JP2010531992A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010531992A5 JP2010531992A5 JP2010514187A JP2010514187A JP2010531992A5 JP 2010531992 A5 JP2010531992 A5 JP 2010531992A5 JP 2010514187 A JP2010514187 A JP 2010514187A JP 2010514187 A JP2010514187 A JP 2010514187A JP 2010531992 A5 JP2010531992 A5 JP 2010531992A5
- Authority
- JP
- Japan
- Prior art keywords
- mer
- disease
- peptide
- amyloid
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290812A EP2009445A1 (en) | 2007-06-29 | 2007-06-29 | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
| PCT/IB2008/002671 WO2009004494A2 (en) | 2007-06-29 | 2008-06-26 | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010531992A JP2010531992A (ja) | 2010-09-30 |
| JP2010531992A5 true JP2010531992A5 (enExample) | 2011-08-04 |
Family
ID=38521104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514187A Withdrawn JP2010531992A (ja) | 2007-06-29 | 2008-06-26 | アミロイドβペプチドのオリゴマー形態を検出するためのラクダ科動物の単一ドメイン抗体の使用及びその適用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100266576A1 (enExample) |
| EP (2) | EP2009445A1 (enExample) |
| JP (1) | JP2010531992A (enExample) |
| CA (1) | CA2691699A1 (enExample) |
| WO (1) | WO2009004494A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| PT1976877E (pt) | 2005-11-30 | 2014-04-29 | Abbvie Inc | Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações |
| BRPI0619249A2 (pt) | 2005-11-30 | 2011-09-20 | Abbott Lab | anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| EP2008666A1 (en) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications |
| EP2143735A1 (en) * | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| EP2273273A1 (en) | 2009-07-11 | 2011-01-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | Inhibitors of the nitration of amyloid ß peptides and their uses in the diagnosis and treatment of alzheimer's disease |
| US8337845B2 (en) | 2010-03-03 | 2012-12-25 | Boehringer Ingelheim International Gmbh | A-beta binding polypeptides |
| EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
| CN105348387B (zh) | 2010-08-14 | 2020-08-25 | Abbvie 公司 | β淀粉样蛋白结合蛋白 |
| WO2012058308A2 (en) | 2010-10-26 | 2012-05-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Antibody based reagent that specifically recognizes toxic oligomeric form of beta-amyloid |
| CN103443277B (zh) | 2011-02-18 | 2016-02-24 | 国立大学法人东京农工大学 | 淀粉样蛋白低聚物结合核酸适体 |
| WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
| CA2862999A1 (en) | 2012-01-11 | 2013-07-18 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Bispecific antibody fragments for neurological disease proteins and methods of use |
| EP2873679A1 (en) * | 2013-11-13 | 2015-05-20 | F.Hoffmann-La Roche Ag | Camelid single-domain antibody directed against amyloid bêta and methods for producing conjugates thereof |
| EP2873680A1 (en) | 2013-11-13 | 2015-05-20 | F.Hoffmann-La Roche Ag | Oligopeptide and methods for producing conjugates thereof |
| KR101977410B1 (ko) * | 2018-08-22 | 2019-05-10 | 주식회사 피플바이오 | 당뇨병에 대한 신규 바이오마커 및 그의 용도 |
| JP2020041861A (ja) * | 2018-09-07 | 2020-03-19 | 国立大学法人東京農工大学 | アミロイド線維を形成可能なタンパク質の脂質二重膜上における存在状態を判定する判定方法及びこれを用いた判定装置、スクリーニング方法、アミロイド線維を形成可能なタンパク質のオリゴマーの合成方法並びに人工βシートタンパク質 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
| FR2846667B1 (fr) * | 2002-11-06 | 2004-12-31 | Pasteur Institut | Fragments variables d'anticorps de camelides a chaine unique diriges contre le peptide beta-amyloide 1-42 et leurs applications pour le diagnostic et le traitement des maladies neuroagregatives |
| JP2007522119A (ja) * | 2004-01-28 | 2007-08-09 | キュリックス エーピーエス | アミロイド関連疾患用ワクチンとしてのアミロイドタンパク質のコンジュゲート |
| WO2006040153A2 (en) * | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| AU2005306997B2 (en) * | 2004-10-25 | 2012-07-05 | Merck Sharp & Dohme Corp. | Anti-ADDL antibodies and uses thereof |
-
2007
- 2007-06-29 EP EP07290812A patent/EP2009445A1/en not_active Withdrawn
-
2008
- 2008-06-26 JP JP2010514187A patent/JP2010531992A/ja not_active Withdrawn
- 2008-06-26 EP EP08826009A patent/EP2174142A2/en not_active Withdrawn
- 2008-06-26 CA CA002691699A patent/CA2691699A1/en not_active Abandoned
- 2008-06-26 US US12/667,172 patent/US20100266576A1/en not_active Abandoned
- 2008-06-26 WO PCT/IB2008/002671 patent/WO2009004494A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Qu et al. | New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties | |
| US11793855B2 (en) | TFPI inhibitors and methods of use | |
| Nelson et al. | The 67 kDa laminin receptor: structure, function and role in disease | |
| NZ621196A (en) | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage | |
| US9873720B2 (en) | TFPI inhibitors and methods of use | |
| Matharu et al. | Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease | |
| TW200831530A (en) | Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity | |
| JP2025120320A (ja) | Ｖｉｐｒ２アンタゴニストペプチド | |
| JP2010229093A (ja) | 新規ＣｈｅｍｅｒｉｎＲアゴニスト | |
| HUE031989T2 (en) | Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity | |
| WO2017101786A1 (zh) | 一种多肽化合物及其制备方法与应用 | |
| CN102180947A (zh) | 一种Aβ聚集抑制剂 | |
| CN102516359B (zh) | 一种抗老年痴呆症先导化合物 | |
| CN108084247B (zh) | 一种合成多肽及其合成方法和应用 | |
| CN114096265B (zh) | 衰老进程抑制剂 | |
| CN118027156A (zh) | 一种psd-95抑制剂及其用途 | |
| CN110128503A (zh) | 一种抗Aβ1-42蛋白聚集的合成多肽及其合成方法、应用与编码该合成多肽的基因 | |
| WO2018130170A1 (zh) | 一种肿瘤坏死因子alpha的高亲和性肽及其应用 | |
| ATE544779T1 (de) | Neue, die migration dendritischer zellen induzierende polypeptide, sowie medikamente und pharmazeutische zusammensetzungen, die diese enthalten | |
| JP2025520739A (ja) | ペプチド阻害剤およびその使用 | |
| CN102492022A (zh) | 一种新型抗老年痴呆症先导化合物 | |
| Cain et al. | P001. Alanine scan of limnonectin peptides on the OvertureTM robotic peptide library synthesizer | |
| WO2025154082A1 (en) | Ubiquitin high affinity cyclic peptides and methods of use thereof | |
| CN103209989A (zh) | 环肽化合物或其药用盐及其制备方法 | |
| Lee | 3D organic molecular architectures: Folding into shape |