PL2019683T5 - Podawanie czynników wzrostu do leczenia zaburzeń OUN - Google Patents
Podawanie czynników wzrostu do leczenia zaburzeń OUNInfo
- Publication number
- PL2019683T5 PL2019683T5 PL07761286.9T PL07761286T PL2019683T5 PL 2019683 T5 PL2019683 T5 PL 2019683T5 PL 07761286 T PL07761286 T PL 07761286T PL 2019683 T5 PL2019683 T5 PL 2019683T5
- Authority
- PL
- Poland
- Prior art keywords
- administration
- treatment
- growth factors
- cns disorders
- cns
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/242—Gold; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/244—Lanthanides; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
- A61K51/1234—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Psychiatry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79501206P | 2006-04-25 | 2006-04-25 | |
PCT/US2007/067423 WO2007127803A2 (en) | 2006-04-25 | 2007-04-25 | Administration of growth factors for the treatment of cns disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
PL2019683T3 PL2019683T3 (pl) | 2017-06-30 |
PL2019683T5 true PL2019683T5 (pl) | 2022-12-05 |
Family
ID=38656355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL07761286.9T PL2019683T5 (pl) | 2006-04-25 | 2007-04-25 | Podawanie czynników wzrostu do leczenia zaburzeń OUN |
Country Status (12)
Country | Link |
---|---|
US (5) | US7922999B2 (pl) |
EP (1) | EP2019683B2 (pl) |
JP (2) | JP6105187B2 (pl) |
AU (1) | AU2007244826B2 (pl) |
BR (1) | BRPI0710800A2 (pl) |
DK (1) | DK2019683T4 (pl) |
ES (1) | ES2618787T5 (pl) |
HU (1) | HUE030903T2 (pl) |
PL (1) | PL2019683T5 (pl) |
PT (1) | PT2019683T (pl) |
SI (1) | SI2019683T2 (pl) |
WO (1) | WO2007127803A2 (pl) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
US7276580B2 (en) | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
NZ574121A (en) | 2003-04-18 | 2011-06-30 | Biogen Idec Inc | Polyethylene glycol-conjugated gylcosylated neublastin and uses thereof for treatment of pain |
NZ553431A (en) * | 2004-08-19 | 2010-04-30 | Biogen Idec Inc | Neublastin variants with decreased heparin binding |
CA2577690C (en) * | 2004-08-19 | 2013-08-06 | Biogen Idec Ma Inc. | Refolding transforming growth factor beta family proteins |
DK1807009T3 (en) | 2004-10-05 | 2015-03-02 | Genzyme Corp | Stair shaped needle |
WO2007024841A2 (en) | 2005-08-23 | 2007-03-01 | The Regents Of The University Of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
TWI501774B (zh) * | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
EP1872790A1 (en) * | 2006-06-26 | 2008-01-02 | DeveloGen Aktiengesellschaft | New formulation for increasing bioavailability of neurturin |
EP2142205B1 (en) | 2007-05-01 | 2014-04-02 | Biogen Idec MA Inc. | Neublastin peptides for use in increasing vascularisation in tissue with impaired blood flow |
US20090130017A1 (en) * | 2007-11-19 | 2009-05-21 | Searete Llc | Targeted short-lived drug delivery |
US20100021422A1 (en) * | 2008-03-05 | 2010-01-28 | Regenerative Research Foundation | Methods and compositions for delivery of exogenous factors to nervous system sites |
JP5874881B2 (ja) | 2009-10-06 | 2016-03-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 遺伝子改変されたマウスおよび移植方法 |
EP2558154B1 (en) | 2010-04-16 | 2020-06-17 | ClearPoint Neuro, Inc. | Mri surgical systems including mri-compatible surgical cannulae for transferring a substance to and/or from a patient |
US9045751B2 (en) | 2010-04-28 | 2015-06-02 | The Regents Of The University Of California | Modified small activating RNA molecules and methods of use |
US8481308B2 (en) | 2010-07-01 | 2013-07-09 | Regenerative Research Foundation | Methods for culturing undifferentiated cells using sustained release compositions |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
AU2011336470B8 (en) | 2010-12-01 | 2017-09-14 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
GB201101167D0 (en) * | 2011-01-22 | 2011-03-09 | Renishaw Plc | Convection enhanced delivery apparatus and method |
MX350385B (es) | 2011-02-15 | 2017-09-04 | Regeneron Pharma | Ratones de m-csf humanizada. |
US20130280222A1 (en) | 2012-04-18 | 2013-10-24 | Board Of Regents Of The University Of Texas System | Non-disruptive gene targeting |
ES2960803T3 (es) | 2012-05-25 | 2024-03-06 | Univ California | Métodos y composiciones para la modificación de ADN diana dirigida por RNA y para la modulación de la transcripción dirigida por RNA |
JP6283031B2 (ja) | 2012-09-07 | 2018-02-21 | イエール ユニバーシティ | 遺伝学的に修飾された非ヒト動物およびその使用法 |
WO2014071397A2 (en) | 2012-11-05 | 2014-05-08 | Regeneron Pharmaceuticals | Genetically modified non-human animals and methods of use thereof |
ES2822584T3 (es) | 2013-05-03 | 2021-05-04 | Univ California | Inducción de dinucleótidos cíclicos del interferón tipo I |
WO2014202833A1 (en) * | 2013-06-18 | 2014-12-24 | University Of Helsinki | Treatment of neuronal injuries |
US9891296B2 (en) | 2013-09-13 | 2018-02-13 | MRI Interventions, Inc. | Intrabody fluid transfer devices, systems and methods |
JP6683615B2 (ja) | 2013-09-19 | 2020-04-22 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 肝細胞様細胞を産生するための方法および組成物 |
US9932607B2 (en) | 2013-11-15 | 2018-04-03 | The Board Of Trustees Of The Leland Stanford Junior University | Site-specific integration of transgenes into human cells |
JP2016537028A (ja) | 2013-11-18 | 2016-12-01 | クリスパー セラピューティクス アーゲー | Crispr−casシステムの材料及び方法 |
EP3835419A1 (en) | 2013-12-12 | 2021-06-16 | The Regents of The University of California | Methods and compositions for modifying a single stranded target nucleic acid |
CN106460009A (zh) | 2014-03-21 | 2017-02-22 | 小利兰·斯坦福大学托管委员会 | 无核酸酶的基因组编辑 |
US10982228B2 (en) | 2014-05-02 | 2021-04-20 | Genzyme Corporation | AAV vectors for retinal and CNS gene therapy |
FI3841877T3 (fi) | 2014-05-19 | 2023-12-01 | Regeneron Pharma | Ihmisen epo:a ilmentäviä geneettisesti muunneltuja hiiriä |
EP3215191A4 (en) | 2014-11-05 | 2018-08-01 | Voyager Therapeutics, Inc. | Aadc polynucleotides for the treatment of parkinson's disease |
US10377818B2 (en) | 2015-01-30 | 2019-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treating glioma |
SG11201706445SA (en) | 2015-02-10 | 2017-09-28 | Genzyme Corp | Enhanced delivery of viral particles to the striatum and cortex |
US10883117B2 (en) | 2015-03-24 | 2021-01-05 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
PT3282835T (pt) | 2015-04-13 | 2023-07-25 | Univ Yale | Ratinhos knockin de sirpa-il15 humanizadas e métodos de utilização dos mesmos |
EP3352776A4 (en) | 2015-09-23 | 2019-03-13 | Sangamo Therapeutics, Inc. | HTT REPRESSORS AND USES THEREOF |
WO2017064546A1 (en) | 2015-09-24 | 2017-04-20 | Crispr Therapeutics Ag | Novel family of rna-programmable endonucleases and their uses in genome editing and other applications |
WO2017142698A1 (en) | 2016-02-17 | 2017-08-24 | MRI Interventions, Inc. | Intrabody surgical fluid transfer assemblies with adjustable exposed cannula to needle tip length, related systems and methods |
US20200291368A1 (en) | 2016-03-11 | 2020-09-17 | Wageningen Universiteit | Improved CRISPR-Cpf1 Genome Editing Tool |
WO2017155408A1 (en) | 2016-03-11 | 2017-09-14 | Erasmus University Medical Center Rotterdam | Improved crispr-cas9 genome editing tool |
US11298041B2 (en) | 2016-08-30 | 2022-04-12 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
US11332713B2 (en) | 2016-11-16 | 2022-05-17 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
AU2017367722B2 (en) | 2016-12-01 | 2024-02-01 | Sangamo Therapeutics, Inc. | Tau modulators and methods and compositions for delivery thereof |
CN110582302A (zh) | 2016-12-14 | 2019-12-17 | 利甘达尔股份有限公司 | 用于核酸和/或蛋白有效负载递送的组合物和方法 |
AU2018272068A1 (en) * | 2017-05-25 | 2020-01-16 | Icahn School Of Medicine At Mount Sinai | Method and composition for generating basal forebrain cholinergic neurons (BFCNs) |
JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
CN111132626B (zh) | 2017-07-17 | 2024-01-30 | 沃雅戈治疗公司 | 轨迹阵列引导系统 |
MA50578A (fr) | 2017-11-09 | 2021-09-15 | Vertex Pharma | Systèmes crispr/cas pour le traitement de dmd |
WO2019118935A1 (en) | 2017-12-14 | 2019-06-20 | Casebia Therapeutics Limited Liability Partnership | Novel rna-programmable endonuclease systems and their use in genome editing and other applications |
WO2019123414A1 (en) | 2017-12-22 | 2019-06-27 | Straximm Llp | Engineered viruses expressing cyclic gmp-amp synthase |
JP2021518160A (ja) | 2018-03-15 | 2021-08-02 | ケーエスキュー セラピューティクス, インコーポレイテッド | 免疫療法の改善のための遺伝子調節組成物及び遺伝子調節方法 |
EP3765094A4 (en) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | GENE REGULATION COMPOSITIONS AND METHODS FOR IMPROVING IMMUNOTHERAPY |
MA52074A (fr) | 2018-03-19 | 2021-01-27 | Bayer Healthcare Llc | Nouveaux systèmes d'endonucléase à arn programmable et leurs utilisations |
US11253237B2 (en) | 2018-05-09 | 2022-02-22 | Clearpoint Neuro, Inc. | MRI compatible intrabody fluid transfer systems and related devices and methods |
EP3781074A1 (en) | 2018-05-09 | 2021-02-24 | ClearPoint Neuro, Inc. | Mri compatible intrabody fluid transfer systems and related devices and methods |
WO2019222564A1 (en) * | 2018-05-18 | 2019-11-21 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of alzheimer's disease |
CN109381488A (zh) * | 2018-12-22 | 2019-02-26 | 包桂荣 | 癫痫病的外用药剂及制备方法 |
WO2020152607A1 (en) | 2019-01-22 | 2020-07-30 | St. Jude Children's Research Hospital | Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration |
US20220145330A1 (en) | 2019-02-10 | 2022-05-12 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads | Modified mitochondrion and methods of use thereof |
WO2020209959A1 (en) | 2019-03-08 | 2020-10-15 | Crispr Therapeutics Ag | Nucleobase-editing fusion protein systems, compositions, and uses thereof |
WO2020186059A2 (en) | 2019-03-12 | 2020-09-17 | Crispr Therapeutics Ag | Novel high fidelity rna-programmable endonuclease systems and uses thereof |
CN110192859B (zh) * | 2019-05-05 | 2020-05-19 | 兰月 | 一种磁共振测量人脑类淋巴通路清除效率的方法 |
US20210047649A1 (en) | 2019-05-08 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Crispr/cas all-in-two vector systems for treatment of dmd |
US11684750B2 (en) | 2019-10-08 | 2023-06-27 | Clearpoint Neuro, Inc. | Extension tube assembly and related medical fluid transfer systems and methods |
WO2022018638A1 (en) | 2020-07-21 | 2022-01-27 | Crispr Therapeutics Ag | Genome-editing compositions and methods to modulate faah for treatment of neurological disorders |
IL308896A (en) | 2021-06-11 | 2024-01-01 | Bayer Ag | Programmable type V RNA endoclase systems |
EP4101928A1 (en) | 2021-06-11 | 2022-12-14 | Bayer AG | Type v rna programmable endonuclease systems |
EP4144841A1 (en) | 2021-09-07 | 2023-03-08 | Bayer AG | Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof |
WO2023118068A1 (en) | 2021-12-23 | 2023-06-29 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
WO2023237587A1 (en) | 2022-06-10 | 2023-12-14 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US37410A (en) | 1863-01-13 | Improvement in machines for seaming metal roofing | ||
US5843473A (en) | 1989-10-20 | 1998-12-01 | Sequus Pharmaceuticals, Inc. | Method of treatment of infected tissues |
DK0610254T3 (da) | 1991-09-20 | 2005-01-10 | Amgen Inc | Glial-afledt neurotrofisk faktor |
WO1995005864A1 (en) | 1993-08-27 | 1995-03-02 | Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Convection-enhanced drug delivery |
FR2717824B1 (fr) | 1994-03-25 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
CN1148812A (zh) | 1994-03-28 | 1997-04-30 | 尼科梅德成像有限公司 | “脂质体” |
WO1995028493A1 (en) | 1994-04-13 | 1995-10-26 | The Rockefeller University | Aav-mediated delivery of dna to cells of the nervous system |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5733875A (en) * | 1994-11-15 | 1998-03-31 | Amgen Inc. | Methods of using GDNF as a neuroprotective agent |
FR2727867B1 (fr) | 1994-12-13 | 1997-01-31 | Rhone Poulenc Rorer Sa | Transfert de genes dans les motoneurones medullaires au moyen de vecteurs adenoviraux |
US5830857A (en) | 1995-07-14 | 1998-11-03 | Amgen Inc. | Method of treating epilepsy |
US5731284A (en) | 1995-09-28 | 1998-03-24 | Amgen Inc. | Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product |
US5741778A (en) | 1996-03-19 | 1998-04-21 | Amgen Inc. | Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product |
WO1998020857A1 (en) | 1996-11-12 | 1998-05-22 | The Regents Of The University Of California | Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery |
US6042579A (en) | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
ES2288766T3 (es) * | 1997-09-09 | 2008-01-16 | Curis, Inc. | Efectos sinergicos de morfogenes op/bmp y factores neurotroficos gdnf/ngf. |
EP1011712B1 (en) | 1997-09-19 | 2004-02-11 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Combination of cytokines having neurotrophic activity |
US7157435B2 (en) | 1998-04-15 | 2007-01-02 | The Regents Of The University Of California | Methods for modulation of the effects of aging on the primate brain |
US6451306B1 (en) | 1998-04-15 | 2002-09-17 | The Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
US6815431B2 (en) | 1998-04-15 | 2004-11-09 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
WO1999061066A2 (en) | 1998-05-27 | 1999-12-02 | Avigen, Inc. | Convection-enhanced delivery of aav vectors |
US7018628B1 (en) | 1998-07-24 | 2006-03-28 | Aventis Pharma S.A. | Vectors derived from baculovirus and use for transferring nucleic acids into nerve cells of vertebrates |
US6800281B2 (en) | 2000-11-09 | 2004-10-05 | Oxford Biomedica (Uk) Limited | Lentiviral-mediated growth factor gene therapy for neurodegenerative diseases |
CA2327208A1 (en) | 2000-11-30 | 2002-05-30 | The Government Of The United States Of America | Methods of increasing distribution of therapeutic agents |
US7182944B2 (en) | 2001-04-25 | 2007-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of increasing distribution of nucleic acids |
IL162838A0 (en) | 2002-01-04 | 2005-11-20 | Univ Rockefeller | Compositions and methods for prevention and treatment peptide-of amyloid- related disorders |
AU2003299140B2 (en) | 2002-09-24 | 2008-07-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for convection enhanced delivery of therapeutic agents |
US8946151B2 (en) | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
US20040209810A1 (en) * | 2003-02-24 | 2004-10-21 | Gill Steven S. | Method of treating Parkinson's disease in humans by intraputaminal infusion of glial cell-line derived neurotrophic factor |
CA2530224A1 (en) | 2003-07-09 | 2005-02-24 | California Pacific Medical Center | Remote detection of substance delivery to cells |
US20060258576A1 (en) * | 2003-09-05 | 2006-11-16 | Licentia, Ltd | Gdnf-related neuropeptides |
CA2566559C (en) | 2004-05-17 | 2014-05-06 | Inex Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
GB2414934A (en) * | 2004-06-11 | 2005-12-14 | Gill Steven Streatfield | Treatment of Parkinson's disease with GDNF |
-
2007
- 2007-04-25 WO PCT/US2007/067423 patent/WO2007127803A2/en active Application Filing
- 2007-04-25 JP JP2009507946A patent/JP6105187B2/ja active Active
- 2007-04-25 ES ES07761286T patent/ES2618787T5/es active Active
- 2007-04-25 DK DK07761286.9T patent/DK2019683T4/da active
- 2007-04-25 AU AU2007244826A patent/AU2007244826B2/en active Active
- 2007-04-25 PT PT77612869T patent/PT2019683T/pt unknown
- 2007-04-25 PL PL07761286.9T patent/PL2019683T5/pl unknown
- 2007-04-25 EP EP07761286.9A patent/EP2019683B2/en active Active
- 2007-04-25 SI SI200731906T patent/SI2019683T2/sl unknown
- 2007-04-25 US US11/740,124 patent/US7922999B2/en active Active
- 2007-04-25 BR BRPI0710800-1A patent/BRPI0710800A2/pt not_active Application Discontinuation
- 2007-04-25 HU HUE07761286A patent/HUE030903T2/en unknown
-
2011
- 2011-04-01 US US13/078,357 patent/US8409548B2/en active Active
-
2013
- 2013-02-28 US US13/781,174 patent/US9050299B2/en active Active
-
2014
- 2014-08-04 JP JP2014158520A patent/JP6190336B2/ja active Active
-
2015
- 2015-05-08 US US14/707,868 patent/US9724387B2/en active Active
-
2017
- 2017-08-04 US US15/669,372 patent/US20180140672A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2618787T3 (es) | 2017-06-22 |
BRPI0710800A2 (pt) | 2012-01-17 |
JP6190336B2 (ja) | 2017-08-30 |
JP2014224140A (ja) | 2014-12-04 |
US20140017297A1 (en) | 2014-01-16 |
US20070254842A1 (en) | 2007-11-01 |
US9050299B2 (en) | 2015-06-09 |
PT2019683T (pt) | 2017-03-17 |
AU2007244826A1 (en) | 2007-11-08 |
ES2618787T5 (es) | 2022-10-21 |
DK2019683T3 (en) | 2017-03-20 |
EP2019683A4 (en) | 2010-08-11 |
WO2007127803A3 (en) | 2008-10-23 |
US9724387B2 (en) | 2017-08-08 |
SI2019683T1 (sl) | 2017-04-26 |
US20150313962A1 (en) | 2015-11-05 |
EP2019683A2 (en) | 2009-02-04 |
DK2019683T4 (da) | 2022-08-29 |
US20120009245A1 (en) | 2012-01-12 |
EP2019683B1 (en) | 2016-12-14 |
WO2007127803A2 (en) | 2007-11-08 |
HUE030903T2 (en) | 2017-06-28 |
US8409548B2 (en) | 2013-04-02 |
PL2019683T3 (pl) | 2017-06-30 |
SI2019683T2 (sl) | 2022-10-28 |
JP2009535359A (ja) | 2009-10-01 |
JP6105187B2 (ja) | 2017-03-29 |
AU2007244826B2 (en) | 2013-04-11 |
US7922999B2 (en) | 2011-04-12 |
US20180140672A1 (en) | 2018-05-24 |
EP2019683B2 (en) | 2022-08-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL2019683T5 (pl) | Podawanie czynników wzrostu do leczenia zaburzeń OUN | |
IL208607A0 (en) | Improved nanobodiestm for the treatment of aggregation-mediated disorders | |
GB201001047D0 (en) | Methods and compositions for the treatment of neurological disorders | |
IL192692A0 (en) | Compounds for the treatment of inflammatory disorders | |
IL192691A0 (en) | Hydantoin compounds for the treatment of inflammatory disorders | |
EP1976377A4 (en) | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | |
EP1983972A4 (en) | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | |
IL195203A0 (en) | Compounds for the treatment of metabolic disorders | |
EP2139475A4 (en) | USE OF PDE7 INHIBITORS IN THE TREATMENT OF | |
ZA200806455B (en) | Use of 2-imidazoles for the treatment of CNS disorders | |
IL192852A0 (en) | Compounds for the treatment of metabolic disorders | |
IL193799A0 (en) | New therapeutic combinations for the treatment or prevention of psycotic disorders | |
IL192877A0 (en) | Use of 2-imidazoles for the treatment of cns disorders | |
IL192933A0 (en) | Benzoisoindole derivatives for the treatment of pain | |
EP1901770A4 (en) | METHOD FOR TREATING GROWTH TROUBLESHOOTING | |
IL192851A0 (en) | Compounds for the treatment of metabolic disorders | |
IL195392A0 (en) | Compounds for the treatment of metabolic disorders | |
PL1982178T3 (pl) | Sposoby leczenia zaburzeń afektywnych | |
GB0604782D0 (en) | Use of substituted pyrimidinyl-2-piperazine compounds for the treatment of food related disorders | |
HK1129112A1 (en) | 2 -alkyl- indazole compounds for the treatment of certain cns-related disorders | |
IL193414A0 (en) | Meridamycin analogues for the treatment ofneurodegenererative disorders | |
GB0604772D0 (en) | Use of substituted amine compounds for the treatment of food related disorders | |
IL192982A0 (en) | Compounds for the treatment of metabolic disorders | |
ZA200806180B (en) | Benzoisoindole derivatives for the treatment of pain | |
GB0724947D0 (en) | Composition for the treatment of psychiatric disorders |