JP2021516240A5 - - Google Patents
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- JP2021516240A5 JP2021516240A5 JP2020546499A JP2020546499A JP2021516240A5 JP 2021516240 A5 JP2021516240 A5 JP 2021516240A5 JP 2020546499 A JP2020546499 A JP 2020546499A JP 2020546499 A JP2020546499 A JP 2020546499A JP 2021516240 A5 JP2021516240 A5 JP 2021516240A5
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- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- halo
- hydrogen
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 77
- 229910052739 hydrogen Inorganic materials 0.000 claims 42
- 239000001257 hydrogen Substances 0.000 claims 42
- 125000003545 alkoxy group Chemical group 0.000 claims 40
- 125000005843 halogen group Chemical group 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 27
- 150000003839 salts Chemical class 0.000 claims 21
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 20
- 150000002431 hydrogen Chemical class 0.000 claims 20
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 15
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 12
- 125000001188 haloalkyl group Chemical group 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 7
- 206010019280 Heart failures Diseases 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 229910052698 phosphorus Inorganic materials 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Chemical group 0.000 claims 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
- 229910052717 sulfur Chemical group 0.000 claims 4
- 239000011593 sulfur Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- -1 R 1 R 2 N Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 230000002861 ventricular Effects 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 208000003037 Diastolic Heart Failure Diseases 0.000 claims 1
- 208000008253 Systolic Heart Failure Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000001269 cardiogenic effect Effects 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- JKIIGSYRQKRWIC-UHFFFAOYSA-N CS(Nc(cccc1)c1-c(ccc(N(CCC1NC(Nc(c(F)c2)ccc2Cl)=O)C1=O)c1F)c1F)(=O)=O Chemical compound CS(Nc(cccc1)c1-c(ccc(N(CCC1NC(Nc(c(F)c2)ccc2Cl)=O)C1=O)c1F)c1F)(=O)=O JKIIGSYRQKRWIC-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862638556P | 2018-03-05 | 2018-03-05 | |
| US62/638,556 | 2018-03-05 | ||
| PCT/US2019/020493 WO2019173182A1 (en) | 2018-03-05 | 2019-03-04 | Phenylpyrrolidinone formyl peptide 2 receptor agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021516240A JP2021516240A (ja) | 2021-07-01 |
| JP2021516240A5 true JP2021516240A5 (enExample) | 2021-08-12 |
| JP7155276B2 JP7155276B2 (ja) | 2022-10-18 |
Family
ID=65812419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020546499A Active JP7155276B2 (ja) | 2018-03-05 | 2019-03-04 | フェニルピロリジノンホルミルペプチド２受容体アゴニスト |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US10676431B2 (enExample) |
| EP (2) | EP3762380B1 (enExample) |
| JP (1) | JP7155276B2 (enExample) |
| KR (1) | KR102803660B1 (enExample) |
| CN (1) | CN111868052B (enExample) |
| AR (1) | AR114429A1 (enExample) |
| AU (1) | AU2019232704B2 (enExample) |
| BR (1) | BR112020017744A2 (enExample) |
| CA (1) | CA3092927A1 (enExample) |
| CL (1) | CL2020002224A1 (enExample) |
| CY (1) | CY1124985T1 (enExample) |
| DK (1) | DK3762380T3 (enExample) |
| EA (1) | EA202092094A1 (enExample) |
| ES (1) | ES2904483T3 (enExample) |
| HR (1) | HRP20220118T1 (enExample) |
| HU (1) | HUE058044T2 (enExample) |
| IL (1) | IL277044B2 (enExample) |
| LT (1) | LT3762380T (enExample) |
| MX (1) | MX2020009000A (enExample) |
| MY (1) | MY204384A (enExample) |
| PE (1) | PE20210046A1 (enExample) |
| PL (1) | PL3762380T3 (enExample) |
| PT (1) | PT3762380T (enExample) |
| RS (1) | RS62833B1 (enExample) |
| SG (1) | SG11202008504SA (enExample) |
| SI (1) | SI3762380T1 (enExample) |
| SM (1) | SMT202200067T1 (enExample) |
| TW (1) | TWI804585B (enExample) |
| WO (1) | WO2019173182A1 (enExample) |
| ZA (1) | ZA202006115B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018005756A (es) * | 2015-11-24 | 2018-08-01 | Squibb Bristol Myers Co | Ubicacion como objetivo del receptor 2 de formilo-peptido/receptor de lipoxina a4 (fpr2/alx) para el tratamiento de enfermedades cardiacas. |
| EP3634412A1 (en) | 2017-06-09 | 2020-04-15 | Bristol-Myers Squibb Company | Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists |
| EP3634956B1 (en) | 2017-06-09 | 2021-04-07 | Bristol-Myers Squibb Company | Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists |
| US11180490B2 (en) | 2017-06-09 | 2021-11-23 | Bristol-Myers Squibb Company | Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists |
| KR102615095B1 (ko) | 2017-06-09 | 2023-12-15 | 브리스톨-마이어스 스큅 컴퍼니 | 피페리디논 포르밀 펩티드 2 수용체 효능제 |
| UA127897C2 (uk) | 2018-03-05 | 2024-02-07 | Аркус Байосайєнсіз, Інк. | Інгібітори аргінази |
| EP3762380B1 (en) | 2018-03-05 | 2021-12-15 | Bristol-Myers Squibb Company | Phenylpyrrolidinone formyl peptide 2 receptor agonists |
| JP7398455B2 (ja) | 2018-11-26 | 2023-12-14 | ブリストル－マイヤーズ スクイブ カンパニー | ピラゾロンホルミルペプチド２受容体アゴニスト |
| ES2946673T3 (es) * | 2019-06-18 | 2023-07-24 | Bristol Myers Squibb Co | Agonistas del FPR2 de óxido de biaril dialquil fosfina |
| KR20230038515A (ko) * | 2020-07-09 | 2023-03-20 | 브리스톨-마이어스 스큅 컴퍼니 | 옥소피롤리딘 fpr2 효능제 |
| WO2022035923A1 (en) * | 2020-08-12 | 2022-02-17 | Bristol-Myers Squibb Company | Oxopyrrolidine urea fpr2 agonists |
| US20240109897A1 (en) * | 2021-01-21 | 2024-04-04 | Beijing Tiantan Hospital | Modulators of fpr1 and methods of using the same |
| JP7717816B2 (ja) * | 2021-01-21 | 2025-08-04 | バイオフロント セラピューティクス （ベイジン） カンパニー リミテッド | Ｆｐｒ１のモジュレーター及びそれを使用する方法 |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| IL313538A (en) | 2021-12-15 | 2024-08-01 | Adama Agan Ltd | Useful compounds for the preparation of various agrochemicals and their markers |
| WO2023229034A1 (ja) | 2022-05-27 | 2023-11-30 | アサヒグループホールディングス株式会社 | 乳酸菌由来の外膜小胞を含有するｆｐｒ２作動剤 |
| WO2024079252A1 (en) | 2022-10-13 | 2024-04-18 | Bayer Aktiengesellschaft | Sos1 inhibitors |
| WO2024220487A1 (en) * | 2023-04-18 | 2024-10-24 | Bristol-Myers Squibb Company | Carbocyclic phenylpyrrolidinone urea fpr2 agonists |
| CN120936594A (zh) * | 2023-04-18 | 2025-11-11 | 百时美施贵宝公司 | 吡咯烷酮脲fpr2激动剂 |
| WO2024220482A1 (en) * | 2023-04-18 | 2024-10-24 | Bristol-Myers Squibb Company | Pyrrolidinone urea fpr2 agonists |
| WO2025202955A1 (en) | 2024-03-28 | 2025-10-02 | Pi Industries Ltd. | Fused bicyclic compounds and their use as pest control agents |
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| US5202344A (en) | 1990-12-11 | 1993-04-13 | G. D. Searle & Co. | N-substituted lactams useful as cholecystokinin antagonists |
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| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| TWI354664B (en) * | 2003-08-21 | 2011-12-21 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine rece |
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| EP1692502A2 (en) | 2003-11-07 | 2006-08-23 | Acadia Pharmaceuticals Inc. | Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation |
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| KR102615095B1 (ko) | 2017-06-09 | 2023-12-15 | 브리스톨-마이어스 스큅 컴퍼니 | 피페리디논 포르밀 펩티드 2 수용체 효능제 |
| EP3634956B1 (en) | 2017-06-09 | 2021-04-07 | Bristol-Myers Squibb Company | Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists |
| US11180490B2 (en) | 2017-06-09 | 2021-11-23 | Bristol-Myers Squibb Company | Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists |
| EP3634412A1 (en) | 2017-06-09 | 2020-04-15 | Bristol-Myers Squibb Company | Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists |
| EP3762380B1 (en) | 2018-03-05 | 2021-12-15 | Bristol-Myers Squibb Company | Phenylpyrrolidinone formyl peptide 2 receptor agonists |
-
2019
- 2019-03-04 EP EP19711769.0A patent/EP3762380B1/en active Active
- 2019-03-04 PE PE2020001309A patent/PE20210046A1/es unknown
- 2019-03-04 PL PL19711769T patent/PL3762380T3/pl unknown
- 2019-03-04 WO PCT/US2019/020493 patent/WO2019173182A1/en not_active Ceased
- 2019-03-04 SG SG11202008504SA patent/SG11202008504SA/en unknown
- 2019-03-04 ES ES19711769T patent/ES2904483T3/es active Active
- 2019-03-04 EA EA202092094A patent/EA202092094A1/ru unknown
- 2019-03-04 HU HUE19711769A patent/HUE058044T2/hu unknown
- 2019-03-04 CN CN201980017438.1A patent/CN111868052B/zh active Active
- 2019-03-04 KR KR1020207028222A patent/KR102803660B1/ko active Active
- 2019-03-04 LT LTEPPCT/US2019/020493T patent/LT3762380T/lt unknown
- 2019-03-04 JP JP2020546499A patent/JP7155276B2/ja active Active
- 2019-03-04 US US16/291,209 patent/US10676431B2/en active Active
- 2019-03-04 TW TW108107094A patent/TWI804585B/zh active
- 2019-03-04 IL IL277044A patent/IL277044B2/en unknown
- 2019-03-04 DK DK19711769.0T patent/DK3762380T3/da active
- 2019-03-04 PT PT197117690T patent/PT3762380T/pt unknown
- 2019-03-04 SI SI201930151T patent/SI3762380T1/sl unknown
- 2019-03-04 HR HRP20220118TT patent/HRP20220118T1/hr unknown
- 2019-03-04 AU AU2019232704A patent/AU2019232704B2/en active Active
- 2019-03-04 EP EP21207176.5A patent/EP3981767A1/en active Pending
- 2019-03-04 CA CA3092927A patent/CA3092927A1/en active Pending
- 2019-03-04 MX MX2020009000A patent/MX2020009000A/es unknown
- 2019-03-04 SM SM20220067T patent/SMT202200067T1/it unknown
- 2019-03-04 BR BR112020017744-0A patent/BR112020017744A2/pt unknown
- 2019-03-04 RS RS20220063A patent/RS62833B1/sr unknown
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2020
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2021
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2022
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