JP2021509009A - Bcmaターゲティングキメラ抗原受容体及びその使用 - Google Patents
Bcmaターゲティングキメラ抗原受容体及びその使用 Download PDFInfo
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- JP2021509009A JP2021509009A JP2020529497A JP2020529497A JP2021509009A JP 2021509009 A JP2021509009 A JP 2021509009A JP 2020529497 A JP2020529497 A JP 2020529497A JP 2020529497 A JP2020529497 A JP 2020529497A JP 2021509009 A JP2021509009 A JP 2021509009A
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- BTSWOEMKZDBIIP-UHFFFAOYSA-N CC(C)(C)C1C=CC(CC(NCc2ccc(C(N(C3)C(CCC(N4)=O)C4=O)O)c3c2)=O)=CC1 Chemical compound CC(C)(C)C1C=CC(CC(NCc2ccc(C(N(C3)C(CCC(N4)=O)C4=O)O)c3c2)=O)=CC1 BTSWOEMKZDBIIP-UHFFFAOYSA-N 0.000 description 1
- UULYDKZWRMVJNZ-UHFFFAOYSA-N Nc1c(CN(C(CCC(N2)O)C2=O)C2=O)c2ccc1 Chemical compound Nc1c(CN(C(CCC(N2)O)C2=O)C2=O)c2ccc1 UULYDKZWRMVJNZ-UHFFFAOYSA-N 0.000 description 1
- UVSMNLNDYGZFPF-UHFFFAOYSA-N Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 description 1
- UEJJHQNACJXSKW-UHFFFAOYSA-N O=C(c1c2cccc1)N(C(CCC(N1)=O)C1=O)C2=O Chemical compound O=C(c1c2cccc1)N(C(CCC(N1)=O)C1=O)C2=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 description 1
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
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- Health & Medical Sciences (AREA)
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- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
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- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
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- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762593043P | 2017-11-30 | 2017-11-30 | |
| US62/593,043 | 2017-11-30 | ||
| US201862752010P | 2018-10-29 | 2018-10-29 | |
| US62/752,010 | 2018-10-29 | ||
| PCT/US2018/063255 WO2019108900A1 (en) | 2017-11-30 | 2018-11-30 | Bcma-targeting chimeric antigen receptor, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021509009A true JP2021509009A (ja) | 2021-03-18 |
| JP2021509009A5 JP2021509009A5 (enExample) | 2022-01-11 |
Family
ID=65010888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020529497A Pending JP2021509009A (ja) | 2017-11-30 | 2018-11-30 | Bcmaターゲティングキメラ抗原受容体及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20200371091A1 (enExample) |
| EP (1) | EP3717907A1 (enExample) |
| JP (1) | JP2021509009A (enExample) |
| KR (1) | KR20200096253A (enExample) |
| CN (1) | CN111727373A (enExample) |
| AU (1) | AU2018375738A1 (enExample) |
| BR (1) | BR112020010579A2 (enExample) |
| CA (1) | CA3083949A1 (enExample) |
| IL (1) | IL274921A (enExample) |
| MX (1) | MX2020005651A (enExample) |
| RU (1) | RU2020121458A (enExample) |
| SG (1) | SG11202005005YA (enExample) |
| TW (1) | TW201925782A (enExample) |
| WO (1) | WO2019108900A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111139256A (zh) | 2013-02-20 | 2020-05-12 | 诺华股份有限公司 | 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症 |
| US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| EP4420663A3 (en) | 2013-12-20 | 2024-10-30 | Novartis AG | Regulatable chimeric antigen receptor |
| ES2963718T3 (es) | 2014-01-21 | 2024-04-01 | Novartis Ag | Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras |
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| WO2019108900A1 (en) | 2019-06-06 |
| KR20200096253A (ko) | 2020-08-11 |
| EP3717907A1 (en) | 2020-10-07 |
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| US20200371091A1 (en) | 2020-11-26 |
| RU2020121458A3 (enExample) | 2022-03-29 |
| CA3083949A1 (en) | 2020-06-06 |
| CN111727373A (zh) | 2020-09-29 |
| SG11202005005YA (en) | 2020-06-29 |
| IL274921A (en) | 2020-07-30 |
| MX2020005651A (es) | 2020-10-28 |
| BR112020010579A2 (pt) | 2020-11-10 |
| TW201925782A (zh) | 2019-07-01 |
| AU2018375738A1 (en) | 2020-06-11 |
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