107A1/en not_active Withdrawn
- 2015-06-16 CN CN201580038419.9A patent/CN106795534A/zh active Pending
-
2018
- 2018-03-26 US US15/935,149 patent/US20180216145A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20180216145A1 (en) | 2018-08-02 |
WO2015195707A1 (en) | 2015-12-23 |
CN106795534A (zh) | 2017-05-31 |
EP3155107A1 (en) | 2017-04-19 |
US9957535B2 (en) | 2018-05-01 |
US20150361468A1 (en) | 2015-12-17 |
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