CN114206850A - 作为crac抑制剂的2h-苯并吡喃衍生物 - Google Patents

作为crac抑制剂的2h-苯并吡喃衍生物 Download PDF

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CN114206850A
CN114206850A CN202080056888.4A CN202080056888A CN114206850A CN 114206850 A CN114206850 A CN 114206850A CN 202080056888 A CN202080056888 A CN 202080056888A CN 114206850 A CN114206850 A CN 114206850A
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compound
pharmaceutically acceptable
isomer
acceptable salt
formula
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CN114206850B (zh
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杨亚讯
江志赶
夏建华
魏巍
贺海鹰
陈曙辉
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Cisen Pharmaceutical Co ltd
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Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

一类带有吡嗪结构的化合物，具体公开了式(VII)所示化合物、其异构体或其药学上可接受的盐，及其在制备CRAC抑制剂中的应用。

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN202080056888.4A 2019-09-25 2020-09-25 作为crac抑制剂的2h-苯并吡喃衍生物 Active CN114206850B (zh)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
CN2019109153791 2019-09-25
CN201910915379 2019-09-25
CN201910942170 2019-09-30
CN2019109421704 2019-09-30
CN2019109951753 2019-10-18
CN201910995175 2019-10-18
CN2020102558520 2020-04-02
CN202010255852 2020-04-02
CN2020103502607 2020-04-28
CN202010350260 2020-04-28
CN202010528780 2020-06-11
CN2020105287802 2020-06-11
CN2020106470839 2020-07-07
CN202010647083 2020-07-07
CN202010885601 2020-08-28
CN2020108856010 2020-08-28
PCT/CN2020/117670 WO2021057890A1 (zh) 2019-09-25 2020-09-25 作为crac抑制剂的2h-苯并吡喃衍生物

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CN114206850A true CN114206850A (zh) 2022-03-18
CN114206850B CN114206850B (zh) 2024-01-26

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US (1) US20220380356A1 (zh)
EP (1) EP4043450A4 (zh)
JP (1) JP7481435B2 (zh)
CN (1) CN114206850B (zh)
WO (1) WO2021057890A1 (zh)

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CN117098756A (zh) * 2021-02-25 2023-11-21 辰欣药业股份有限公司 一种环丙基取代的苯并呋喃类化合物的晶型及其制备方法
WO2023090859A1 (ko) * 2021-11-17 2023-05-25 일동제약(주) 아이속사졸 유도체의 제조 방법 및 그의 신규한 중간체
CN114276310B (zh) * 2021-12-27 2023-11-03 武汉天马微电子有限公司 一种有机化合物及其应用
CN116396330B (zh) * 2023-06-09 2023-08-25 天津辰欣药物研究有限公司 一种环丙基取代的2h-苯并吡喃衍生物的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110263612A1 (en) * 2010-04-27 2011-10-27 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2014207648A1 (en) * 2013-06-24 2014-12-31 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
WO2017027400A1 (en) * 2015-08-07 2017-02-16 Calcimedica, Inc. Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury
WO2018140796A1 (en) * 2017-01-26 2018-08-02 Calcimedica, Inc. Crac channel inhibitor compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070057965A (ko) * 2004-09-21 2007-06-07 신타 파마슈티칼스 코프. 염증 및 면역 관련 용도를 위한 화합물
US8518950B2 (en) * 2005-01-25 2013-08-27 Synta Pharmaceuticals Corp. 2-amido pyrazines for inflammation and immune related uses
US20140256771A1 (en) * 2011-10-19 2014-09-11 Calcimedica, Inc. Compounds that modulate intracellular calcium
PT3778595T (pt) * 2015-02-27 2021-11-09 Calcimedica Inc Tratamento de pancreatite

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110263612A1 (en) * 2010-04-27 2011-10-27 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2014207648A1 (en) * 2013-06-24 2014-12-31 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
WO2017027400A1 (en) * 2015-08-07 2017-02-16 Calcimedica, Inc. Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury
WO2018140796A1 (en) * 2017-01-26 2018-08-02 Calcimedica, Inc. Crac channel inhibitor compositions

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EP4043450A4 (en) 2023-10-25
WO2021057890A1 (zh) 2021-04-01
US20220380356A1 (en) 2022-12-01
EP4043450A1 (en) 2022-08-17
CN114206850B (zh) 2024-01-26
JP7481435B2 (ja) 2024-05-10
JP2022549866A (ja) 2022-11-29

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