JP2021098728A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021098728A5 JP2021098728A5 JP2021037000A JP2021037000A JP2021098728A5 JP 2021098728 A5 JP2021098728 A5 JP 2021098728A5 JP 2021037000 A JP2021037000 A JP 2021037000A JP 2021037000 A JP2021037000 A JP 2021037000A JP 2021098728 A5 JP2021098728 A5 JP 2021098728A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- acceptable salt
- orally administered
- acceptable excipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023032872A JP2023060145A (ja) | 2018-05-14 | 2023-03-03 | Ｍｃｌ－１阻害剤 |
| JP2025080314A JP7792036B2 (ja) | 2018-05-14 | 2025-05-13 | Ｍｃｌ－１阻害剤 |
| JP2025247816A JP2026034586A (ja) | 2018-05-14 | 2025-12-12 | Ｍｃｌ－１阻害剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862671306P | 2018-05-14 | 2018-05-14 | |
| US62/671,306 | 2018-05-14 | ||
| US201862749918P | 2018-10-24 | 2018-10-24 | |
| US62/749,918 | 2018-10-24 | ||
| JP2020564228A JP6899975B2 (ja) | 2018-05-14 | 2019-05-13 | Ｍｃｌ−１阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564228A Division JP6899975B2 (ja) | 2018-05-14 | 2019-05-13 | Ｍｃｌ−１阻害剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023032872A Division JP2023060145A (ja) | 2018-05-14 | 2023-03-03 | Ｍｃｌ－１阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021098728A JP2021098728A (ja) | 2021-07-01 |
| JP2021098728A5 true JP2021098728A5 (https=) | 2022-10-12 |
| JP7240431B2 JP7240431B2 (ja) | 2023-03-15 |
Family
ID=66770559
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564228A Active JP6899975B2 (ja) | 2018-05-14 | 2019-05-13 | Ｍｃｌ−１阻害剤 |
| JP2021037000A Active JP7240431B2 (ja) | 2018-05-14 | 2021-03-09 | Ｍｃｌ－１阻害剤 |
| JP2023032872A Pending JP2023060145A (ja) | 2018-05-14 | 2023-03-03 | Ｍｃｌ－１阻害剤 |
| JP2025080314A Active JP7792036B2 (ja) | 2018-05-14 | 2025-05-13 | Ｍｃｌ－１阻害剤 |
| JP2025247816A Pending JP2026034586A (ja) | 2018-05-14 | 2025-12-12 | Ｍｃｌ－１阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564228A Active JP6899975B2 (ja) | 2018-05-14 | 2019-05-13 | Ｍｃｌ−１阻害剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023032872A Pending JP2023060145A (ja) | 2018-05-14 | 2023-03-03 | Ｍｃｌ－１阻害剤 |
| JP2025080314A Active JP7792036B2 (ja) | 2018-05-14 | 2025-05-13 | Ｍｃｌ－１阻害剤 |
| JP2025247816A Pending JP2026034586A (ja) | 2018-05-14 | 2025-12-12 | Ｍｃｌ－１阻害剤 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US10703733B2 (https=) |
| EP (2) | EP4029868A1 (https=) |
| JP (5) | JP6899975B2 (https=) |
| KR (4) | KR102551319B1 (https=) |
| CN (2) | CN112118845B (https=) |
| AU (4) | AU2019269391B2 (https=) |
| BR (1) | BR112020021648A2 (https=) |
| CA (1) | CA3099152C (https=) |
| CL (1) | CL2020002919A1 (https=) |
| CO (1) | CO2020014009A2 (https=) |
| CR (1) | CR20200544A (https=) |
| CY (1) | CY1125065T1 (https=) |
| DK (1) | DK3793565T3 (https=) |
| ES (1) | ES2907923T3 (https=) |
| HR (1) | HRP20220215T1 (https=) |
| HU (1) | HUE057852T2 (https=) |
| IL (2) | IL291430B2 (https=) |
| LT (1) | LT3793565T (https=) |
| MX (1) | MX2020012137A (https=) |
| MY (1) | MY198871A (https=) |
| PE (1) | PE20210004A1 (https=) |
| PH (1) | PH12020551881A1 (https=) |
| PL (1) | PL3793565T3 (https=) |
| PT (1) | PT3793565T (https=) |
| SG (1) | SG11202010964VA (https=) |
| SI (1) | SI3793565T1 (https=) |
| TW (3) | TWI813957B (https=) |
| UA (1) | UA125163C2 (https=) |
| WO (1) | WO2019222112A1 (https=) |
| ZA (1) | ZA202007007B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102551319B1 (ko) | 2018-05-14 | 2023-07-05 | 길리애드 사이언시즈, 인코포레이티드 | Mcl-1 억제제 |
| EP3643711A1 (en) | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| KR20220034136A (ko) | 2019-07-09 | 2022-03-17 | 얀센 파마슈티카 엔.브이. | Mcl-1 억제제로서의 거대환식 스피로사이클 유도체 |
| ES2973832T3 (es) | 2019-10-18 | 2024-06-24 | Forty Seven Inc | Terapias combinadas para el tratamiento de síndromes mielodisplásicos y leucemia mieloide aguda |
| JP2022552748A (ja) | 2019-10-31 | 2022-12-19 | フォーティ セブン， インコーポレイテッド | 抗ｃｄ４７及び抗ｃｄ２０による血液癌の治療 |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| AU2020391106B2 (en) | 2019-11-26 | 2024-03-21 | Gilead Sciences, Inc. | Processes and intermediates for preparing MCL1 inhibitors |
| IL294032A (en) | 2019-12-24 | 2022-08-01 | Carna Biosciences Inc | Compounds that regulate diacylglycerol kinase |
| US20230212191A1 (en) * | 2020-04-16 | 2023-07-06 | Prelude Therapeutics, Incorporated | Spiro-sulfonimidamide derivatives as inhibitors of myeloid cell leukemia-1 (mcl-1) protein |
| AU2021288987A1 (en) * | 2020-06-10 | 2023-02-09 | Janssen Pharmaceutica Nv | Macrocyclic 2-amino-3-fluoro-but-3-enamides as inhibitors of MCL-1 |
| WO2022108984A1 (en) * | 2020-11-19 | 2022-05-27 | Gilead Sciences, Inc. | Processes and intermediates for preparing macrocyclic mcl1 inhibitors |
| MX2023007297A (es) | 2020-12-17 | 2023-07-04 | Janssen Pharmaceutica Nv | 3-fluoro-but-3-enamidas ramificadas macrociclicas como inhibidores de mcl-1. |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| ES3017082T3 (en) | 2021-04-26 | 2025-05-12 | Janssen Pharmaceutica Nv | Macrocyclic 2-allyltetrahydrofurans as inhibitors of mcl-1 |
| WO2022245671A1 (en) | 2021-05-18 | 2022-11-24 | Gilead Sciences, Inc. | Methods of using flt3l-fc fusion proteins |
| US11931424B2 (en) * | 2021-06-11 | 2024-03-19 | Gilead Sciences, Inc. | Combination MCL-1 inhibitors with anti-body drug conjugates |
| TWI910028B (zh) * | 2021-06-11 | 2025-12-21 | 美商基利科學股份有限公司 | Mcl-1抑制劑與抗癌劑之組合 |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| MX2023014762A (es) | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| KR20240107105A (ko) | 2021-11-16 | 2024-07-08 | 얀센 파마슈티카 엔브이 | Mcl-1의 억제제로서의 매크로사이클릭 2-아미노-부트-3-엔아미드 |
| KR20240165995A (ko) | 2022-03-24 | 2024-11-25 | 길리애드 사이언시즈, 인코포레이티드 | Trop-2 발현 암의 치료를 위한 병용요법 |
| TWI876305B (zh) | 2022-04-05 | 2025-03-11 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
| EP4519271A1 (en) | 2022-05-04 | 2025-03-12 | Gilead Sciences, Inc. | Salts and polymorphs of certain mcl-1 inhibitors |
| WO2024064668A1 (en) | 2022-09-21 | 2024-03-28 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US7405295B2 (en) | 2003-06-04 | 2008-07-29 | Cgi Pharmaceuticals, Inc. | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
| WO2005113556A1 (en) | 2004-05-13 | 2005-12-01 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| US20090142345A1 (en) | 2005-03-15 | 2009-06-04 | Takeda Pharmaceutical Company Limited | Prophylactic/therapeutic agent for cancer |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| KR101566840B1 (ko) | 2007-03-12 | 2015-11-06 | 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 | 페닐 아미노 피리미딘 화합물 및 이의 용도 |
| ES2700141T3 (es) | 2007-08-02 | 2019-02-14 | Gilead Biologics Inc | Anticuerpos inhibidores LOXL2 y usos de los mismos |
| ES2538122T3 (es) | 2008-07-21 | 2015-06-17 | Apogenix Gmbh | Moléculas de una sola cadena de TNFSF |
| US8652843B2 (en) | 2008-08-12 | 2014-02-18 | Oncomed Pharmaceuticals, Inc. | DDR1-binding agents and methods of use thereof |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| BR112012019693A2 (pt) | 2010-02-04 | 2017-06-20 | Gilead Biologics Inc | anticorpos que se ligam à lisil oxidase-like 2 (loxl2) e métodos de uso para eles. |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| EP2608809B1 (en) | 2010-08-27 | 2019-05-22 | Gilead Biologics, Inc. | Antibodies to matrix metalloproteinase 9 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| TWI567061B (zh) | 2011-07-01 | 2017-01-21 | 吉李德科學股份有限公司 | 用於治療成癮之化合物 |
| US9550835B2 (en) | 2011-08-23 | 2017-01-24 | Chugai Seiyaku Kabushiki Kaisha | Anti-DDR1 antibody having anti-tumor activity |
| GB201115529D0 (en) | 2011-09-08 | 2011-10-26 | Imp Innovations Ltd | Antibodies, uses and methods |
| HK1201065A1 (en) | 2011-10-04 | 2015-08-21 | Gilead Calistoga Llc | Novel quinoxaline inhibitors of pi3k |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| WO2013116562A1 (en) | 2012-02-03 | 2013-08-08 | Gilead Calistoga Llc | Compositions and methods of treating a disease with (s)-4 amino-6-((1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile |
| WO2014047624A1 (en) | 2012-09-24 | 2014-03-27 | Gilead Sciences, Inc. | Anti-ddr1 antibodies |
| JP6207100B2 (ja) | 2012-12-21 | 2017-10-04 | ギリアード カリストガ エルエルシー | イソキノリノンまたはキナゾリノンホスファチジルイノシトール３−キナーゼ阻害剤 |
| AU2013364068B2 (en) | 2012-12-21 | 2016-10-20 | Gilead Calistoga Llc | Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors |
| TWI527811B (zh) | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | 作爲溴結構域抑制劑的苯並咪唑衍生物 |
| PL3008053T3 (pl) | 2013-06-14 | 2018-08-31 | Gilead Calistoga Llc | Inhibitory 3-kinazy fosfatydyloinozytolu |
| KR101810798B1 (ko) | 2013-07-30 | 2017-12-19 | 질레드 코네티컷 인코포레이티드 | Ｓｙｋ 억제제의 다형체 |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| CN106456602B (zh) * | 2014-03-27 | 2020-11-24 | 范德比尔特大学 | 取代的吲哚mcl-1抑制剂 |
| US10611837B2 (en) | 2014-04-10 | 2020-04-07 | Seattle Children's Hospital | Transgene genetic tags and methods of use |
| TWI751102B (zh) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對ｃｄ１９具專一性之抗體及嵌合抗原受體 |
| JO3474B1 (ar) * | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
| NZ729618A (en) | 2014-09-26 | 2018-07-27 | Gilead Sciences Inc | Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds |
| ES2819553T3 (es) | 2014-12-03 | 2021-04-16 | Juno Therapeutics Inc | Métodos y composiciones para terapia celular adoptiva |
| EP3234144B1 (en) | 2014-12-15 | 2020-08-26 | Bellicum Pharmaceuticals, Inc. | Methods for controlled elimination of therapeutic cells |
| CN107849024A (zh) | 2015-05-15 | 2018-03-27 | 吉利德科学公司 | 具有作为吲哚胺2,3‑二加氧酶抑制剂活性的苯并咪唑和咪唑并吡啶亚氨代甲酰胺化合物 |
| WO2016196388A1 (en) | 2015-05-29 | 2016-12-08 | Juno Therapeutics, Inc. | Composition and methods for regulating inhibitory interactions in genetically engineered cells |
| AU2016323985B2 (en) | 2015-09-17 | 2022-12-15 | Novartis Ag | CAR T cell therapies with enhanced efficacy |
| US11306107B2 (en) * | 2016-02-25 | 2022-04-19 | Amgen Inc. | Compounds that inhibit MCL-1 protein |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| ES3036998T3 (en) | 2017-08-18 | 2025-09-26 | Amgen Inc | Compounds that inhibit mcl-1 protein |
| MA50033A (fr) | 2017-08-29 | 2020-07-08 | Amgen Inc | Composés macrocycliques permettant d'inhiber la protéine mcl-1 |
| HUE070649T2 (hu) | 2017-10-19 | 2025-06-28 | Teijin Pharma Ltd | Benzimidazol-származékok és felhasználásuk |
| EP3762393B1 (en) | 2018-03-05 | 2023-01-11 | Amgen Inc. | Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere mcl-1 protein antagonists |
| KR20210021457A (ko) | 2018-05-14 | 2021-02-26 | 리아타 파마슈티컬즈, 아이엔씨. | 열충격 단백질 경로와 연관된 질환의 치료를 위한 변형된 당기를 가진 바이아릴 아마이드 |
| KR102551319B1 (ko) | 2018-05-14 | 2023-07-05 | 길리애드 사이언시즈, 인코포레이티드 | Mcl-1 억제제 |
| KR20210010475A (ko) | 2018-05-15 | 2021-01-27 | 룬드벡 라 졸라 리서치 센터 인코포레이티드 | Magl 저해제 |
| MA53377A (fr) | 2018-07-24 | 2021-06-02 | Epizyme Inc | Composés de pyridin-2-one utiles en tant qu'antagonistes de smarca2 |
| KR20210089662A (ko) | 2018-11-09 | 2021-07-16 | 프렐루드 테라퓨틱스, 인코포레이티드 | 골수 세포 백혈병-1 (mcl-1) 단백질의 억제제로서 스피로-술폰아미드 유도체 |
| TWI745836B (zh) | 2019-01-18 | 2021-11-11 | 大陸商蘇州亞盛藥業有限公司 | 作為mcl-1抑製劑的大螺環醚 |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| AU2020391106B2 (en) | 2019-11-26 | 2024-03-21 | Gilead Sciences, Inc. | Processes and intermediates for preparing MCL1 inhibitors |
| JP2021161114A (ja) | 2020-03-31 | 2021-10-11 | アムジエン・インコーポレーテツド | Ｍｃｌ−１化合物のメチル化 |
| CN115485268B (zh) | 2020-05-06 | 2024-06-18 | 安进公司 | 乙烯基保护的醇中间体的合成 |
| TWI827924B (zh) | 2020-05-06 | 2024-01-01 | 美商安進公司 | 大環Mcl-1抑制劑中間體的閉環合成 |
| AU2021288987A1 (en) | 2020-06-10 | 2023-02-09 | Janssen Pharmaceutica Nv | Macrocyclic 2-amino-3-fluoro-but-3-enamides as inhibitors of MCL-1 |
| BR112023000212A2 (pt) | 2020-07-08 | 2023-01-31 | Janssen Pharmaceutica Nv | Éter macrocíclico contendo derivados de indol como inibidores de mcl-1 |
| WO2022108984A1 (en) | 2020-11-19 | 2022-05-27 | Gilead Sciences, Inc. | Processes and intermediates for preparing macrocyclic mcl1 inhibitors |
-
2019
- 2019-05-13 KR KR1020207035485A patent/KR102551319B1/ko active Active
- 2019-05-13 PL PL19728793T patent/PL3793565T3/pl unknown
- 2019-05-13 US US16/410,457 patent/US10703733B2/en active Active
- 2019-05-13 UA UAA202006695A patent/UA125163C2/uk unknown
- 2019-05-13 LT LTEPPCT/US2019/032053T patent/LT3793565T/lt unknown
- 2019-05-13 ES ES19728793T patent/ES2907923T3/es active Active
- 2019-05-13 KR KR1020237022152A patent/KR102666717B1/ko active Active
- 2019-05-13 HU HUE19728793A patent/HUE057852T2/hu unknown
- 2019-05-13 CR CR20200544A patent/CR20200544A/es unknown
- 2019-05-13 PE PE2020001829A patent/PE20210004A1/es unknown
- 2019-05-13 JP JP2020564228A patent/JP6899975B2/ja active Active
- 2019-05-13 DK DK19728793.1T patent/DK3793565T3/da active
- 2019-05-13 EP EP21218221.6A patent/EP4029868A1/en active Pending
- 2019-05-13 BR BR112020021648-8A patent/BR112020021648A2/pt not_active Application Discontinuation
- 2019-05-13 MX MX2020012137A patent/MX2020012137A/es unknown
- 2019-05-13 EP EP19728793.1A patent/EP3793565B1/en active Active
- 2019-05-13 AU AU2019269391A patent/AU2019269391B2/en active Active
- 2019-05-13 IL IL291430A patent/IL291430B2/en unknown
- 2019-05-13 MY MYPI2020005671A patent/MY198871A/en unknown
- 2019-05-13 CN CN201980032695.2A patent/CN112118845B/zh active Active
- 2019-05-13 KR KR1020247015778A patent/KR102732008B1/ko active Active
- 2019-05-13 SI SI201930181T patent/SI3793565T1/sl unknown
- 2019-05-13 SG SG11202010964VA patent/SG11202010964VA/en unknown
- 2019-05-13 CA CA3099152A patent/CA3099152C/en active Active
- 2019-05-13 KR KR1020247038029A patent/KR20240165483A/ko active Pending
- 2019-05-13 PT PT197287931T patent/PT3793565T/pt unknown
- 2019-05-13 WO PCT/US2019/032053 patent/WO2019222112A1/en not_active Ceased
- 2019-05-13 HR HRP20220215TT patent/HRP20220215T1/hr unknown
- 2019-05-13 CN CN202310897123.9A patent/CN117304130A/zh active Pending
- 2019-05-14 TW TW110107128A patent/TWI813957B/zh active
- 2019-05-14 TW TW108116508A patent/TWI719478B/zh active
- 2019-05-14 TW TW112131732A patent/TWI844454B/zh active
-
2020
- 2020-04-23 US US16/857,021 patent/US10988451B2/en active Active
- 2020-10-27 IL IL278336A patent/IL278336B/en unknown
- 2020-11-03 PH PH12020551881A patent/PH12020551881A1/en unknown
- 2020-11-10 ZA ZA2020/07007A patent/ZA202007007B/en unknown
- 2020-11-10 CL CL2020002919A patent/CL2020002919A1/es unknown
- 2020-11-10 CO CONC2020/0014009A patent/CO2020014009A2/es unknown
-
2021
- 2021-02-09 US US17/171,201 patent/US11643400B2/en active Active
- 2021-03-09 JP JP2021037000A patent/JP7240431B2/ja active Active
- 2021-05-25 AU AU2021203373A patent/AU2021203373B2/en active Active
-
2022
- 2022-03-16 CY CY20221100208T patent/CY1125065T1/el unknown
-
2023
- 2023-03-03 JP JP2023032872A patent/JP2023060145A/ja active Pending
- 2023-03-09 US US18/181,336 patent/US12162844B2/en active Active
- 2023-11-24 AU AU2023270332A patent/AU2023270332B2/en active Active
-
2024
- 2024-10-17 US US18/918,629 patent/US20250154116A1/en active Pending
-
2025
- 2025-05-13 JP JP2025080314A patent/JP7792036B2/ja active Active
- 2025-12-12 JP JP2025247816A patent/JP2026034586A/ja active Pending
- 2025-12-24 AU AU2025287356A patent/AU2025287356A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021098728A5 (https=) | ||
| JP2022009090A5 (https=) | ||
| JP2023506532A5 (https=) | ||
| JP2022121594A5 (https=) | ||
| JP2024133475A5 (https=) | ||
| JP2023002662A5 (https=) | ||
| JP2024133474A5 (https=) | ||
| JP2023504249A5 (https=) | ||
| JP2022191257A5 (https=) | ||
| JP2015523397A5 (https=) | ||
| JP2023548055A5 (https=) | ||
| JP2013522212A5 (https=) | ||
| JP2015508103A5 (https=) | ||
| JP2024540183A5 (https=) | ||
| JP2025161856A5 (https=) | ||
| JP2024512425A5 (https=) | ||
| JP2023116697A5 (https=) | ||
| JP2019533660A5 (https=) | ||
| JP2022551691A5 (https=) | ||
| JP2023115271A5 (https=) | ||
| JP2024541569A5 (https=) | ||
| JP2024502446A5 (https=) | ||
| JP2025502064A5 (https=) | ||
| JP2008536853A5 (https=) | ||
| RU2017124371A (ru) | Комбинация производного 6-оксо-1,6-дигидро-пиридазина, обладающего противораковой активностью, с производным хиназолина |