JP2025161856A5 - - Google Patents

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Publication number
JP2025161856A5
JP2025161856A5 JP2025134784A JP2025134784A JP2025161856A5 JP 2025161856 A5 JP2025161856 A5 JP 2025161856A5 JP 2025134784 A JP2025134784 A JP 2025134784A JP 2025134784 A JP2025134784 A JP 2025134784A JP 2025161856 A5 JP2025161856 A5 JP 2025161856A5
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pharmaceutically acceptable
compound
pharmaceutical composition
acceptable excipient
compound described
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JP2025134784A
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English (en)
Japanese (ja)
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JP2025161856A (ja
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Priority claimed from PCT/US2023/020235 external-priority patent/WO2023212219A1/en
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Publication of JP2025161856A publication Critical patent/JP2025161856A/ja
Publication of JP2025161856A5 publication Critical patent/JP2025161856A5/ja
Pending legal-status Critical Current

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JP2025134784A 2022-04-28 2025-08-13 三環式parp1阻害剤及びその使用 Pending JP2025161856A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202263336078P 2022-04-28 2022-04-28
US63/336,078 2022-04-28
US202263381482P 2022-10-28 2022-10-28
US63/381,482 2022-10-28
PCT/US2023/020235 WO2023212219A1 (en) 2022-04-28 2023-04-27 Tricyclic parp1 inhibitors and uses thereof
JP2024563302A JP7728989B2 (ja) 2022-04-28 2023-04-27 三環式parp1阻害剤及びその使用

Related Parent Applications (1)

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JP2024563302A Division JP7728989B2 (ja) 2022-04-28 2023-04-27 三環式parp1阻害剤及びその使用

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JP2025161856A JP2025161856A (ja) 2025-10-24
JP2025161856A5 true JP2025161856A5 (https=) 2026-04-28

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JP2024563302A Active JP7728989B2 (ja) 2022-04-28 2023-04-27 三環式parp1阻害剤及びその使用
JP2025134784A Pending JP2025161856A (ja) 2022-04-28 2025-08-13 三環式parp1阻害剤及びその使用

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US (3) US11795173B1 (https=)
EP (3) EP4355749B1 (https=)
JP (2) JP7728989B2 (https=)
KR (2) KR20260004578A (https=)
CN (1) CN119173516A (https=)
AU (2) AU2023259236B2 (https=)
CA (1) CA3250945A1 (https=)
CL (2) CL2024003262A1 (https=)
CO (1) CO2024014603A2 (https=)
CR (1) CR20240461A (https=)
DK (2) DK4497438T3 (https=)
DO (1) DOP2024000218A (https=)
ES (2) ES3038967T3 (https=)
FI (2) FI4497438T3 (https=)
HR (2) HRP20250969T1 (https=)
HU (1) HUE072274T2 (https=)
IL (1) IL316278A (https=)
LT (2) LT4497438T (https=)
MX (2) MX2025008920A (https=)
NZ (1) NZ815323A (https=)
PL (2) PL4497438T3 (https=)
PT (2) PT4355749T (https=)
SI (2) SI4497438T1 (https=)
TW (2) TWI891000B (https=)
WO (1) WO2023212219A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022334408A1 (en) * 2021-08-27 2024-02-15 Impact Therapeutics (Shanghai), Inc. Substituted tricyclic compounds as parp inhibitors and use thereof
CN120081844A (zh) 2022-01-21 2025-06-03 新特拉有限公司 Parp1抑制剂及其用途
CN119013279A (zh) * 2022-03-11 2024-11-22 上海瑛派药业有限公司 作为parp抑制剂的取代的三环类化合物及其应用
AU2023235233A1 (en) 2022-03-14 2024-09-12 Slap Pharmaceuticals Llc Multicyclic compounds
AU2023259236B2 (en) 2022-04-28 2025-01-09 Xinthera, Inc. Tricyclic parp1 inhibitors and uses thereof
CN117263943A (zh) * 2022-09-09 2023-12-22 轩竹生物科技股份有限公司 聚(adp核糖)聚合酶选择性抑制剂
WO2024099416A1 (zh) * 2022-11-10 2024-05-16 上海海和药物研究开发股份有限公司 一种稠合三环类parp1抑制剂、其制备方法及用途
TW202525808A (zh) * 2023-09-13 2025-07-01 大陸商上海瑛派藥業有限公司 用作parp1抑制劑的化合物、其用途及包含其之組合物
AU2024359243A1 (en) * 2023-10-09 2026-04-23 Incyte Corporation Processes for preparing kras inhibitors

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPS137402A0 (en) 2002-03-26 2002-05-09 Fujisawa Pharmaceutical Co., Ltd. Novel tricyclic compounds
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
BRPI0820701A2 (pt) 2007-12-11 2015-06-16 Cytopathfinder Inc Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
CN102341394B (zh) 2009-01-23 2015-04-15 武田药品工业株式会社 聚(adp-核糖)聚合酶(parp)抑制剂
EP2459561A1 (en) 2009-07-30 2012-06-06 Takeda Pharmaceutical Company Limited Poly (adp-ribose) polymerase (parp) inhibitors
US20110071136A1 (en) 2009-09-16 2011-03-24 Cylene Pharmaceuticals, Inc Novel tricyclic protein kinase modulators
PL2912032T3 (pl) 2012-10-26 2020-11-16 Nerviano Medical Sciences S.R.L. Pochodne 4-karboksyamido-izoindolinonu jako selektywne inhibitory parp-1
CN104370898A (zh) 2013-08-14 2015-02-25 黄传满 咪唑并[1,2-a]吡啶类化合物及其制备方法和用途
CA2941716A1 (en) 2014-03-07 2015-09-11 The Johns Hopkins University Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs)
CN105753814A (zh) 2015-01-01 2016-07-13 成都贝斯凯瑞生物科技有限公司 取代氮杂环衍生物及其应用
MX375707B (es) 2015-06-09 2025-03-06 Onconic Therapeutics Inc Compuesto derivativo triciclico, metodo para prepararlo y composicion farmaceutica que comprende el mismo.
CR20180168A (es) 2015-08-17 2018-06-27 Lupin Ltd Derivados de heteroarilo como inhibidores de parp
AU2018273356B2 (en) 2017-05-22 2021-09-16 Amgen Inc. KRAS G12C inhibitors and methods of using the same
IL283127B1 (en) 2018-11-14 2026-02-01 Smilebiotek Zhuhai Ltd Animal-based models, scanning methods, and methods of treating intraocular diseases or disorders
SI3999506T1 (sl) 2019-07-19 2025-06-30 Astrazeneca Ab Zaviralci PARP1
US12459899B2 (en) 2019-10-30 2025-11-04 DIGMBIO, Inc. Isoquinolinone derivatives, method for preparing the same, and pharmaceutical composition for preventing or treating poly(ADP-ribose) polymerase-1-related diseases, comprising the same as active ingredient
US11795158B2 (en) 2020-06-25 2023-10-24 Astrazeneca Ab Chemical compounds
US11591331B2 (en) 2021-04-19 2023-02-28 Xinthera, Inc. PARP1 inhibitors and uses thereof
EP4328224A4 (en) 2021-04-22 2025-06-18 Wigen Biomedicine Technology (Shanghai) Co., Ltd. PARP INHIBITOR WITH PIPERAZINE STRUCTURE, MANUFACTURING METHOD THEREOF AND PHARMACEUTICAL USE THEREOF
AU2022261029A1 (en) 2021-04-23 2023-10-19 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Heterocyclic derivative inhibitor and preparation method therefor and application thereof
WO2022222965A1 (zh) 2021-04-23 2022-10-27 成都百裕制药股份有限公司 吡啶衍生物及其在医药上的应用
WO2022222966A1 (zh) 2021-04-23 2022-10-27 成都百裕制药股份有限公司 一种选择性parp1抑制剂及其应用
CN115702156A (zh) 2021-04-23 2023-02-14 南京明德新药研发有限公司 吡啶酰胺类化合物
WO2022228387A1 (en) 2021-04-26 2022-11-03 Fochon Biosciences, Ltd. Compounds as parp inhibitors
BR112023022496A2 (pt) 2021-05-24 2024-01-16 Jiangsu Hengrui Pharmaceuticals Co Ltd Composto heterocíclico contendo nitrogênio, método de preparação do mesmo, e aplicação do mesmo em medicamentos
CN115403595A (zh) 2021-05-27 2022-11-29 江苏恒瑞医药股份有限公司 含氮杂环类化合物、其制备方法及其在医药上的应用
BR112023024942A2 (pt) 2021-06-16 2024-02-15 Repare Therapeutics Inc Uso de inibidores de atr em combinação com inibidores de parp para tratamento de câncer
AU2022334408A1 (en) * 2021-08-27 2024-02-15 Impact Therapeutics (Shanghai), Inc. Substituted tricyclic compounds as parp inhibitors and use thereof
CN118119618A (zh) 2021-09-09 2024-05-31 南京奥利墨斯医药科技有限公司 一种杂芳环类化合物及其应用
WO2023046034A1 (zh) 2021-09-22 2023-03-30 明慧医药(杭州)有限公司 一种含氮杂环化合物、其制备方法、其中间体及其应用
WO2023046158A1 (zh) 2021-09-26 2023-03-30 张文燕 氮杂喹啉酮类化合物及其医药用途
WO2023046149A1 (zh) 2021-09-26 2023-03-30 张文燕 喹喔啉类化合物及其医药用途
EP4410792A4 (en) 2021-09-30 2025-12-03 Xizang Haisco Pharmaceutical Co Ltd NITROGEN-CONTAINS HETEROCYCLIC DERIVATIVE FOR USE AS A PARP INHIBITOR AND ITS USE
EP4410791A4 (en) 2021-09-30 2025-10-22 Xizang Haisco Pharmaceutical Co Ltd BICYCLIC DERIVATIVE PARP INHIBITOR AND ITS USE
WO2023051716A1 (zh) 2021-09-30 2023-04-06 海思科医药集团股份有限公司 杂芳基衍生物parp抑制剂及其用途
KR102867210B1 (ko) 2021-10-01 2025-10-14 신테라, 인크. 아제티딘 및 피롤리딘 parp1 저해제, 및 이의 용도
WO2023061406A1 (zh) 2021-10-12 2023-04-20 微境生物医药科技(上海)有限公司 含三并环结构的parp抑制剂、及其制备方法和医药用途
US20250289800A1 (en) 2021-11-19 2025-09-18 Kangbaida (Sichuan) Biotechnology Co., Ltd. Selective Parp1 Inhibitor And Application Thereof
CN116143776A (zh) 2021-11-22 2023-05-23 南京圣和药业股份有限公司 Parp1抑制剂及其应用
KR20240144125A (ko) 2021-12-17 2024-10-02 키테라 (쑤저우) 바이오-파마슈티컬스 컴퍼니 리미티드 Parp 억제제, 이를 포함하는 약제학적 조성물, 및 이의 용도
WO2023133413A1 (en) 2022-01-07 2023-07-13 Slap Pharmaceuticals Llc Multicyclic compounds
KR20240134366A (ko) 2022-01-13 2024-09-09 에이스랜드 테라퓨틱스 (홍콩) 리미티드 피페라진 고리 함유 유도체, 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 용도
CN118434725B (zh) 2022-01-20 2026-01-02 微境生物医药科技(上海)有限公司 吡啶酰胺类parp抑制剂、及其制备方法和医药用途
CN120081844A (zh) 2022-01-21 2025-06-03 新特拉有限公司 Parp1抑制剂及其用途
CN116535401A (zh) 2022-01-25 2023-08-04 南京圣和药业股份有限公司 新的parp1抑制剂及其应用
WO2023143236A1 (zh) 2022-01-26 2023-08-03 中国药科大学 2h-吲唑-7-甲酰胺类化合物、制备方法、药物组合物和应用
JP7794989B2 (ja) 2022-01-27 2026-01-06 シンセラ, インコーポレイテッド Parp1阻害薬及びその使用
WO2023147009A1 (en) 2022-01-27 2023-08-03 The Johns Hopkins University Clinical-grade therapeutic progenitors generated from tankyrase/parp-inhibited pluripotent stem cell banks
KR20230116457A (ko) 2022-01-28 2023-08-04 경북대학교 산학협력단 작약 추출물을 포함하는 만성폐쇄성폐질환 예방 또는 치료용 약학적 조성물
WO2023146960A1 (en) 2022-01-28 2023-08-03 Xinthera, Inc. Parp1 inhibitors and uses thereof
EP4469046A1 (en) 2022-01-28 2024-12-04 Oulun Yliopisto Compounds for use in the treatment of cancer and inflammatory conditions
IL314895A (en) 2022-02-16 2024-10-01 Duke Street Bio Ltd Pharmaceutical compound
CN119013279A (zh) 2022-03-11 2024-11-22 上海瑛派药业有限公司 作为parp抑制剂的取代的三环类化合物及其应用
CN119487027A (zh) 2022-04-28 2025-02-18 宁波新湾科技发展有限公司 作为parp1抑制剂的化合物
AU2023259236B2 (en) 2022-04-28 2025-01-09 Xinthera, Inc. Tricyclic parp1 inhibitors and uses thereof
WO2023207284A1 (en) 2022-04-28 2023-11-02 Ningbo Newbay Technology Development Co., Ltd Piperazine derivatives as parp1 inhibitiors
JP7835895B2 (ja) 2022-05-07 2026-03-25 サイブランチ セラピューティクス カンパニー リミテッド Parp1を選択的に阻害するフルオロキノキサリノン誘導体
EP4534537A4 (en) 2022-05-25 2025-12-10 Xizang Haisco Pharmaceutical Co Ltd BICYCLE-DERIVED PARP INHIBITOR AND ITS USE
US20250346573A1 (en) 2022-06-02 2025-11-13 Chengdu Easton Biopharmaceuticals Co., Ltd. Azaquinolinone derivative, preparation method therefor and use thereof
CN117447449A (zh) 2022-07-13 2024-01-26 南京圣和药业股份有限公司 Parp1抑制剂及其应用
CN115232129B (zh) 2022-08-18 2023-12-01 上海闻耐医药科技有限公司 一种parp1选择性抑制剂及其制备方法和用途
WO2024041643A1 (zh) 2022-08-25 2024-02-29 江苏恒瑞医药股份有限公司 稠合三环类化合物、其制备方法及其在医药上的应用
WO2024050370A1 (en) 2022-08-30 2024-03-07 1Cbio, Inc. Heterocyclic compounds and methods of use thereof
WO2024046420A1 (zh) 2022-08-31 2024-03-07 江苏恒瑞医药股份有限公司 稠合二环类化合物、其制备方法及其在医药上的应用
CN117658983A (zh) 2022-09-01 2024-03-08 浙江文达医药科技有限公司 选择性parp1抑制剂
CN118119629A (zh) 2022-09-30 2024-05-31 中国医药研究开发中心有限公司 含氮杂环类化合物及其医药用途
WO2024067694A1 (zh) 2022-09-30 2024-04-04 中国医药研究开发中心有限公司 含氮杂环类化合物及其医药用途
US20240174669A1 (en) 2022-10-06 2024-05-30 Xinthera, Inc. Crystalline forms of a parp1 inhibitor
WO2024083218A1 (zh) 2022-10-20 2024-04-25 成都赜灵生物医药科技有限公司 取代四氢吡啶类化合物及其用途
WO2024083211A1 (zh) 2022-10-20 2024-04-25 成都赜灵生物医药科技有限公司 并杂环类氘代化合物及其用途
CN117946074A (zh) 2022-10-20 2024-04-30 上海海和药物研究开发股份有限公司 具有parp1抑制活性的化合物及其用途
WO2024083201A1 (zh) 2022-10-20 2024-04-25 成都赜灵生物医药科技有限公司 并杂环类化合物及其用途
CN120603832A (zh) 2022-11-09 2025-09-05 来凯制药(宁波)有限公司 稠合多环化合物及其作为parp1抑制剂的用途
WO2024099416A1 (zh) 2022-11-10 2024-05-16 上海海和药物研究开发股份有限公司 一种稠合三环类parp1抑制剂、其制备方法及用途
CN120035596A (zh) 2022-11-23 2025-05-23 江苏恒瑞医药股份有限公司 一种含氮杂环类化合物的可药用盐、晶型及制备方法
CN118084916A (zh) 2022-11-25 2024-05-28 成都赜灵生物医药科技有限公司 三并杂环类化合物及其用途
WO2024206172A1 (en) 2023-03-24 2024-10-03 Xinthera, Inc. Crystalline forms of an azetidine parp1 inhibitor
CN116987066B (zh) 2023-06-20 2025-07-25 四川大学 一种嘧啶类化合物及其制备方法和应用
CN117017962A (zh) 2023-08-23 2023-11-10 复旦大学附属肿瘤医院 一种hdaci抑制剂在制备治疗卵巢癌药物中的用途

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