CN111868052B - 苯基吡咯烷酮甲酰肽2受体激动剂 - Google Patents

苯基吡咯烷酮甲酰肽2受体激动剂 Download PDF

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CN111868052B
CN111868052B CN201980017438.1A CN201980017438A CN111868052B CN 111868052 B CN111868052 B CN 111868052B CN 201980017438 A CN201980017438 A CN 201980017438A CN 111868052 B CN111868052 B CN 111868052B
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alkyl
halogen
hydrogen
pharmaceutically acceptable
alkoxy
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CN111868052A (zh
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P·S·希鲁德
V·巴里加
B·塞沙德里
A·K·查托帕德哈耶
N·R·沃思
E·K·基克
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Bristol Myers Squibb Co
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201980017438.1A 2018-03-05 2019-03-04 苯基吡咯烷酮甲酰肽2受体激动剂 Active CN111868052B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862638556P 2018-03-05 2018-03-05
US62/638,556 2018-03-05
PCT/US2019/020493 WO2019173182A1 (en) 2018-03-05 2019-03-04 Phenylpyrrolidinone formyl peptide 2 receptor agonists

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CN111868052A CN111868052A (zh) 2020-10-30
CN111868052B true CN111868052B (zh) 2024-03-08

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KR (1) KR102803660B1 (enExample)
CN (1) CN111868052B (enExample)
AR (1) AR114429A1 (enExample)
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JP7094989B2 (ja) 2017-06-09 2022-07-04 ブリストル－マイヤーズ スクイブ カンパニー シクロプロピルウレアホルミルペプチド２受容体およびホルミルペプチド１受容体アゴニスト
WO2018227065A1 (en) * 2017-06-09 2018-12-13 Bristol-Myers Squibb Company Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
KR102615095B1 (ko) * 2017-06-09 2023-12-15 브리스톨-마이어스 스큅 컴퍼니 피페리디논 포르밀 펩티드 2 수용체 효능제
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CN113166134B (zh) 2018-11-26 2024-06-14 百时美施贵宝公司 作为甲酰肽2受体激动剂的吡咯烷酮衍生物
JP7494224B2 (ja) * 2019-06-18 2024-06-03 ブリストル－マイヤーズ スクイブ カンパニー ビアリールジアルキルホスフィンオキシドｆｐｒ２アゴニスト
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CN120112538A (zh) 2022-10-13 2025-06-06 拜耳公司 Sos1抑制剂
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