JP2024071370A5 - - Google Patents
Info
- Publication number
- JP2024071370A5 JP2024071370A5 JP2023193597A JP2023193597A JP2024071370A5 JP 2024071370 A5 JP2024071370 A5 JP 2024071370A5 JP 2023193597 A JP2023193597 A JP 2023193597A JP 2023193597 A JP2023193597 A JP 2023193597A JP 2024071370 A5 JP2024071370 A5 JP 2024071370A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- represented
- formula
- following structure
- pharma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025149982A JP2025179208A (ja) | 2022-11-14 | 2025-09-10 | 大環状ｋｒａｓ阻害剤及び使用方法 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263383674P | 2022-11-14 | 2022-11-14 | |
| US63/383,674 | 2022-11-14 | ||
| US202363497978P | 2023-04-24 | 2023-04-24 | |
| US63/497,978 | 2023-04-24 | ||
| US202363582751P | 2023-09-14 | 2023-09-14 | |
| US63/582,751 | 2023-09-14 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025149982A Division JP2025179208A (ja) | 2022-11-14 | 2025-09-10 | 大環状ｋｒａｓ阻害剤及び使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024071370A JP2024071370A (ja) | 2024-05-24 |
| JP2024071370A5 true JP2024071370A5 (https=) | 2025-07-22 |
| JP7743484B2 JP7743484B2 (ja) | 2025-09-24 |
Family
ID=91085388
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023193597A Active JP7743484B2 (ja) | 2022-11-14 | 2023-11-14 | 大環状ｋｒａｓ阻害剤及び使用方法 |
| JP2025527103A Pending JP2025539080A (ja) | 2022-11-14 | 2023-11-14 | 大環状ｋｒａｓ阻害剤及び使用方法 |
| JP2025149982A Pending JP2025179208A (ja) | 2022-11-14 | 2025-09-10 | 大環状ｋｒａｓ阻害剤及び使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025527103A Pending JP2025539080A (ja) | 2022-11-14 | 2023-11-14 | 大環状ｋｒａｓ阻害剤及び使用方法 |
| JP2025149982A Pending JP2025179208A (ja) | 2022-11-14 | 2025-09-10 | 大環状ｋｒａｓ阻害剤及び使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US12570672B2 (https=) |
| EP (1) | EP4598921A1 (https=) |
| JP (3) | JP7743484B2 (https=) |
| KR (2) | KR102919887B1 (https=) |
| CN (1) | CN120500482A (https=) |
| AU (1) | AU2023382606A1 (https=) |
| CL (1) | CL2025001425A1 (https=) |
| CO (1) | CO2025006813A2 (https=) |
| IL (1) | IL320388A (https=) |
| JO (1) | JOP20250111A1 (https=) |
| MX (1) | MX2025005539A (https=) |
| PE (1) | PE20252237A1 (https=) |
| TW (1) | TW202430532A (https=) |
| UY (1) | UY40522A (https=) |
| WO (1) | WO2024107686A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120813588A (zh) | 2023-02-14 | 2025-10-17 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的三环化合物 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025123007A1 (en) * | 2023-12-08 | 2025-06-12 | Kestrel Therapeutics Inc. | Ras inhibitors and methods of use thereof |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025194054A1 (en) * | 2024-03-14 | 2025-09-18 | Amgen Inc. | Spirocyclic compounds as modulators of kras and uses thereof |
| TW202602882A (zh) * | 2024-03-14 | 2026-01-16 | 美商安進公司 | 作為ｋｒａｓ調節劑的大環化合物及其用途 |
| WO2025230862A1 (en) * | 2024-04-29 | 2025-11-06 | Amgen Inc. | Macrocyclic amino compounds as modulators of kras and uses therof |
| WO2025230860A1 (en) * | 2024-04-29 | 2025-11-06 | Amgen Inc. | Solid forms of macrocyclic compounds and uses thereof |
| WO2025230878A1 (en) * | 2024-04-29 | 2025-11-06 | Amgen Inc. | Macrocyclic compounds as modulators of kras and uses thereof |
| WO2025240465A1 (en) * | 2024-05-14 | 2025-11-20 | Amgen Inc. | Processes for preparing macrocyclic compounds |
| WO2025240582A1 (en) * | 2024-05-14 | 2025-11-20 | Amgen Inc. | Macrocyclic compounds as modulators of kras and uses thereof |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026035947A1 (en) | 2024-08-07 | 2026-02-12 | Tesseract Medicines Us, Llc | Kras-targeting covalent-induced drug conjugates comprising a topoisomerase payload |
| WO2026035945A1 (en) | 2024-08-07 | 2026-02-12 | Tesseract Medicines Us, Llc | Covalent-induced drug conjugates targeting kras and comprising a topoisomerase payload |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026055477A1 (en) * | 2024-09-06 | 2026-03-12 | Amgen Inc. | Macrocyclic compounds as modulators of kras and uses thereof |
| WO2026064527A1 (en) | 2024-09-19 | 2026-03-26 | Tesseract Medicines Us, Llc | Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload |
| WO2026064520A1 (en) | 2024-09-19 | 2026-03-26 | Tesseract Medicines Us, Llc | Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4302834A3 (en) | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| AU2018273356B2 (en) | 2017-05-22 | 2021-09-16 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| AU2018329920B2 (en) | 2017-09-08 | 2022-12-01 | Amgen Inc. | Inhibitors of KRAS G12C and methods of using the same |
| TW201930292A (zh) | 2017-10-12 | 2019-08-01 | 美商銳新醫藥公司 | 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物 |
| JP2022513967A (ja) | 2018-12-20 | 2022-02-09 | アムジエン・インコーポレーテツド | Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド |
| JP7686559B2 (ja) | 2018-12-20 | 2025-06-02 | アムジエン・インコーポレーテツド | Ｋｉｆ１８ａ阻害剤 |
| AU2019401495B2 (en) | 2018-12-20 | 2025-06-26 | Amgen Inc. | Heteroaryl amides useful as KIF18A inhibitors |
| MA54543A (fr) | 2018-12-20 | 2022-03-30 | Amgen Inc | Inhibiteurs de kif18a |
| MX2022002465A (es) * | 2019-08-29 | 2022-05-19 | Mirati Therapeutics Inc | Inhibidores de kras g12d. |
| CN115003668A (zh) * | 2020-01-21 | 2022-09-02 | 南京明德新药研发有限公司 | 作为kras抑制剂的大环类化合物 |
| JP2023553492A (ja) * | 2020-12-15 | 2023-12-21 | ミラティ セラピューティクス， インコーポレイテッド | アザキナゾリン汎ＫＲａｓ阻害剤 |
| EP4262803A4 (en) * | 2020-12-16 | 2025-03-12 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| BR112023016299A2 (pt) * | 2021-02-16 | 2023-11-28 | L Livermore Nat Security Llc | Composições e métodos para inibir kras |
| CA3211725A1 (en) * | 2021-03-17 | 2022-09-22 | Tao Jiang | Pyrimidine-fused cyclic compound, preparation method therefor and use thereof |
| US20250255868A1 (en) * | 2021-04-09 | 2025-08-14 | Hangzhou Innogate Pharma Co., Ltd. | Heterocyclic compound acting as kras g12d inhibitor |
| CN115304623A (zh) * | 2021-04-30 | 2022-11-08 | 四川海思科制药有限公司 | 一种嘧啶并环衍生物及其在医药上的应用 |
| WO2022246092A1 (en) | 2021-05-21 | 2022-11-24 | Blossomhill Therapeutics, Inc. | Macrocyclic compounds for treating disease |
| WO2023040989A1 (en) | 2021-09-16 | 2023-03-23 | Suzhou Zanrong Pharma Limited | Kras g12c inhibitors and uses thereof |
| EP4573095A1 (en) | 2022-08-17 | 2025-06-25 | Treeline Biosciences, Inc. | Pyridopyrimidine kras inhibitors |
-
2023
- 2023-11-14 AU AU2023382606A patent/AU2023382606A1/en active Pending
- 2023-11-14 EP EP23892383.3A patent/EP4598921A1/en active Pending
- 2023-11-14 UY UY0001040522A patent/UY40522A/es unknown
- 2023-11-14 IL IL320388A patent/IL320388A/en unknown
- 2023-11-14 PE PE2025001022A patent/PE20252237A1/es unknown
- 2023-11-14 TW TW112143850A patent/TW202430532A/zh unknown
- 2023-11-14 KR KR1020257019826A patent/KR102919887B1/ko active Active
- 2023-11-14 KR KR1020267002540A patent/KR20260017504A/ko active Pending
- 2023-11-14 JP JP2023193597A patent/JP7743484B2/ja active Active
- 2023-11-14 WO PCT/US2023/079582 patent/WO2024107686A1/en not_active Ceased
- 2023-11-14 JP JP2025527103A patent/JP2025539080A/ja active Pending
- 2023-11-14 CN CN202380088000.9A patent/CN120500482A/zh active Pending
-
2024
- 2024-03-25 US US18/614,911 patent/US12570672B2/en active Active
- 2024-10-30 US US18/931,588 patent/US20250304599A1/en active Pending
-
2025
- 2025-04-11 US US19/176,333 patent/US20250236631A1/en active Pending
- 2025-05-12 MX MX2025005539A patent/MX2025005539A/es unknown
- 2025-05-13 JO JOJO/P/2025/0111A patent/JOP20250111A1/ar unknown
- 2025-05-14 CL CL2025001425A patent/CL2025001425A1/es unknown
- 2025-05-23 CO CONC2025/0006813A patent/CO2025006813A2/es unknown
- 2025-09-10 JP JP2025149982A patent/JP2025179208A/ja active Pending