CO2017010530A2 - Derivados de pirrolidincarboxamido y métodos para prepararlos y usarlos - Google Patents

Derivados de pirrolidincarboxamido y métodos para prepararlos y usarlos

Info

Publication number
CO2017010530A2
CO2017010530A2 CONC2017/0010530A CO2017010530A CO2017010530A2 CO 2017010530 A2 CO2017010530 A2 CO 2017010530A2 CO 2017010530 A CO2017010530 A CO 2017010530A CO 2017010530 A2 CO2017010530 A2 CO 2017010530A2
Authority
CO
Colombia
Prior art keywords
pyrrolidinecarboxamide
derivatives
methods
prepare
salts
Prior art date
Application number
CONC2017/0010530A
Other languages
English (en)
Inventor
Gildon Choi
Sang Dal Rhee
Imran Ali
Chong Hak Chae
Seok Hee Park
Moon Kook Jeon
Youn Sook Lee
Kwangho Lee
Original Assignee
Research & Business Found Sungkyunkwan Univ
Korea Res Inst Chemical Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research & Business Found Sungkyunkwan Univ, Korea Res Inst Chemical Tech filed Critical Research & Business Found Sungkyunkwan Univ
Publication of CO2017010530A2 publication Critical patent/CO2017010530A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporcionan derivados de pirrolidincarboxamido, sus isómeros ópticos y sus sales que son capaces de prevenir, mejorar y/o tratar condiciones inflamatorias, que incluyen enfermedad de intestino inflamatorio y métodos para prepararlos y usarlos.
CONC2017/0010530A 2015-07-08 2017-10-13 Derivados de pirrolidincarboxamido y métodos para prepararlos y usarlos CO2017010530A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150097040 2015-07-08
PCT/US2016/041563 WO2017008033A1 (en) 2015-07-08 2016-07-08 Pyrrolidine carboxamido derivatives and methods for preparing and using the same

Publications (1)

Publication Number Publication Date
CO2017010530A2 true CO2017010530A2 (es) 2018-01-05

Family

ID=57686085

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0010530A CO2017010530A2 (es) 2015-07-08 2017-10-13 Derivados de pirrolidincarboxamido y métodos para prepararlos y usarlos

Country Status (25)

Country Link
US (3) US20170008924A1 (es)
EP (1) EP3265443B1 (es)
JP (1) JP6692371B2 (es)
KR (1) KR101963559B1 (es)
CN (2) CN107531753A (es)
AU (1) AU2016290963B2 (es)
BR (1) BR112017022857B1 (es)
CA (1) CA2980001C (es)
CL (1) CL2017002689A1 (es)
CO (1) CO2017010530A2 (es)
DK (1) DK3265443T3 (es)
EA (1) EA033342B1 (es)
ES (1) ES2784703T3 (es)
HK (1) HK1243078A1 (es)
IL (1) IL254327B (es)
MX (1) MX2017013335A (es)
MY (1) MY189670A (es)
NZ (1) NZ735250A (es)
PH (1) PH12017501790A1 (es)
PL (1) PL3265443T3 (es)
PT (1) PT3265443T (es)
SA (1) SA517390034B1 (es)
SG (1) SG11201707145QA (es)
UA (1) UA121890C2 (es)
WO (1) WO2017008033A1 (es)

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ES2784703T3 (es) 2015-07-08 2020-09-30 Research & Business Found Sungkyunkwan Univ Derivados de la pirrolidina carboxamida y métodos para preparar y utilizar la misma
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WO2021075870A1 (ko) * 2019-10-17 2021-04-22 주식회사 스템모어 Rip 키나아제 억제제를 포함하는 탈모 방지 또는 발모 촉진용 조성물
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Also Published As

Publication number Publication date
US20180208625A1 (en) 2018-07-26
DK3265443T3 (da) 2020-03-09
WO2017008033A8 (en) 2017-11-16
EP3265443A4 (en) 2018-11-07
PH12017501790A1 (en) 2018-04-02
KR101963559B1 (ko) 2019-03-28
CN115368438A (zh) 2022-11-22
UA121890C2 (uk) 2020-08-10
CL2017002689A1 (es) 2018-04-20
PL3265443T3 (pl) 2020-06-29
KR20170127000A (ko) 2017-11-20
HK1243078A1 (zh) 2018-07-06
MX2017013335A (es) 2018-06-06
EP3265443B1 (en) 2020-01-08
NZ735250A (en) 2020-08-28
EA033342B1 (ru) 2019-09-30
US20230018246A1 (en) 2023-01-19
SA517390034B1 (ar) 2021-12-23
US20170008924A1 (en) 2017-01-12
BR112017022857B1 (pt) 2023-09-26
US11365215B2 (en) 2022-06-21
WO2017008033A1 (en) 2017-01-12
AU2016290963A1 (en) 2017-09-28
EA201791945A1 (ru) 2018-06-29
CN107531753A (zh) 2018-01-02
EP3265443A1 (en) 2018-01-10
ES2784703T3 (es) 2020-09-30
JP2018519244A (ja) 2018-07-19
IL254327A0 (en) 2017-11-30
MY189670A (en) 2022-02-24
PT3265443T (pt) 2020-02-14
IL254327B (en) 2021-04-29
CA2980001A1 (en) 2017-01-12
SG11201707145QA (en) 2017-10-30
AU2016290963B2 (en) 2019-06-27
BR112017022857A2 (pt) 2018-07-17
JP6692371B2 (ja) 2020-05-13
CA2980001C (en) 2021-05-04

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