CA3083949A1 - Bcma-targeting chimeric antigen receptor, and uses thereof - Google Patents

Bcma-targeting chimeric antigen receptor, and uses thereof Download PDF

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Publication number
CA3083949A1
CA3083949A1 CA3083949A CA3083949A CA3083949A1 CA 3083949 A1 CA3083949 A1 CA 3083949A1 CA 3083949 A CA3083949 A CA 3083949A CA 3083949 A CA3083949 A CA 3083949A CA 3083949 A1 CA3083949 A1 CA 3083949A1
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Canada
Prior art keywords
subject
car
cell therapy
expressing cell
cells
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Pending
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CA3083949A
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English (en)
French (fr)
Inventor
Iulian PRUTEANU-MALINICI
Keith MANSFIELD
Boris ENGELS
Jan J. Melenhorst
Adam David Cohen
Edward A. Stadtmauer
Alfred GARFALL
Michael C. Milone
Joseph A. Fraietta
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Novartis AG
University of Pennsylvania Penn
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Novartis AG
University of Pennsylvania Penn
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Publication of CA3083949A1 publication Critical patent/CA3083949A1/en
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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CA3083949A 2017-11-30 2018-11-30 Bcma-targeting chimeric antigen receptor, and uses thereof Pending CA3083949A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762593043P 2017-11-30 2017-11-30
US62/593,043 2017-11-30
US201862752010P 2018-10-29 2018-10-29
US62/752,010 2018-10-29
PCT/US2018/063255 WO2019108900A1 (en) 2017-11-30 2018-11-30 Bcma-targeting chimeric antigen receptor, and uses thereof

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CA3083949A1 true CA3083949A1 (en) 2020-06-06

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US (1) US20200371091A1 (enExample)
EP (1) EP3717907A1 (enExample)
JP (1) JP2021509009A (enExample)
KR (1) KR20200096253A (enExample)
CN (1) CN111727373A (enExample)
AU (1) AU2018375738A1 (enExample)
BR (1) BR112020010579A2 (enExample)
CA (1) CA3083949A1 (enExample)
IL (1) IL274921A (enExample)
MX (1) MX2020005651A (enExample)
RU (1) RU2020121458A (enExample)
SG (1) SG11202005005YA (enExample)
TW (1) TW201925782A (enExample)
WO (1) WO2019108900A1 (enExample)

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WO2014130657A1 (en) 2013-02-20 2014-08-28 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
ES2769574T3 (es) 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
WO2016028896A1 (en) 2014-08-19 2016-02-25 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
PT3280729T (pt) 2015-04-08 2022-08-01 Novartis Ag Terapias para cd20, terapias para cd22 e terapias de combinação com uma célula que expressa o recetor de antigénio quimérico (car) para cd19
CN108473957B (zh) 2015-04-17 2024-07-16 诺华股份有限公司 改善嵌合抗原受体表达细胞的功效和扩增的方法
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