JP2012525856A5 - - Google Patents
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- JP2012525856A5 JP2012525856A5 JP2012510039A JP2012510039A JP2012525856A5 JP 2012525856 A5 JP2012525856 A5 JP 2012525856A5 JP 2012510039 A JP2012510039 A JP 2012510039A JP 2012510039 A JP2012510039 A JP 2012510039A JP 2012525856 A5 JP2012525856 A5 JP 2012525856A5
- Authority
- JP
- Japan
- Prior art keywords
- coa
- amino
- oxidoreductase
- aminotransferase
- reductase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000854 Oxidoreductases Proteins 0.000 claims 117
- 102000004316 Oxidoreductases Human genes 0.000 claims 117
- 230000000813 microbial effect Effects 0.000 claims 41
- 102000003929 Transaminases Human genes 0.000 claims 40
- 108090000340 Transaminases Proteins 0.000 claims 40
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims 40
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 36
- 230000037361 pathway Effects 0.000 claims 31
- IYNRULSFFKEOLT-UHFFFAOYSA-N 3-oxopimelic acid Chemical compound OC(=O)CCCC(=O)CC(O)=O IYNRULSFFKEOLT-UHFFFAOYSA-N 0.000 claims 28
- 238000005576 amination reaction Methods 0.000 claims 28
- 102000004357 Transferases Human genes 0.000 claims 27
- 108090000992 Transferases Proteins 0.000 claims 27
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims 26
- 102000003960 Ligases Human genes 0.000 claims 26
- 108090000364 Ligases Proteins 0.000 claims 26
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims 24
- NMDDZEVVQDPECF-LURJTMIESA-N (2s)-2,7-diaminoheptanoic acid Chemical compound NCCCCC[C@H](N)C(O)=O NMDDZEVVQDPECF-LURJTMIESA-N 0.000 claims 21
- 150000007523 nucleic acids Chemical class 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102100026105 3-ketoacyl-CoA thiolase, mitochondrial Human genes 0.000 claims 19
- 108010003902 Acetyl-CoA C-acyltransferase Proteins 0.000 claims 19
- GSDLHWPNIOWYHJ-UHFFFAOYSA-N 2-amino-7-oxoheptanoic acid Chemical compound OC(=O)C(N)CCCCC=O GSDLHWPNIOWYHJ-UHFFFAOYSA-N 0.000 claims 16
- SYKWLIJQEHRDNH-CKRMAKSASA-N glutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 SYKWLIJQEHRDNH-CKRMAKSASA-N 0.000 claims 16
- 108090001042 Hydro-Lyases Proteins 0.000 claims 15
- 102000004867 Hydro-Lyases Human genes 0.000 claims 15
- MIPJCYQFTDLIGF-HDRQGHTBSA-N s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 6-aminohexanethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCN)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MIPJCYQFTDLIGF-HDRQGHTBSA-N 0.000 claims 14
- OKDNHROSUNKBKT-UHFFFAOYSA-N 3-amino-7-oxoheptanoic acid Chemical compound OC(=O)CC(N)CCCC=O OKDNHROSUNKBKT-UHFFFAOYSA-N 0.000 claims 13
- 150000001299 aldehydes Chemical class 0.000 claims 13
- 229960002684 aminocaproic acid Drugs 0.000 claims 13
- 229940040102 levulinic acid Drugs 0.000 claims 13
- RGUBYIAMAWCQSP-UHFFFAOYSA-N 3-aminoheptanedioic acid Chemical compound OC(=O)CC(N)CCCC(O)=O RGUBYIAMAWCQSP-UHFFFAOYSA-N 0.000 claims 12
- 102000004190 Enzymes Human genes 0.000 claims 12
- 108090000790 Enzymes Proteins 0.000 claims 12
- 230000015572 biosynthetic process Effects 0.000 claims 12
- 101710088194 Dehydrogenase Proteins 0.000 claims 11
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 claims 11
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- FGSBMPLRSMYGCV-UHFFFAOYSA-N 2,4-dioxooctanoic acid Chemical compound CCCCC(=O)CC(=O)C(O)=O FGSBMPLRSMYGCV-UHFFFAOYSA-N 0.000 claims 10
- 108091000080 Phosphotransferase Proteins 0.000 claims 10
- 102000020233 phosphotransferase Human genes 0.000 claims 10
- PJDINCOFOROBQW-UHFFFAOYSA-N 3,7-Diaminoheptanoic Acid Chemical compound NCCCCC(N)CC(O)=O PJDINCOFOROBQW-UHFFFAOYSA-N 0.000 claims 8
- 101710202061 N-acetyltransferase Proteins 0.000 claims 8
- YMNZNYSOUAKJAV-HDRQGHTBSA-N s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 6-amino-3-oxohexanethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCCN)O[C@H]1N1C2=NC=NC(N)=C2N=C1 YMNZNYSOUAKJAV-HDRQGHTBSA-N 0.000 claims 8
- JUQLUIFNNFIIKC-UHFFFAOYSA-N 2-aminopimelic acid Chemical compound OC(=O)C(N)CCCCC(O)=O JUQLUIFNNFIIKC-UHFFFAOYSA-N 0.000 claims 7
- 108010069175 acyl-CoA transferase Proteins 0.000 claims 7
- CCYXEHOXJOKCCJ-UHFFFAOYSA-N 6-aminohexanal Chemical compound NCCCCCC=O CCYXEHOXJOKCCJ-UHFFFAOYSA-N 0.000 claims 6
- BGJIRLKEICEKSQ-UHFFFAOYSA-N 7-amino-2-oxoheptanoic acid Chemical compound NCCCCCC(=O)C(O)=O BGJIRLKEICEKSQ-UHFFFAOYSA-N 0.000 claims 6
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 6
- SPNAEHGLBRRCGL-BIEWRJSYSA-N adipoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 SPNAEHGLBRRCGL-BIEWRJSYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- WDSCBUNMANHPFH-UHFFFAOYSA-M 6-acetamidohexanoate Chemical compound CC(=O)NCCCCCC([O-])=O WDSCBUNMANHPFH-UHFFFAOYSA-M 0.000 claims 5
- PNPPVRALIYXJBW-UHFFFAOYSA-N 6-oxohexanoic acid Chemical compound OC(=O)CCCCC=O PNPPVRALIYXJBW-UHFFFAOYSA-N 0.000 claims 5
- RRGHQGSYMGPKCO-UHFFFAOYSA-N 7-amino-3-oxoheptanoic acid Chemical compound NCCCCC(=O)CC(O)=O RRGHQGSYMGPKCO-UHFFFAOYSA-N 0.000 claims 5
- 101000985286 Escherichia coli 2-oxo-hept-4-ene-1,7-dioate hydratase Proteins 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- OTEACGAEDCIMBS-FOLKQPSDSA-N 3-hydroxyadipyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OTEACGAEDCIMBS-FOLKQPSDSA-N 0.000 claims 4
- VKKKAAPGXHWXOO-BIEWRJSYSA-N 3-oxoadipyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VKKKAAPGXHWXOO-BIEWRJSYSA-N 0.000 claims 4
- QQUWQLAQVGXPPE-UHFFFAOYSA-N 7-amino-4-hydroxy-2-oxoheptanoic acid Chemical compound NCCCC(O)CC(=O)C(O)=O QQUWQLAQVGXPPE-UHFFFAOYSA-N 0.000 claims 4
- 102000002932 Thiolase Human genes 0.000 claims 4
- 108060008225 Thiolase Proteins 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 4
- LKNUIOZKLGQZEF-UHFFFAOYSA-N n-(6-oxohexyl)acetamide Chemical compound CC(=O)NCCCCCC=O LKNUIOZKLGQZEF-UHFFFAOYSA-N 0.000 claims 4
- PKVRQLMDAMASTB-SNIDVWGTSA-N 2-amino-7-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-7-oxoheptanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCC(N)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 PKVRQLMDAMASTB-SNIDVWGTSA-N 0.000 claims 3
- 108010027577 3-oxoadipyl-coenzyme A thiolase Proteins 0.000 claims 3
- 102000004317 Lyases Human genes 0.000 claims 3
- 108090000856 Lyases Proteins 0.000 claims 3
- UWMORNRVRUIQPR-HDRQGHTBSA-N S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 6-aminohex-2-enethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C=CCCCN)O[C@H]1N1C2=NC=NC(N)=C2N=C1 UWMORNRVRUIQPR-HDRQGHTBSA-N 0.000 claims 3
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 3
- 235000011037 adipic acid Nutrition 0.000 claims 3
- 239000001361 adipic acid Substances 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 150000004715 keto acids Chemical class 0.000 claims 3
- 108010060146 pyruvate formate-lyase activating enzyme Proteins 0.000 claims 3
- HRARGSXSLJCCFQ-SNIDVWGTSA-N s-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 6-amino-3-hydroxyhexanethioate Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)CCCN)O[C@H]1N1C2=NC=NC(N)=C2N=C1 HRARGSXSLJCCFQ-SNIDVWGTSA-N 0.000 claims 3
- ZFXICKRXPZTFPB-FZHFFJAKSA-N (Z)-2,3-dehydroadipoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)\C=C/CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZFXICKRXPZTFPB-FZHFFJAKSA-N 0.000 claims 2
- FPZRHFKFGHMXTD-UHFFFAOYSA-N 2,3-dioxooctanoic acid Chemical compound CCCCCC(=O)C(=O)C(O)=O FPZRHFKFGHMXTD-UHFFFAOYSA-N 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
- FOKABCOGWXJDTD-IMKGSZBMSA-N 2-amino-7-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-5-hydroxy-7-oxoheptanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)CCC(N)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 FOKABCOGWXJDTD-IMKGSZBMSA-N 0.000 claims 2
- DUXOPGJKCDTPLF-JXUSAFQPSA-N 3-amino-7-[2-[3-[[(2r)-4-[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-7-oxoheptanoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCC(N)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 DUXOPGJKCDTPLF-JXUSAFQPSA-N 0.000 claims 2
- URKANQMYNHOVKS-RCICKGJNSA-N 3-amino-8-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-8-oxooct-6-enoic acid Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C=CCCC(N)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 URKANQMYNHOVKS-RCICKGJNSA-N 0.000 claims 2
- RTGHRDFWYQHVFW-UHFFFAOYSA-N 3-oxoadipic acid Chemical compound OC(=O)CCC(=O)CC(O)=O RTGHRDFWYQHVFW-UHFFFAOYSA-N 0.000 claims 2
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 claims 2
- WFSCDWVPBNOBNO-UHFFFAOYSA-N 7-amino-2-oxohept-3-enoic acid Chemical compound NCCCC=CC(=O)C(O)=O WFSCDWVPBNOBNO-UHFFFAOYSA-N 0.000 claims 2
- 108010074122 Ferredoxins Proteins 0.000 claims 2
- 229920002292 Nylon 6 Polymers 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- WRJPJZTWQTUPQK-UHFFFAOYSA-N n-(6-aminohexyl)acetamide Chemical compound CC(=O)NCCCCCCN WRJPJZTWQTUPQK-UHFFFAOYSA-N 0.000 claims 2
- ZFXICKRXPZTFPB-KCQRSJHASA-N trans-2,3-didehydroadipoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)\C=C\CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZFXICKRXPZTFPB-KCQRSJHASA-N 0.000 claims 2
- 108010069997 2-enoate reductase Proteins 0.000 claims 1
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 claims 1
- HABHUTWTLGRDDU-UHFFFAOYSA-N 2-oxopimelic acid Chemical compound OC(=O)CCCCC(=O)C(O)=O HABHUTWTLGRDDU-UHFFFAOYSA-N 0.000 claims 1
- 102000052553 3-Hydroxyacyl CoA Dehydrogenase Human genes 0.000 claims 1
- 108700020831 3-Hydroxyacyl-CoA Dehydrogenase Proteins 0.000 claims 1
- YVOMYDHIQVMMTA-UHFFFAOYSA-N 3-Hydroxyadipic acid Chemical compound OC(=O)CC(O)CCC(O)=O YVOMYDHIQVMMTA-UHFFFAOYSA-N 0.000 claims 1
- HNOAJOYERZTSNK-UHFFFAOYSA-N 4-hydroxy-2-oxoheptanedioic acid Chemical compound OC(=O)CCC(O)CC(=O)C(O)=O HNOAJOYERZTSNK-UHFFFAOYSA-N 0.000 claims 1
- QAMKYKJQNLRRAJ-UHFFFAOYSA-N 6-amino-3-hydroxyhexanoic acid Chemical compound NCCCC(O)CC(O)=O QAMKYKJQNLRRAJ-UHFFFAOYSA-N 0.000 claims 1
- PUIRLTLMCJRHFF-UHFFFAOYSA-N 6-amino-3-oxohexanoic acid Chemical compound NCCCC(=O)CC(O)=O PUIRLTLMCJRHFF-UHFFFAOYSA-N 0.000 claims 1
- CLGRLBOVAMSRKG-UHFFFAOYSA-N 6-aminohept-3-enedioic acid Chemical compound OC(=O)C(N)CC=CCC(O)=O CLGRLBOVAMSRKG-UHFFFAOYSA-N 0.000 claims 1
- SNACICYKKILLEK-UHFFFAOYSA-N 6-aminohex-2-enoic acid Chemical compound NCCCC=CC(O)=O SNACICYKKILLEK-UHFFFAOYSA-N 0.000 claims 1
- ICGKEQXHPZUYSF-UHFFFAOYSA-N 6-oxohept-3-enedioic acid Chemical compound OC(=O)CC=CCC(=O)C(O)=O ICGKEQXHPZUYSF-UHFFFAOYSA-N 0.000 claims 1
- HQVMCJCRIZSIFE-UHFFFAOYSA-N 6-oxohex-4-enoic acid Chemical compound OC(=O)CCC=CC=O HQVMCJCRIZSIFE-UHFFFAOYSA-N 0.000 claims 1
- ZSLZBFCDCINBPY-ZSJPKINUSA-N Acetyl-CoA Natural products O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 1
- 102000057234 Acyl transferases Human genes 0.000 claims 1
- 108700016155 Acyl transferases Proteins 0.000 claims 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims 1
- GMEONFUTDYJSNV-UHFFFAOYSA-N Ethyl levulinate Chemical compound CCOC(=O)CCC(C)=O GMEONFUTDYJSNV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 108010020056 Hydrogenase Proteins 0.000 claims 1
- 229920002302 Nylon 6,6 Polymers 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- JARKCYVAAOWBJS-UHFFFAOYSA-N caproic aldehyde Natural products CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 claims 1
- 229910002091 carbon monoxide Inorganic materials 0.000 claims 1
- 108010031234 carbon monoxide dehydrogenase Proteins 0.000 claims 1
- 239000000446 fuel Substances 0.000 claims 1
- 230000002363 herbicidal effect Effects 0.000 claims 1
- 239000004009 herbicide Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 230000002269 spontaneous effect Effects 0.000 claims 1
- VNOYUJKHFWYWIR-ITIYDSSPSA-N succinyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-ITIYDSSPSA-N 0.000 claims 1
- 229920003051 synthetic elastomer Polymers 0.000 claims 1
- 239000005061 synthetic rubber Substances 0.000 claims 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17619609P | 2009-05-07 | 2009-05-07 | |
| US61/176,196 | 2009-05-07 | ||
| US21936509P | 2009-06-22 | 2009-06-22 | |
| US61/219,365 | 2009-06-22 | ||
| US24484409P | 2009-09-22 | 2009-09-22 | |
| US61/244,844 | 2009-09-22 | ||
| US24697309P | 2009-09-29 | 2009-09-29 | |
| US61/246,973 | 2009-09-29 | ||
| US24753309P | 2009-09-30 | 2009-09-30 | |
| US61/247,533 | 2009-09-30 | ||
| PCT/US2010/034144 WO2010129936A1 (en) | 2009-05-07 | 2010-05-07 | Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044127A Division JP6215244B2 (ja) | 2009-05-07 | 2015-03-06 | アジペート、ヘキサメチレンジアミン、及び６−アミノカプロン酸の生合成のための微生物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525856A JP2012525856A (ja) | 2012-10-25 |
| JP2012525856A5 true JP2012525856A5 (enExample) | 2013-06-20 |
| JP5773990B2 JP5773990B2 (ja) | 2015-09-02 |
Family
ID=43050517
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
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| JP2012510039A Active JP5773990B2 (ja) | 2009-05-07 | 2010-05-07 | アジペート、ヘキサメチレンジアミン、及び６−アミノカプロン酸の生合成のための微生物及び方法 |
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Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2265709T1 (en) | 2008-03-27 | 2018-03-30 | Genomatica, Inc. | MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| KR20110097951A (ko) | 2008-12-16 | 2011-08-31 | 게노마티카 인코포레이티드 | 합성가스와 다른 탄소원을 유용 제품으로 전환시키기 위한 미생물 및 방법 |
| US8404465B2 (en) | 2009-03-11 | 2013-03-26 | Celexion, Llc | Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks |
| ES2749423T3 (es) | 2009-05-07 | 2020-03-20 | Genomatica Inc | Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico |
| JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ， インク． | Ｍｅｋ及び２−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
| EP2462221B1 (en) | 2009-08-05 | 2017-02-22 | Genomatica, Inc. | Semi-synthetic terephthalic acid via microorganisms that produce muconic acid |
| CN109136161A (zh) | 2009-12-10 | 2019-01-04 | 基因组股份公司 | 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体 |
| US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| FR2963362B1 (fr) * | 2010-07-30 | 2012-08-17 | Pcas Biosolution | Procede d'acylation enzymatique avec un donneur acyl-phosphonate |
| US20120259138A1 (en) * | 2011-04-05 | 2012-10-11 | BioAmber International S.à.r.I. | Methods and systems of producing dicarboxylic acids |
| US9334508B2 (en) | 2011-06-17 | 2016-05-10 | Invista North America S.A.R.L. | Methods of producing carboxylic acids |
| US8852899B2 (en) * | 2011-06-17 | 2014-10-07 | Invista North America S.A.R.L. | Methods of making nylon intermediates from glycerol |
| US20130034884A1 (en) * | 2011-06-22 | 2013-02-07 | Genomatica, Inc. | Microorganisms for producing 1,4-butanediol and methods related thereto |
| AU2012273093A1 (en) * | 2011-06-22 | 2013-05-02 | Genomatica, Inc. | Microorganisms for producing 6-aminocaproic acid |
| BR112013033672A2 (pt) | 2011-06-30 | 2017-03-14 | Invista Tech Sarl | método para converter um composto, cultura substancialmente pura de células hospedeiras e cèlula isolada |
| SG2014012520A (en) | 2011-07-12 | 2014-06-27 | Scientist Of Fortune Sa | Recombinant microorganism for the production of useful metabolites |
| KR101884022B1 (ko) * | 2011-10-06 | 2018-08-02 | 성균관대학교산학협력단 | 카프로산 생산용 재조합 미생물 및 이를 이용하여 카프로산을 대량 생산하는 방법 |
| US9102958B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| US9102960B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| CN104066710B (zh) | 2012-01-18 | 2016-06-29 | 莱诺维亚公司 | 从5-羟甲基糠醛产生六亚甲基二胺的方法 |
| EP2820141B1 (en) | 2012-02-29 | 2018-04-11 | Duke University | Novel oxidoreductases for enantioselective reactions |
| US20130288320A1 (en) * | 2012-04-27 | 2013-10-31 | Bioamber Inc. | Methods and microorganisms for increasing the biological synthesis of difunctional alkanes |
| US9803209B2 (en) | 2012-05-18 | 2017-10-31 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| EP2885400A1 (en) * | 2012-08-17 | 2015-06-24 | Celexion, LLC | Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks |
| EP2898082B1 (en) * | 2012-09-20 | 2019-09-04 | LCY Bioscience Inc. | Pathways to adipate semialdehyde and other organic products |
| WO2014052630A1 (en) | 2012-09-27 | 2014-04-03 | Novozymes, Inc. | Bacterial mutants with improved transformation efficiency |
| WO2014093847A2 (en) | 2012-12-14 | 2014-06-19 | Invista North America S.A.R.L. | METHODS OF PRODUCING 7-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE |
| MY175370A (en) | 2012-12-17 | 2020-06-23 | Genomatica Inc | Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto |
| EP2746397A1 (de) * | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Omega-Aminofettsäuren |
| US10196657B2 (en) | 2012-12-31 | 2019-02-05 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation |
| EP2938734A2 (en) | 2012-12-31 | 2015-11-04 | Invista Technologies S.A R.L. | Methods of producing 7-carbon chemicals via aromatic compounds |
| CN105073214A (zh) * | 2012-12-31 | 2015-11-18 | 英威达技术有限责任公司 | 通过甲酯保护的碳链延伸生产6碳化学物的方法 |
| EP2938736A2 (en) | 2012-12-31 | 2015-11-04 | Invista Technologies S.A R.L. | Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis |
| EP2938732A1 (en) | 2012-12-31 | 2015-11-04 | Invista Technologies S.à.r.l. | Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage |
| US9738911B2 (en) | 2012-12-31 | 2017-08-22 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation |
| CN105189770A (zh) | 2012-12-31 | 2015-12-23 | 英威达技术有限责任公司 | 通过与环己烷羧酸合成相关的碳链延伸生产7碳化学物的方法 |
| WO2014144293A2 (en) * | 2013-03-15 | 2014-09-18 | Genomatica, Inc. | Development and use of microbes for impurity reduction in biomass hydrolysates and fermentation broths |
| EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHOD FOR THE PRODUCTION OF BUTADIENE AND RELATED COMPOUNDS BY FORMATASSIMILATION |
| KR101609448B1 (ko) | 2013-05-06 | 2016-04-05 | 한국생명공학연구원 | 6-아미노카프로산의 생물학적 합성 및 이를 위한 형질전환 미생물 |
| WO2014182016A1 (ko) * | 2013-05-06 | 2014-11-13 | 한국생명공학연구원 | 6-아미노카프로산의 생물학적 합성 및 이를 위한 형질전환 미생물 |
| BR112016005689A2 (pt) * | 2013-09-17 | 2018-01-30 | Zymochem Inc | rota de alto rendimento para a produção de compostos a partir de fontes renováveis |
| US12104160B2 (en) | 2013-09-17 | 2024-10-01 | Zymochem, Inc. | Production of 4,6-dihydroxy-2-oxo-hexanoic acid |
| PL3077501T3 (pl) | 2013-12-03 | 2022-01-31 | Genomatica, Inc. | Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa |
| WO2015100338A2 (en) | 2013-12-27 | 2015-07-02 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| TW201609681A (zh) * | 2014-05-12 | 2016-03-16 | 微麥得斯公司 | 自５－（鹵甲基）糠醛製造化合物之方法 |
| CN103937841B (zh) * | 2014-05-13 | 2015-10-28 | 上海交通大学 | 烯酰辅酶a水合酶在己二酸生物合成中的应用 |
| CN106574283A (zh) | 2014-05-15 | 2017-04-19 | 英威达技术有限责任公司 | 使用2,6‑二氨基庚二酸作为2‑氨基庚二酸的前体生产6‑碳化学品的方法 |
| CN106795519A (zh) | 2014-06-16 | 2017-05-31 | 英威达技术有限责任公司 | 用于生成戊二酸和戊二酸甲酯的方法 |
| BR112016029375A2 (pt) | 2014-06-16 | 2017-10-17 | Invista Tech Sarl | métodos, reagentes e células para biossintetizar compostos |
| BR112016029388A2 (pt) | 2014-06-16 | 2017-10-17 | Invista Tech Sarl | métodos, reagentes e células para biossintetizar compostos |
| BR112016029399A2 (pt) | 2014-06-16 | 2017-10-17 | Invista Tech Sarl | métodos, reagentes e células para biossintetizar composto |
| EP3741865B1 (en) | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| TW201636096A (zh) | 2014-12-02 | 2016-10-16 | 瑞諾維亞公司 | 自５－羥甲基糠醛產生己三醇之方法 |
| EP3237629A1 (en) * | 2014-12-23 | 2017-11-01 | Genomatica, Inc. | Method of producing&processing diamines |
| KR101715882B1 (ko) | 2015-03-06 | 2017-03-27 | 한국생명공학연구원 | 신규 ε-카프로락탐 전환 효소 및 이를 이용한 ε-카프로락탐 생산 방법 |
| WO2016167519A1 (ko) * | 2015-04-13 | 2016-10-20 | 한국과학기술원 | 락탐의 제조방법 |
| KR101839595B1 (ko) | 2015-04-13 | 2018-04-26 | 한국과학기술원 | 락탐의 제조방법 |
| WO2016209883A1 (en) * | 2015-06-23 | 2016-12-29 | Genomatica, Inc. | Microorganisms and methods for the production of biosynthesized target products having reduced levels of byproducts |
| KR101651239B1 (ko) * | 2015-07-02 | 2016-08-25 | 씨제이제일제당 주식회사 | 신규 슈도모나스 종 균주 및 이를 이용한 6-아미노카프로산의 탈아민 방법 |
| KR101750856B1 (ko) | 2015-10-22 | 2017-06-30 | 한국과학기술원 | 1,3-다이아미노프로판 생산능을 가지는 재조합 미생물 및 이를 이용한 1,3-다이아미노프로판의 제조방법 |
| US11162121B2 (en) | 2015-10-27 | 2021-11-02 | Korea Research Institute Of Bioscience And Biotechnology | Method for producing medium chain diamine |
| SG11201803164SA (en) | 2015-10-30 | 2018-05-30 | Genomatica Inc | Methanol dehydrogenase fusion proteins |
| US11939611B2 (en) * | 2016-02-19 | 2024-03-26 | Inv Nylon Chemicals Americas, Llc | Biocatalytic processes and materials for enhanced carbon utilization |
| US20230139445A1 (en) | 2016-11-15 | 2023-05-04 | Danmarks Tekniske Universitet | Bacterial cells with improved tolerance to diacids |
| CN107164477A (zh) * | 2017-05-27 | 2017-09-15 | 山西维尔生物乳制品有限公司 | 一种鉴别罗伦氏隐球酵母的探针、引物和基因芯片 |
| US11708590B2 (en) | 2017-07-18 | 2023-07-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Synthetic metabolic funneling for biochemical production |
| KR101971480B1 (ko) | 2017-09-26 | 2019-04-23 | 한국생명공학연구원 | 돌연변이 재설계 유전자 회로를 이용한 니트릴계, 락톤계 또는 락탐계 화합물의 감지 및 정량 방법 |
| KR101898171B1 (ko) * | 2018-01-19 | 2018-09-12 | 씨제이제일제당 주식회사 | 신규 트랜스아미나제 및 이를 이용한 아미노 화합물의 탈아민 방법 |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| EP3814515A2 (en) | 2018-06-26 | 2021-05-05 | Genomatica, Inc. | Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy |
| IT201800021409A1 (it) | 2018-12-28 | 2020-06-28 | Aquafil S P A | Processo per la produzione di epsilon caprolattame dallacido 6-aminocaproico. |
| US20220235385A1 (en) * | 2019-04-24 | 2022-07-28 | Genomatica, Inc. | Engineered microorganisms and methods for improved aldehyde dehydrogenase activity |
| AU2020262490A1 (en) | 2019-04-25 | 2021-11-25 | Zymochem, Inc. | Production of chemicals from renewable sources |
| BR112021021601A2 (pt) | 2019-05-10 | 2021-12-21 | Toray Industries | Microrganismo geneticamente modificado e método de produção de ácido 3-hidroxiadípico, ácido a-hidromucônico e/ou ácido adípico |
| US20220213514A1 (en) | 2019-05-10 | 2022-07-07 | Toray Industries, Inc. | Genetically modified microorganism for producing 3-hydroxyhexanedioic acid, (e)-hex-2-enedioic acid and/or hexanedioic acid, and production method for said chemicals |
| KR20220032084A (ko) | 2019-07-22 | 2022-03-15 | 아사히 가세이 가부시키가이샤 | 유전자 재조합 미생물 및 디아민 화합물의 제조 방법 |
| CN111122720B (zh) * | 2019-12-11 | 2022-09-02 | 湖北三宁碳磷基新材料产业技术研究院有限公司 | 己内酰胺、6-氨基己酰胺和6-氨基己腈的分析方法 |
| KR20230003072A (ko) * | 2020-04-24 | 2023-01-05 | 게노마티카 인코포레이티드 | 조작된 효소 및 이의 이용 및 제조 방법 |
| CN116406420A (zh) | 2020-11-11 | 2023-07-07 | 东丽株式会社 | 用于生产3-羟基己二酸和/或α-氢化己二烯二酸的基因修饰微生物以及该化学品的制造方法 |
| JP2024503868A (ja) | 2021-01-17 | 2024-01-29 | ジェノマティカ， インコーポレイテッド | アミド化合物を生成する方法および組成物 |
| JP7038241B1 (ja) | 2021-03-30 | 2022-03-17 | 旭化成株式会社 | 組換え微生物及びアジピン酸又はその誘導体の製造方法 |
| JPWO2022209994A1 (enExample) | 2021-03-30 | 2022-10-06 | ||
| WO2022209763A1 (ja) | 2021-03-30 | 2022-10-06 | 旭化成株式会社 | カルボン酸還元活性を有する組換えポリペプチド |
| WO2022244809A1 (ja) | 2021-05-19 | 2022-11-24 | 旭化成株式会社 | ジアミン生産能を有する組換え微生物およびジアミンの製造方法 |
| CN118591634A (zh) * | 2022-02-15 | 2024-09-03 | 东丽株式会社 | 用于生产3-羟基己二酸和/或α-氢化己二烯二酸的基因修饰微生物以及该化学品的制造方法 |
| CN114990043B (zh) * | 2022-06-28 | 2024-04-30 | 滨州医学院 | 代谢赖氨酸的工程菌及其构建方法与应用 |
Family Cites Families (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3513209A (en) | 1968-08-19 | 1970-05-19 | Du Pont | Method of making 1,4-cyclohexadiene |
| US4076948A (en) | 1968-10-10 | 1978-02-28 | El Paso Products Company | Process for treatment of adipic acid mother liquor |
| GB1230276A (enExample) | 1968-12-09 | 1971-04-28 | ||
| US3965182A (en) | 1969-10-02 | 1976-06-22 | Ethyl Corporation | Preparation of aniline from phenol and ammonia |
| JPS4831084B1 (enExample) | 1970-09-04 | 1973-09-26 | ||
| GB1344557A (en) | 1972-06-23 | 1974-01-23 | Mitsubishi Petrochemical Co | Process for preparing 1,4-butanediol |
| JPS5543759B2 (enExample) | 1972-06-28 | 1980-11-07 | ||
| JPS506776A (enExample) | 1973-05-28 | 1975-01-23 | ||
| JPS5721310B2 (enExample) * | 1974-03-19 | 1982-05-06 | ||
| DE2455617C3 (de) | 1974-11-23 | 1982-03-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons |
| DE2501499A1 (de) | 1975-01-16 | 1976-07-22 | Hoechst Ag | Verfahren zur herstellung von butandiol-(1.4) |
| US4190495A (en) | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| FR2403571A1 (fr) | 1977-09-14 | 1979-04-13 | Cables De Lyon Geoffroy Delore | Dispositif mecanique de raccordement de fibres optiques |
| US4301077A (en) | 1980-12-22 | 1981-11-17 | Standard Oil Company | Process for the manufacture of 1-4-butanediol and tetrahydrofuran |
| JPS60114197A (ja) | 1983-11-25 | 1985-06-20 | Agency Of Ind Science & Technol | 微生物によるジカルボン酸の製造法 |
| US4871667A (en) | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
| US4652685A (en) | 1985-11-15 | 1987-03-24 | General Electric Company | Hydrogenation of lactones to glycols |
| US5143834A (en) | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| US5168055A (en) | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| ES2036188T3 (es) | 1986-06-11 | 1993-05-16 | Michigan Biotechnology Institute | Un procedimiento para la produccion de acido succinico por fermentacion anaerobia. |
| US5182199A (en) | 1987-05-27 | 1993-01-26 | Hartley Brian S | Thermophilic ethanol production in a two-stage closed system |
| US5219757A (en) | 1988-04-27 | 1993-06-15 | Daicel Chemical Industries, Ltd. | Production of optically active 1,3-butanediol by asymmetric assimilation or reduction of 4-hydroxy-2-butanone |
| CA2062753C (en) | 1989-04-27 | 2005-04-26 | N. Robert Ward, Jr. | Precipitate test for microorganisms |
| US5192673A (en) | 1990-04-30 | 1993-03-09 | Michigan Biotechnology Institute | Mutant strain of C. acetobutylicum and process for making butanol |
| US5079143A (en) | 1990-05-02 | 1992-01-07 | The Upjohn Company | Method of indentifying compounds useful as antiparasitic drugs |
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| US5416020A (en) | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
| US5266694A (en) | 1992-10-19 | 1993-11-30 | E. I. Du Pont De Nemours And Company | Nylon component reclamation |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| US5302756A (en) | 1992-12-23 | 1994-04-12 | E. I. Du Pont De Nemours And Company | Ammonolysis of nylon |
| FR2702492B1 (fr) | 1993-03-12 | 1995-05-24 | Rhone Poulenc Chimie | Procédé de production par fermentation d'acide itaconique. |
| US5487987A (en) | 1993-09-16 | 1996-01-30 | Purdue Research Foundation | Synthesis of adipic acid from biomass-derived carbon sources |
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5700934A (en) | 1995-03-01 | 1997-12-23 | Dsm N.V. | Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors |
| US5478952A (en) | 1995-03-03 | 1995-12-26 | E. I. Du Pont De Nemours And Company | Ru,Re/carbon catalyst for hydrogenation in aqueous solution |
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| FR2736927B1 (fr) * | 1995-07-18 | 1997-10-17 | Rhone Poulenc Fibres & Polymer | Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| US5869301A (en) | 1995-11-02 | 1999-02-09 | Lockhead Martin Energy Research Corporation | Method for the production of dicarboxylic acids |
| US5770435A (en) | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| JP2000506012A (ja) | 1996-02-27 | 2000-05-23 | ミシガン ステイト ユニヴァーシティー | サーモアンエアロバクター・エタノリカス３９ｅの第二級アルコールデヒドロゲナーゼをコードする遺伝子のクローニング及び発現並びに酵素の生化学的特徴付け |
| US5958745A (en) | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
| JP4101295B2 (ja) | 1996-07-01 | 2008-06-18 | バイオエンジニアリング・リソーシズ・インコーポレーテツド | 廃ガスからの酢酸の生物学的生産 |
| KR100459818B1 (ko) | 1996-09-02 | 2004-12-03 | 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 | ε-카프로락탐의 제조방법 |
| US6117658A (en) | 1997-02-13 | 2000-09-12 | James Madison University | Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units |
| KR100516986B1 (ko) | 1997-02-19 | 2005-09-26 | 코닌클리즈케 디에스엠 엔.브이. | 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법 |
| US6274790B1 (en) | 1997-04-14 | 2001-08-14 | The University Of British Columbia | Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis |
| KR19990013007A (ko) | 1997-07-31 | 1999-02-25 | 박원훈 | 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법 |
| JPH11103863A (ja) | 1997-10-08 | 1999-04-20 | Nippon Shokubai Co Ltd | マレイン酸異性化酵素遺伝子 |
| US6280986B1 (en) | 1997-12-01 | 2001-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities |
| WO1999053035A1 (en) | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US20030087381A1 (en) | 1998-04-13 | 2003-05-08 | University Of Georgia Research Foundation, Inc. | Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals |
| US6159738A (en) | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| US6432686B1 (en) | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| US6444784B1 (en) | 1998-05-29 | 2002-09-03 | Exxonmobil Research & Engineering Company | Wax crystal modifiers (LAW657) |
| DE19831889A1 (de) * | 1998-07-17 | 2000-01-27 | Basf Ag | Verbessertes Verfahren zur Herstellung von Hexamethylendiamin |
| US5961788A (en) | 1998-10-09 | 1999-10-05 | E. I. Du Pont De Nemours And Company | Sequential distillation process for removing tetrahydroazepine from aminocapronitrile and/or hexamethylenediamine |
| DE19856136C2 (de) | 1998-12-04 | 2002-10-24 | Pasteur Institut | Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension |
| WO2000046405A2 (en) | 1999-02-02 | 2000-08-10 | Bernhard Palsson | Methods for identifying drug targets based on genomic sequence data |
| US6686310B1 (en) | 1999-02-09 | 2004-02-03 | E. I. Du Pont De Nemours And Company | High surface area sol-gel route prepared hydrogenation catalysts |
| US6365376B1 (en) | 1999-02-19 | 2002-04-02 | E. I. Du Pont De Nemours And Company | Genes and enzymes for the production of adipic acid intermediates |
| US6448473B1 (en) | 1999-03-05 | 2002-09-10 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| CA2374482C (en) | 1999-05-21 | 2012-09-18 | Cargill Dow Llc | Methods and materials for the synthesis of organic products |
| US6852517B1 (en) | 1999-08-30 | 2005-02-08 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| US6660857B2 (en) | 2000-02-03 | 2003-12-09 | Dsm N.V. | Process for the preparation of ε-caprolactam |
| US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
| NZ523484A (en) | 2000-07-25 | 2005-01-28 | Emmaus Foundation Inc | Methods for increasing the production of ethanol from microbial fermentation |
| US7698463B2 (en) | 2000-09-12 | 2010-04-13 | Sri International | System and method for disseminating topology and link-state information to routing nodes in a mobile ad hoc network |
| US6248926B1 (en) | 2000-10-26 | 2001-06-19 | E. I. Du Pont De Nemours And Company | Recovery of hexamethylenediamine (HMD) with low polarographically reducible impurities (PRI) from mixtures of HMD, aminocapronitirle and PRI |
| JP4490628B2 (ja) | 2000-11-20 | 2010-06-30 | カーギル インコーポレイテッド | ３−ヒドロキシプロピオン酸および他の有機化合物 |
| US7109010B2 (en) | 2000-11-22 | 2006-09-19 | Nature Works Llc | Methods and materials for the synthesis of organic products |
| CN1358841A (zh) | 2000-12-11 | 2002-07-17 | 云南省微生物研究所 | 云南链霉菌 |
| US7501268B2 (en) | 2000-12-28 | 2009-03-10 | Toyota Jidosha Kabushiki Kaisha | Methods of producing prenyl alcohols |
| CA2434224C (en) | 2001-01-10 | 2013-04-02 | The Penn State Research Foundation | Method and system for modeling cellular metabolism |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| US20030059792A1 (en) | 2001-03-01 | 2003-03-27 | Palsson Bernhard O. | Models and methods for determining systemic properties of regulated reaction networks |
| US6743610B2 (en) | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| CA2356540A1 (en) | 2001-08-30 | 2003-02-28 | Emory University | Expressed dna sequences involved in mitochondrial functions |
| CA2466133A1 (en) | 2001-11-02 | 2003-05-15 | Rice University | Recycling system for manipulation of intracellular nadh availability |
| DE60327804D1 (de) | 2002-01-18 | 2009-07-09 | Novozymes As | Alanin-2,3-aminomutase |
| WO2003066863A1 (fr) | 2002-02-06 | 2003-08-14 | Showa Denko K.K. | Gene reductase d'un compose carbonyle alpha-substitue-alpha, beta-insature |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| CA2480216A1 (en) | 2002-03-29 | 2003-10-09 | Genomatica, Inc. | Human metabolic models and methods |
| US20050287655A1 (en) | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| US7856317B2 (en) | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
| US7826975B2 (en) | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| EP1532516A4 (en) | 2002-07-10 | 2007-05-23 | Penn State Res Found | Method for determining gene knockout strategies |
| WO2004007688A2 (en) | 2002-07-15 | 2004-01-22 | Kosan Biosciences, Inc. | Metabolic pathways for starter units in polyketide biosynthesis |
| AU2003287028B2 (en) | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| AU2003222214B2 (en) | 2002-10-15 | 2010-08-12 | The Regents Of The University Of California | Methods and systems to identify operational reaction pathways |
| AU2003287625A1 (en) | 2002-11-06 | 2004-06-03 | University Of Florida | Materials and methods for the efficient production of acetate and other products |
| US7432091B2 (en) | 2003-02-24 | 2008-10-07 | Research Institute Of Innovative Technology For The Earth | Highly efficient hydrogen production method using microorganism |
| US6887352B2 (en) | 2003-03-07 | 2005-05-03 | Invista North America S.A.R.L. | Distillative method for separating hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine |
| RU2268300C2 (ru) | 2003-04-07 | 2006-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA |
| US7927859B2 (en) | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| WO2005026349A1 (ja) | 2003-09-17 | 2005-03-24 | Mitsubishi Chemical Corporation | 非アミノ有機酸の製造方法 |
| US7244610B2 (en) | 2003-11-14 | 2007-07-17 | Rice University | Aerobic succinate production in bacteria |
| CA2545529A1 (en) | 2003-11-26 | 2005-06-16 | E.I. Du Pont De Nemours And Company | High flow, toughened, weatherable polyamide compositions containing a blend of stabilizers |
| FR2864967B1 (fr) | 2004-01-12 | 2006-05-19 | Metabolic Explorer Sa | Microorganisme evolue pour la production de 1,2-propanediol |
| CN1926240B (zh) | 2004-01-19 | 2010-06-02 | 帝斯曼知识产权资产管理有限公司 | 6-氨基己酸的生物化学合成 |
| US7608700B2 (en) * | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
| DE102004031177A1 (de) | 2004-06-29 | 2006-01-19 | Henkel Kgaa | Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren |
| EA011232B1 (ru) * | 2004-07-15 | 2009-02-27 | ДСМ АйПи АССЕТС Б.В. | Биохимический синтез 1,4-бутандиамина |
| US7262046B2 (en) | 2004-08-09 | 2007-08-28 | Rice University | Aerobic succinate production in bacteria |
| CN101044245B (zh) | 2004-08-27 | 2012-05-02 | 莱斯大学 | 具有增加的琥珀酸产量的突变大肠杆菌菌株 |
| EP2434015B1 (en) | 2004-09-09 | 2013-11-20 | Research Institute Of Innovative Technology For The Earth | DNA fragment having promoter function |
| US7468119B2 (en) | 2004-09-10 | 2008-12-23 | Invista North America S.A.R.L. | Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine |
| US7208632B2 (en) | 2004-09-10 | 2007-04-24 | Invista North America S.A R.L. | Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine |
| EP1789569A2 (en) | 2004-09-17 | 2007-05-30 | Rice University | High succinate producing bacteria |
| US7569380B2 (en) | 2004-12-22 | 2009-08-04 | Rice University | Simultaneous anaerobic production of isoamyl acetate and succinic acid |
| JP2006204255A (ja) | 2005-01-31 | 2006-08-10 | Canon Inc | アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法 |
| EP1874334A4 (en) * | 2005-04-15 | 2011-03-30 | Vascular Biogenics Ltd | COMPOSITIONS WITH BETA 2-GLYCOPROTEIN I-PEPTIDES FOR THE PREVENTION AND / OR TREATMENT OF VASCULAR DISEASES |
| KR100679638B1 (ko) | 2005-08-19 | 2007-02-06 | 한국과학기술원 | 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법 |
| KR100676160B1 (ko) | 2005-08-19 | 2007-02-01 | 한국과학기술원 | 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| AU2006287257A1 (en) | 2005-09-09 | 2007-03-15 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of succinate |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US20080274526A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of isobutanol |
| NZ566406A (en) | 2005-10-26 | 2012-04-27 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| WO2007103687A2 (en) * | 2006-03-01 | 2007-09-13 | Tristrata, Inc. | Composition and method for topical treatment of tar-responsive dermatological disorders |
| US7801128B2 (en) | 2006-03-31 | 2010-09-21 | Amazon Technologies, Inc. | Managing communications between computing nodes |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| US20070271453A1 (en) | 2006-05-19 | 2007-11-22 | Nikia Corporation | Identity based flow control of IP traffic |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| US7231906B1 (en) | 2006-06-27 | 2007-06-19 | Gm Global Technology Operations, Inc. | Simultaneous EGR correction and individual cylinder combustion phase balancing |
| BRPI0716212A2 (pt) | 2006-08-30 | 2013-10-15 | Cargill Inc | Beta-alanina/alfa-cetoglutarato aminotransferase para produção de ácido 3-hidroxipropiônico |
| JP2008061501A (ja) * | 2006-09-04 | 2008-03-21 | Hyogo Prefecture | 遊離カルボン酸・アミンの直接縮合反応を触媒する酵素の設計方法及びナイロンオリゴマーの酵素的製造方法 |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| WO2008080124A2 (en) | 2006-12-21 | 2008-07-03 | Gevo, Inc. | Butanol production by metabolically engineered yeast |
| CA2678946C (en) | 2007-03-16 | 2019-02-12 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
| KR101573775B1 (ko) | 2007-04-18 | 2015-12-04 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산 |
| EP2147111A4 (en) | 2007-04-18 | 2010-06-23 | Gevo Inc | MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL |
| US20080274522A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of 2-butanone |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| EP2017344A1 (en) | 2007-07-20 | 2009-01-21 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Production of itaconic acid |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| AU2008310573A1 (en) | 2007-10-12 | 2009-04-16 | The Regents Of The University Of California | Microorganism engineered to produce isopropanol |
| CA2712779C (en) | 2008-01-22 | 2021-03-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
| US20090246842A1 (en) | 2008-02-15 | 2009-10-01 | Gevo, Inc. | Engineered microorganisms for producing propanol |
| TWI701230B (zh) | 2008-03-11 | 2020-08-11 | 美商吉諾瑪蒂卡股份有限公司 | 由α-酮庚二酸製備６-胺己酸之技術 |
| ES2655710T3 (es) | 2008-03-11 | 2018-02-21 | Genomatica, Inc. | Síntesis de éster o tioéster de adipato |
| SI2265709T1 (en) * | 2008-03-27 | 2018-03-30 | Genomatica, Inc. | MICROORGANISMS FOR PREPARATION OF ADYPIC ACID AND OTHER COMPOUNDS |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| US8357826B2 (en) | 2008-10-16 | 2013-01-22 | Karl Kharas | Methods and apparatus for synthesis of alcohols from syngas |
| MY153590A (en) | 2008-12-12 | 2015-02-26 | Celexion Llc | Biological synthesis of difunctional alkanes from alpha ketoacids |
| EP3260532A1 (en) | 2008-12-12 | 2017-12-27 | CJ Research Center LLC | Green process and compositions for producing poly(5hv) and 5 carbon chemicals |
| ES2749423T3 (es) * | 2009-05-07 | 2020-03-20 | Genomatica Inc | Microorganismos y métodos para la biosíntesis de adipato, hexametilendiamina y ácido 6-aminocaproico |
| US9073867B2 (en) | 2011-04-09 | 2015-07-07 | Amyris, Inc. | Process for preparing caprolactam and polyamides therefrom |
| WO2012170059A1 (en) | 2011-06-10 | 2012-12-13 | Bioamber S.A.S. | Processes for producing hexanediol (hdo), hexamethylenediamine (hmd) from fermentation broths containing adipic acid |
| US8852899B2 (en) | 2011-06-17 | 2014-10-07 | Invista North America S.A.R.L. | Methods of making nylon intermediates from glycerol |
| WO2013090837A2 (en) | 2011-12-16 | 2013-06-20 | Invista North America S.A.R.L. | METHODS OF PRODUCING 6-CARBON CHEMICALS VIA CoA-DEPENDENT CARBON CHAIN ELONGATION ASSOCIATED WITH CARBON STORAGE |
| US9102958B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| CN104066710B (zh) | 2012-01-18 | 2016-06-29 | 莱诺维亚公司 | 从5-羟甲基糠醛产生六亚甲基二胺的方法 |
| CN105073214A (zh) | 2012-12-31 | 2015-11-18 | 英威达技术有限责任公司 | 通过甲酯保护的碳链延伸生产6碳化学物的方法 |
| JP2016521562A (ja) | 2013-06-12 | 2016-07-25 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション | トランスアミナーゼ生体触媒 |
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2010
- 2010-05-07 ES ES10772921T patent/ES2749423T3/es active Active
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- 2010-05-07 KR KR1020207009669A patent/KR20200038334A/ko not_active Abandoned
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2012
- 2012-07-13 US US13/549,239 patent/US20120282661A1/en active Granted
- 2012-12-28 US US13/730,612 patent/US9458480B2/en active Active
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2015
- 2015-03-06 JP JP2015044127A patent/JP6215244B2/ja active Active
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2016
- 2016-03-10 AU AU2016201560A patent/AU2016201560B2/en active Active
- 2016-09-12 US US15/263,149 patent/US10150977B2/en active Active
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2017
- 2017-04-10 JP JP2017077217A patent/JP2017163985A/ja active Pending
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2018
- 2018-06-28 AU AU2018204702A patent/AU2018204702B2/en active Active
- 2018-12-07 US US16/213,671 patent/US11208673B2/en active Active
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2019
- 2019-10-23 JP JP2019192511A patent/JP2020036594A/ja active Pending
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2021
- 2021-06-24 AU AU2021204276A patent/AU2021204276A1/en not_active Abandoned
- 2021-11-04 JP JP2021179960A patent/JP7370366B2/ja active Active
- 2021-11-16 US US17/527,902 patent/US11834690B2/en active Active
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2023
- 2023-10-17 JP JP2023179025A patent/JP7751361B2/ja active Active
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