|
US4711955A
(en)
|
1981-04-17 |
1987-12-08 |
Yale University |
Modified nucleotides and methods of preparing and using same
|
|
CA1223831A
(en)
|
1982-06-23 |
1987-07-07 |
Dean Engelhardt |
Modified nucleotides, methods of preparing and utilizing and compositions containing the same
|
|
DE3538677A1
(de)
|
1985-10-31 |
1987-05-07 |
Schloemann Siemag Ag |
Wendehaspel
|
|
DE69233046T2
(de)
|
1991-10-24 |
2004-03-04 |
Isis Pharmaceuticals, Inc., Carlsfeld |
Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen
|
|
US5792608A
(en)
|
1991-12-12 |
1998-08-11 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
|
NL9201440A
(nl)
|
1992-08-11 |
1994-03-01 |
Univ Leiden |
Triantennaire clusterglycosiden, hun bereiding en toepassing.
|
|
JP2002502222A
(ja)
*
|
1992-11-06 |
2002-01-22 |
ノバーティス アクチエンゲゼルシャフト |
Ｂ型肝炎表面抗原に対して活性なヒトモノクローナル抗体の生産
|
|
US20040157780A1
(en)
|
1993-11-29 |
2004-08-12 |
Epimmune Inc. |
CTL inducing peptides from c-erb2 (HER-2/neu)
|
|
EP0754238A4
(en)
|
1994-04-05 |
1998-01-28 |
Pharmagenics Inc |
DETERMINATION AND IDENTIFICATION OF ACTIVE SUBSTANCES IN SUBSTANCE LIBRARIES
|
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
JP4236812B2
(ja)
|
1997-09-12 |
2009-03-11 |
エクシコン エ／エス |
オリゴヌクレオチド類似体
|
|
ES2234563T5
(es)
|
1999-02-12 |
2018-01-17 |
Daiichi Sankyo Company, Limited |
Nuevos análogos de nucleósidos y oligonucleótidos
|
|
US7053207B2
(en)
|
1999-05-04 |
2006-05-30 |
Exiqon A/S |
L-ribo-LNA analogues
|
|
US6617442B1
(en)
|
1999-09-30 |
2003-09-09 |
Isis Pharmaceuticals, Inc. |
Human Rnase H1 and oligonucleotide compositions thereof
|
|
WO2003022987A2
(en)
|
2001-07-26 |
2003-03-20 |
Eos Biotechnology, Inc. |
Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection
|
|
AU2003295600A1
(en)
|
2002-11-14 |
2004-06-15 |
Dharmacon, Inc. |
Functional and hyperfunctional sirna
|
|
WO2004046160A2
(en)
|
2002-11-18 |
2004-06-03 |
Santaris Pharma A/S |
Amino-lna, thio-lna and alpha-l-oxy-ln
|
|
US20060257851A1
(en)
|
2002-11-26 |
2006-11-16 |
Itzhak Bentwich |
Bioinformatically detectable group of novel viral regulatory genes and uses thereof
|
|
EP2270162B1
(en)
|
2003-06-12 |
2018-10-03 |
Alnylam Pharmaceuticals Inc. |
Conserved hbv and hcv sequences useful for gene silencing
|
|
US7374927B2
(en)
|
2004-05-03 |
2008-05-20 |
Affymetrix, Inc. |
Methods of analysis of degraded nucleic acid samples
|
|
WO2005116204A1
(ja)
|
2004-05-11 |
2005-12-08 |
Rnai Co., Ltd. |
Ｒｎａ干渉を生じさせるポリヌクレオチド、および、これを用いた遺伝子発現抑制方法
|
|
US20070154896A1
(en)
|
2005-02-11 |
2007-07-05 |
International Business Machines Corporation |
System and method for identification of MicroRNA target sites and corresponding targeting MicroRNA sequences
|
|
WO2007031091A2
(en)
|
2005-09-15 |
2007-03-22 |
Santaris Pharma A/S |
Rna antagonist compounds for the modulation of p21 ras expression
|
|
WO2007090071A2
(en)
|
2006-01-27 |
2007-08-09 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
AU2007225238A1
(en)
|
2006-03-10 |
2007-09-20 |
Wyeth |
Microarray for monitoring gene expression in multiple strains of Streptococcus pneumoniae
|
|
JP2009536222A
(ja)
|
2006-05-05 |
2009-10-08 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
Ｐｃｓｋ９の発現を調節するための化合物および方法
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
AU2007249349B2
(en)
|
2006-05-11 |
2012-03-08 |
Isis Pharmaceuticals, Inc. |
5'-Modified bicyclic nucleic acid analogs
|
|
WO2008082730A2
(en)
|
2006-09-19 |
2008-07-10 |
Novartis Ag |
Biomarkers of target modulation, efficacy, diagnosis and/or prognosis for raf inhibitors
|
|
ES2526295T5
(es)
|
2006-10-18 |
2021-05-04 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido
|
|
DK2149605T3
(da)
|
2007-03-22 |
2013-09-30 |
Santaris Pharma As |
Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
|
|
CA2688321A1
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
|
AU2008272918B2
(en)
|
2007-07-05 |
2012-09-13 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
WO2009043759A2
(en)
|
2007-10-04 |
2009-04-09 |
Santaris Pharma A/S |
Short rna antagonist compounds for the modulation of hif1alpha
|
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
|
US20090203037A1
(en)
|
2007-12-27 |
2009-08-13 |
Abbott Laboratories |
Anti-T. Cruzi Antibodies and Methods of Use
|
|
WO2009090182A1
(en)
|
2008-01-14 |
2009-07-23 |
Santaris Pharma A/S |
C4'-substituted - dna nucleotide gapmer oligonucleotides
|
|
US9290534B2
(en)
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
|
WO2010006111A2
(en)
|
2008-07-10 |
2010-01-14 |
Merck & Co., Inc. |
Methods of using compositions comprising mir-192 and/or mir-215 for the treatment of cancer
|
|
DK2356129T3
(da)
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituerede alpha-L-bicykliske nukleosider
|
|
EP2177615A1
(en)
|
2008-10-10 |
2010-04-21 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
|
|
US20100249214A1
(en)
|
2009-02-11 |
2010-09-30 |
Dicerna Pharmaceuticals |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
KR101728655B1
(ko)
|
2008-12-18 |
2017-04-19 |
다이서나 파마수이티컬, 인크. |
유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법
|
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
BR112012008865A2
(pt)
|
2009-10-16 |
2019-09-24 |
Glaxo Group Ltd |
inibidores de hbv anti-sentido.
|
|
JP2013126374A
(ja)
|
2010-03-04 |
2013-06-27 |
Kyushu Univ |
イソフラボン類の作用に関連する遺伝子
|
|
EP2580228B1
(en)
|
2010-06-08 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US9029341B2
(en)
|
2010-08-17 |
2015-05-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
|
|
LT3124610T
(lt)
|
2010-10-28 |
2019-08-12 |
Benitec Biopharma Limited |
Hbv gydymas
|
|
EP2673361B1
(en)
|
2011-02-08 |
2016-04-13 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
RS61447B1
(sr)
|
2011-04-21 |
2021-03-31 |
Glaxo Group Ltd |
Modulacija ekspresije virusa hepatitisa b (hbv)
|
|
EA024762B9
(ru)
|
2011-06-30 |
2017-04-28 |
Эрроухэд Рисерч Корпорейшн |
Композиции и способы ингибирования экспрессии генов вируса гепатита в
|
|
US10202599B2
(en)
|
2011-08-11 |
2019-02-12 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
WO2013033230A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
EP2753631A1
(en)
|
2011-09-07 |
2014-07-16 |
Marina Biotech, Inc. |
Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
|
|
WO2013113326A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
CA2869729C
(en)
|
2012-04-10 |
2021-12-28 |
Vib Vzw |
Novel markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the dna base excision repair pathway
|
|
WO2013159109A1
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Modulation of hepatitis b virus (hbv) expression
|
|
WO2013166264A2
(en)
|
2012-05-02 |
2013-11-07 |
University Of Georgia Research Foundation, Inc. |
Methods for altering virus replication
|
|
KR102213609B1
(ko)
|
2012-07-13 |
2021-02-08 |
웨이브 라이프 사이언시스 리미티드 |
키랄 제어
|
|
CA2882966A1
(en)
|
2012-08-31 |
2014-03-06 |
Aptamir Therapeutics, Inc. |
Mirna modulators of chronic visceral inflammation
|
|
CN104837996A
(zh)
|
2012-11-15 |
2015-08-12 |
罗氏创新中心哥本哈根有限公司 |
抗apob反义缀合物化合物
|
|
AU2014211406B2
(en)
*
|
2013-01-30 |
2019-07-18 |
Roche Innovation Center Copenhagen A/S |
LNA oligonucleotide carbohydrate conjugates
|
|
DK2992098T3
(da)
|
2013-05-01 |
2019-06-17 |
Ionis Pharmaceuticals Inc |
Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression
|
|
WO2014204723A1
(en)
*
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
|
|
HUE048738T2
(hu)
|
2013-06-27 |
2020-08-28 |
Roche Innovation Ct Copenhagen As |
Antiszensz oligomerek és konjugátumok, amelyek a PCK9-t célozzák meg
|
|
CN105980615A
(zh)
|
2013-08-28 |
2016-09-28 |
卡里斯生命科学瑞士控股有限公司 |
寡核苷酸探针及其用途
|
|
EP2845607A1
(en)
*
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
|
EA201691261A1
(ru)
|
2014-01-30 |
2016-11-30 |
Ф. Хоффманн-Ля Рош Аг |
Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b
|
|
CA2935426C
(en)
|
2014-01-30 |
2023-07-25 |
F. Hoffmann-La Roche Ag |
Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target
|
|
KR20160148715A
(ko)
|
2014-05-13 |
2016-12-26 |
에프. 호프만-라 로슈 아게 |
B형 간염 바이러스 감염의 치료 또는 예방을 위한 신규한 다이하이드로퀴놀리진온
|
|
GB201408623D0
(en)
*
|
2014-05-15 |
2014-07-02 |
Santaris Pharma As |
Oligomers and oligomer conjugates
|
|
TW201610169A
(zh)
|
2014-07-01 |
2016-03-16 |
泰瓦藥品工業有限公司 |
利用哺乳動物及人類細胞進行之格拉雷姆（ｇｌａｔｉｒａｍｅｒ）乙酸鹽相關藥物產品之生物特徵化
|
|
EP3201338B1
(en)
|
2014-10-02 |
2021-11-03 |
Arbutus Biopharma Corporation |
Compositions and methods for silencing hepatitis b virus gene expression
|
|
FR3026868B1
(fr)
|
2014-10-02 |
2019-08-16 |
Dav |
Dispositif et procede de commande pour vehicule automobile
|
|
CN106795200B
(zh)
|
2014-10-10 |
2020-06-19 |
豪夫迈·罗氏有限公司 |
Galnac亚磷酰胺、其核酸缀合物及其用途
|
|
US9637485B2
(en)
|
2014-11-03 |
2017-05-02 |
Hoffmann-La Roche Inc. |
6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
|
|
WO2016079183A1
(en)
|
2014-11-19 |
2016-05-26 |
Roche Innovation Center Copenhagen A/S |
Lna chiral phosphorothioates
|
|
WO2016081941A1
(en)
*
|
2014-11-21 |
2016-05-26 |
Caris Science, Inc. |
Oligonucleotide probes and uses thereof
|
|
US10815481B2
(en)
|
2014-12-16 |
2020-10-27 |
Roche Innovation Center Copenhagen A/S |
Chiral library screen
|
|
CN107108610B
(zh)
|
2014-12-30 |
2019-06-04 |
豪夫迈·罗氏有限公司 |
用于治疗和预防肝炎b病毒感染的新的四氢吡啶并嘧啶和四氢吡啶并吡啶化合物
|
|
WO2016127002A1
(en)
*
|
2015-02-04 |
2016-08-11 |
Bristol-Myers Squibb Company |
Lna oligonucleotides with alternating flanks
|
|
HK1244281B
(zh)
|
2015-02-11 |
2020-02-07 |
F. Hoffmann-La Roche Ag |
治疗和预防乙型肝炎病毒感染的2-氧代-6，7-二氢苯并[a]喹嗪-3-甲酸衍生物
|
|
WO2016177655A1
(en)
|
2015-05-04 |
2016-11-10 |
F. Hoffmann-La Roche Ag |
Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of hbsag (hbv surface antigen) and hbv dna production for the treatment of hepatitis b virus infections
|
|
CA2996722A1
(en)
|
2015-07-17 |
2017-01-26 |
Arcturus Therapeutics, Inc. |
Compositions and agents against hepatitis b virus and uses thereof
|
|
AU2016306275A1
(en)
|
2015-08-07 |
2018-02-08 |
Arrowhead Pharmaceuticals, Inc. |
RNAi therapy for Hepatitis B virus infection
|
|
WO2017066796A2
(en)
*
|
2015-10-16 |
2017-04-20 |
The Children's Medical Center Corporation |
Modulators of telomere disease
|
|
WO2017066712A2
(en)
|
2015-10-16 |
2017-04-20 |
The Children's Medical Center Corporation |
Modulators of telomere disease
|
|
RU2747822C2
(ru)
*
|
2016-03-14 |
2021-05-14 |
Ф. Хоффманн-Ля Рош Аг |
Олигонуклеотиды для понижения экспрессии pd-l1
|
|
WO2017178656A1
(en)
|
2016-04-14 |
2017-10-19 |
Roche Innovation Center Copenhagen A/S |
TRITYL-MONO-GalNAc COMPOUNDS AND THEIR USE
|
|
EP4219767A1
(en)
|
2016-06-17 |
2023-08-02 |
F. Hoffmann-La Roche AG |
Papd5 and papd7 inhibitors for treating a hepatitis b infection
|
|
CN109311880B
(zh)
|
2016-06-29 |
2021-09-03 |
豪夫迈·罗氏有限公司 |
用于治疗和预防乙型肝炎病毒感染的新的四氢吡啶并嘧啶类化合物
|
|
WO2018059718A1
(en)
|
2016-09-30 |
2018-04-05 |
Rijk Zwaan Zaadteelt En Zaadhandel B.V. |
Peronospora resistance in spinacia oleracea
|
|
CN111511914B
(zh)
|
2017-10-16 |
2023-11-17 |
豪夫迈·罗氏有限公司 |
减少PAPD5和PAPD7 mRNA的核酸分子用于治疗乙型肝炎感染
|
|
CL2020001638A1
(es)
|
2017-10-16 |
2020-10-16 |
Hoffmann La Roche |
Molécula de ácidos nucleicos para la reducción del arnm de papd5 y papd7 en el tratamiento de la infección de la hepatitis b. (divisional solicitud 202000945)
|
|
IL276043B2
(en)
*
|
2018-01-29 |
2024-06-01 |
Hoffmann La Roche |
Process for the preparation of galnac oligonucleotide conjugates
|
|
CL2019000945A1
(es)
|
2019-04-09 |
2019-07-12 |
Energy Harvest As |
Dispositivo de válvula rotatoria y sus métodos.
|