JP2010531992A - アミロイドβペプチドのオリゴマー形態を検出するためのラクダ科動物の単一ドメイン抗体の使用及びその適用 - Google Patents
アミロイドβペプチドのオリゴマー形態を検出するためのラクダ科動物の単一ドメイン抗体の使用及びその適用 Download PDFInfo
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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| Application Number | Priority Date | Filing Date | Title |
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| EP07290812A EP2009445A1 (en) | 2007-06-29 | 2007-06-29 | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
| PCT/IB2008/002671 WO2009004494A2 (en) | 2007-06-29 | 2008-06-26 | Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications |
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| JP2010531992A true JP2010531992A (ja) | 2010-09-30 |
| JP2010531992A5 JP2010531992A5 (enExample) | 2011-08-04 |
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| JP2010514187A Withdrawn JP2010531992A (ja) | 2007-06-29 | 2008-06-26 | アミロイドβペプチドのオリゴマー形態を検出するためのラクダ科動物の単一ドメイン抗体の使用及びその適用 |
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| Country | Link |
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| US (1) | US20100266576A1 (enExample) |
| EP (2) | EP2009445A1 (enExample) |
| JP (1) | JP2010531992A (enExample) |
| CA (1) | CA2691699A1 (enExample) |
| WO (1) | WO2009004494A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012111842A1 (ja) | 2011-02-18 | 2012-08-23 | 国立大学法人東京農工大学 | アミロイドタンパク質オリゴマー結合アプタマー |
| KR20180100085A (ko) * | 2018-08-22 | 2018-09-07 | 가천대학교 산학협력단 | 당뇨병에 대한 신규 바이오마커 및 그의 용도 |
| JP2020041861A (ja) * | 2018-09-07 | 2020-03-19 | 国立大学法人東京農工大学 | アミロイド線維を形成可能なタンパク質の脂質二重膜上における存在状態を判定する判定方法及びこれを用いた判定装置、スクリーニング方法、アミロイド線維を形成可能なタンパク質のオリゴマーの合成方法並びに人工βシートタンパク質 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| EP2008666A1 (en) * | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications |
| EP2143735A1 (en) * | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| EP2273273A1 (en) * | 2009-07-11 | 2011-01-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | Inhibitors of the nitration of amyloid ß peptides and their uses in the diagnosis and treatment of alzheimer's disease |
| WO2011107507A1 (en) * | 2010-03-03 | 2011-09-09 | Boehringer Ingelheim International Gmbh | Biparatopic abeta binding polypeptides |
| EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| WO2012058334A1 (en) | 2010-10-26 | 2012-05-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Morphology & protein specific reagents as diagnostics for neurodegenerative diseases |
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| WO2013106572A1 (en) | 2012-01-11 | 2013-07-18 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Bispecific antibody fragments for neurological disease proteins and methods of use |
| EP2873679A1 (en) * | 2013-11-13 | 2015-05-20 | F.Hoffmann-La Roche Ag | Camelid single-domain antibody directed against amyloid bêta and methods for producing conjugates thereof |
| EP2873680A1 (en) | 2013-11-13 | 2015-05-20 | F.Hoffmann-La Roche Ag | Oligopeptide and methods for producing conjugates thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
| FR2846667B1 (fr) * | 2002-11-06 | 2004-12-31 | Pasteur Institut | Fragments variables d'anticorps de camelides a chaine unique diriges contre le peptide beta-amyloide 1-42 et leurs applications pour le diagnostic et le traitement des maladies neuroagregatives |
| JP2007522119A (ja) * | 2004-01-28 | 2007-08-09 | キュリックス エーピーエス | アミロイド関連疾患用ワクチンとしてのアミロイドタンパク質のコンジュゲート |
| BRPI0518151A2 (pt) * | 2004-10-13 | 2009-06-16 | Ablynx Nv | polipetìdeos contra amiloide-beta, ácido nucléico que codifica tal polipetìdeo, composição compreendendo tal polipetìdeo, método para produzir um polipetìdeo e uso do mesmo |
| WO2006055178A2 (en) * | 2004-10-25 | 2006-05-26 | Merck & Co., Inc. | Anti-addl antibodies and uses thereof |
-
2007
- 2007-06-29 EP EP07290812A patent/EP2009445A1/en not_active Withdrawn
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2008
- 2008-06-26 CA CA002691699A patent/CA2691699A1/en not_active Abandoned
- 2008-06-26 US US12/667,172 patent/US20100266576A1/en not_active Abandoned
- 2008-06-26 JP JP2010514187A patent/JP2010531992A/ja not_active Withdrawn
- 2008-06-26 WO PCT/IB2008/002671 patent/WO2009004494A2/en not_active Ceased
- 2008-06-26 EP EP08826009A patent/EP2174142A2/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012111842A1 (ja) | 2011-02-18 | 2012-08-23 | 国立大学法人東京農工大学 | アミロイドタンパク質オリゴマー結合アプタマー |
| US9238816B2 (en) | 2011-02-18 | 2016-01-19 | National University Corporation Tokyo University Of Agriculture And Technology | Amyloid protein oligomer-binding aptamer |
| KR20180100085A (ko) * | 2018-08-22 | 2018-09-07 | 가천대학교 산학협력단 | 당뇨병에 대한 신규 바이오마커 및 그의 용도 |
| KR101977410B1 (ko) | 2018-08-22 | 2019-05-10 | 주식회사 피플바이오 | 당뇨병에 대한 신규 바이오마커 및 그의 용도 |
| JP2020041861A (ja) * | 2018-09-07 | 2020-03-19 | 国立大学法人東京農工大学 | アミロイド線維を形成可能なタンパク質の脂質二重膜上における存在状態を判定する判定方法及びこれを用いた判定装置、スクリーニング方法、アミロイド線維を形成可能なタンパク質のオリゴマーの合成方法並びに人工βシートタンパク質 |
| JP2022160547A (ja) * | 2018-09-07 | 2022-10-19 | 国立大学法人東京農工大学 | アミロイド線維を形成可能なタンパク質の脂質二重膜上における存在状態を判定する判定方法及びこれを用いた判定装置、スクリーニング方法、アミロイド線維を形成可能なタンパク質のオリゴマーの合成方法並びに人工βシートタンパク質 |
| JP7387954B2 (ja) | 2018-09-07 | 2023-11-29 | 国立大学法人東京農工大学 | アミロイド線維を形成可能なタンパク質の脂質二重膜上における存在状態を判定する判定方法、アミロイド線維を形成するβシートタンパク質における凝集体の形成を制御する凝集制御剤のスクリーニング方法、アミロイド線維を形成可能なタンパク質のオリゴマーの合成方法、及び人工βシートタンパク質 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2009445A1 (en) | 2008-12-31 |
| WO2009004494A3 (en) | 2009-04-02 |
| EP2174142A2 (en) | 2010-04-14 |
| CA2691699A1 (en) | 2009-01-08 |
| US20100266576A1 (en) | 2010-10-21 |
| WO2009004494A2 (en) | 2009-01-08 |
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