JP2022017333A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2022017333A5 JP2022017333A5 JP2021169396A JP2021169396A JP2022017333A5 JP 2022017333 A5 JP2022017333 A5 JP 2022017333A5 JP 2021169396 A JP2021169396 A JP 2021169396A JP 2021169396 A JP2021169396 A JP 2021169396A JP 2022017333 A5 JP2022017333 A5 JP 2022017333A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- human
- pharmaceutical composition
- population
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022176776A JP2023014100A (ja) | 2014-09-19 | 2022-11-02 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462053068P | 2014-09-19 | 2014-09-19 | |
| US62/053,068 | 2014-09-19 | ||
| JP2017515139A JP6657195B2 (ja) | 2014-09-19 | 2015-09-18 | L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
| JP2020017583A JP6986190B2 (ja) | 2014-09-19 | 2020-02-05 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020017583A Division JP6986190B2 (ja) | 2014-09-19 | 2020-02-05 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022176776A Division JP2023014100A (ja) | 2014-09-19 | 2022-11-02 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022017333A JP2022017333A (ja) | 2022-01-25 |
| JP2022017333A5 true JP2022017333A5 (enExample) | 2022-06-03 |
| JP7171871B2 JP7171871B2 (ja) | 2022-11-15 |
Family
ID=55533940
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515139A Active JP6657195B2 (ja) | 2014-09-19 | 2015-09-18 | L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
| JP2017515138A Active JP6711819B2 (ja) | 2014-09-19 | 2015-09-21 | 養子t細胞療法のためのセントラルメモリーt細胞 |
| JP2020017583A Active JP6986190B2 (ja) | 2014-09-19 | 2020-02-05 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
| JP2020093109A Active JP7216045B2 (ja) | 2014-09-19 | 2020-05-28 | 養子t細胞療法のためのセントラルメモリーt細胞 |
| JP2021169396A Active JP7171871B2 (ja) | 2014-09-19 | 2021-10-15 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞 |
| JP2022176776A Pending JP2023014100A (ja) | 2014-09-19 | 2022-11-02 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
| JP2023006410A Ceased JP2023052506A (ja) | 2014-09-19 | 2023-01-19 | 養子t細胞療法のためのセントラルメモリーt細胞 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017515139A Active JP6657195B2 (ja) | 2014-09-19 | 2015-09-18 | L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
| JP2017515138A Active JP6711819B2 (ja) | 2014-09-19 | 2015-09-21 | 養子t細胞療法のためのセントラルメモリーt細胞 |
| JP2020017583A Active JP6986190B2 (ja) | 2014-09-19 | 2020-02-05 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
| JP2020093109A Active JP7216045B2 (ja) | 2014-09-19 | 2020-05-28 | 養子t細胞療法のためのセントラルメモリーt細胞 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022176776A Pending JP2023014100A (ja) | 2014-09-19 | 2022-11-02 | IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 |
| JP2023006410A Ceased JP2023052506A (ja) | 2014-09-19 | 2023-01-19 | 養子t細胞療法のためのセントラルメモリーt細胞 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9914909B2 (enExample) |
| EP (4) | EP3194433B1 (enExample) |
| JP (7) | JP6657195B2 (enExample) |
| KR (3) | KR102683584B1 (enExample) |
| CN (3) | CN107002084B (enExample) |
| AU (4) | AU2015317351B2 (enExample) |
| BR (3) | BR122024000360A2 (enExample) |
| CA (2) | CA2961654A1 (enExample) |
| DK (1) | DK3200591T3 (enExample) |
| ES (2) | ES2738705T3 (enExample) |
| IL (6) | IL292650B2 (enExample) |
| MX (4) | MX387135B (enExample) |
| RU (2) | RU2749922C2 (enExample) |
| WO (2) | WO2016044811A1 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6445434B2 (ja) | 2012-08-09 | 2018-12-26 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | スーパーカインおよびシンセカイン:新規かつ増強されたシグナル伝達活性を有する再利用されるサイトカイン |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| US9657105B2 (en) | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| WO2016044811A1 (en) | 2014-09-19 | 2016-03-24 | City Of Hope | COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Rα2 |
| KR20180029201A (ko) | 2015-05-18 | 2018-03-20 | 티씨알2 테라퓨틱스 인크. | 융합 단백질을 이용하는 tcr 리프로그래밍을 위한 조성물 및 방법 |
| CN108348550A (zh) | 2015-07-21 | 2018-07-31 | 希望之城公司 | 用于表达嵌合抗原受体和其它受体的t细胞 |
| ES2877090T3 (es) * | 2015-08-05 | 2021-11-16 | Cellabmed Inc | Receptor de antígenos quiméricos y células T en las que se expresa el receptor de antígenos quiméricos |
| PE20190201A1 (es) * | 2016-04-01 | 2019-02-05 | Amgen Inc | Receptores quimericos de flt3 y metodos de uso de los mismos |
| PL3436079T3 (pl) | 2016-04-01 | 2021-12-20 | Kite Pharma, Inc. | Antygen chimeryczny i receptory komórek t oraz sposoby ich stosowania |
| PE20190356A1 (es) | 2016-04-01 | 2019-03-07 | Kite Pharma Inc | Receptores quimericos y metodos de uso de los mismos |
| US10689450B2 (en) * | 2016-04-01 | 2020-06-23 | Kite Pharma, Inc | BCMA binding molecules and methods of use thereof |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| WO2017192536A1 (en) | 2016-05-02 | 2017-11-09 | University Of Kansas | Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy |
| US12048718B2 (en) | 2016-06-07 | 2024-07-30 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Geminschaft | Chimeric antigen receptor and CAR-T cells that bind BCMA |
| US11787848B2 (en) * | 2016-06-08 | 2023-10-17 | Precigen, Inc. | CD33 specific chimeric antigen receptors |
| WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| KR102501827B1 (ko) * | 2016-09-16 | 2023-02-22 | 베이롤 칼리지 오브 메드신 | 바이러스-특이적인 t-세포의 활성화 및 확장을 위한 플랫폼 |
| IL302917A (en) | 2016-10-07 | 2023-07-01 | Tcr2 Therapeutics Inc | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| JP7291396B2 (ja) | 2016-11-22 | 2023-06-15 | ティーシーアール2 セラピューティクス インク. | 融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法 |
| US20200095547A1 (en) | 2016-12-02 | 2020-03-26 | Darya ALIZADEH | Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors |
| US20200078401A1 (en) * | 2016-12-07 | 2020-03-12 | La Jolla Institute For Allergy And Immunology | Compositions for cancer treatment and methods and uses for cancer treatment and prognosis |
| US12473343B2 (en) | 2017-01-10 | 2025-11-18 | The General Hospital Corporation | Targeted t cells with cytotoxicity toward immunosuppressive cells |
| EP3579870A4 (en) | 2017-02-07 | 2020-12-30 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS |
| CN108395481B (zh) * | 2017-02-08 | 2021-02-05 | 西比曼生物科技(香港)有限公司 | 一种靶向cd20的car的构建及其工程化t细胞的活性鉴定 |
| WO2018156711A1 (en) * | 2017-02-22 | 2018-08-30 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Il13ra2-binding chimeric antigen receptors |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| RU2770002C2 (ru) * | 2017-03-27 | 2022-04-14 | Нойл-Иммьюн Байотек, Инк. | Химерный антигенный рецептор |
| AU2018251206A1 (en) | 2017-04-14 | 2019-10-31 | The General Hospital Corporation | Chimeric antigen receptor T cells targeting the tumor microenvironment |
| CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
| CN107267555B (zh) * | 2017-05-27 | 2020-03-20 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用 |
| EP3664841A1 (en) * | 2017-08-11 | 2020-06-17 | City of Hope | Oncolytic virus expressing a car t cell target and uses thereof |
| WO2019073299A1 (en) | 2017-10-10 | 2019-04-18 | Medicenna Therapeutics, Inc. | IL-4 FUSION FORMULATIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) TUMORS |
| KR20200076732A (ko) * | 2017-11-03 | 2020-06-29 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Cd38-지시된 키메라 항원 수용체 작제물 |
| US20200345823A1 (en) * | 2017-11-07 | 2020-11-05 | Xiuli Wang | Treatment of cns lymphoma and systemic lymphoma with intracerebroventricularly administered cd19 car |
| CN109971712B (zh) * | 2017-12-28 | 2023-06-20 | 上海细胞治疗研究院 | 特异性靶向cd19抗原且高水平稳定表达pd-1抗体的car-t细胞及用途 |
| CN109971721B (zh) * | 2017-12-28 | 2023-10-31 | 上海细胞治疗研究院 | 自表达cd47抗体的间皮素特异性car-t细胞及其用途 |
| AU2019209432A1 (en) | 2018-01-22 | 2020-08-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| US11701405B2 (en) * | 2018-01-26 | 2023-07-18 | City Of Hope | Chimeric antigen receptors and methods for reducing toxicity |
| CN111936518A (zh) * | 2018-02-06 | 2020-11-13 | 西雅图儿童医院(Dba西雅图儿童研究所) | 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car |
| CA3090546A1 (en) * | 2018-02-12 | 2019-08-15 | The General Hospital Corporation | Chimeric antigen receptors targeting the tumor microenvironment |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| WO2019165237A1 (en) | 2018-02-23 | 2019-08-29 | Endocyte, Inc. | Sequencing method for car t cell therapy |
| EA202091982A1 (ru) * | 2018-03-14 | 2021-06-10 | Сиэтл Чилдрен'С Хоспитал (Дба Сиэтл Чилдрен'С Ресёрч Инститьют) | Химерный антигенный рецептор к рецептору il-13 альфа 2 (il13r2) для опухолеспецифической т-клеточной иммунотерапии |
| EP4491718A3 (en) * | 2018-03-14 | 2025-03-26 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | Il-13 receptor alpha 2 targeted, zetakine directed t cell immunotherapy |
| US12090170B2 (en) | 2018-04-06 | 2024-09-17 | The Regents Of The University Of California | Methods of treating glioblastomas |
| WO2019195586A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating egfrviii expressing glioblastomas |
| JP2021524248A (ja) * | 2018-05-21 | 2021-09-13 | バイオセプター・(ユーケー)・リミテッド | 修飾されたリンカードメインを有するキメラ抗原受容体およびその使用 |
| WO2019232523A1 (en) * | 2018-06-01 | 2019-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Il-13/il-4 superkines: immune cell targeting constructs and methods of use thereof |
| US12404497B2 (en) | 2018-06-01 | 2025-09-02 | Medicenna Therapeutics Inc. | Uses and methods for oncolytic virus targeting of IL-4/IL-13 and fusions thereof |
| CN112638478B (zh) | 2018-06-29 | 2025-08-15 | 希望之城公司 | 用于治疗某些自身免疫病症的cd6靶向性嵌合抗原受体 |
| EP3834833A4 (en) * | 2018-08-10 | 2022-05-18 | Eutilex Co., Ltd. | Cancer antigen-specific cytotoxic t cells |
| US20220073585A1 (en) * | 2018-11-06 | 2022-03-10 | Washington University | Chimeric antigen receptor memory-like (carml) nk cells and methods of making and using same |
| WO2020191336A1 (en) | 2019-03-21 | 2020-09-24 | Yamaguchi, Yukiko | Composition and method for reducing expression of checkpoint inhibitors in t cells expressing a car or ctl |
| WO2020205751A1 (en) | 2019-03-29 | 2020-10-08 | City Of Hope | Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors |
| WO2020243007A1 (en) * | 2019-05-24 | 2020-12-03 | City Of Hope | Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies |
| CN112204135A (zh) * | 2019-07-06 | 2021-01-08 | 苏州克睿基因生物科技有限公司 | 一种表达cd3抗体受体复合物的免疫细胞及其用途 |
| WO2021004400A1 (zh) * | 2019-07-06 | 2021-01-14 | 苏州克睿基因生物科技有限公司 | 一种表达cd3抗体受体复合物的免疫细胞及其用途 |
| CN114174345B (zh) * | 2019-07-24 | 2024-11-26 | 瑞泽恩制药公司 | 具有mage-a4特异性的嵌合抗原受体和其用途 |
| EP3769816A1 (en) * | 2019-07-25 | 2021-01-27 | Ospedale Pediatrico Bambino Gesù | Car-cd123 vector and uses thereof |
| US20230076643A1 (en) | 2019-12-30 | 2023-03-09 | City Of Hope | Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers |
| JP2023512250A (ja) * | 2020-01-31 | 2023-03-24 | シティ・オブ・ホープ | IL13Rα2陽性悪性腫瘍の治療のための標的キメラ抗原受容体修飾T細胞 |
| US20230374085A1 (en) * | 2020-03-11 | 2023-11-23 | City Of Hope | Dual-targeting chimeric antigen receptor modified t cells comprising il-13 and chlorotoxin for cancer treatment |
| WO2021183960A1 (en) * | 2020-03-12 | 2021-09-16 | City Of Hope | TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF IL13RαA2 POSITIVE MALIGNANCIES |
| CN115768879A (zh) | 2020-04-28 | 2023-03-07 | 莱尔免疫制药公司 | 用于培养细胞的方法 |
| WO2021242719A1 (en) * | 2020-05-27 | 2021-12-02 | The Medical College Of Wisconsin, Inc. | Improved lentiviral vector transfer plasmid and methods of use |
| GB202011993D0 (en) | 2020-07-31 | 2020-09-16 | Adc Therapeutics Sa | ANTI-IL 13Ra2 antibodies |
| CA3189051A1 (en) * | 2020-08-11 | 2022-02-17 | Yair Reisner | Veto car-t cells |
| CN116963759A (zh) * | 2020-09-10 | 2023-10-27 | 野马生物股份有限公司 | 包含靶向癌症的car-t细胞的组合疗法及使用其治疗癌症的方法 |
| WO2022098797A1 (en) * | 2020-11-04 | 2022-05-12 | Fred Hutchinson Cancer Research Center | Therapeutic targeting of mesothelin in acute myeloid leukemia with chimeric antigen receptor t cell therapy |
| US20230364138A1 (en) | 2020-11-23 | 2023-11-16 | City Of Hope | Engineered t cells for expression of chimeric anitgen receptors |
| AU2021392032A1 (en) | 2020-12-03 | 2023-06-22 | Century Therapeutics, Inc. | Genetically engineered cells and uses thereof |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| CN114907485B (zh) * | 2021-02-08 | 2024-04-26 | 浙江大学 | 一种以内源性蛋白质分子替代单结构域抗体的嵌合抗原受体 |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| CA3212593A1 (en) * | 2021-03-18 | 2022-09-22 | David Weiner | Dna-encoded bispecific antibodies targeting il13r?2 and methods of use in cancer therapeutics |
| US20240366662A1 (en) | 2021-03-30 | 2024-11-07 | City Of Hope | Car t cell therapy and ifn gamma |
| US20230190799A1 (en) * | 2021-07-21 | 2023-06-22 | City Of Hope | Chimeric antigen receptor t cells targeting cea and anti-cea-il2 immunocytokines for cancer therapy |
| CN113621077B (zh) * | 2021-09-02 | 2023-01-31 | 山东大学 | 一种tim-3/cd28融合蛋白及所述融合蛋白修饰的car-t细胞 |
| EP4176895A1 (en) * | 2021-11-08 | 2023-05-10 | AvenCell Europe GmbH | Targeting modules against il13ra2 or her2 for use in combination with a chimeric antigen receptor |
| WO2023130462A1 (zh) * | 2022-01-10 | 2023-07-13 | 卡瑞济(北京)生命科技有限公司 | 靶向IL13Rα2的嵌合抗原受体及其用途 |
| CN115960257B (zh) * | 2022-09-29 | 2023-10-27 | 卡瑞济(北京)生命科技有限公司 | 靶向IL13Rα2的经优化的嵌合抗原受体及其用途 |
| EP4588939A1 (en) | 2024-01-16 | 2025-07-23 | Universitat de Barcelona | Interleukin-13 receptor subunit alpha-2 (il13ralpha2) targeting moieties for the treatment and prevention of il13ralpha2-positive cancer |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU643109B2 (en) | 1990-12-14 | 1993-11-04 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| WO1996025953A1 (en) * | 1995-02-24 | 1996-08-29 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
| GB9526131D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Recombinant chimeric receptors |
| US6576232B1 (en) | 1998-04-03 | 2003-06-10 | The Penn State Research Foundation | IL13 mutants |
| PT1100529E (pt) | 1998-07-30 | 2005-10-31 | Us Gov Health & Human Serv | A timosina beta 4 promove a preparacao de feridas |
| AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| AU1599301A (en) * | 1999-11-11 | 2001-06-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Modulating IL-13 activity using mutated IL-13 molecules that are antagonists or agonists of IL-13 |
| US7560280B2 (en) | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| CA2445746C (en) | 2001-04-30 | 2012-09-18 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| US11278594B2 (en) * | 2001-04-30 | 2022-03-22 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| US7514537B2 (en) | 2001-04-30 | 2009-04-07 | City Of Hope | Chimeric immunoreceptor useful in treating human gliomas |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| EP1501226B1 (en) | 2003-07-24 | 2007-09-19 | Matsushita Electric Industrial Co., Ltd. | Method, encoder and communication device for encoding parallel concatenated data |
| US20050113564A1 (en) | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
| US7754441B2 (en) * | 2003-11-17 | 2010-07-13 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| DE102004043271A1 (de) * | 2004-09-07 | 2006-03-09 | Linde Ag | Verfahren zur Synthese von Zirkoniumcarboxylaten |
| JP2008521406A (ja) | 2004-11-24 | 2008-06-26 | フレッド ハッチンソン キャンサー リサーチ センター | 養子免疫療法のためのil−21の使用法および腫瘍抗原の同定法 |
| EP1963551A4 (en) | 2005-12-21 | 2009-07-29 | Univ Montreal | MARKINGS FOR MEMORY T CELLS AND USES THEREOF |
| ATE483470T1 (de) * | 2005-12-21 | 2010-10-15 | Sentoclone Ab | Verfahren zur expansion tumorreaktiver t- lymphozyten zur immuntherapie von patienten mit krebs |
| US20100135974A1 (en) | 2007-01-31 | 2010-06-03 | Yeda Research And Development Co. Ltd. | Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease |
| ES2667729T3 (es) * | 2007-09-26 | 2018-05-14 | Ucb Biopharma Sprl | Fusiones de anticuerpos con doble especificidad |
| PL3006459T3 (pl) * | 2008-08-26 | 2022-01-17 | City Of Hope | Sposób i kompozycje dla wzmocnionego działania efektorowego komórek t przeciw guzowi nowotworowemu |
| AU2010334974A1 (en) * | 2009-12-22 | 2012-07-12 | Novartis Ag | Tetravalent CD47-antibody constant region fusion protein for use in therapy |
| GB2481983A (en) * | 2010-07-12 | 2012-01-18 | Hart Fenton & Co Ltd | A ship including a gas tank room |
| CA2809255A1 (en) * | 2010-08-18 | 2012-02-23 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Methods of identifying central memory t cells and obtaining antigen-specific t cell populations |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| KR101976882B1 (ko) * | 2011-03-23 | 2019-05-09 | 프레드 헛친슨 켄서 리서치 센터 | 세포 면역요법용 방법 및 조성물 |
| KR20160044598A (ko) * | 2011-03-29 | 2016-04-25 | 로슈 글리카트 아게 | 항체 Fc 변이체 |
| EP2532740A1 (en) * | 2011-06-11 | 2012-12-12 | Michael Schmück | Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy |
| JP6850528B2 (ja) * | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| PL2884999T3 (pl) * | 2012-08-20 | 2021-07-05 | Fred Hutchinson Cancer Research Center | Sposób i kompozycje do immunoterapii komórkowej |
| US9657105B2 (en) * | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| EP3626748A1 (en) * | 2014-01-13 | 2020-03-25 | Stephen J. Forman | Chimeric antigen receptors (cars) having mutations in the fc spacer region and methods for their use |
| WO2016044811A1 (en) * | 2014-09-19 | 2016-03-24 | City Of Hope | COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Rα2 |
-
2015
- 2015-09-18 WO PCT/US2015/051089 patent/WO2016044811A1/en not_active Ceased
- 2015-09-18 AU AU2015317351A patent/AU2015317351B2/en active Active
- 2015-09-18 IL IL292650A patent/IL292650B2/en unknown
- 2015-09-18 EP EP15775539.8A patent/EP3194433B1/en active Active
- 2015-09-18 CA CA2961654A patent/CA2961654A1/en active Pending
- 2015-09-18 RU RU2017111298A patent/RU2749922C2/ru active
- 2015-09-18 IL IL308324A patent/IL308324A/en unknown
- 2015-09-18 EP EP19175730.1A patent/EP3587446A1/en not_active Withdrawn
- 2015-09-18 BR BR122024000360-0A patent/BR122024000360A2/pt not_active Application Discontinuation
- 2015-09-18 MX MX2017003596A patent/MX387135B/es unknown
- 2015-09-18 CN CN201580061133.2A patent/CN107002084B/zh active Active
- 2015-09-18 BR BR112017005631-3A patent/BR112017005631A2/pt not_active IP Right Cessation
- 2015-09-18 JP JP2017515139A patent/JP6657195B2/ja active Active
- 2015-09-18 ES ES15775539T patent/ES2738705T3/es active Active
- 2015-09-18 KR KR1020177010183A patent/KR102683584B1/ko active Active
- 2015-09-21 EP EP21166086.5A patent/EP3916084A1/en active Pending
- 2015-09-21 WO PCT/US2015/051280 patent/WO2016044853A1/en not_active Ceased
- 2015-09-21 IL IL251188A patent/IL251188B/en unknown
- 2015-09-21 ES ES15842405T patent/ES2876235T5/es active Active
- 2015-09-21 DK DK15842405.1T patent/DK3200591T3/da active
- 2015-09-21 KR KR1020177010184A patent/KR102610715B1/ko active Active
- 2015-09-21 EP EP15842405.1A patent/EP3200591B2/en active Active
- 2015-09-21 MX MX2017003557A patent/MX383042B/es unknown
- 2015-09-21 BR BR112017005630-5A patent/BR112017005630B1/pt not_active IP Right Cessation
- 2015-09-21 JP JP2017515138A patent/JP6711819B2/ja active Active
- 2015-09-21 CA CA2961676A patent/CA2961676A1/en active Pending
- 2015-09-21 CN CN201580062281.6A patent/CN107404881B/zh active Active
- 2015-09-21 KR KR1020237041649A patent/KR20230169455A/ko not_active Ceased
- 2015-09-21 RU RU2017111300A patent/RU2763523C2/ru active
- 2015-09-21 CN CN202110690954.XA patent/CN113637640A/zh active Pending
-
2016
- 2016-05-27 US US15/167,869 patent/US9914909B2/en active Active
-
2017
- 2017-03-15 IL IL251196A patent/IL251196B/en active IP Right Grant
- 2017-03-16 MX MX2021006400A patent/MX2021006400A/es unknown
- 2017-03-17 MX MX2021012720A patent/MX2021012720A/es unknown
-
2018
- 2018-03-12 US US15/918,901 patent/US10676717B2/en active Active
-
2020
- 2020-02-05 JP JP2020017583A patent/JP6986190B2/ja active Active
- 2020-05-06 US US16/867,803 patent/US20200318069A1/en active Pending
- 2020-05-28 JP JP2020093109A patent/JP7216045B2/ja active Active
- 2020-06-03 AU AU2020203651A patent/AU2020203651A1/en not_active Abandoned
-
2021
- 2021-02-02 IL IL280576A patent/IL280576B/en unknown
- 2021-10-15 JP JP2021169396A patent/JP7171871B2/ja active Active
- 2021-11-30 AU AU2021277651A patent/AU2021277651A1/en not_active Abandoned
-
2022
- 2022-05-08 IL IL292828A patent/IL292828A/en unknown
- 2022-11-02 JP JP2022176776A patent/JP2023014100A/ja active Pending
-
2023
- 2023-01-19 JP JP2023006410A patent/JP2023052506A/ja not_active Ceased
-
2024
- 2024-02-28 AU AU2024201326A patent/AU2024201326A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022017333A5 (enExample) | ||
| JP2022051744A5 (enExample) | ||
| US20240148821A1 (en) | Pharmaceutical use of cyclic peptide compound | |
| JP5548616B2 (ja) | Vegfr−1/nrp−1標的化ペプチド | |
| ES2661500T3 (es) | Variantes de HMGB1 y sus usos | |
| AU2012257774C1 (en) | High-affinity, dimeric inhibitors of PSD-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain | |
| RU2016101711A (ru) | Высокостабильный т-клеточный рецептор и способ его получения и применения | |
| CN102307896A (zh) | 基于ⅲ型纤连蛋白结构域的支架组合物、方法及用途 | |
| US11993645B2 (en) | Compositions comprising R-Spondin (RSPO) surrogate molecules | |
| JP2006513724A5 (enExample) | ||
| JP2011504458A5 (enExample) | ||
| AR066794A1 (es) | Proteina de union que comprende un dominio de union a antigeno que se une al globulomero beta amiloide (20-42), anticuerpos, molecula de acido nucleico que la codifica vector, celula huesped, metodo para su produccion, usos, composicion farmaceutia y metodo de diagnostico | |
| JP2014519852A5 (enExample) | ||
| US11041157B2 (en) | Slit2D2-HSA fusion protein and use thereof against tumours | |
| CN107973838A (zh) | 一种促进皮肤损伤修复的小分子多肽及其应用 | |
| JP2015533372A5 (enExample) | ||
| RU2017104284A (ru) | Выделенные полипептиды cd44 и их применение | |
| ES2987275T3 (es) | Péptido antagonista de la actividad de la interleucina-15 | |
| CN107805282A (zh) | 一种靶向疗法和免疫疗法联合的多肽 | |
| CN107383173A (zh) | 诱导前列腺癌细胞凋亡的多肽及其应用 | |
| CN107446024B (zh) | 一种可拮抗ddx3蛋白rna结合活性的多肽dip-13及其应用 | |
| KR20180086277A (ko) | 폴리펩티드 화합물, 그리고 이의 제조 방법 및 적용 | |
| JP2005512509A5 (enExample) | ||
| CN108084247B (zh) | 一种合成多肽及其合成方法和应用 | |
| CN108676071B (zh) | 一种抗Aβ蛋白聚集的七肽及其应用与编码该合成多肽的基因 |