RU2020121458A - Химерный антигенный рецептор, нацеливающийся на bcma, и его пути применения - Google Patents

Химерный антигенный рецептор, нацеливающийся на bcma, и его пути применения Download PDF

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RU2020121458A
RU2020121458A RU2020121458A RU2020121458A RU2020121458A RU 2020121458 A RU2020121458 A RU 2020121458A RU 2020121458 A RU2020121458 A RU 2020121458A RU 2020121458 A RU2020121458 A RU 2020121458A RU 2020121458 A RU2020121458 A RU 2020121458A
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car
bcma
cells
subject
therapy
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RU2020121458A
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RU2020121458A3 (enExample
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Юлиан ПРУТЕАНУ-МАЛИНИЧИ
Кит МАНСФИЛЬД
Борис Энгельс
Ян Дж. МИЛЕНХОРСТ
Адам Дэвид КОЭН
Эдвард А. ШТАДТМАУЭР
Альфред ГАРФАЛЛ
Майкл С. МАЙЛОН
Джозеф А. ФРАЙЕТТА
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Новартис Аг
Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of RU2020121458A publication Critical patent/RU2020121458A/ru
Publication of RU2020121458A3 publication Critical patent/RU2020121458A3/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • G01N33/5073—Stem cells

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RU2020121458A 2017-11-30 2018-11-30 Химерный антигенный рецептор, нацеливающийся на bcma, и его пути применения RU2020121458A (ru)

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Application Number Priority Date Filing Date Title
US201762593043P 2017-11-30 2017-11-30
US62/593,043 2017-11-30
US201862752010P 2018-10-29 2018-10-29
US62/752,010 2018-10-29
PCT/US2018/063255 WO2019108900A1 (en) 2017-11-30 2018-11-30 Bcma-targeting chimeric antigen receptor, and uses thereof

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RU2020121458A true RU2020121458A (ru) 2021-12-30
RU2020121458A3 RU2020121458A3 (enExample) 2022-03-29

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US (1) US20200371091A1 (enExample)
EP (1) EP3717907A1 (enExample)
JP (1) JP2021509009A (enExample)
KR (1) KR20200096253A (enExample)
CN (1) CN111727373A (enExample)
AU (1) AU2018375738A1 (enExample)
BR (1) BR112020010579A2 (enExample)
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IL (1) IL274921A (enExample)
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Publication number Priority date Publication date Assignee Title
WO2014130657A1 (en) 2013-02-20 2014-08-28 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
ES2769574T3 (es) 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
US11028143B2 (en) 2014-01-21 2021-06-08 Novartis Ag Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
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BR112020010579A2 (pt) 2020-11-10
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