BR122020018622A2 - Molécula de ácido nucleico para redução de papd5 e papd7 de mrna para o tratamento de infecção hepatite b - Google Patents

Molécula de ácido nucleico para redução de papd5 e papd7 de mrna para o tratamento de infecção hepatite b Download PDF

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Publication number
BR122020018622A2
BR122020018622A2 BR122020018622-4A BR122020018622A BR122020018622A2 BR 122020018622 A2 BR122020018622 A2 BR 122020018622A2 BR 122020018622 A BR122020018622 A BR 122020018622A BR 122020018622 A2 BR122020018622 A2 BR 122020018622A2
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Brazil
Prior art keywords
oligonucleotide
antisense oligonucleotide
nucleosides
conjugated
papd7
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BR122020018622-4A
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English (en)
Portuguese (pt)
Inventor
Susanne Kammler
Anaïs Lopez
Henrik Mueller
Søren OTTOSEN
Lykke Pedersen
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F. Hoffmann-La Roche Ag
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Publication of BR122020018622A2 publication Critical patent/BR122020018622A2/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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BR122020018622-4A 2017-10-16 2018-10-16 Molécula de ácido nucleico para redução de papd5 e papd7 de mrna para o tratamento de infecção hepatite b BR122020018622A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17196554 2017-10-16
EP17196554.4 2017-10-16
EP17208056.6 2017-12-18
EP17208056 2017-12-18
BR112020007417-9 2018-10-16
BR112020007417-9A BR112020007417A2 (pt) 2017-10-16 2018-10-16 molécula de ácido nucleico para redução de papd5 e papd7 de mrna para o tratamento de infecção hepatite b
PCT/EP2018/078136 WO2019076842A1 (en) 2017-10-16 2018-10-16 NUCLEIC ACID MOLECULE FOR THE REDUCTION OF PAPD5 AND PAPD7 MRNA FOR THE TREATMENT OF HEPATITIS B INFECTION

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BR122020018622A2 true BR122020018622A2 (pt) 2021-02-09

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BR122020018622-4A BR122020018622A2 (pt) 2017-10-16 2018-10-16 Molécula de ácido nucleico para redução de papd5 e papd7 de mrna para o tratamento de infecção hepatite b
BR112020007417-9A BR112020007417A2 (pt) 2017-10-16 2018-10-16 molécula de ácido nucleico para redução de papd5 e papd7 de mrna para o tratamento de infecção hepatite b

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BR112020007417-9A BR112020007417A2 (pt) 2017-10-16 2018-10-16 molécula de ácido nucleico para redução de papd5 e papd7 de mrna para o tratamento de infecção hepatite b

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US (4) US10953034B2 (https=)
EP (1) EP3645723A1 (https=)
JP (4) JP2021500013A (https=)
KR (5) KR102769100B1 (https=)
CN (2) CN111511914B (https=)
AU (3) AU2018350693B2 (https=)
BR (2) BR122020018622A2 (https=)
CA (1) CA3072314A1 (https=)
CL (1) CL2020000945A1 (https=)
CR (2) CR20200205A (https=)
IL (2) IL272566B2 (https=)
MA (1) MA52151A (https=)
MX (1) MX2020003464A (https=)
PE (1) PE20200868A1 (https=)
PH (1) PH12020550436A1 (https=)
RU (1) RU2766360C2 (https=)
SG (1) SG11202003461TA (https=)
TW (3) TWI762732B (https=)
UA (1) UA126931C2 (https=)
WO (1) WO2019076842A1 (https=)

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EP4219767A1 (en) 2016-06-17 2023-08-02 F. Hoffmann-La Roche AG Papd5 and papd7 inhibitors for treating a hepatitis b infection
CN111511914B (zh) 2017-10-16 2023-11-17 豪夫迈·罗氏有限公司 减少PAPD5和PAPD7 mRNA的核酸分子用于治疗乙型肝炎感染
WO2019157531A1 (en) * 2018-02-12 2019-08-15 Ionis Pharmaceuticals, Inc. Modified compounds and uses thereof
PE20210346A1 (es) 2018-07-03 2021-02-25 Hoffmann La Roche Oligonucleotidos para modular la expresion de tau
CN112534055A (zh) 2018-07-13 2021-03-19 豪夫迈·罗氏有限公司 用于调节rtel1表达的寡核苷酸
US20220220483A1 (en) * 2019-05-30 2022-07-14 Seoul National University R&Db Foundation Method for inhibiting infection and activation of virus
SG11202112741XA (en) * 2019-05-31 2021-12-30 Aligos Therapeutics Inc Modified gapmer oligonucleotides and methods of use
EP4081217A1 (en) * 2019-12-24 2022-11-02 F. Hoffmann-La Roche AG Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
WO2022109129A1 (en) * 2020-11-20 2022-05-27 Aligos Therapeutics, Inc. Conjugates of s-antigen transport inhibiting oligonucleotide polymers having enhanced liver targeting
WO2025199466A1 (en) 2024-03-22 2025-09-25 Purdue Research Foundation Liver-specific asialoglycoprotein receptor targeting ligands, conjugates comprising same, and related compositions and methods of use

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