JP2021074025A5 - - Google Patents
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- JP2021074025A5 JP2021074025A5 JP2021025792A JP2021025792A JP2021074025A5 JP 2021074025 A5 JP2021074025 A5 JP 2021074025A5 JP 2021025792 A JP2021025792 A JP 2021025792A JP 2021025792 A JP2021025792 A JP 2021025792A JP 2021074025 A5 JP2021074025 A5 JP 2021074025A5
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- cyclic dinucleotide
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- 125000004122 cyclic group Chemical group 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 8
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 8
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 4
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 4
- 102100031256 Cyclic GMP-AMP synthase Human genes 0.000 claims 4
- 101710118064 Cyclic GMP-AMP synthase Proteins 0.000 claims 4
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 4
- 229960005305 adenosine Drugs 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 229940029575 guanosine Drugs 0.000 claims 4
- 210000005260 human cell Anatomy 0.000 claims 4
- 102000002227 Interferon Type I Human genes 0.000 claims 2
- 108010014726 Interferon Type I Proteins 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Claims (8)
- ＳＴＩＮＧ活性を増加させるか、
ｃＧＡＭＰシンターゼ（ｃＧＡＳ）の活性を増大させるか、
ヒト細胞における2'−5'ホスホジエステル連結を含む環状ジヌクレオチドのレベルを増大させるか、または
ヒト細胞におけるＩ型インターフェロン（ＩＦＮ）の産生を増大させる
ための、有効量の環状ジヌクレオチドを含む薬学的組成物であって、
該環状ジヌクレオチドが、１個の２'−５'ホスホジエステル連結および１個の３'−５'ホスホジエステル連結を含み、かつ該環状ジヌクレオチドのヌクレオシドがグアノシンおよびアデノシンからそれぞれ独立して選択されるが、ただし、該環状ジヌクレオチドが環状［Ｇ（２'５'）ｐＡ（３'５'）ｐ］ではない、薬学的組成物。 - ＳＴＩＮＧ活性を増加させるか、
ｃＧＡＭＰシンターゼ（ｃＧＡＳ）の活性を増大させるか、
ヒト細胞における2'−5'ホスホジエステル連結を含む環状ジヌクレオチドのレベルを増大させるか、または
ヒト細胞におけるＩ型インターフェロン（ＩＦＮ）の産生を増大させる
ことにより細胞増殖性疾患を治療するための、有効量の環状ジヌクレオチドを含む薬学的組成物であって、
該環状ジヌクレオチドが、１個の２'−５'ホスホジエステル連結および１個の３'−５'ホスホジエステル連結を含み、かつ該環状ジヌクレオチドのヌクレオシドがグアノシンおよびアデノシンからそれぞれ独立して選択されるが、ただし、該環状ジヌクレオチドが環状［Ｇ（２'５'）ｐＡ（３'５'）ｐ］ではない、薬学的組成物。 - 前記環状ジヌクレオチドが、グアノシンを含む、請求項１または２に記載の薬学的組成物。
- 前記環状ジヌクレオチドが、環状［Ｇ（２'５'）ｐＧ（３'５'）ｐ］である、請求項３に記載の薬学的組成物。
- 前記環状ジヌクレオチドが、アデノシンを含む、請求項１または２に記載の薬学的組成物。
- 前記環状ジヌクレオチドが、環状［Ａ（２'５'）ｐＡ（３'５'）ｐ］である、請求項５に記載の薬学的組成物。
- 前記環状ジヌクレオチドが、アデノシンおよびグアノシンを含む、請求項１または２に記載の薬学的組成物。
- 前記環状ジヌクレオチドが、環状［Ａ（２'５'）ｐＧ（３'５'）ｐ］である、請求項７に記載の薬学的組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361819499P | 2013-05-03 | 2013-05-03 | |
| US61/819,499 | 2013-05-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018237955A Division JP2019068829A (ja) | 2013-05-03 | 2018-12-20 | Ｉ型インターフェロンの環状ジヌクレオチド誘導法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021074025A JP2021074025A (ja) | 2021-05-20 |
| JP2021074025A5 true JP2021074025A5 (ja) | 2021-08-19 |
Family
ID=51841746
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512084A Pending JP2016518140A (ja) | 2013-05-03 | 2014-05-02 | Ｉ型インターフェロンの環状ジヌクレオチド誘導法 |
| JP2018237955A Pending JP2019068829A (ja) | 2013-05-03 | 2018-12-20 | Ｉ型インターフェロンの環状ジヌクレオチド誘導法 |
| JP2021025792A Withdrawn JP2021074025A (ja) | 2013-05-03 | 2021-02-22 | Ｉ型インターフェロンの環状ジヌクレオチド誘導法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512084A Pending JP2016518140A (ja) | 2013-05-03 | 2014-05-02 | Ｉ型インターフェロンの環状ジヌクレオチド誘導法 |
| JP2018237955A Pending JP2019068829A (ja) | 2013-05-03 | 2018-12-20 | Ｉ型インターフェロンの環状ジヌクレオチド誘導法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20140329889A1 (ja) |
| EP (1) | EP2992000B1 (ja) |
| JP (3) | JP2016518140A (ja) |
| CN (1) | CN105377867B (ja) |
| ES (1) | ES2822584T3 (ja) |
| WO (1) | WO2014179760A1 (ja) |
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2014
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2019
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2021
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