PL4497438T3 - Trójpierścieniowe inhibitory parp1 i ich zastosowania - Google Patents
Trójpierścieniowe inhibitory parp1 i ich zastosowaniaInfo
- Publication number
- PL4497438T3 PL4497438T3 PL24217893.7T PL24217893T PL4497438T3 PL 4497438 T3 PL4497438 T3 PL 4497438T3 PL 24217893 T PL24217893 T PL 24217893T PL 4497438 T3 PL4497438 T3 PL 4497438T3
- Authority
- PL
- Poland
- Prior art keywords
- tricyclic
- parp1 inhibitors
- parp1
- inhibitors
- tricyclic parp1
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263336078P | 2022-04-28 | 2022-04-28 | |
| US202263381482P | 2022-10-28 | 2022-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4497438T3 true PL4497438T3 (pl) | 2026-01-26 |
Family
ID=88420972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL23797297.1T PL4355749T3 (pl) | 2022-04-28 | 2023-04-27 | Trójpierścieniowe inhibitory parp1 i ich zastosowania |
| PL24217893.7T PL4497438T3 (pl) | 2022-04-28 | 2023-04-27 | Trójpierścieniowe inhibitory parp1 i ich zastosowania |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL23797297.1T PL4355749T3 (pl) | 2022-04-28 | 2023-04-27 | Trójpierścieniowe inhibitory parp1 i ich zastosowania |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US11795173B1 (pl) |
| EP (3) | EP4355749B1 (pl) |
| JP (2) | JP7728989B2 (pl) |
| KR (2) | KR102903399B1 (pl) |
| CN (1) | CN119173516A (pl) |
| AU (2) | AU2023259236B2 (pl) |
| CA (1) | CA3250945A1 (pl) |
| CL (2) | CL2024003262A1 (pl) |
| CO (1) | CO2024014603A2 (pl) |
| CR (1) | CR20240461A (pl) |
| DK (2) | DK4355749T3 (pl) |
| DO (1) | DOP2024000218A (pl) |
| ES (2) | ES3038967T3 (pl) |
| FI (2) | FI4355749T3 (pl) |
| HR (2) | HRP20251173T1 (pl) |
| HU (1) | HUE072274T2 (pl) |
| IL (1) | IL316278A (pl) |
| LT (2) | LT4355749T (pl) |
| MX (2) | MX2024013195A (pl) |
| NZ (1) | NZ815323A (pl) |
| PL (2) | PL4355749T3 (pl) |
| PT (2) | PT4355749T (pl) |
| SI (2) | SI4355749T1 (pl) |
| TW (2) | TW202540112A (pl) |
| WO (1) | WO2023212219A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL311024A (en) * | 2021-08-27 | 2024-04-01 | Impact Therapeutics Shanghai Inc | Substituted tricyclic compounds as parp inhibitors and use thereof |
| WO2023141290A1 (en) | 2022-01-21 | 2023-07-27 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| AU2023229992A1 (en) * | 2022-03-11 | 2024-10-10 | Impact Therapeutics (Shanghai), Inc. | Substituted tricyclic compounds as parp inhibitors and the use thereof |
| EP4493551A1 (en) | 2022-03-14 | 2025-01-22 | Slap Pharmaceuticals LLC | Multicyclic compounds |
| FI4355749T3 (fi) | 2022-04-28 | 2025-07-23 | Xinthera Inc | Trisyklisiä parp1:n estäjiä ja niiden käyttötapoja |
| CN117263943A (zh) * | 2022-09-09 | 2023-12-22 | 轩竹生物科技股份有限公司 | 聚（adp核糖）聚合酶选择性抑制剂 |
| IL320626A (en) * | 2022-11-10 | 2025-07-01 | Haihe Biopharma Co Ltd | Fused tricyclic parp1 inhibitor, method of preparation thereof, and use thereof |
| TW202525808A (zh) * | 2023-09-13 | 2025-07-01 | 大陸商上海瑛派藥業有限公司 | 用作ｐａｒｐ１抑制劑的化合物、其用途及包含其之組合物 |
| WO2025080589A1 (en) * | 2023-10-09 | 2025-04-17 | Incyte Corporation | Processes for preparing kras inhibitors |
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| IL320626A (en) | 2022-11-10 | 2025-07-01 | Haihe Biopharma Co Ltd | Fused tricyclic parp1 inhibitor, method of preparation thereof, and use thereof |
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| CN116987066B (zh) | 2023-06-20 | 2025-07-25 | 四川大学 | 一种嘧啶类化合物及其制备方法和应用 |
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