JP2018519244A5 - - Google Patents
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- JP2018519244A5 JP2018519244A5 JP2017551335A JP2017551335A JP2018519244A5 JP 2018519244 A5 JP2018519244 A5 JP 2018519244A5 JP 2017551335 A JP2017551335 A JP 2017551335A JP 2017551335 A JP2017551335 A JP 2017551335A JP 2018519244 A5 JP2018519244 A5 JP 2018519244A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compounds
- disease activity
- dose
- examples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 5
- 230000009266 disease activity Effects 0.000 description 3
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- TVZRAEYQIKYCPH-UHFFFAOYSA-N 3-(trimethylsilyl)propane-1-sulfonic acid Chemical compound C[Si](C)(C)CCCS(O)(=O)=O TVZRAEYQIKYCPH-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 125000002669 linoleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000005645 linoleyl group Chemical group 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150097040 | 2015-07-08 | ||
| KR20150097040 | 2015-07-08 | ||
| PCT/US2016/041563 WO2017008033A1 (en) | 2015-07-08 | 2016-07-08 | Pyrrolidine carboxamido derivatives and methods for preparing and using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018519244A JP2018519244A (ja) | 2018-07-19 |
| JP2018519244A5 true JP2018519244A5 (https=) | 2019-03-22 |
| JP6692371B2 JP6692371B2 (ja) | 2020-05-13 |
Family
ID=57686085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551335A Active JP6692371B2 (ja) | 2015-07-08 | 2016-07-08 | ピロリジンカルボキサミド誘導体ならびにその調製および使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20170008924A1 (https=) |
| EP (1) | EP3265443B1 (https=) |
| JP (1) | JP6692371B2 (https=) |
| KR (1) | KR101963559B1 (https=) |
| CN (2) | CN115368438A (https=) |
| AU (1) | AU2016290963B2 (https=) |
| BR (1) | BR112017022857B1 (https=) |
| CA (1) | CA2980001C (https=) |
| CL (1) | CL2017002689A1 (https=) |
| CO (1) | CO2017010530A2 (https=) |
| DK (1) | DK3265443T3 (https=) |
| EA (1) | EA033342B1 (https=) |
| ES (1) | ES2784703T3 (https=) |
| IL (1) | IL254327B (https=) |
| MX (1) | MX2017013335A (https=) |
| MY (1) | MY189670A (https=) |
| NZ (1) | NZ735250A (https=) |
| PH (1) | PH12017501790A1 (https=) |
| PL (1) | PL3265443T3 (https=) |
| PT (1) | PT3265443T (https=) |
| SA (1) | SA517390034B1 (https=) |
| SG (1) | SG11201707145QA (https=) |
| UA (1) | UA121890C2 (https=) |
| WO (1) | WO2017008033A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ735250A (en) | 2015-07-08 | 2020-08-28 | Research & Business Found Sungkyunkwan Univ | Pyrrolidine carboxamido derivatives and methods for preparing and using the same |
| EP3759070A4 (en) * | 2018-02-28 | 2021-12-08 | Bridge Biotherapeutics, Inc. | WATER-SOLUBLE SALTS OF LIPID PEPTIDES AND THEIR PREPARATION AND USE PROCESSES |
| SG11202104802RA (en) | 2018-11-08 | 2021-06-29 | Arizona Board Of Regents On Behalf Arizona State Univ | Synthetic immunomodulation with a crispr super-repressor in vivo |
| KR102104507B1 (ko) | 2019-08-23 | 2020-04-24 | 브릿지바이오테라퓨틱스(주) | 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법 |
| CN114585383B (zh) * | 2019-10-17 | 2024-04-19 | 艾弼生物科技有限公司 | 包含rip激酶抑制剂的用于防脱发或促生发的组合物 |
| KR102268702B1 (ko) * | 2019-10-17 | 2021-06-24 | 주식회사 에피바이오텍 | Rip 키나아제 억제제를 포함하는 탈모 방지 또는 발모 촉진용 조성물 |
| KR102394875B1 (ko) * | 2021-05-11 | 2022-05-06 | 주식회사 비드테크 | 피롤리딘을 링커로 포함하는 화합물 및 이를 포함하는 약학 조성물 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3839127A1 (de) * | 1988-11-19 | 1990-05-23 | Hoechst Ag | Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung |
| AUPM906594A0 (en) | 1994-10-26 | 1994-11-17 | Peptide Technology Limited | Synthetic polyunsaturated fatty acid analogues |
| ES2243996T3 (es) * | 1996-05-01 | 2005-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | Derivados carboxamida de pirrolidina, piperidina y hexahidroazepina utilizados en el tratamiento de trastornos de trombosis. |
| EP1004578B1 (en) * | 1998-11-05 | 2004-02-25 | Pfizer Products Inc. | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives |
| US7049283B2 (en) * | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
| JP2002297664A (ja) | 2001-04-03 | 2002-10-11 | Fuji Photo Film Co Ltd | 画像データ提供装置および画像データ提供プログラム |
| WO2003007876A2 (en) | 2001-06-25 | 2003-01-30 | University Of Massachusetts | N-fatty acid-amino acid conjugates and therapeutic uses |
| DE10259672A1 (de) * | 2002-12-18 | 2004-07-01 | Basf Ag | Verfahren zur Herstellung von Alkoxycarbonylamino-triazinen |
| JP2006157623A (ja) * | 2004-11-30 | 2006-06-15 | Funai Electric Co Ltd | 放送受信装置 |
| WO2006113942A2 (en) * | 2005-04-20 | 2006-10-26 | Schering Corporation | Method of inhibiting cathepsin activity |
| US7842662B2 (en) * | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| JP2010536341A (ja) * | 2007-08-15 | 2010-12-02 | アムニクス， インコーポレイテッド | 生物学的に活性なポリペプチドの特性を改変するための組成物および方法 |
| CN102067197A (zh) | 2008-06-26 | 2011-05-18 | 夏普株式会社 | 显示装置和电子设备 |
| JP5740689B2 (ja) | 2008-08-18 | 2015-06-24 | エンテラ バイオ エルティーディー． | タンパク質の経口投与用の方法および組成物 |
| KR101033041B1 (ko) | 2008-11-13 | 2011-05-09 | 조선대학교산학협력단 | 경보장치 고정 장치 |
| WO2010059922A1 (en) * | 2008-11-21 | 2010-05-27 | Ligand Pharmaceuticals Incorporated | Pyrrolidine carboxamide compounds |
| KR101151878B1 (ko) | 2010-06-08 | 2012-05-31 | 미원상사주식회사 | 지방산 트리펩타이드염 및 이를 함유하는 항균 조성물 |
| KR20100110282A (ko) | 2010-08-16 | 2010-10-12 | 황규태 | 쓰레기봉투용 뚜껑 |
| KR101348284B1 (ko) * | 2010-09-09 | 2014-01-03 | 주식회사 나이벡 | 인간 유래 세포 투과성 펩타이드와 생리활성 펩타이드 결합체 및 그 용도 |
| KR20120048864A (ko) | 2010-11-08 | 2012-05-16 | 주식회사 네오디엠 | 트리 펩타이드 유도체를 함유한 아토피 피부염 예방 및 치료용 조성물과 그 제조방법 |
| KR20130038426A (ko) | 2011-10-07 | 2013-04-18 | 성균관대학교산학협력단 | 지방산이 결합된 항당뇨 펩티드가 소수성 결합된 글리콜 키토산 히드로겔 및 이를 포함하는 당뇨병 예방 또는 치료용 약학적 조성물 |
| KR101359886B1 (ko) | 2011-12-28 | 2014-02-12 | 성균관대학교산학협력단 | 스매드 6번(Ｓｍａｄ６)으로부터 유래된 펩타이드를 유효성분으로 포함하는 패혈증 또는 패혈성 쇼크의 치료용 조성물 |
| US20150368197A1 (en) * | 2012-06-21 | 2015-12-24 | Radikal Therapeutics Ins. | Compositions and methods for treatment of inflammatory diseases of the lung |
| WO2015057820A2 (en) * | 2013-10-15 | 2015-04-23 | Roberts S Kenny | Peptide constructs and well-defined aggregates thereof |
| NZ735250A (en) | 2015-07-08 | 2020-08-28 | Research & Business Found Sungkyunkwan Univ | Pyrrolidine carboxamido derivatives and methods for preparing and using the same |
-
2016
- 2016-07-08 NZ NZ735250A patent/NZ735250A/en unknown
- 2016-07-08 MY MYPI2017703626A patent/MY189670A/en unknown
- 2016-07-08 AU AU2016290963A patent/AU2016290963B2/en active Active
- 2016-07-08 BR BR112017022857-2A patent/BR112017022857B1/pt active IP Right Grant
- 2016-07-08 PT PT168220531T patent/PT3265443T/pt unknown
- 2016-07-08 PL PL16822053T patent/PL3265443T3/pl unknown
- 2016-07-08 US US15/205,853 patent/US20170008924A1/en not_active Abandoned
- 2016-07-08 CN CN202210589872.0A patent/CN115368438A/zh active Pending
- 2016-07-08 DK DK16822053.1T patent/DK3265443T3/da active
- 2016-07-08 ES ES16822053T patent/ES2784703T3/es active Active
- 2016-07-08 EP EP16822053.1A patent/EP3265443B1/en active Active
- 2016-07-08 EA EA201791945A patent/EA033342B1/ru not_active IP Right Cessation
- 2016-07-08 MX MX2017013335A patent/MX2017013335A/es active IP Right Grant
- 2016-07-08 JP JP2017551335A patent/JP6692371B2/ja active Active
- 2016-07-08 CA CA2980001A patent/CA2980001C/en active Active
- 2016-07-08 WO PCT/US2016/041563 patent/WO2017008033A1/en not_active Ceased
- 2016-07-08 SG SG11201707145QA patent/SG11201707145QA/en unknown
- 2016-07-08 UA UAA201710114A patent/UA121890C2/uk unknown
- 2016-07-08 KR KR1020177028207A patent/KR101963559B1/ko active Active
- 2016-07-08 CN CN201680020220.8A patent/CN107531753A/zh active Pending
-
2017
- 2017-09-04 IL IL254327A patent/IL254327B/en active IP Right Grant
- 2017-09-27 SA SA517390034A patent/SA517390034B1/ar unknown
- 2017-09-28 PH PH12017501790A patent/PH12017501790A1/en unknown
- 2017-10-13 CO CONC2017/0010530A patent/CO2017010530A2/es unknown
- 2017-10-23 CL CL2017002689A patent/CL2017002689A1/es unknown
-
2018
- 2018-03-14 US US15/921,596 patent/US11365215B2/en active Active
-
2022
- 2022-08-03 US US17/817,252 patent/US20230018246A1/en not_active Abandoned
-
2024
- 2024-04-26 US US18/648,015 patent/US20240352067A1/en active Pending
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