JP2022000444A5 - - Google Patents
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- JP2022000444A5 JP2022000444A5 JP2021152371A JP2021152371A JP2022000444A5 JP 2022000444 A5 JP2022000444 A5 JP 2022000444A5 JP 2021152371 A JP2021152371 A JP 2021152371A JP 2021152371 A JP2021152371 A JP 2021152371A JP 2022000444 A5 JP2022000444 A5 JP 2022000444A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pseudo
- alkenyl
- solid phase
- single bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000006239 protecting group Chemical group 0.000 claims 28
- 239000007790 solid phase Substances 0.000 claims 22
- 239000002777 nucleoside Substances 0.000 claims 19
- 108091034117 Oligonucleotide Proteins 0.000 claims 17
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 16
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 16
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 16
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 15
- 125000000262 haloalkenyl group Chemical group 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 8
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 6
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003835 nucleoside group Chemical group 0.000 claims 4
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023079618A JP7531018B2 (ja) | 2015-11-17 | 2023-05-12 | オリゴヌクレオチドの製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015224617 | 2015-11-17 | ||
| JP2015224617 | 2015-11-17 | ||
| JP2017551927A JP6950529B2 (ja) | 2015-11-17 | 2016-11-17 | オリゴヌクレオチドの製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551927A Division JP6950529B2 (ja) | 2015-11-17 | 2016-11-17 | オリゴヌクレオチドの製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023079618A Division JP7531018B2 (ja) | 2015-11-17 | 2023-05-12 | オリゴヌクレオチドの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022000444A JP2022000444A (ja) | 2022-01-04 |
| JP2022000444A5 true JP2022000444A5 (https=) | 2022-11-29 |
Family
ID=58718980
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551927A Active JP6950529B2 (ja) | 2015-11-17 | 2016-11-17 | オリゴヌクレオチドの製造方法 |
| JP2021152371A Pending JP2022000444A (ja) | 2015-11-17 | 2021-09-17 | オリゴヌクレオチドの製造方法 |
| JP2023079618A Active JP7531018B2 (ja) | 2015-11-17 | 2023-05-12 | オリゴヌクレオチドの製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551927A Active JP6950529B2 (ja) | 2015-11-17 | 2016-11-17 | オリゴヌクレオチドの製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023079618A Active JP7531018B2 (ja) | 2015-11-17 | 2023-05-12 | オリゴヌクレオチドの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11548910B2 (https=) |
| EP (1) | EP3378869A4 (https=) |
| JP (3) | JP6950529B2 (https=) |
| CN (1) | CN108350018A (https=) |
| TW (1) | TWI729028B (https=) |
| WO (1) | WO2017086397A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108350018A (zh) * | 2015-11-17 | 2018-07-31 | 日产化学工业株式会社 | 寡核苷酸的制造方法 |
| WO2017104836A1 (ja) | 2015-12-16 | 2017-06-22 | 味の素株式会社 | オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド |
| JPWO2017111137A1 (ja) | 2015-12-22 | 2018-10-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| WO2017221929A1 (ja) * | 2016-06-21 | 2017-12-28 | 株式会社ジーンデザイン | リボ核酸ｈ－ホスホネートモノマーの合成方法および本モノマーを用いたオリゴヌクレオチド合成 |
| TW201906855A (zh) * | 2017-05-02 | 2019-02-16 | 日商日產化學工業股份有限公司 | 寡核苷酸之製造方法 |
| WO2018212236A1 (ja) * | 2017-05-16 | 2018-11-22 | 日産化学株式会社 | オリゴヌクレオチドの製造方法 |
| US11891412B2 (en) | 2017-12-27 | 2024-02-06 | Knc Laboratories Co., Ltd. | Production of highly fat-soluble phosphoramidite |
| CN108586449A (zh) * | 2018-06-08 | 2018-09-28 | 山东阳谷华泰化工股份有限公司 | 一种n-（2-巯基苯并噻唑）邻苯二甲酰亚胺及其制备方法和应用 |
| JP7296636B2 (ja) * | 2018-07-20 | 2023-06-23 | 藤本化学製品株式会社 | アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法 |
| JP6770553B2 (ja) | 2018-07-20 | 2020-10-14 | 藤本化学製品株式会社 | アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法 |
| WO2020166705A1 (ja) | 2019-02-15 | 2020-08-20 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| JP7632276B2 (ja) * | 2019-03-28 | 2025-02-19 | 味の素株式会社 | ホスホロチオエート化部位を有するオリゴヌクレオチドの製造方法 |
| CN113924309A (zh) * | 2019-05-21 | 2022-01-11 | 株式会社纳蒂亚斯 | 寡核苷酸合成中使用的多氟嵌段聚体以及使用其的寡核苷酸合成方法 |
| AU2021377229A1 (en) * | 2020-11-11 | 2023-06-29 | Biogen Ma Inc. | Oligonucleotides, reagents and preparation thereof |
| KR20240028416A (ko) * | 2021-07-06 | 2024-03-05 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머를 함유하는 조성물 |
| JP7220439B1 (ja) * | 2022-03-14 | 2023-02-10 | 国立大学法人東北大学 | キメラ分子の製造方法 |
| WO2024083746A1 (en) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
| CN120813558A (zh) | 2023-03-06 | 2025-10-17 | 斯佩拉制药株式会社 | 长链烯氧基取代的苯甲酰衍生物及使用该衍生物的寡核苷酸合成方法 |
| JPWO2024228396A1 (https=) | 2023-05-01 | 2024-11-07 | ||
| JP7433684B1 (ja) | 2023-05-24 | 2024-02-20 | 塩野フィネス株式会社 | 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法 |
| EP4695265A1 (en) | 2023-10-16 | 2026-02-18 | Bachem Holding AG | Method and composition for oligonucleotide synthesis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3707529A (en) * | 1970-09-04 | 1972-12-26 | Du Pont | Elastomeric vinylidene fluoride polymers with 55-95 percent non-ionic end groups |
| US3860722A (en) * | 1972-09-22 | 1975-01-14 | Richardson Merrell Inc | Hypolipidemic agents |
| JPS60174797A (ja) | 1984-02-21 | 1985-09-09 | Funai Corp | Ν−アロイルチミジン誘導体ならびに抗腫瘍活性物質の毒性低下剤 |
| EP0863910A1 (en) | 1995-10-19 | 1998-09-16 | NeXstar Pharmaceuticals, Inc. | Method for solution phase synthesis of oligonucleotides |
| JP2004503560A (ja) | 2000-06-13 | 2004-02-05 | プロリゴ・エルエルシー | 固相オリゴ合成の普遍固形支持体とその製造及び使用の方法 |
| JP3947483B2 (ja) | 2003-02-28 | 2007-07-18 | 財団法人野口研究所 | ジアミド型ゲル化剤 |
| KR20070087266A (ko) * | 2003-04-03 | 2007-08-28 | 세마포르 파머슈티컬즈, 아이엔씨. | 피아이-3 키나아제 억제제 프로드러그 |
| WO2005028494A1 (ja) | 2003-09-02 | 2005-03-31 | Takeshi Wada | ５'-ホスフィチル化モノマーおよびh-ホスホネートオリゴヌクレオチド誘導体の製造方法 |
| JP5548852B2 (ja) * | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| CN102139203B (zh) * | 2011-01-14 | 2013-01-23 | 河北师范大学 | 一种选择性凝胶化苯胺(或取代苯胺)的有机小分子凝胶剂及其应用 |
| JP5979139B2 (ja) * | 2011-05-17 | 2016-08-24 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| EP2816053B1 (en) * | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| EP2857412B1 (en) | 2012-05-30 | 2017-01-11 | Hokkaido System Science Co., Ltd. | Oligonucleotide synthesis method using highly dispersible liquid-phase support |
| US9303056B2 (en) | 2012-07-25 | 2016-04-05 | Kochi University | Monomer for synthesis of RNA, method for producing same, and method for producing RNA |
| EP2921499B1 (en) * | 2012-11-14 | 2020-01-22 | Takeda Pharmaceutical Company Limited | Method for liquid-phase synthesis of nucleic acids |
| EP3263579B1 (en) * | 2015-01-21 | 2022-11-30 | Ajinomoto Co., Inc. | Precipitation promoter and precipitation method in which same is used |
| CN108350018A (zh) * | 2015-11-17 | 2018-07-31 | 日产化学工业株式会社 | 寡核苷酸的制造方法 |
| WO2017104836A1 (ja) * | 2015-12-16 | 2017-06-22 | 味の素株式会社 | オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド |
-
2016
- 2016-11-17 CN CN201680064758.9A patent/CN108350018A/zh active Pending
- 2016-11-17 WO PCT/JP2016/084150 patent/WO2017086397A1/ja not_active Ceased
- 2016-11-17 US US15/776,709 patent/US11548910B2/en active Active
- 2016-11-17 TW TW105137671A patent/TWI729028B/zh not_active IP Right Cessation
- 2016-11-17 JP JP2017551927A patent/JP6950529B2/ja active Active
- 2016-11-17 EP EP16866398.7A patent/EP3378869A4/en not_active Withdrawn
-
2021
- 2021-09-17 JP JP2021152371A patent/JP2022000444A/ja active Pending
-
2023
- 2023-05-12 JP JP2023079618A patent/JP7531018B2/ja active Active
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