JP2019512498A5 - - Google Patents
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- JP2019512498A5 JP2019512498A5 JP2018548393A JP2018548393A JP2019512498A5 JP 2019512498 A5 JP2019512498 A5 JP 2019512498A5 JP 2018548393 A JP2018548393 A JP 2018548393A JP 2018548393 A JP2018548393 A JP 2018548393A JP 2019512498 A5 JP2019512498 A5 JP 2019512498A5
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- JP
- Japan
- Prior art keywords
- antisense oligonucleotide
- pharmaceutical composition
- composition according
- conjugate
- oligonucleotide conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16160149.7 | 2016-03-14 | ||
| EP16160149 | 2016-03-14 | ||
| PCT/EP2017/055925 WO2017157899A1 (en) | 2016-03-14 | 2017-03-14 | Oligonucleotides for reduction of pd-l1 expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020106728A Division JP7002603B2 (ja) | 2016-03-14 | 2020-06-22 | Ｐｄ－ｌ１発現低減用のオリゴヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019512498A JP2019512498A (ja) | 2019-05-16 |
| JP2019512498A5 true JP2019512498A5 (https=) | 2020-04-16 |
| JP6748219B2 JP6748219B2 (ja) | 2020-08-26 |
Family
ID=58314191
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548393A Active JP6748219B2 (ja) | 2016-03-14 | 2017-03-14 | Ｐｄ−ｌ１発現低減用のオリゴヌクレオチド |
| JP2020106728A Active JP7002603B2 (ja) | 2016-03-14 | 2020-06-22 | Ｐｄ－ｌ１発現低減用のオリゴヌクレオチド |
| JP2021212541A Active JP7447073B2 (ja) | 2016-03-14 | 2021-12-27 | Ｐｄ－ｌ１発現低減用のオリゴヌクレオチド |
| JP2024000251A Active JP7791222B2 (ja) | 2016-03-14 | 2024-01-04 | Ｐｄ－ｌ１発現低減用のオリゴヌクレオチド |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020106728A Active JP7002603B2 (ja) | 2016-03-14 | 2020-06-22 | Ｐｄ－ｌ１発現低減用のオリゴヌクレオチド |
| JP2021212541A Active JP7447073B2 (ja) | 2016-03-14 | 2021-12-27 | Ｐｄ－ｌ１発現低減用のオリゴヌクレオチド |
| JP2024000251A Active JP7791222B2 (ja) | 2016-03-14 | 2024-01-04 | Ｐｄ－ｌ１発現低減用のオリゴヌクレオチド |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US20170283496A1 (https=) |
| EP (2) | EP3430141B1 (https=) |
| JP (4) | JP6748219B2 (https=) |
| KR (5) | KR102580776B1 (https=) |
| CN (5) | CN114736900B (https=) |
| AR (2) | AR108038A1 (https=) |
| AU (4) | AU2017235278C1 (https=) |
| CA (2) | CA3013683C (https=) |
| CL (4) | CL2018002570A1 (https=) |
| CO (1) | CO2018007761A2 (https=) |
| CR (2) | CR20180432A (https=) |
| DK (1) | DK3430141T3 (https=) |
| ES (1) | ES2857702T3 (https=) |
| HR (1) | HRP20210315T1 (https=) |
| HU (1) | HUE053172T2 (https=) |
| IL (5) | IL317818A (https=) |
| LT (1) | LT3430141T (https=) |
| MX (2) | MX2018010830A (https=) |
| MY (1) | MY194912A (https=) |
| PE (3) | PE20201499A1 (https=) |
| PH (1) | PH12018501964A1 (https=) |
| PL (1) | PL3430141T3 (https=) |
| PT (1) | PT3430141T (https=) |
| RS (1) | RS61528B1 (https=) |
| RU (1) | RU2747822C2 (https=) |
| SG (1) | SG11201807854SA (https=) |
| SI (1) | SI3430141T1 (https=) |
| TW (5) | TW202428874A (https=) |
| UA (1) | UA127432C2 (https=) |
| WO (1) | WO2017157899A1 (https=) |
Families Citing this family (45)
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| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108047A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| BR112016016400A2 (pt) | 2014-01-16 | 2017-10-03 | Wave Life Sciences Ltd | Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos |
| US20180214487A1 (en) | 2015-07-21 | 2018-08-02 | The Children's Medical Center Corporation | Pd-l1 expressing hematopoietic stem cells and uses |
| RU2747822C2 (ru) | 2016-03-14 | 2021-05-14 | Ф. Хоффманн-Ля Рош Аг | Олигонуклеотиды для понижения экспрессии pd-l1 |
| WO2017220751A1 (en) | 2016-06-22 | 2017-12-28 | Proqr Therapeutics Ii B.V. | Single-stranded rna-editing oligonucleotides |
| EP3494219A1 (en) * | 2016-08-03 | 2019-06-12 | Aalborg Universitet | ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS |
| CN110352244B (zh) | 2016-09-01 | 2023-03-21 | ProQR治疗上市公司Ⅱ | 化学修饰的编辑rna的单链寡核苷酸 |
| CN110191952A (zh) * | 2016-10-07 | 2019-08-30 | 瑟卡尔纳制药有限公司 | 治疗癌症的新方法 |
| US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
| CN111511914B (zh) * | 2017-10-16 | 2023-11-17 | 豪夫迈·罗氏有限公司 | 减少PAPD5和PAPD7 mRNA的核酸分子用于治疗乙型肝炎感染 |
| UA128786C2 (uk) | 2017-10-20 | 2024-10-23 | Дайсерна Фармасьютикалз, Інк | Олігонуклеотид для лікування інфекції гепатиту в |
| CN120310791A (zh) | 2018-01-12 | 2025-07-15 | 百时美施贵宝公司 | 靶向α-突触核蛋白的反义寡核苷酸及其用途 |
| SG11202006528XA (en) | 2018-01-12 | 2020-08-28 | Bristol Myers Squibb Co | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| EP3810776A1 (en) | 2018-06-22 | 2021-04-28 | F. Hoffmann-La Roche AG | Oligonucleotides for modulating scn9a expression |
| WO2020007772A1 (en) * | 2018-07-02 | 2020-01-09 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting gbp-1 |
| WO2020011653A1 (en) * | 2018-07-09 | 2020-01-16 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting kynu |
| CN112534055A (zh) | 2018-07-13 | 2021-03-19 | 豪夫迈·罗氏有限公司 | 用于调节rtel1表达的寡核苷酸 |
| US20210380978A1 (en) * | 2018-10-15 | 2021-12-09 | The Brigham And Women`S Hospital, Inc. | The long non-coding RNA INCA1 and Homo sapiens heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1) as therapeutic targets for immunotherapy |
| CN113507942A (zh) * | 2019-03-05 | 2021-10-15 | 豪夫迈·罗氏有限公司 | 分子的细胞内靶向 |
| US20220177894A1 (en) | 2019-04-02 | 2022-06-09 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for immunotherapy |
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| WO2021122735A1 (en) * | 2019-12-19 | 2021-06-24 | F. Hoffmann-La Roche Ag | Use of sept9 inhibitors for treating hepatitis b virus infection |
| EP4077672A1 (en) * | 2019-12-20 | 2022-10-26 | F. Hoffmann-La Roche AG | Enhanced oligonucleotides for inhibiting scn9a expression |
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| TW202221122A (zh) | 2020-08-05 | 2022-06-01 | 瑞士商赫孚孟拉羅股份公司 | Ｂ型肝炎患者之寡核苷酸治療 |
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| TW202246500A (zh) * | 2021-02-02 | 2022-12-01 | 瑞士商赫孚孟拉羅股份公司 | 用於抑制 ｒｔｅｌ１ 表現之增強型寡核苷酸 |
| CN115216474B (zh) * | 2021-04-15 | 2025-09-30 | 武汉大学 | 促进pd-l1外显子3跳跃的反义寡核苷酸及其应用 |
| EP4380623A4 (en) * | 2021-08-04 | 2026-05-06 | Hepagene Therapeutics Hk Ltd | Ligand conjugates for delivery of therapeutically active agents |
| CN113789324B (zh) * | 2021-08-17 | 2023-08-25 | 广东省大湾区华南理工大学聚集诱导发光高等研究院 | 一种aie探针及其制备方法与在荧光定量pcr方法中的应用 |
| KR20240101580A9 (ko) | 2021-11-11 | 2025-12-10 | 에프. 호프만-라 로슈 아게 | Hbv 치료를 위한 약학 조합물 |
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| CN116597936A (zh) * | 2023-01-30 | 2023-08-15 | 溪砾科技(深圳)有限公司 | 一种识别mRNA非翻译区药物作用靶点的方法、装置及计算机可读存储介质 |
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